Abstracts tagged "osteoarthritis and pain"

Abstract Number: 2182 • 2019 ACR/ARP Annual Meeting
Relation of MRI-detected Structural Damage in the Knee to Anterior Knee Pain: The MOST Study
Joshua Stefanik¹, Tuhina Neogi ², Mohamed Jarraya ³, Ali Guermazi ⁴, Irina Tolstykh ⁵, John Lynch ⁶, James Torner ⁷, Cora Lewis ⁸ and Erin Macri ⁹, ¹Northeastern University, Boston, ²Boston University School of Medicine, Boston, MA, ³Mercy Catholic Medical Center, Darby, ⁴Boston Medical Center, Boston, ⁵UCSF, San Francisco, ⁶University of California at San Francisco, San Francisco, CA, ⁷University of Iowa at Iowa City, Iowa City, ⁸UAB, Birmingham, ⁹Erasmus MC, Rotterdam, Netherlands
Background/Purpose: Discordance between knee osteoarthritis (OA) and knee pain is common yet not well understood. Specifically, anterior knee pain (AKP) is widely held to be…
Abstract Number: 2412 • 2019 ACR/ARP Annual Meeting
Use of Minimal Important Difference (MID) in Randomized Clinical Trials of Pain in Osteoarthritis
Lavalley Michael¹, Matthew Parkes ², Daniel White ³, Stephan Reichebach ⁴, Timothy McAlindon ⁵ and David Felson ⁶, ¹Boston University, Boston, ²University of Manchester, Manchester, England, United Kingdom, ³University of Delaware, Newark, DE, ⁴University of Bern, Bern, Switzerland, ⁵Tufts Medical Center, Boston, MA, ⁶Boston University School of Medicine, Department of Rheumatology, Boston
Background/Purpose: Minimal important differences (MID), based on within-subject evaluation of attaining an improvement in a continuous outcome such as a pain scale, are important for…
Abstract Number: 2761 • 2019 ACR/ARP Annual Meeting
Cartilage Thickness Modification with Sprifermin in Knee Osteoarthritis Patients Translates into Symptomatic Improvement over Placebo in Patients at Risk of Further Structural and Symptomatic Progression: Post-Hoc Analysis of a Phase II Trial
Hans Guehring¹, Jeffrey Kraines ², Flavie Moreau ², Benjamin Daelken ¹, Christoph Ladel ¹, Wolfgang Wirth ³, Philip G Conaghan ⁴, Felix Eckstein ⁵ and Marc C. Hochberg ⁶, ¹Merck KGaA, Darmstadt, Germany, ²EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ³Paracelsus Medical University, Salzbury, Austria, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ⁵Paracelsus Medical University, Salzburg, Austria, ⁶University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Results from the 5-year Phase II FORWARD study showed significant dose-dependent modification of total femorotibial joint (TFTJ) cartilage thickness change with sprifermin at 2…
Abstract Number: 954 • 2018 ACR/ARHP Annual Meeting
A New Way to Think about Composite Magnetic Resonance Imaging Scores to Measure Osteoarthritis Severity and Progression
Lori Lyn Price^1,2, Jeffrey B. Driban³, Grace H. Lo⁴, Ming Zhang⁵, Michael P. LaValley⁶ and Timothy E. McAlindon⁷, ¹Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ²Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ³Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁴Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ⁵Tufts Medical Center, Boston, MA, ⁶Biostatistics, Boston University School of Public Health, Boston, MA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: For some rheumatologic diseases (e.g. lupus), separate scores evaluate cumulative damage and disease activity. No such strategy exists for osteoarthritis (OA). The prevailing approach…
Abstract Number: 1167 • 2018 ACR/ARHP Annual Meeting
The Role of Fear-Avoidance Model on Pain and Disability in Knee Osteoarthritis Patients
Leticia Leon^1,2, Marta Redondo², Sara Lopez de Felipe², Daniel Garriguez³, Lydia A Alcazar⁴ and Luis Rodriguez-Rodriguez⁵, ¹Rheumatology Department, Hospital Clínical San Carlos, and IdISSC, Madrid, Spain, ²Health Sciences, Universidad Camilo Jose Cela, Madrid, Spain, ³Orthopedics Unit, Hospital Clinico San Carlos, Madrid, Spain, ⁴Rheumatology Department and Heath Research Institute (IdISSC), Hospital Clinico San Carlos, Madrid, Spain, ⁵Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain
Background/Purpose: The model of Fear-Avoidance of pain (anxiety, catastrophization and hypervigilance) appears when the pain has maladaptive interpretations, being associated with greater pain and limitations…
Abstract Number: 1169 • 2018 ACR/ARHP Annual Meeting
Association between Depressive Symptom Subtypes and Disease Severity in Knee Osteoarthritis
Alan Rathbun¹, Megan Schuler², Elizabeth Stuart³, Michelle Shardell⁴, Michelle S. Yau⁵, Joseph Gallo⁶ and Marc C. Hochberg⁷, ¹Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, ²Rand Coportation, Boston, MA, ³Mental Health, Biostatistics, and Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁴Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, ⁵Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, ⁶Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁷University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Latent and modifiable factors, such as depressive symptoms, may affect the course of knee OA. Depression is clinically heterogeneous, and effects on pain and…
Abstract Number: 1170 • 2018 ACR/ARHP Annual Meeting
Sex-Specific Associations between Systemic Inflammatory Cytokines and Osteoarthritis Knee Pain
Anthony V. Perruccio¹, J. Denise Power¹, Mayilee Canizares¹, Elizabeth M. Badley^1,2, Mohit Kapoor¹, Rajiv Gandhi¹ and Y. Raja Rampersaud¹, ¹Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Background/Purpose: Significant challenges remain in mitigating OA pain and despite growing evidence of sex differences, including in pain and in response to NSAIDs, sex has…
Abstract Number: 1364 • 2018 ACR/ARHP Annual Meeting
Treatment of Knee Osteoarthritis with SM04690 Improved WOMAC A1 “Pain on Walking” – Results from a 52-Week, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of a Novel, Intra-Articular, Wnt Pathway Inhibitor
Jeyanesh Tambiah¹, Sarah Kennedy¹, Heli Ghandehari¹, Christopher Swearingen¹ and Marc C. Hochberg², ¹Samumed, LLC, San Diego, CA, ²University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, functional limitation, and physical disability due to articular cartilage degradation and bone remodeling. Wnt signaling is involved…
Abstract Number: 1377 • 2018 ACR/ARHP Annual Meeting
Knee Osteoarthritis Symptom Duration Is Associated with Conditioned Pain Modulation and Vibration Perception Threshold Impairment
Kharma C. Foucher¹, Samuel Chmell² and Carol Courtney³, ¹Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, ²Orthopedic Surgery, University of Illinois at Chicago, Chicago, IL, ³Physical Therapy, University of Illinois at Chicago, Chicago, IL
Background/Purpose: Impaired descending pain inhibition has been observed in people with knee OA and may be associated with development of chronic pain as well as…
Abstract Number: 425 • 2018 ACR/ARHP Annual Meeting
Efficacy, Safety, and Tolerability of ONO-4474, an Orally Available Pan-Tropomyosin Receptor Kinase Inhibitor, in Japanese Patients with Moderate-to-Severe Osteoarthritis of the Knee: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparative Study
Naoki Ishiguro¹, Shusuke Oyama², Ryunosuke Higashi³ and Kunio Yanagida⁴, ¹Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²Data Science, Ono Pharmaceutical Co., Ltd., Osaka, Japan, ³Translational Science, Translational Medicine Center, Ono Pharmaceutical Co., Ltd., Osaka, Japan, ⁴Translational Science, Translational Medicine Center, Ono Pharmaceutical Co., Ltd, Osaka, Japan
Background/Purpose: ONO-4474 is an orally available, peripheral-specific, pan-tropomyosin receptor kinase (pan-Trk) inhibitor currently under development for treatment of musculoskeletal pain in OA patients. This study…
Abstract Number: 1920 • 2018 ACR/ARHP Annual Meeting
Is There Objective Evidence of Neuropathy in Knee Osteoarthritis Based on Clinical Evaluation?
Priyanka Ballal¹, Joachim Scholz², Laura Frey-Law³, Na Wang¹, Michael C. Nevitt⁴, Cora E. Lewis⁵ and Tuhina Neogi⁶, ¹Boston University School of Medicine, Boston, MA, ²Departments of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, NY, ³University of Iowa, Iowa City, IA, ⁴Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Self-reported descriptors of pain in knee osteoarthritis (OA) such as burning and stabbing pain are suggestive of a neuropathic component of pain beyond that…
Abstract Number: 426 • 2018 ACR/ARHP Annual Meeting
The Association of Dietary Patterns with Knee Symptoms and MRI Detected Structures in Patients with Knee Osteoarthritis (OA)
Shuang Zheng¹, Feitong Wu¹, Flavia Cicuttini², Anita E Wluka², Dawn Aitken¹, Tania Winzeberg^1,3, Leigh Blizzard¹, Graeme Jones⁴ and Changhai Ding^1,5, ¹Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ²Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, ³Faculty of Health, University of Tasmania, Hobart, Australia, ⁴Menzies Institute for Medical Research, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ⁵Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China
The association of dietary patterns with knee symptoms and MRI detected structures in patients with knee osteoarthritis (OA)Abstract Background/Purpose: This study aimed to examine the…
Abstract Number: 1994 • 2018 ACR/ARHP Annual Meeting
Osteoarthritis Severity Is Reduced By Intra-Articular Administration of Hydrogen Sulfide
Elena F. Burguera^1,2, Angela Vela-Anero³, Carlos Vaamonde-Garcia³, Tamara Hermida-Gómez^1,2, Purificacion Filgueira-Fernandez^1,2, Lucía Gato-Calvo², Rosa Meijide-Failde⁴ and Francisco J Blanco⁵, ¹CIBER-BBN, Madrid, Spain, ²Unidad de Medicina Regenerativa, Grupo de Investigación en Reumatología, Agrupación Estratégica CICA-INIBIC, Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade de A Coruña (UDC), A Coruña, Spain, ³Department of Physiotherapy, Medicine and Biological sciences, Tissue Engineering and Regenerative Medicine group (University of A Coruña), A Coruña, Spain, ⁴Department of Physiotherapy, Medicine and Biological Sciences, Tissue Engineering and Regenerative Medicine group (University of A Coruña), A Coruña, Spain, ⁵Grupo de Investigación en Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose: Hydrogen sulphide (H2S) is recognized as a therapeutic target in osteoarthritis (OA). Exogenous supplementation with synthetic salts in in vitro models of OA has…
Abstract Number: 427 • 2018 ACR/ARHP Annual Meeting
One Year Efficacy and Safety of One or Three Injections of Hylan G-F 20 for Knee Osteoarthritis: A Systematic Literature Review and Meta-Analysis
Orazio De Lucia¹, Georgios Filippou², Joerg Jerosch³, Sophie Yoon⁴, Jean-Francois Bitsch⁴, Tobias Sayre⁴ and Wilson Ngai⁵, ¹Division of Clinical Rheumatology, G. Pini Hospital, Milan, Italy, ²Section of Rheumatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy, ³Department of Orthopedic Surgery, Johanna-Etienne Krankenhaus, Neuss, Germany, ⁴Doctor Evidence, Santa Monica, CA, ⁵Global Medical Affairs, General Medicines and Emerging Markets, Sanofi, Bridgewater, NJ
Background/Purpose: Hylan G-F 20 is indicated for the treatment of pain in knee osteoarthritis (OA) in patients who failed to respond adequately to conservative nonpharmacologic…
Abstract Number: 432 • 2018 ACR/ARHP Annual Meeting
Relation of Patellofemoral Joint Alignment, Morphology, and Radiographic Osteoarthritis to Frequent Anterior Knee Pain
Erin Macri¹, Tuhina Neogi², Irina Tolstykh³, Cora E. Lewis⁴, James Torner⁵, Michael C. Nevitt⁶ and Joshua J. Stefanik⁷, ¹Physical Therapy, University of Delaware, Newark, DE, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵University of Iowa, Iowa City, IA, ⁶Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁷Department of Physical Therapy, University of Delaware, Newark, DE
Background/Purpose: Radiographic patellofemoral osteoarthritis (OA) is prevalent in approximately 25% of population-based samples and 39% of individuals with knee pain. Discordance between knee OA features…

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