ACR Meeting Abstracts

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Abstracts tagged "osteoarthritis and pain"

  • Abstract Number: 2182 • 2019 ACR/ARP Annual Meeting

    Relation of MRI-detected Structural Damage in the Knee to Anterior Knee Pain: The MOST Study

    Joshua Stefanik1, Tuhina Neogi 2, Mohamed Jarraya 3, Ali Guermazi 4, Irina Tolstykh 5, John Lynch 6, James Torner 7, Cora Lewis 8 and Erin Macri 9, 1Northeastern University, Boston, 2Boston University School of Medicine, Boston, MA, 3Mercy Catholic Medical Center, Darby, 4Boston Medical Center, Boston, 5UCSF, San Francisco, 6University of California at San Francisco, San Francisco, CA, 7University of Iowa at Iowa City, Iowa City, 8UAB, Birmingham, 9Erasmus MC, Rotterdam, Netherlands

    Background/Purpose: Discordance between knee osteoarthritis (OA) and knee pain is common yet not well understood. Specifically, anterior knee pain (AKP) is widely held to be…
  • Abstract Number: 2412 • 2019 ACR/ARP Annual Meeting

    Use of Minimal Important Difference (MID) in Randomized Clinical Trials of Pain in Osteoarthritis

    Lavalley Michael1, Matthew Parkes 2, Daniel White 3, Stephan Reichebach 4, Timothy McAlindon 5 and David Felson 6, 1Boston University, Boston, 2University of Manchester, Manchester, England, United Kingdom, 3University of Delaware, Newark, DE, 4University of Bern, Bern, Switzerland, 5Tufts Medical Center, Boston, MA, 6Boston University School of Medicine, Department of Rheumatology, Boston

    Background/Purpose: Minimal important differences (MID), based on within-subject evaluation of attaining  an improvement in a continuous outcome such as a pain scale, are important for…
  • Abstract Number: 2761 • 2019 ACR/ARP Annual Meeting

    Cartilage Thickness Modification with Sprifermin in Knee Osteoarthritis Patients Translates into Symptomatic Improvement over Placebo in Patients at Risk of Further Structural and Symptomatic Progression: Post-Hoc Analysis of a Phase II Trial

    Hans Guehring1, Jeffrey Kraines 2, Flavie Moreau 2, Benjamin Daelken 1, Christoph Ladel 1, Wolfgang Wirth 3, Philip G Conaghan 4, Felix Eckstein 5 and Marc C. Hochberg 6, 1Merck KGaA, Darmstadt, Germany, 2EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 3Paracelsus Medical University, Salzbury, Austria, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 5Paracelsus Medical University, Salzburg, Austria, 6University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Results from the 5-year Phase II FORWARD study showed significant dose-dependent modification of total femorotibial joint (TFTJ) cartilage thickness change with sprifermin at 2…
  • Abstract Number: 1364 • 2018 ACR/ARHP Annual Meeting

    Treatment of Knee Osteoarthritis with SM04690 Improved WOMAC A1 “Pain on Walking” – Results from a 52-Week, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of a Novel, Intra-Articular, Wnt Pathway Inhibitor

    Jeyanesh Tambiah1, Sarah Kennedy1, Heli Ghandehari1, Christopher Swearingen1 and Marc C. Hochberg2, 1Samumed, LLC, San Diego, CA, 2University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, functional limitation, and physical disability due to articular cartilage degradation and bone remodeling. Wnt signaling is involved…
  • Abstract Number: 1377 • 2018 ACR/ARHP Annual Meeting

    Knee Osteoarthritis Symptom Duration Is Associated with Conditioned Pain Modulation and Vibration Perception Threshold Impairment

    Kharma C. Foucher1, Samuel Chmell2 and Carol Courtney3, 1Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, 2Orthopedic Surgery, University of Illinois at Chicago, Chicago, IL, 3Physical Therapy, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: Impaired descending pain inhibition has been observed in people with knee OA and may be associated with development of chronic pain as well as…
  • Abstract Number: 425 • 2018 ACR/ARHP Annual Meeting

    Efficacy, Safety, and Tolerability of ONO-4474, an Orally Available Pan-Tropomyosin Receptor Kinase Inhibitor, in Japanese Patients with Moderate-to-Severe Osteoarthritis of the Knee: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparative Study

    Naoki Ishiguro1, Shusuke Oyama2, Ryunosuke Higashi3 and Kunio Yanagida4, 1Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Data Science, Ono Pharmaceutical Co., Ltd., Osaka, Japan, 3Translational Science, Translational Medicine Center, Ono Pharmaceutical Co., Ltd., Osaka, Japan, 4Translational Science, Translational Medicine Center, Ono Pharmaceutical Co., Ltd, Osaka, Japan

    Background/Purpose: ONO-4474 is an orally available, peripheral-specific, pan-tropomyosin receptor kinase (pan-Trk) inhibitor currently under development for treatment of musculoskeletal pain in OA patients. This study…
  • Abstract Number: 1920 • 2018 ACR/ARHP Annual Meeting

    Is There Objective Evidence of Neuropathy in Knee Osteoarthritis Based on Clinical Evaluation?

    Priyanka Ballal1, Joachim Scholz2, Laura Frey-Law3, Na Wang1, Michael C. Nevitt4, Cora E. Lewis5 and Tuhina Neogi6, 1Boston University School of Medicine, Boston, MA, 2Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY, 3University of Iowa, Iowa City, IA, 4Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 5University of Alabama Birmingham, Birmingham, AL, 6Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA

    Background/Purpose: Self-reported descriptors of pain in knee osteoarthritis (OA) such as burning and stabbing pain are suggestive of a neuropathic component of pain beyond that…
  • Abstract Number: 426 • 2018 ACR/ARHP Annual Meeting

    The Association of Dietary Patterns with Knee Symptoms and MRI Detected Structures in Patients with Knee Osteoarthritis (OA)

    Shuang Zheng1, Feitong Wu1, Flavia Cicuttini2, Anita E Wluka2, Dawn Aitken1, Tania Winzeberg1,3, Leigh Blizzard1, Graeme Jones4 and Changhai Ding1,5, 1Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, 2Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, 3Faculty of Health, University of Tasmania, Hobart, Australia, 4Menzies Institute for Medical Research, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, 5Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China

    The association of dietary patterns with knee symptoms and MRI detected structures in patients with knee osteoarthritis (OA)Abstract Background/Purpose: This study aimed to examine the…
  • Abstract Number: 1994 • 2018 ACR/ARHP Annual Meeting

    Osteoarthritis Severity Is Reduced By Intra-Articular Administration of Hydrogen Sulfide

    Elena F. Burguera1,2, Angela Vela-Anero3, Carlos Vaamonde-Garcia3, Tamara Hermida-Gómez1,2, Purificacion Filgueira-Fernandez1,2, Lucía Gato-Calvo2, Rosa Meijide-Failde4 and Francisco J Blanco5, 1CIBER-BBN, Madrid, Spain, 2Unidad de Medicina Regenerativa, Grupo de Investigación en Reumatología, Agrupación Estratégica CICA-INIBIC, Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade de A Coruña (UDC), A Coruña, Spain, 3Department of Physiotherapy, Medicine and Biological sciences, Tissue Engineering and Regenerative Medicine group (University of A Coruña), A Coruña, Spain, 4Department of Physiotherapy, Medicine and Biological Sciences, Tissue Engineering and Regenerative Medicine group (University of A Coruña), A Coruña, Spain, 5Grupo de Investigación en Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain

    Background/Purpose: Hydrogen sulphide (H2S) is recognized as a therapeutic target in osteoarthritis (OA). Exogenous supplementation with synthetic salts in in vitro models of OA has…
  • Abstract Number: 427 • 2018 ACR/ARHP Annual Meeting

    One Year Efficacy and Safety of One or Three Injections of Hylan G-F 20 for Knee Osteoarthritis: A Systematic Literature Review and Meta-Analysis

    Orazio De Lucia1, Georgios Filippou2, Joerg Jerosch3, Sophie Yoon4, Jean-Francois Bitsch4, Tobias Sayre4 and Wilson Ngai5, 1Division of Clinical Rheumatology, G. Pini Hospital, Milan, Italy, 2Section of Rheumatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy, 3Department of Orthopedic Surgery, Johanna-Etienne Krankenhaus, Neuss, Germany, 4Doctor Evidence, Santa Monica, CA, 5Global Medical Affairs, General Medicines and Emerging Markets, Sanofi, Bridgewater, NJ

    Background/Purpose: Hylan G-F 20 is indicated for the treatment of pain in knee osteoarthritis (OA) in patients who failed to respond adequately to conservative nonpharmacologic…
  • Abstract Number: 432 • 2018 ACR/ARHP Annual Meeting

    Relation of Patellofemoral Joint Alignment, Morphology, and Radiographic Osteoarthritis to Frequent Anterior Knee Pain

    Erin Macri1, Tuhina Neogi2, Irina Tolstykh3, Cora E. Lewis4, James Torner5, Michael C. Nevitt6 and Joshua J. Stefanik7, 1Physical Therapy, University of Delaware, Newark, DE, 2Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, 3Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, 4University of Alabama Birmingham, Birmingham, AL, 5University of Iowa, Iowa City, IA, 6Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 7Department of Physical Therapy, University of Delaware, Newark, DE

    Background/Purpose: Radiographic patellofemoral osteoarthritis (OA) is prevalent in approximately 25% of population-based samples and 39% of individuals with knee pain. Discordance between knee OA features…
  • Abstract Number: 441 • 2018 ACR/ARHP Annual Meeting

    The Presence of Neuropathic Pain Does Not Influence the Response to Hyaluronic Acid (HA) in Patients with Knee Osteoarthritis but HA Injections Modify Pain Phenotype

    Evariste Tiendrebeogo1, Thierry Conrozier2, Xavier Chevalier3 and Florent Eymard4, 1Rheumatology, APHP Henri Mondor Hospital, Creteil, France, 2Department of Rheumatology,, Nord Franche-Comté Hospital, Belfort, France, 3Rheumatology, APHP Henri Mondor Hospital, Créteil, France, 4Department of Rheumatology, APHP Henri Mondor Hospital, Creteil, France

    Background/Purpose: Twenty to forty percent of patients with symptomatic knee osteoarthritis (OA) described neuropathic pain (NP). Several studies have shown that hyaluronic acid (HA) is…
  • Abstract Number: 446 • 2018 ACR/ARHP Annual Meeting

    Participation in American Football Is Associated with Increased Risk for Knee Pain and Osteoarthritis: Data from the Osteoarthritis Initiative

    Grace H. Lo1, Timothy E. McAlindon2, Andrea Kriska3, Lori Lyn Price4, Bonny Rockette-Wagner5, Lisa A. Mandl6, Charles B. Eaton7, Marc C. Hochberg8, Rebecca D. Jackson9, C. Kent Kwoh10, Michael C. Nevitt11 and Jeffrey B. Driban12, 1Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, 2Division of Rheumatology, Tufts Medical Center, Boston, MA, 3University of Pittsburgh, Pittsburgh, PA, 4Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, 5University of Pittsburgh Medical Center, Pittsburgh, PA, 6Rheumatology, Hospital for Special Surgery, New York, NY, 7Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, 8University of Maryland School of Medicine, Baltimore, MD, 9Ohio State University, Columbus, OH, 10Medicine, Division of Rheumatology, University of Arizona School of Medicine, University of Arizona Arthritis Center, Tucson, AZ, 11Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 12Rheumatology, Tufts Medical Center, BOSTON, MA

    Background/Purpose: Male youth commonly participate in American football.  Little data inform whether this is associated with knee pain or osteoarthritis (OA) later in life.  We…
  • Abstract Number: 454 • 2018 ACR/ARHP Annual Meeting

    Effects of Prolonged Chemogenetic Inhibition of Nociceptors in a Murine Surgical Model of Osteoarthritis

    Phuong B. Tran1, Shingo Ishihara1, Rachel E. Miller2, Richard J. Miller3 and Anne-Marie Malfait4, 1Internal Medicine, Rush University Medical Center, Chicago, IL, 2Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, 3Pharmacology/Medical Humanities and Bioethics, Northwestern University, Chicago, IL, 4Biochemistry & Rheumatology, Rush University Medical Center, Chicago, IL

    Background/Purpose: The aim of this study was to investigate the effects of prolonged chemogenetic inhibition of NaV1.8 nociceptors on pain-related behaviors and cellular changes in…
  • Abstract Number: 455 • 2018 ACR/ARHP Annual Meeting

    Metabolic Syndrome and Trajectories of Pain Severity and Number of Painful Sites in Knee Osteoarthritis: Data from a 10.7-Year Prospective Study

    Feng Pan1, Jing Tian2, Flavia Cicuttini3 and Graeme Jones4, 1Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, 2Public health unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, 3Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, 4Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia

    Background/Purpose: Metabolic syndrome (MetS) has been suggested as having a role in osteoarthritis (OA) pathogenesis. No study has assessed whether MetS and its components are…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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