Abstracts tagged "osteoarthritis and pain"

Abstract Number: 2231 • 2014 ACR/ARHP Annual Meeting
Combined Chondroitin Sulfate and Glucosamine Is Comparable to Celecoxib for Painful Knee Osteoarthritis. Results from a Multicenter, Randomized, Double-Blind, PHASE IV NON-Inferiority TRIAL
Marc Hochberg¹, Johanne Martel-Pelletier², Jordi Monfort³, Ingrid Moller⁴, Juan Ramon Castillo⁵, Nigel K. Arden^6,7,8, Francis Berenbaum^9,10, Jean-Pierre Pelletier¹¹, Francisco J. Blanco¹², Philip G. Conaghan¹³, Yves Henrotin^14,15, Thomas Pap¹⁶, Pascal Richette^17,18,19, Allen Sawitzke²⁰, Patrick du Souich²¹ and Moves Investigation Group²², ¹University of Maryland School of Medicine, Baltimore, MD, ²Osteoarthritis Research Unit CR-CHUM, Notre-Dame Hospital 1560 Sherbrooke St East, Montreal, QC, Canada, ³Department of Rheumatology, Grup de recerca cel•lular en inflamació i cartílag. IMIM (Institut de Recerca Hospital del Mar), Barcelona, Spain, ⁴Instituto Poal, Barcelona, Spain, ⁵Head of Clinical Pharmacology Unit Hospital Universitario Virgen del Rocío, Sevilla, Spain;, Sevilla, Spain, ⁶NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ⁷Arthritis Research UK (ARUK), Center for Sports, Exercise and Osteoarthritis, University of Oxford, Nuffield Orthopaedic Centre, Oxford, United Kingdom, ⁸MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom, ⁹Sorbonne University, INSERM UMR S938, UPMC, University of Paris 06, DHU i2B, Paris, France, ¹⁰Department of Rheumatology, Assistance Publique – Hôpitaux de Paris, Saint-Antoine Hospital, Paris, France, ¹¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ¹²Rheumatology Service, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ¹³University of Leeds, Leeds, United Kingdom, ¹⁴Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Marche-en-Famenne, Belgium, ¹⁵Bone and Cartilage Research Unit, Arthropôle Liège, University of Liège, Institute of Pathology, CHU Sart-Tilman, Liege, Belgium, ¹⁶Institute of Experimental Muskuloskeletal Medicine University Hospital Münster, Münster, Germany, ¹⁷Université Paris Diderot, UFR médicale, Paris, France, ¹⁸INSERM 1132, Université Paris-Diderot, Hôpital Lariboisière, Paris, France, ¹⁹2 Rue Ambroise Pare, Hopital Lariboisiere, Paris, France, ²⁰Rheumatology, University of Utah Medical Center, Salt Lake City, UT, ²¹Department of Pharmacology, Faculty of Medicine, University of Montreal, Montreal, QC, Canada, ²²Spain, Germany, France and Poland, Barcelona, Spain
Background/Purpose The Multicentre Osteoarthritis interVEntion trial with Sysadoa (MOVES) compared efficacy and safety of Chondroitin sulfate (CS) and Glucosamine Hydrochloride (GH) with that of Celecoxib…
Abstract Number: 2241 • 2014 ACR/ARHP Annual Meeting
Intermittent Analgesic Use and Risk of Pain Exacerbation in Knee Osteoarthritis: A Web Based Case-Crossover Study
Tahereh Erfani¹, Yuqing Zhang², Joanna Makovey¹, Ben Metcalf³, Lyn March¹, Kim Bennell³ and David J. Hunter¹, ¹Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ²Boston University School of Medicine, Boston, MA, ³University of Melbourne, Melbourne, Australia
Background/Purpose: The pain experienced by osteoarthritis (OA) patients is neither constant nor stable and most patients experience episodes of pain exacerbations or flares. A number…
Abstract Number: 1822 • 2014 ACR/ARHP Annual Meeting
Increasing Synovitis and Bone Marrow Lesions Are Associated with Incident Joint Tenderness in Hand Osteoarthritis
Ida K. Haugen¹, Barbara Slatkowsky-Christensen¹, Pernille Boyesen¹, Sølve Sesseng², Désirée van der Heijde^1,3 and Tore K. Kvien⁴, ¹Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Radiology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Leiden University Medical Ctr, Leiden, Netherlands, ⁴PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose: As hand osteoarthritis (OA) studies with repeated MRI are lacking, longitudinal associations between synovitis and bone marrow lesions (BMLs) and pain are unknown. Our…
Abstract Number: 2752 • 2013 ACR/ARHP Annual Meeting
Good, Moderate and Poor Outcome Trajectories Of Pain Severity In Early Symptomatic Knee Osteoarthritis; 5 Year Follow-Up Of Check study
Janet Wesseling¹, Alex N. Bastick², Sita M.A. Bierma-Zeinstra³ and Johannes W.J. Bijlsma⁴, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²General Practice, Erasmus MC - University Medical Center, Rotterdam, Netherlands, ³Orthopaedics and General Practice, Erasmus MC - University Medical Center, Rotterdam, Netherlands, ⁴Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Knee pain is often the first sign of knee OA (osteoarthritis) and it is known that its course can be very different between patients over…
Abstract Number: 2753 • 2013 ACR/ARHP Annual Meeting
Relationship Of Pre-Radiographic MRI Lesions With Prevalent Frequent Knee Symptoms and Incident Persistent Knee Symptoms In Persons At Higher Risk For Knee Osteoarthritis
Leena Sharma¹, Joan S. Chmiel¹, Orit Almagor¹, Dorothy D. Dunlop², Marc C. Hochberg³, Charles Eaton⁴, C. Kent Kwoh⁵, Rebecca D. Jackson⁶, Joan M. Bathon⁷, Ali Guermazi⁸, Frank Roemer⁹, Michel Crema⁸, W. Jerry Mysiw⁶ and Michael C. Nevitt¹⁰, ¹Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine, University of Maryland School of Medicine, Baltimore, MD, ⁴Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁵School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Ohio State University, Columbus, OH, ⁷Columbia University, New York, NY, ⁸Boston University, Boston, MA, ⁹Klinikum Augsburg, Augsburg, Germany, ¹⁰Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA
Background/Purpose: The clinical significance of pre-radiographic MRI lesions in persons at risk for knee OA is unclear. Understanding whether such lesions are inconsequential or early…
Abstract Number: 2755 • 2013 ACR/ARHP Annual Meeting
The Clinical Significance and Natural History Of Knee Bone Marrow Lesions Over 8 Years
Yi Chao Foong¹, Hussain Ijaz Khan¹, Dawn Aitken¹, Changhai Ding², Flavia Cicuttini³ and Graeme Jones², ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Department of Epidemiology and Preventive Medicine, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 3004, Australia
Background/Purpose: There is increasing evidence to suggest that bone marrow lesions (BMLs) play a key role in the pathogenesis of OA. Whilst many studies have…
Abstract Number: 2154 • 2013 ACR/ARHP Annual Meeting
Improvement In Clinical Symptoms After 48 Weeks Of Wearing Flexible Footwear In Osteoarthritis Of Knee: A Randomized Placebo-Controlled Study
Najia Shakoor¹, Roy H. Lidtke², Louis F. Fogg³, Laura E. Thorp⁴, Markus A. Wimmer⁵, Rachel A. Mikolaitis² and Joel A. Block², ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Section of Rheumatology, Rush University Medical Center, Chicago, IL, ³Department of Nursing, Rush University Medical Center, Chicago, IL, ⁴Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL, ⁵Orthopedic Surgery, Rush University Medical Center, Chicago, IL
Background/Purpose: Osteoarthritis (OA), the most common form of arthritis, is a major cause of pain and disability. Biomechanical interventions that reduce dynamic loading are…
Abstract Number: 2142 • 2013 ACR/ARHP Annual Meeting
Long-Term Safety and Efficacy Of Subcutaneous Tanezumab In Patients With Knee Or Hip Osteoarthritis (NCT00994890)
Leslie Tive¹, Eugene J. Dabezies², Robert J. Fountaine³, Mark T. Brown³, Michael D. Smith³, Kenneth M. Verburg³ and Christine R. West⁴, ¹Arthritis, Pfizer Inc, New York, NY, ²Pensacola Research Consultants, Pensacola, FL, ³Pfizer, Inc., Groton, CT, ⁴Clinical Sciences, Pfizer, Williamston, MI
Background/Purpose : Tanezumab (TNZ), a monoclonal antibody that inhibits nerve growth factor, reduces hip or knee osteoarthritis (OA) pain. A non-controlled, randomized, double-blind study of…
Abstract Number: 2146 • 2013 ACR/ARHP Annual Meeting
Effects Of Chondroitin Sulfate On Brain Response To Painful Stimulation In Knee Osteoarthritis Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Jordi Monfort¹, Jesús Pujol², O Contreras-Rodriguez², Jone Llorente-Onaindia², M López-Solà², Laura Blanco-Hinojo², J Deus², H Ortiz², Francisco Montañés³, M Campillo², Pere Benito², Laura Sánchez⁴, Marta Herrero⁵ and Josep Vergés⁶, ¹Reumatologia, Hospital del Mar, Barcelona, Spain, ²Hospital del Mar, Barcelona, Spain, ³Rhaumatology, Hospital del Mar, Barcelona, Spain, ⁴Bioiberica, Barcelona, Spain, ⁵Pharmascience Division, Bioiberica S.A., Barcelona, Spain, ⁶Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain
Background/Purpose: Knee osteoarthritis (OA) is a degenerative joint disease causing symptoms in 12% of people over the age of 65 . A variety of treatments…
Abstract Number: 2128 • 2013 ACR/ARHP Annual Meeting
Longitudinal Relation Of Sensitization To Incident Knee Pain, Incident Symptomatic Knee Osteoarthritis and Increase In Pain Severity: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, Michael C. Nevitt², Joachim Scholz³, Lars Arendt-Nielsen⁴, Clifford Woolf⁵, Laurence A. Bradley⁶, Emily Sisson¹ and Laura Frey-Law⁷, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ³Columbia University, New York, NY, ⁴Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁵F.M. Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA, ⁶Div of Rheumatology, Univ of Alabama-Birmingham, Birmingham, AL, ⁷University of Iowa, Iowa City, IA
Background/Purpose: Peripheral and central sensitization is associated with knee pain severity in knee osteoarthritis (OA). Whether sensitization occurs prior to or only concurrently with development…
Abstract Number: 1249 • 2013 ACR/ARHP Annual Meeting
Contrasting Pathophysiology and Behavioural Responses Associated With Osteoarthritis and An Inflammatory Arthropathy
Sanaa Zaki¹, Margaret M. Smith², Susan Smith¹, Mark Connor³ and Christopher B. Little², ¹Raymond Purves Bone and Joint Research Laboratories, University of Sydney, St Leonards, Australia, ²Raymond Purves Bone and Joint Research Labs, University of Sydney, St Leonards, Australia, ³Australian School of Advanced Medicine, Macquarie University, North Ryde, Australia
Background/Purpose: Osteoarthritis (OA) affects more than 15% of the population, and is the major cause of disability in people over 60. There are no therapies…
Abstract Number: 260 • 2013 ACR/ARHP Annual Meeting
Pain, Functional Impairment and Ultrasound Detected Changes In Patients With Erosive and Non-Erosive Hand Osteoarthritis
Olga Sleglova¹, Olga Ruzickova², Karel Pavelka³ and Ladislav Senolt⁴, ¹Institute of Rheumatology, Prague, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³Institute of Rheumatology and Department of Rheumatology, 1st Medical Faculty, Charles University Prague, Prague, Czech Republic, ⁴Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
Background/Purpose: Hand osteoarthritis (HOA) is a common and frequent cause of pain. HOA is a heterogeneous group of disorders with two main subsets including non-erosive…
Abstract Number: 256 • 2013 ACR/ARHP Annual Meeting
Classification Of Alignment By Self-Report Versus Radiograph Results In Unexpected and Discrepant Pain and Functional Outcomes
E Megan Erickson¹, Jeffrey B. Driban¹, Lori Lyn Price², Chenchen Wang¹, Timothy E. McAlindon³ and William F. Harvey¹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ³Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Malalignment is a potential risk factor for structural progression of knee osteoarthritis (OA), but data conflict as to its association with knee pain. We…
Abstract Number: 81 • 2013 ACR/ARHP Annual Meeting
Synovial Expression Of CCL19, MCP-1, and Their Receptors In Patients With Meniscal Injury: Variability and Relationship With Knee Symptoms
Justin B. Gan¹, Anjali Nair², Kanta Saha¹, Nikhil Verma³, Charles Bush-Joseph³, Matthew Tetreault³, Anne-Marie Malfait⁴, Kumar B. Rajan⁵ and Carla R. Scanzello¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Section of Rheumatology, Rush University Medical Center, Chicago, IL, ³Orthopedics, Rush University Medical Center, Chicago, IL, ⁴Internal Medicine/Biochemistry, Rush University Medical Center, Chicago, IL, ⁵Department of Internal Medicine, Biostatistics, Rush University Medical Center, Chicago, IL
Background/Purpose: Patients with meniscal injury are at increased risk for symptomatic knee osteoarthritis (OA), and often already have intraoperative signs of early-stage cartilage degradation. We…
Abstract Number: 98 • 2013 ACR/ARHP Annual Meeting
Prevalence Of Femoroacetabular Impingement Among Chinese Living In Vancouver, Canada: A Population-Based Study
Linda C. Li¹, Jacek A. Kopec², Hubert Wong³, Jolanda Cibere⁴, Charlie Zhang⁵, Eric C. Sayre², Joanna Ye², Morgan Barber², Helen Prlic⁶ and John Esdaile⁷, ¹Physical Therapy, Arthritis Centre of Canada, Richmond, BC, Canada, ²Arthritis Research Centre of Canada, Richmond, BC, Canada, ³School of Population and Public Health, University of British Columbia, St Paul's Hospital, University of British Columbia, Vancouver, V6Z 1Y6, Canada, Vancouver, BC, Canada, ⁴Division of Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁵Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Arthritis Research Centre of Canada, Vancouver, BC, Canada, ⁷Rheumatology, Arthritis Research Centre of Canada, University of British Columbia, Richmond, BC, Canada
Background/Purpose: Femoroacetabular Impingement (FAI) is one source of hip pain in young adults and has been suggested as a major cause of hip osteoarthritis (OA).…

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