Abstracts tagged "Osteoarthritis"

Abstract Number: L04 • ACR Convergence 2024
Performance of an Artificial Intelligence Model Compared to Multiple Human Experts in Scoring Synovitis Severity and Osteophyte Severity on Joint Ultrasound Images
Anders Weber¹, Mads Ammitzbøll Danielsen², Bill Aplin Frederiksen³, Hilde Berner Hammer⁴, Benjamin Schultz Overgaard³, Lene Terslev², Thiusius Rajeeth Savarimuthu⁵ and Soren Andreas Just³, ¹ROPCA, Odense, Denmark, ²Center for Rheumatology and Spine Disease, Rigshospitalet, Glostrup, Denmark, ³Section of Rheumatology, Department of Medicine, Svendborg Sygehus OUH, Svendborg, Denmark, ⁴Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, Faculty of Medicine, University of Oslo, Oslo, Norway, ⁵Mærsk Mc-Kinney Møller Institute, University of Southern Denmark, Odense, Denmark
Background/Purpose: To evaluate the agreement of an artificial intelligence (AI) model designed to assess greyscale and Doppler synovitis severity and osteophyte severity in hand joints…
Abstract Number: L08 • ACR Convergence 2024
A Phase 2b, Randomized, Double-blind, Placebo-controlled, Dose-ranging and Parallel-group Study to Evaluate the Safety and Efficacy of XG005 in Subjects with Painful Osteoarthritis of the Knee
Limin Ren¹, Wenjie Zheng², Zhenpeng Guan³, Yang Zhang⁴, Zeyu Huang⁵, Tong Li⁶, Yuwei Peng⁷, Qiuli Wu⁸, Wei Gou⁹, Wei Zhao¹⁰, Pengyan Qiao¹¹, Xiaoli Pan¹² and Guang-Liang Jiang¹³, ¹Peking University, People’s Hospital, Rheumatology and Immunology Department, Beijing, China, ²Yantai Yuhuangding Hospital of Qingdao University, Department of Orthopedics, Yantai, China, ³Peking University, Shougang Hospital, Department of Orthopedics, Beijing, China, ⁴Division of Orthopaedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁵West China Hospital of Sichuan University, Department of Orthopedics, Chengdu, China, ⁶Xiangya Hospital of Central South University, Rheumatology and Immunology Department, Changsha, China, ⁷PingXiang People’s Hospital, Rheumatology and Immunology Department, Pingxiang, China, ⁸Tianjin Medical University General Hospital, Department of Orthopedics, Tianjin, China, ⁹Hebei Petrochina Central Hospital, Rheumatology and Immunology Department, Langfang, China, ¹⁰Central Hospital Affiliated to Shenyang Medical College, Department of Orthopedics, Shenyang, China, ¹¹Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Rheumatology and Immunology Department, Taiyuan, China, ¹²Affiliated Hospital of Zunyi Medical University, Rheumatology and Immunology Department, Zunyi, China, ¹³Xgene Pharmaceutical, Lexington, MA
Background/Purpose: Osteoarthritis (OA) affects 595 million people globally; cases are projected to increase 49-95% for various joints by 2050 as populations age (GBD 2023). OA…
Abstract Number: L15 • ACR Convergence 2024
LEVI-04, a Novel neurotrophin-3 Inhibitor, Substantially Improves Pain and Function Without Deleterious Effects on Joint Structure in People with Knee Osteoarthritis: A Randomized Controlled Phase II Trial
Philip Conaghan¹, Ali Guermazi², Nathaniel Katz³, Asger Bihlet⁴, Dror Rom⁵, Michael Perkins⁶, Bernadette Hughes⁶, Claire Herholdt⁶, Iwona Bombelka⁶ and Simon Westbrook⁶, ¹University of Leeds, Leeds, United Kingdom, ²Boston University, West Roxbury, MA, ³Rin Sof Innovation, Ltd, Boston, MA, ⁴NBCD A/S, Soeborg, Denmark, ⁵Prosoft Clinical, Chesterbrook, ⁶Levicept Ltd, Ramsgate, United Kingdom
Background/Purpose: There is an urgent need for new therapies to treat OA. Excess neurotrophins (NT) are implicated in OA and other painful conditions. Previous OA…
Abstract Number: 0023 • ACR Convergence 2024
Adenosine and Guanosine-based Oligonucleotide Attenuates Catabolic Phenotypes in Chondrocytes and Slows Progression of Surgically Induced Osteoarthritis
Yoonhee Kim¹, Jin Han² and Seungwoo Han³, ¹Kyungpook National University School of Medicine, Buk-gu, Daegu, Republic of Korea, ²Kyungpook National University, Buk-gu, Daegu, Republic of Korea, ³Kyungpook national university hospital, Daegu, South Korea
Background/Purpose: Adenosine is a potent endogenous modulator of inflammation; however, its clinical application is limited due to its extremely short half-life in blood. In this…
Abstract Number: 0790 • ACR Convergence 2024
CoLchicine for Treatment of OsteoArthritis of the Knee: Clinical Outcomes from a 90-day Double-Blind, Placebo-Controlled Study
Jonathan Samuels¹, Katherine Tse², Wei David², maryfe Coronel², Fernando Bomfim², Renata La Rocca Vieira³, Nicole Leung⁴, Svetlana Krasnokutsky Samuels⁵, Michael Toprover⁶ and Michael Pillinger⁷, ¹NYU Langone, Rye Brook, NY, ²NYU Langone Health, new york, NY, ³NYU., New York, NY, ⁴New York University Langone Medical Center, New York, NY, ⁵Summit Health, Rye Brook, NY, ⁶New York University Langone Health, New York, NY, ⁷New York University Grossman School of Medicine, New York,, NY
Background/Purpose: Knee osteoarthritis (OA) leads to progressive disability, but approved pharmacologic treatments target analgesia without affecting disease course. Colchicine is well-tolerated and inhibits inflammation thought…
Abstract Number: 1172 • ACR Convergence 2024
Participation in Baseball/Softball Associates with Increased Risk for Knee Pain and Osteoarthritis as an Adult: Data from the Osteoarthritis Initiative
Christopher Boldt¹, Jeffrey Driban², Timothy McAlindon², Andrea Kriska³, Bonny Rockette-Wagner³, Charles Eaton⁴, Marc Hochberg⁵, Kent Kwoh⁶, Michael Nevitt⁷ and Grace Lo⁸, ¹Baylor College of Medicine, Houston, TX, ²University of Massachusets, Worchester, MA, ³University of Pittsburgh, Pittsburgh, PA, ⁴Memorial Hospital of Rhode Island, Pawtucket, RI, ⁵University of Maryland School of Medicine, Cambridge, MD, ⁶University of Arizona, Tucson, AZ, ⁷University of California, San Francisco, San Francisco, CA, ⁸Baylor College of Medicine / MEDVAMC, Houston, TX
Background/Purpose: Baseball is often referred to as “America’s Pastime” and youth in the United States commonly participate in baseball and softball. With the increasing popularity…
Abstract Number: 1194 • ACR Convergence 2024
Treatment Effect of Lorecivivint Across Multiple Trials in Patients with Knee OA: A Meta-analysis
Christopher Swearingen¹, Jeyanesh Tambiah² and Yusuf Yazici³, ¹Biosplice Therapeutics, Inc, San Diego, CA, ²Biosplice Therapeutics Inc., San Diego, CA, ³NYU Grossman School of Medicine, La Jolla, CA
Background/Purpose: Lorecivivint (LOR), an intra-articular (IA) CLK/DYRK inhibitor thought to modulate inflammatory and Wnt pathways has previously appeared safe, improved patient-reported outcomes (PROs) compared with…
Abstract Number: 1210 • ACR Convergence 2024
Optimal Definitions of Worsening Cartilage Using Sequential MRI OsteoArthritis Knee Scores (MOAKS)
Kathryn Bacon¹, mike LaValley², Tuhina Neogi³, Ali Guermazi³, Frank Roemer³, Neil Segal⁴, Cora Lewis⁵, Michael Nevitt⁶, David Felson⁷ and John Lynch⁸, ¹Boston University, Webster, NH, ²Boston University School of Public Health, Arlington, MA, ³Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁴University of Kansas, Kansas City, KS, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶University of California, San Francisco, San Francisco, CA, ⁷Boston University, Boston, MA, ⁸UCSF, San Francisco, CA
Background/Purpose: The MRI OsteoArthritis Knee Score (MOAKS) is increasingly used in studies of knee osteoarthritis. Our aim was to evaluate methods using MOAKS scores to…
Abstract Number: 1667 • ACR Convergence 2024
Correlates of Physical Activity (PA) in Persons Undergoing Total Knee Arthroplasty (TKA): Does Pain Matter?
Elena Losina¹, Jamie Collins¹, Clare Safran-Norton¹, Mike Paskewicz¹, Faith Selzer², Sonia Pavlesen³, Kelly Frier¹, Jon Dhani¹, Darya Lee¹, Ella Macdonald³, Alexa Streicher³, Linda Ehrlich-Jones⁴, Neil Segal⁵, Christine Pellegrini⁶, Elizabeth Wellsandt⁷, Rowland Chang⁸ and Jeffrey Katz¹, and KArAT Team, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Amesbury, MA, ³University of Buffalo, Buffalo, NY, ⁴Shirley Ryan Ability Lab, Chicago, IL, ⁵University of Kansas, Kansas City, KS, ⁶University of South Carolina, Columbia, SC, ⁷University of Nebraska Medical Center, Omaha, NE, ⁸Northwestern University Division of Rheumatology, Chicago, IL
Background/Purpose: Low PA in persons with symptomatic knee osteoarthritis (OA) has often been attributed to pain. Evolving data suggest that TKA recipients do not increase…
Abstract Number: 2090 • ACR Convergence 2024
Prevalence of Steatotic Liver Disease and Liver Fibrosis Among Patients with Osteoarthritis (OA)
Athanasios Vassilopoulos¹, Stephanos Vassilopoulos², Markos Kalligeros², Eleftherios Mylonakis³ and Anthony M. Reginato⁴, ¹Warren Alpert Medical School of Brown University, Providence, RI, ²Division of Internal Medicine, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island, Providence, RI, ³Department of Medicine, Houston Methodist Hospital, Houston, ⁴Brown University, Providence, RI
Background/Purpose: Steatotic liver disease (SLD) and osteoarthritis (OA) affect a large proportion of the general population and prevalence of both is expected to increase given…
Abstract Number: 2106 • ACR Convergence 2024
EP-104IAR (Long-Acting Intra-Articular Injection of Fluticasone Propionate) Shows Sustained Improvement in Pain for Subjects with Moderate Baseline Pain and BMI Less Than 30 in SPRINGBOARD, a Phase 2, Randomized, 24-Week Study of Osteoarthritis of the Knee
Amanda Malone¹, James Helliwell¹, Mark Kowalski¹, Helene Rovsing², Sidsel Lynggaard Boll³, Asger Reinstrup Bihlet⁴, Claire Prener Miller⁵, Alejandro Castillo Mondragón⁶, Yanqi Li⁶, Christine Dobek¹, Vik Peck¹, Andrew Dye¹, Mike Wilmink⁷, Lee Simon⁸ and Philip G Conaghan⁹, ¹Eupraxia Pharmaceuticals, Victoria, BC, Canada, ²NBCD A/S, Nordjylland, Denmark, ³NBCD A/S, Syddanmark, Denmark, ⁴NBCD A/S, Soeborg, Denmark, ⁵Novo Nordisk A/S, Bagsværd, Denmark, ⁶NBCD A/S, Soborg, Denmark, ⁷OrthoArizona, Phoenix, AZ, ⁸SDG LLC, West Newton, MA, ⁹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Knee osteoarthritis (KOA) is a leading cause of disability associated with risk of cardiovascular disease and reduced self-management of diabetes and hypertension. Recommended treatment…
Abstract Number: 0024 • ACR Convergence 2024
Trans-Signaling by Soluble CD14 Sensitizes Chondrocytes to Lipopolysaccharide Stimuli, Increasing Chondrocyte Inflammatory Responses
Anna E. Rapp, Baofeng Hu and Carla Scanzello, University of Pennsylvania, Philadelphia, PA
Background/Purpose: The understanding of osteoarthritis (OA) has evolved significantly over the past decade. Recently attention is being drawn to the role of pattern-recognition receptor (PRR)…
Abstract Number: 0791 • ACR Convergence 2024
Optimizing Knee Osteoarthritis Treatment with the Precision Medicine Approach in a Clinical Trial Dataset
Caroline Walton¹, Forrest Hurley², Liubov Arbeeva³, Stephen Messier⁴, Shannon Mihalko⁴, Jeffrey Katz⁵, Richard Loeser⁶, David Hunter⁷, Leigh Callahan⁸ and Amanda Nelson², ¹UNC School of Medicine, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina, Chapel Hill, Carrboro, NC, ⁴Wake Forest University, Winston Salem, NC, ⁵Brigham and Women's Hospital, Brookline, MA, ⁶University of North Carolina, Chapel Hill, NC, ⁷Sydney Musculoskeletal Health, University of Sydney, St Leonards, New South Wales, Australia, ⁸University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC
Background/Purpose: Precision medicine has previously identified subgroups of clinical trial participants with knee osteoarthritis (kOA) that benefit more from a specific intervention than others. We…
Abstract Number: 1174 • ACR Convergence 2024
Effects of Electroacupuncture on Pain and Joint Deformity in Rat Models of Knee Osteoarthritis: A Study on the Differences in Acupoints Used
Hideshi Ikemoto, Oyunchimeg Chuluunbat, Takayuki Okumo, Naoki Adachi, Tadashi Hisamitsu and Masataka Sunagawa, Showa university, Shinagawa-ku, Tokyo, Japan
Background/Purpose: ADAMTS5, a member of the ADAMTS enzyme family, is a key enzyme in the degradation of cartilage in the early stages of knee osteoarthritis…
Abstract Number: 1195 • ACR Convergence 2024
The Relations of Analgesic Antidepressants Use to Knee or Hip Replacement Among Osteoarthritis Patients Compared to Selective Serotonin Reuptake Inhibitors in a Large Prospective Cohort
Zhiqiang Wang¹, Maggie Westerland², Christine Peloquin³, mike LaValley⁴, Margaret Clancy³, Changhai Ding⁵ and Tuhina Neogi³, ¹Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China, Guangzhou, Guangdong, China (People's Republic), ²Boston University School of Medicine, Boston, MA, ³Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁴Boston University School of Public Health, Arlington, MA, ⁵Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China, Guangzhou, China (People's Republic)
Background/Purpose: Some antidepressants and anticonvulsants are effective in treating pain through mechanisms thought to be independent from their effects on depression, such as tricyclic antidepressants…

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