Abstracts tagged "osteoarthritis and pain"

Abstract Number: 335 • 2015 ACR/ARHP Annual Meeting
Prevalence of Hand Osteoarthritis and Factors Associated with Pain in Korean Farmers
Young Sun Suh¹, Yun-Hong Cheon¹, Hyun-Ok Kim¹, Ki-Soo Park², Hye Song Lim¹, Min-Gyu Jeon¹, Young-Sool Hah³ and Sang-Il Lee¹, ¹Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, ²Department of Preventive Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, ³Clinical Research Institute, Gyeongsang National University School of Medicine, Jinju, South Korea
Background/Purpose: Farming activity is burdened work with excessive use of hands. Thus, farmers are expected to have high prevalence of hand osteoarthritis (HOA). However, there…
Abstract Number: 1006 • 2015 ACR/ARHP Annual Meeting
Incident Frequent Knee Pain Is Associated with Changes in Semi-Quantitative Imaging Biomarkers of Inflammation
C.Kent Kwoh¹, Michael J. Hannon², Tomoko Fujii³, Frank W Roemer⁴, Ali Guermazi⁵, David Hunter⁶, Felix Eckstein⁷ and Robert M. Boudreau⁸, ¹Department of Medicine, The University of Arizona Arthritis Center and Division of Rheumatology, Tucson, AZ, ²Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ³University of Pittsburgh, Pittsburgh, PA, ⁴Department of Radiology, Boston University School of Medicine, Boston, MA, ⁵Boston University School of Medicine, Boston, MA, ⁶Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁷Paracelsus Med Univ, Chondrometrics GmbH, Salzburg, Austria, ⁸Epidemiology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: The cause of knee pain in osteoarthritis (OA) is multi-factorial, and there is increasing evidence of the role of inflammation in OA. The goal…
Abstract Number: 1018 • 2015 ACR/ARHP Annual Meeting
A 32-Mer Aggrecan Fragment Generated through Adamts-4/5 and MMP-Mediated Cleavage Can Directly Excite Nociceptive Neurons
Rachel E. Miller¹, Richard J. Miller², Abdelhak Belmadani³, Suzanne Golub⁴, Amanda J. Fosang⁴ and Anne-Marie Malfait⁵, ¹Biochemistry, Rush University Medical Center, Chicago, IL, ²Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴University of Melbourne, Melbourne, Australia, ⁵Rush University Medeical Center, Chicago, IL
Background/Purpose: Cleavage of aggrecan in the interglobular domain (E373-374A) by ADAMTS-4/5 is an early event in osteoarthritis pathogenesis. Further cleavage by MMPs (N341-342F) releases a…
Abstract Number: 1301 • 2015 ACR/ARHP Annual Meeting
Pain Central Sensitization Assessed By Functional Magnetic Resonance Imaging in Patients with Knee Osteoarthritis
Jordi Monfort¹, Jesus Pujol², Marina Lopez³, Jone Llorente³, Gerard Martinez², Didac Macià², Francisco Montañés³, Miguel Angel Campillo³, Pedro Benito Ruiz⁴ and Joan Deus², ¹Rheumatology Department, Hospital del Mar, Barcelona, Spain, ²Magnetic Ressonance Imaging Unit, Barcelona, Spain, ³Rheumatology Department, Barcelona, Spain, ⁴Rheumatology Service, Hospital del Mar, Barcelona, Spain
Background/Purpose: An important aspect in chronic pain is central sensitization (CS) which involves increased responsiveness of the central neurons and it is clinically expressed like…
Abstract Number: 1431 • 2015 ACR/ARHP Annual Meeting
Age and Sex Impacts the Development of Hypersensitivity in the Murine Partial Medial Menisectomy Model of Osteoarthritis
Ada Delaney¹, Azar Barharpoor¹, Tianle Gao¹, Jie Su¹, NIlesh Agalave¹ and Camilla Svensson², ¹Dept. of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden, ²Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Osteoarthritis (OA) is the leading cause of chronic pain in European adults (37%; painineurope.com). Pain is the foremost symptom of OA, with both episodes…
Abstract Number: 2395 • 2015 ACR/ARHP Annual Meeting
Predictors of and Longitudinal Factors Associated with Change in Pain, Stiffness and Physical Function over 8 Years in a Midlife Cohort with a Low Prevalence of Knee Osteoarthritis
Hussain Ijaz Khan¹, Andrew McBride², Louisa Chou³, Dawn Aitken⁴, Leigh Blizzard⁵, Changhai Ding⁶, Jean-Pierre Pelletier⁷, Johanne Martel-Pelletier⁸, Flavia Cicuttini⁹ and Graeme Jones⁶, ¹Musculoskeletal Unit, Menzies Institute of Medical Research, Hobart, Australia, ²Musculoskeletal Unit, Menzies Institute of Medical Research, Hobart, 7000, Australia, ³Menzies Institute of Medical Research, University of Tasmania, Hobart, 7000, Australia, ⁴Muscyloskeletal Unit, Menzies Institute of Medical Research, Hobart, Australia, ⁵Biostatistics, Menzies Institute of Medical Research, Hobart, Australia, ⁶Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ⁷Rheumatology, Institut de recherche en rhumatologie de Montréal (IRRM), Montréal, QC, Canada, ⁸Pharmacology, Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ⁹Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: Knee Osteoarthritis (OA) is the most common musculoskeletal condition affecting quality of life and was one of the leading causes of the years lived…
Abstract Number: 2783 • 2014 ACR/ARHP Annual Meeting
Effect of Synovitis, Effusion and Bone Marrow Lesions on Development of Sensitization in Knee OA: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, Michael C. Nevitt², Joachim Scholz³, Lars Arendt-Nielsen⁴, Clifford Woolf⁵, Laurence A. Bradley⁶, Emily K. Quinn⁷ and Laura Frey-Law⁸, ¹Boston University School of Medicine, Boston, MA, ²Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ³Columbia University, New York, NY, ⁴Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁵F.M. Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA, ⁶Div of Rheumatology, Univ of Alabama-Birmingham, Birmingham, AL, ⁷Clinical Epidemiology Unit, Boston University, Boston, MA, ⁸University of Iowa, Iowa City, IA
Background/Purpose: Alterations in the peripheral and central nervous systems including sensitization are thought to play an important role in the pain experience in knee OA.…
Abstract Number: 2231 • 2014 ACR/ARHP Annual Meeting
Combined Chondroitin Sulfate and Glucosamine Is Comparable to Celecoxib for Painful Knee Osteoarthritis. Results from a Multicenter, Randomized, Double-Blind, PHASE IV NON-Inferiority TRIAL
Marc Hochberg¹, Johanne Martel-Pelletier², Jordi Monfort³, Ingrid Moller⁴, Juan Ramon Castillo⁵, Nigel K. Arden^6,7,8, Francis Berenbaum^9,10, Jean-Pierre Pelletier¹¹, Francisco J. Blanco¹², Philip G. Conaghan¹³, Yves Henrotin^14,15, Thomas Pap¹⁶, Pascal Richette^17,18,19, Allen Sawitzke²⁰, Patrick du Souich²¹ and Moves Investigation Group²², ¹University of Maryland School of Medicine, Baltimore, MD, ²Osteoarthritis Research Unit CR-CHUM, Notre-Dame Hospital 1560 Sherbrooke St East, Montreal, QC, Canada, ³Department of Rheumatology, Grup de recerca cel•lular en inflamació i cartílag. IMIM (Institut de Recerca Hospital del Mar), Barcelona, Spain, ⁴Instituto Poal, Barcelona, Spain, ⁵Head of Clinical Pharmacology Unit Hospital Universitario Virgen del Rocío, Sevilla, Spain;, Sevilla, Spain, ⁶NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ⁷Arthritis Research UK (ARUK), Center for Sports, Exercise and Osteoarthritis, University of Oxford, Nuffield Orthopaedic Centre, Oxford, United Kingdom, ⁸MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom, ⁹Sorbonne University, INSERM UMR S938, UPMC, University of Paris 06, DHU i2B, Paris, France, ¹⁰Department of Rheumatology, Assistance Publique – Hôpitaux de Paris, Saint-Antoine Hospital, Paris, France, ¹¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ¹²Rheumatology Service, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ¹³University of Leeds, Leeds, United Kingdom, ¹⁴Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Marche-en-Famenne, Belgium, ¹⁵Bone and Cartilage Research Unit, Arthropôle Liège, University of Liège, Institute of Pathology, CHU Sart-Tilman, Liege, Belgium, ¹⁶Institute of Experimental Muskuloskeletal Medicine University Hospital Münster, Münster, Germany, ¹⁷Université Paris Diderot, UFR médicale, Paris, France, ¹⁸INSERM 1132, Université Paris-Diderot, Hôpital Lariboisière, Paris, France, ¹⁹2 Rue Ambroise Pare, Hopital Lariboisiere, Paris, France, ²⁰Rheumatology, University of Utah Medical Center, Salt Lake City, UT, ²¹Department of Pharmacology, Faculty of Medicine, University of Montreal, Montreal, QC, Canada, ²²Spain, Germany, France and Poland, Barcelona, Spain
Background/Purpose The Multicentre Osteoarthritis interVEntion trial with Sysadoa (MOVES) compared efficacy and safety of Chondroitin sulfate (CS) and Glucosamine Hydrochloride (GH) with that of Celecoxib…
Abstract Number: 2241 • 2014 ACR/ARHP Annual Meeting
Intermittent Analgesic Use and Risk of Pain Exacerbation in Knee Osteoarthritis: A Web Based Case-Crossover Study
Tahereh Erfani¹, Yuqing Zhang², Joanna Makovey¹, Ben Metcalf³, Lyn March¹, Kim Bennell³ and David J. Hunter¹, ¹Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ²Boston University School of Medicine, Boston, MA, ³University of Melbourne, Melbourne, Australia
Background/Purpose: The pain experienced by osteoarthritis (OA) patients is neither constant nor stable and most patients experience episodes of pain exacerbations or flares. A number…
Abstract Number: 1822 • 2014 ACR/ARHP Annual Meeting
Increasing Synovitis and Bone Marrow Lesions Are Associated with Incident Joint Tenderness in Hand Osteoarthritis
Ida K. Haugen¹, Barbara Slatkowsky-Christensen¹, Pernille Boyesen¹, Sølve Sesseng², Désirée van der Heijde^1,3 and Tore K. Kvien⁴, ¹Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Radiology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Leiden University Medical Ctr, Leiden, Netherlands, ⁴PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose: As hand osteoarthritis (OA) studies with repeated MRI are lacking, longitudinal associations between synovitis and bone marrow lesions (BMLs) and pain are unknown. Our…
Abstract Number: 1281 • 2014 ACR/ARHP Annual Meeting
Knee Pain and a Prior Injury Are Associated with Increased Risk of a New Knee Injury: Data from the Osteoarthritis Initiative
Jeffrey B. Driban¹, Grace H. Lo², Lori Lyn Price³, Charles Eaton⁴, Bing Lu⁵ and Timothy E. McAlindon⁶, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ³Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁴Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁵Rheumatology, Brigham and Women's Hospital, Foxboro, MA, ⁶Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: A knee injury increases the risk for early-onset osteoarthritis (OA) and accelerated knee OA progression but little is known about risk factors for injuries…
Abstract Number: 1282 • 2014 ACR/ARHP Annual Meeting
Systemic Pain Modulation Is Related to Body Perception in People with Knee Osteoarthritis
Jennifer Stevens-Lapsley¹ and Andrew Kittelson², ¹Physical Therapy Program, UCD Physical Therapy Program, Aurora, CO, ²Rehabilitation Science PhD Program, University of Colorado Denver, Aurora, CO
Background/Purpose Cortically mediated changes in body perception have been linked to a variety of chronic pain conditions, including knee osteoarthritis (OA). However, associations between body…
Abstract Number: 1280 • 2014 ACR/ARHP Annual Meeting
Relationship of Buckling and Knee Injury to Pain Exacerbation in Knee Osteoarthritis: A Web-Based Case-Crossover Stud
Isabelle Zobel^1,2, Tahereh Erfani³, Kim Bennell⁴, Joanna Makovey³, Ben Metcalf⁴, Jian Sheng Chen⁵, Lyn March³, Yuqing Zhang⁶, Felix Eckstein⁷ and David J. Hunter³, ¹Institute of Anatomy, Paracelsus Medical University Salzburg, Salzburg, Austria, ²Institute of Bone and Joint Research, Kolling Institute, University of Sydney, St Leonards, Australia, ³Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁴University of Melbourne, Melbourne, Australia, ⁵Rheumatology Royal North Shore Hospital, University of Sydney Institute of Bone and Joint Research, St Leonards, Australia, ⁶Boston University School of Medicine, Boston, MA, ⁷Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
Background/Purpose Knee osteoarthritis (OA) pain is neither constant nor stable and exacerbations of pain are disabling. We examined whether knee injury and buckling (giving way)…
Abstract Number: 926 • 2014 ACR/ARHP Annual Meeting
Does a Family History of Total Knee Replacement for Knee Osteoarthritis Influence Knee Pain and Structural Progression? a Prospective Longitudinal Cohort Study
Feng Pan¹, Hussain Khan¹, Changhai Ding¹, Tania Winzenberg², Johanne Martel-Pelletier³, Jean-Pierre Pelletier³, Flavia Cicuttini⁴ and Graeme Jones¹, ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ²Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ⁴Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: Genetic factors appear to play an important role in the pathogenesis of both knee pain and radiographic osteoarthritis (OA) based on cross-sectional studies but…
Abstract Number: 924 • 2014 ACR/ARHP Annual Meeting
Characteristics of Pain Flares in Knee Osteoarthritis
Susan L. Murphy¹, Angela K. Lyden², Arnold Gammaitoni³, David A. Williams⁴, Daniel J. Clauw⁵, J. Ryan Scott⁶ and Kristine Phillips⁷, ¹Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, MI, ²Department of Anesthesiology, University of Michigan, Ann Arbor, MI, ³Zogenix, Inc, San Diego, CA, ⁴Chronic Pain & Fatigue Rsch Ctr, Univ of MI Hlth System-Lobby M, Ann Arbor, MI, ⁵Anesthesiology/Internal Medicine (Rheum), University of Michigan, Ann Arbor, MI, ⁶Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, ⁷Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: For inclusion in osteoarthritis clinical trials, participants often need to have a pain ‘flare’, usually defined as a pain increase over a period of…

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