Abstracts tagged "osteoarthritis and pain"

Abstract Number: 1282 • 2014 ACR/ARHP Annual Meeting
Systemic Pain Modulation Is Related to Body Perception in People with Knee Osteoarthritis
Jennifer Stevens-Lapsley¹ and Andrew Kittelson², ¹Physical Therapy Program, UCD Physical Therapy Program, Aurora, CO, ²Rehabilitation Science PhD Program, University of Colorado Denver, Aurora, CO
Background/Purpose Cortically mediated changes in body perception have been linked to a variety of chronic pain conditions, including knee osteoarthritis (OA). However, associations between body…
Abstract Number: 1280 • 2014 ACR/ARHP Annual Meeting
Relationship of Buckling and Knee Injury to Pain Exacerbation in Knee Osteoarthritis: A Web-Based Case-Crossover Stud
Isabelle Zobel^1,2, Tahereh Erfani³, Kim Bennell⁴, Joanna Makovey³, Ben Metcalf⁴, Jian Sheng Chen⁵, Lyn March³, Yuqing Zhang⁶, Felix Eckstein⁷ and David J. Hunter³, ¹Institute of Anatomy, Paracelsus Medical University Salzburg, Salzburg, Austria, ²Institute of Bone and Joint Research, Kolling Institute, University of Sydney, St Leonards, Australia, ³Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁴University of Melbourne, Melbourne, Australia, ⁵Rheumatology Royal North Shore Hospital, University of Sydney Institute of Bone and Joint Research, St Leonards, Australia, ⁶Boston University School of Medicine, Boston, MA, ⁷Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
Background/Purpose Knee osteoarthritis (OA) pain is neither constant nor stable and exacerbations of pain are disabling. We examined whether knee injury and buckling (giving way)…
Abstract Number: 926 • 2014 ACR/ARHP Annual Meeting
Does a Family History of Total Knee Replacement for Knee Osteoarthritis Influence Knee Pain and Structural Progression? a Prospective Longitudinal Cohort Study
Feng Pan¹, Hussain Khan¹, Changhai Ding¹, Tania Winzenberg², Johanne Martel-Pelletier³, Jean-Pierre Pelletier³, Flavia Cicuttini⁴ and Graeme Jones¹, ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ²Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ⁴Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: Genetic factors appear to play an important role in the pathogenesis of both knee pain and radiographic osteoarthritis (OA) based on cross-sectional studies but…
Abstract Number: 2142 • 2013 ACR/ARHP Annual Meeting
Long-Term Safety and Efficacy Of Subcutaneous Tanezumab In Patients With Knee Or Hip Osteoarthritis (NCT00994890)
Leslie Tive¹, Eugene J. Dabezies², Robert J. Fountaine³, Mark T. Brown³, Michael D. Smith³, Kenneth M. Verburg³ and Christine R. West⁴, ¹Arthritis, Pfizer Inc, New York, NY, ²Pensacola Research Consultants, Pensacola, FL, ³Pfizer, Inc., Groton, CT, ⁴Clinical Sciences, Pfizer, Williamston, MI
Background/Purpose : Tanezumab (TNZ), a monoclonal antibody that inhibits nerve growth factor, reduces hip or knee osteoarthritis (OA) pain. A non-controlled, randomized, double-blind study of…
Abstract Number: 2146 • 2013 ACR/ARHP Annual Meeting
Effects Of Chondroitin Sulfate On Brain Response To Painful Stimulation In Knee Osteoarthritis Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Jordi Monfort¹, Jesús Pujol², O Contreras-Rodriguez², Jone Llorente-Onaindia², M López-Solà², Laura Blanco-Hinojo², J Deus², H Ortiz², Francisco Montañés³, M Campillo², Pere Benito², Laura Sánchez⁴, Marta Herrero⁵ and Josep Vergés⁶, ¹Reumatologia, Hospital del Mar, Barcelona, Spain, ²Hospital del Mar, Barcelona, Spain, ³Rhaumatology, Hospital del Mar, Barcelona, Spain, ⁴Bioiberica, Barcelona, Spain, ⁵Pharmascience Division, Bioiberica S.A., Barcelona, Spain, ⁶Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain
Background/Purpose: Knee osteoarthritis (OA) is a degenerative joint disease causing symptoms in 12% of people over the age of 65 . A variety of treatments…
Abstract Number: 2128 • 2013 ACR/ARHP Annual Meeting
Longitudinal Relation Of Sensitization To Incident Knee Pain, Incident Symptomatic Knee Osteoarthritis and Increase In Pain Severity: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, Michael C. Nevitt², Joachim Scholz³, Lars Arendt-Nielsen⁴, Clifford Woolf⁵, Laurence A. Bradley⁶, Emily Sisson¹ and Laura Frey-Law⁷, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ³Columbia University, New York, NY, ⁴Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁵F.M. Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA, ⁶Div of Rheumatology, Univ of Alabama-Birmingham, Birmingham, AL, ⁷University of Iowa, Iowa City, IA
Background/Purpose: Peripheral and central sensitization is associated with knee pain severity in knee osteoarthritis (OA). Whether sensitization occurs prior to or only concurrently with development…
Abstract Number: 1249 • 2013 ACR/ARHP Annual Meeting
Contrasting Pathophysiology and Behavioural Responses Associated With Osteoarthritis and An Inflammatory Arthropathy
Sanaa Zaki¹, Margaret M. Smith², Susan Smith¹, Mark Connor³ and Christopher B. Little², ¹Raymond Purves Bone and Joint Research Laboratories, University of Sydney, St Leonards, Australia, ²Raymond Purves Bone and Joint Research Labs, University of Sydney, St Leonards, Australia, ³Australian School of Advanced Medicine, Macquarie University, North Ryde, Australia
Background/Purpose: Osteoarthritis (OA) affects more than 15% of the population, and is the major cause of disability in people over 60. There are no therapies…
Abstract Number: 260 • 2013 ACR/ARHP Annual Meeting
Pain, Functional Impairment and Ultrasound Detected Changes In Patients With Erosive and Non-Erosive Hand Osteoarthritis
Olga Sleglova¹, Olga Ruzickova², Karel Pavelka³ and Ladislav Senolt⁴, ¹Institute of Rheumatology, Prague, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³Institute of Rheumatology and Department of Rheumatology, 1st Medical Faculty, Charles University Prague, Prague, Czech Republic, ⁴Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
Background/Purpose: Hand osteoarthritis (HOA) is a common and frequent cause of pain. HOA is a heterogeneous group of disorders with two main subsets including non-erosive…
Abstract Number: 256 • 2013 ACR/ARHP Annual Meeting
Classification Of Alignment By Self-Report Versus Radiograph Results In Unexpected and Discrepant Pain and Functional Outcomes
E Megan Erickson¹, Jeffrey B. Driban¹, Lori Lyn Price², Chenchen Wang¹, Timothy E. McAlindon³ and William F. Harvey¹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ³Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Malalignment is a potential risk factor for structural progression of knee osteoarthritis (OA), but data conflict as to its association with knee pain. We…
Abstract Number: 81 • 2013 ACR/ARHP Annual Meeting
Synovial Expression Of CCL19, MCP-1, and Their Receptors In Patients With Meniscal Injury: Variability and Relationship With Knee Symptoms
Justin B. Gan¹, Anjali Nair², Kanta Saha¹, Nikhil Verma³, Charles Bush-Joseph³, Matthew Tetreault³, Anne-Marie Malfait⁴, Kumar B. Rajan⁵ and Carla R. Scanzello¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Section of Rheumatology, Rush University Medical Center, Chicago, IL, ³Orthopedics, Rush University Medical Center, Chicago, IL, ⁴Internal Medicine/Biochemistry, Rush University Medical Center, Chicago, IL, ⁵Department of Internal Medicine, Biostatistics, Rush University Medical Center, Chicago, IL
Background/Purpose: Patients with meniscal injury are at increased risk for symptomatic knee osteoarthritis (OA), and often already have intraoperative signs of early-stage cartilage degradation. We…
Abstract Number: 98 • 2013 ACR/ARHP Annual Meeting
Prevalence Of Femoroacetabular Impingement Among Chinese Living In Vancouver, Canada: A Population-Based Study
Linda C. Li¹, Jacek A. Kopec², Hubert Wong³, Jolanda Cibere⁴, Charlie Zhang⁵, Eric C. Sayre², Joanna Ye², Morgan Barber², Helen Prlic⁶ and John Esdaile⁷, ¹Physical Therapy, Arthritis Centre of Canada, Richmond, BC, Canada, ²Arthritis Research Centre of Canada, Richmond, BC, Canada, ³School of Population and Public Health, University of British Columbia, St Paul's Hospital, University of British Columbia, Vancouver, V6Z 1Y6, Canada, Vancouver, BC, Canada, ⁴Division of Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁵Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Arthritis Research Centre of Canada, Vancouver, BC, Canada, ⁷Rheumatology, Arthritis Research Centre of Canada, University of British Columbia, Richmond, BC, Canada
Background/Purpose: Femoroacetabular Impingement (FAI) is one source of hip pain in young adults and has been suggested as a major cause of hip osteoarthritis (OA).…
Abstract Number: 2859 • 2013 ACR/ARHP Annual Meeting
Pain Pathway Activation In Dorsal Root Ganglia and Dorsal Horn In a Murine Surgical Model Of Osteoarthritis
Rachel E. Miller¹, Phuong Tran², Richard J. Miller³ and Anne-Marie Malfait⁴, ¹Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, ²Rheumatology, Rush University Medical Center, Chicago, IL, ³Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, ⁴Internal Medicine/Biochemistry, Rush University Medical Center, Chicago, IL
Background/Purpose: Using a surgical mouse model of osteoarthritis (OA), destabilization of the medial meniscus (DMM), we monitor pain and associated pathways over a period of…
Abstract Number: 2752 • 2013 ACR/ARHP Annual Meeting
Good, Moderate and Poor Outcome Trajectories Of Pain Severity In Early Symptomatic Knee Osteoarthritis; 5 Year Follow-Up Of Check study
Janet Wesseling¹, Alex N. Bastick², Sita M.A. Bierma-Zeinstra³ and Johannes W.J. Bijlsma⁴, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²General Practice, Erasmus MC - University Medical Center, Rotterdam, Netherlands, ³Orthopaedics and General Practice, Erasmus MC - University Medical Center, Rotterdam, Netherlands, ⁴Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Knee pain is often the first sign of knee OA (osteoarthritis) and it is known that its course can be very different between patients over…
Abstract Number: 2753 • 2013 ACR/ARHP Annual Meeting
Relationship Of Pre-Radiographic MRI Lesions With Prevalent Frequent Knee Symptoms and Incident Persistent Knee Symptoms In Persons At Higher Risk For Knee Osteoarthritis
Leena Sharma¹, Joan S. Chmiel¹, Orit Almagor¹, Dorothy D. Dunlop², Marc C. Hochberg³, Charles Eaton⁴, C. Kent Kwoh⁵, Rebecca D. Jackson⁶, Joan M. Bathon⁷, Ali Guermazi⁸, Frank Roemer⁹, Michel Crema⁸, W. Jerry Mysiw⁶ and Michael C. Nevitt¹⁰, ¹Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine, University of Maryland School of Medicine, Baltimore, MD, ⁴Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁵School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Ohio State University, Columbus, OH, ⁷Columbia University, New York, NY, ⁸Boston University, Boston, MA, ⁹Klinikum Augsburg, Augsburg, Germany, ¹⁰Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA
Background/Purpose: The clinical significance of pre-radiographic MRI lesions in persons at risk for knee OA is unclear. Understanding whether such lesions are inconsequential or early…
Abstract Number: 2755 • 2013 ACR/ARHP Annual Meeting
The Clinical Significance and Natural History Of Knee Bone Marrow Lesions Over 8 Years
Yi Chao Foong¹, Hussain Ijaz Khan¹, Dawn Aitken¹, Changhai Ding², Flavia Cicuttini³ and Graeme Jones², ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Department of Epidemiology and Preventive Medicine, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 3004, Australia
Background/Purpose: There is increasing evidence to suggest that bone marrow lesions (BMLs) play a key role in the pathogenesis of OA. Whilst many studies have…

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