Abstracts tagged "osteoarthritis and pain"

Abstract Number: 329 • 2015 ACR/ARHP Annual Meeting
Serum Leptin and Risk of Knee Pain and Osteoarthritis: Multicenter Osteoarthritis Study
Devyani Misra¹, Jingbo Niu², David T. Felson², Michael C. Nevitt³, James Torner⁴, Cora E. Lewis⁵, Anyu Hu⁶, Sadao Jinno⁷ and Tuhina Neogi⁸, ¹Medicine, Section of, BUSM, Boston, MA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Epidemiology and Biostatistics, UCSF, San Francisco, CA, ⁴University of Iowa, UIowa, Iowa City, IA, ⁵Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁶Clinical Epidemiology Research Unit, Boston University School of Medicine, Boston, MA, ⁷BUSM, Boston, MA, ⁸Clinical Epidemiology, BUSM, Boston, MA
Serum Leptin and Risk of Knee Pain and Osteoarthritis: Multicenter Osteoarthritis StudyD. Misra, J. Niu, D.T. Felson, M. Nevitt, J. Torner, C.E. Lewis, A. Hu,…
Abstract Number: 335 • 2015 ACR/ARHP Annual Meeting
Prevalence of Hand Osteoarthritis and Factors Associated with Pain in Korean Farmers
Young Sun Suh¹, Yun-Hong Cheon¹, Hyun-Ok Kim¹, Ki-Soo Park², Hye Song Lim¹, Min-Gyu Jeon¹, Young-Sool Hah³ and Sang-Il Lee¹, ¹Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, ²Department of Preventive Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, ³Clinical Research Institute, Gyeongsang National University School of Medicine, Jinju, South Korea
Background/Purpose: Farming activity is burdened work with excessive use of hands. Thus, farmers are expected to have high prevalence of hand osteoarthritis (HOA). However, there…
Abstract Number: 1006 • 2015 ACR/ARHP Annual Meeting
Incident Frequent Knee Pain Is Associated with Changes in Semi-Quantitative Imaging Biomarkers of Inflammation
C.Kent Kwoh¹, Michael J. Hannon², Tomoko Fujii³, Frank W Roemer⁴, Ali Guermazi⁵, David Hunter⁶, Felix Eckstein⁷ and Robert M. Boudreau⁸, ¹Department of Medicine, The University of Arizona Arthritis Center and Division of Rheumatology, Tucson, AZ, ²Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ³University of Pittsburgh, Pittsburgh, PA, ⁴Department of Radiology, Boston University School of Medicine, Boston, MA, ⁵Boston University School of Medicine, Boston, MA, ⁶Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁷Paracelsus Med Univ, Chondrometrics GmbH, Salzburg, Austria, ⁸Epidemiology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: The cause of knee pain in osteoarthritis (OA) is multi-factorial, and there is increasing evidence of the role of inflammation in OA. The goal…
Abstract Number: 1018 • 2015 ACR/ARHP Annual Meeting
A 32-Mer Aggrecan Fragment Generated through Adamts-4/5 and MMP-Mediated Cleavage Can Directly Excite Nociceptive Neurons
Rachel E. Miller¹, Richard J. Miller², Abdelhak Belmadani³, Suzanne Golub⁴, Amanda J. Fosang⁴ and Anne-Marie Malfait⁵, ¹Biochemistry, Rush University Medical Center, Chicago, IL, ²Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴University of Melbourne, Melbourne, Australia, ⁵Rush University Medeical Center, Chicago, IL
Background/Purpose: Cleavage of aggrecan in the interglobular domain (E373-374A) by ADAMTS-4/5 is an early event in osteoarthritis pathogenesis. Further cleavage by MMPs (N341-342F) releases a…
Abstract Number: 1301 • 2015 ACR/ARHP Annual Meeting
Pain Central Sensitization Assessed By Functional Magnetic Resonance Imaging in Patients with Knee Osteoarthritis
Jordi Monfort¹, Jesus Pujol², Marina Lopez³, Jone Llorente³, Gerard Martinez², Didac Macià², Francisco Montañés³, Miguel Angel Campillo³, Pedro Benito Ruiz⁴ and Joan Deus², ¹Rheumatology Department, Hospital del Mar, Barcelona, Spain, ²Magnetic Ressonance Imaging Unit, Barcelona, Spain, ³Rheumatology Department, Barcelona, Spain, ⁴Rheumatology Service, Hospital del Mar, Barcelona, Spain
Background/Purpose: An important aspect in chronic pain is central sensitization (CS) which involves increased responsiveness of the central neurons and it is clinically expressed like…
Abstract Number: 1431 • 2015 ACR/ARHP Annual Meeting
Age and Sex Impacts the Development of Hypersensitivity in the Murine Partial Medial Menisectomy Model of Osteoarthritis
Ada Delaney¹, Azar Barharpoor¹, Tianle Gao¹, Jie Su¹, NIlesh Agalave¹ and Camilla Svensson², ¹Dept. of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden, ²Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Osteoarthritis (OA) is the leading cause of chronic pain in European adults (37%; painineurope.com). Pain is the foremost symptom of OA, with both episodes…
Abstract Number: 1822 • 2014 ACR/ARHP Annual Meeting
Increasing Synovitis and Bone Marrow Lesions Are Associated with Incident Joint Tenderness in Hand Osteoarthritis
Ida K. Haugen¹, Barbara Slatkowsky-Christensen¹, Pernille Boyesen¹, Sølve Sesseng², Désirée van der Heijde^1,3 and Tore K. Kvien⁴, ¹Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Radiology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Leiden University Medical Ctr, Leiden, Netherlands, ⁴PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose: As hand osteoarthritis (OA) studies with repeated MRI are lacking, longitudinal associations between synovitis and bone marrow lesions (BMLs) and pain are unknown. Our…
Abstract Number: 1281 • 2014 ACR/ARHP Annual Meeting
Knee Pain and a Prior Injury Are Associated with Increased Risk of a New Knee Injury: Data from the Osteoarthritis Initiative
Jeffrey B. Driban¹, Grace H. Lo², Lori Lyn Price³, Charles Eaton⁴, Bing Lu⁵ and Timothy E. McAlindon⁶, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ³Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁴Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁵Rheumatology, Brigham and Women's Hospital, Foxboro, MA, ⁶Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: A knee injury increases the risk for early-onset osteoarthritis (OA) and accelerated knee OA progression but little is known about risk factors for injuries…
Abstract Number: 1282 • 2014 ACR/ARHP Annual Meeting
Systemic Pain Modulation Is Related to Body Perception in People with Knee Osteoarthritis
Jennifer Stevens-Lapsley¹ and Andrew Kittelson², ¹Physical Therapy Program, UCD Physical Therapy Program, Aurora, CO, ²Rehabilitation Science PhD Program, University of Colorado Denver, Aurora, CO
Background/Purpose Cortically mediated changes in body perception have been linked to a variety of chronic pain conditions, including knee osteoarthritis (OA). However, associations between body…
Abstract Number: 1280 • 2014 ACR/ARHP Annual Meeting
Relationship of Buckling and Knee Injury to Pain Exacerbation in Knee Osteoarthritis: A Web-Based Case-Crossover Stud
Isabelle Zobel^1,2, Tahereh Erfani³, Kim Bennell⁴, Joanna Makovey³, Ben Metcalf⁴, Jian Sheng Chen⁵, Lyn March³, Yuqing Zhang⁶, Felix Eckstein⁷ and David J. Hunter³, ¹Institute of Anatomy, Paracelsus Medical University Salzburg, Salzburg, Austria, ²Institute of Bone and Joint Research, Kolling Institute, University of Sydney, St Leonards, Australia, ³Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁴University of Melbourne, Melbourne, Australia, ⁵Rheumatology Royal North Shore Hospital, University of Sydney Institute of Bone and Joint Research, St Leonards, Australia, ⁶Boston University School of Medicine, Boston, MA, ⁷Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
Background/Purpose Knee osteoarthritis (OA) pain is neither constant nor stable and exacerbations of pain are disabling. We examined whether knee injury and buckling (giving way)…
Abstract Number: 926 • 2014 ACR/ARHP Annual Meeting
Does a Family History of Total Knee Replacement for Knee Osteoarthritis Influence Knee Pain and Structural Progression? a Prospective Longitudinal Cohort Study
Feng Pan¹, Hussain Khan¹, Changhai Ding¹, Tania Winzenberg², Johanne Martel-Pelletier³, Jean-Pierre Pelletier³, Flavia Cicuttini⁴ and Graeme Jones¹, ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ²Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ⁴Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: Genetic factors appear to play an important role in the pathogenesis of both knee pain and radiographic osteoarthritis (OA) based on cross-sectional studies but…
Abstract Number: 924 • 2014 ACR/ARHP Annual Meeting
Characteristics of Pain Flares in Knee Osteoarthritis
Susan L. Murphy¹, Angela K. Lyden², Arnold Gammaitoni³, David A. Williams⁴, Daniel J. Clauw⁵, J. Ryan Scott⁶ and Kristine Phillips⁷, ¹Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, MI, ²Department of Anesthesiology, University of Michigan, Ann Arbor, MI, ³Zogenix, Inc, San Diego, CA, ⁴Chronic Pain & Fatigue Rsch Ctr, Univ of MI Hlth System-Lobby M, Ann Arbor, MI, ⁵Anesthesiology/Internal Medicine (Rheum), University of Michigan, Ann Arbor, MI, ⁶Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, ⁷Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: For inclusion in osteoarthritis clinical trials, participants often need to have a pain ‘flare’, usually defined as a pain increase over a period of…
Abstract Number: 263 • 2014 ACR/ARHP Annual Meeting
Nutraceutical Products and Pain or Non-Pain Medications Use in Patients with Knee Osteoarthritis
Mei Chung¹, John B. Wong², Shaoyu Chang³ and Chenchen Wang⁴, ¹Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, ²Medicine/Clinical Decision Making, Tufts Medical Center, Boston, MA, ³Tufts Medical Center, Boston, MA, ⁴Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Knee osteoarthritis (OA) causes substantial health burden and economic costs including medications and neutraceuticals for pain. The aim of this analysis was to describe…
Abstract Number: 220 • 2014 ACR/ARHP Annual Meeting
Lower Extremity Presarcopenia Is Associated with the Severity of Knee Pain
Yun-Hong Cheon¹, Wan-Hee Yoo², Young Sun Suh³, Hyun-Ok Kim³, Ki-Soo Park⁴, Sang-Il Lee³ and Hye-Ji Jeon⁴, ¹Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Chonbuk National University School of Medicine, Jeonju, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, ⁴Department of Preventive Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea
Background/Purpose Presarcopenia, which is defined as skeletal muscle mass loss, and knee pain have been gained attention with ageing. Little is known about the association…
Abstract Number: 216 • 2014 ACR/ARHP Annual Meeting
Hip Adiposity, Not Local Knee Adiposity, Is Associated with Knee Pain Independent of Radiographic Osteoarthritis Severity
Grace H. Lo¹, Ajay Balasubramanyam², Jeffrey B. Driban³, Lori Lyn Price⁴, Charles B. Eaton⁵ and Timothy E. McAlindon⁶, ¹VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ²Medicine, Baylor College of Medicine, Houston, TX, ³Tufts Medical Center, Boston, MA, ⁴Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵Family Medicine, Memorial Hospital of Rhode Island, Pawtucket, RI, ⁶Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose Elevated body mass index (BMI) is associated with pain in knee OA. However, it is unclear if adiposity closer in proximity to the knee…

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