ACR Meeting Abstracts

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Abstracts tagged "Osteoarthritis"

  • Abstract Number: L04 • ACR Convergence 2024

    Performance of an Artificial Intelligence Model Compared to Multiple Human Experts in Scoring Synovitis Severity and Osteophyte Severity on Joint Ultrasound Images

    Anders Weber1, Mads Ammitzbøll Danielsen2, Bill Aplin Frederiksen3, Hilde Berner Hammer4, Benjamin Schultz Overgaard3, Lene Terslev2, Thiusius Rajeeth Savarimuthu5 and Soren Andreas Just3, 1ROPCA, Odense, Denmark, 2Center for Rheumatology and Spine Disease, Rigshospitalet, Glostrup, Denmark, 3Section of Rheumatology, Department of Medicine, Svendborg Sygehus OUH, Svendborg, Denmark, 4Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, Faculty of Medicine, University of Oslo, Oslo, Norway, 5Mærsk Mc-Kinney Møller Institute, University of Southern Denmark, Odense, Denmark

    Background/Purpose: To evaluate the agreement of an artificial intelligence (AI) model designed to assess greyscale and Doppler synovitis severity and osteophyte severity in hand joints…
  • Abstract Number: L08 • ACR Convergence 2024

    A Phase 2b, Randomized, Double-blind, Placebo-controlled, Dose-ranging and Parallel-group Study to Evaluate the Safety and Efficacy of XG005 in Subjects with Painful Osteoarthritis of the Knee

    Limin Ren1, Wenjie Zheng2, Zhenpeng Guan3, Yang Zhang4, Zeyu Huang5, Tong Li6, Yuwei Peng7, Qiuli Wu8, Wei Gou9, Wei Zhao10, Pengyan Qiao11, Xiaoli Pan12 and Guang-Liang Jiang13, 1Peking University, People’s Hospital, Rheumatology and Immunology Department, Beijing, China, 2Yantai Yuhuangding Hospital of Qingdao University, Department of Orthopedics, Yantai, China, 3Peking University, Shougang Hospital, Department of Orthopedics, Beijing, China, 4Division of Orthopaedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China, 5West China Hospital of Sichuan University, Department of Orthopedics, Chengdu, China, 6Xiangya Hospital of Central South University, Rheumatology and Immunology Department, Changsha, China, 7PingXiang People’s Hospital, Rheumatology and Immunology Department, Pingxiang, China, 8Tianjin Medical University General Hospital, Department of Orthopedics, Tianjin, China, 9Hebei Petrochina Central Hospital, Rheumatology and Immunology Department, Langfang, China, 10Central Hospital Affiliated to Shenyang Medical College, Department of Orthopedics, Shenyang, China, 11Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Rheumatology and Immunology Department, Taiyuan, China, 12Affiliated Hospital of Zunyi Medical University, Rheumatology and Immunology Department, Zunyi, China, 13Xgene Pharmaceutical, Lexington, MA

    Background/Purpose: Osteoarthritis (OA) affects 595 million people globally; cases are projected to increase 49-95% for various joints by 2050 as populations age (GBD 2023). OA…
  • Abstract Number: L15 • ACR Convergence 2024

    LEVI-04, a Novel neurotrophin-3 Inhibitor, Substantially Improves Pain and Function Without Deleterious Effects on Joint Structure in People with Knee Osteoarthritis: A Randomized Controlled Phase II Trial

    Philip Conaghan1, Ali Guermazi2, Nathaniel Katz3, Asger Bihlet4, Dror Rom5, Michael Perkins6, Bernadette Hughes6, Claire Herholdt6, Iwona Bombelka6 and Simon Westbrook6, 1University of Leeds, Leeds, United Kingdom, 2Boston University, West Roxbury, MA, 3Rin Sof Innovation, Ltd, Boston, MA, 4NBCD A/S, Soeborg, Denmark, 5Prosoft Clinical, Chesterbrook, 6Levicept Ltd, Ramsgate, United Kingdom

    Background/Purpose: There is an urgent need for new therapies to treat OA. Excess neurotrophins (NT) are implicated in OA and other painful conditions. Previous OA…
  • Abstract Number: 0028 • ACR Convergence 2024

    Human Meniscus Histopathological and Transcriptomic Changes at Early and Advanced Stages of Knee Osteoarthritis

    Takuya Sakamoto1, Hannah Swahn1, Merissa Olmer1, Rachel Miller2, Anne-Marie Malfait3 and Martin Lotz1, 1Scripps Research Institute, La Jolla, CA, 2Rush University Medical Center, Chicago, IL, 3Rush University Medical Center, Division of Rheumatology, Chicago, IL

    Background/Purpose: The knee menisci are essential elements in joint biomechanics and meniscus damage is a driver of cartilage destruction and knee osteoarthritis. Meniscus damage and…
  • Abstract Number: 0852 • ACR Convergence 2024

    3-dimensional Shape Changes of the Knee over 4 Years Are Linear and Progressive but Much More Rapid in Osteoarthritic Joints: Data from the Osteoarthritis Initiative

    Alan Brett1, Philip G Conaghan2 and Michael Bowes3, 1Imorphics, Austin, TX, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3Imorphics, Manchester, United Kingdom

    Background/Purpose: The specific bony changes of osteophyte growth and “bone attrition” (broadening and flattening of the femoral condyles) associated with OA have been recognized in…
  • Abstract Number: 1180 • ACR Convergence 2024

    Relationship Between Changes in Physical Activity and Early Onset Knee Osteoarthritis in Individuals After ACL Reconstruction

    David Werner1, Yvonne Golightly1, Michael Rosenthal1, Balasrinivasa Sajja1, Christopher Wichman1, Melissa Manzer2, Matthew Tao1 and Elizabeth Wellsandt1, 1University of Nebraska Medical Center, Omaha, NE, 2Private Practice, Omaha

    Background/Purpose: Low physical activity levels are associated with osteoarthritis (OA) development and progression in individuals at risk for OA development. Including both structural and symptomatic…
  • Abstract Number: 1198 • ACR Convergence 2024

    Impact of Metabolic Syndrome on Knee Osteoarthritis Severity and Progression: A PROCOAC Cohort Study

    Natividad Oreiro1, Ana Raga2, Vanesa Balboa-Barreiro3, Ignacio Rego-Perez4, Belen Acasuso5, Laura Galindo Domínguez6 and francisco J Blanco7, 1CHUAC, La Coruna, Galicia, Spain, 2Grupo de Investigación en Reumatología (GIR). INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC). SERGAS, A Coruña, Spain, 3Unidad de Epidemiología Clínica y Bioeostadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC)., A Coruña, Spain, 4Instituto de Investigacion Biomedica de A Coruña-SERGAS, A Coruña, Spain, 5Unidad de Investigacion Clinica. Grupo de Investigación de Reumatología (GIR). Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas., Investigation, A Coruña, Spain, A Coruña, Spain, 6Instituto de Investigacion Biomedica de A Coruña (INIBIC), A Coruña, Spain, 7INIBIC-University of A Coruña, A Coruña, Spain

    Background/Purpose: The contribution of metabolic factors to the development of osteoarthritis (OA) has not been fully elucidated. The aim of this study is to analyze…
  • Abstract Number: 1292 • ACR Convergence 2024

    Primary Care Provider Educational Tool to Improve Osteoarthritis Management in the Primary Care Setting

    Tessalyn Morrison1, Luke Giangregorio2, Emily Hadley-Strout1 and Jeanne Gosselin3, 1University of Vermont Medical Center, Burlington, VT, 2Larner College of Medicine at the University of Vermont, Burlington, VT, 3University of Vermont Medical Center, Waterbury, VT

    Background/Purpose: Osteoarthritis is the most common form of arthritis and its prevalence is increasing. As a non-inflammatory type of arthritis, it can be managed in…
  • Abstract Number: 1906 • ACR Convergence 2024

    Bayesian Algorithm to Identify Osteoarthritis in Administrative Health Data Without Requiring Chart Review

    S. Reza Jafarzadeh1, Sarah Tilley1, Anup Arvind1 and David Felson2, 1Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 2Boston University, Boston, MA

    Background/Purpose: Osteoarthritis (OA) is the most prevalent arthritis and a significant contributor to Years Lived with Disability. Administrative health data are widely used to study…
  • Abstract Number: 2094 • ACR Convergence 2024

    Cross-sectional Associations of Radiographic Multiple Joint Osteoarthritis and Pain with Demographic and Clinical Characteristics: Design of a Multi-modal Study in Human and Pet Dogs

    Liubov Arbeeva1, Kelly Johnson2, Serena Savage-Guin3, Tessa Walker2, Masataka Enomoto4, Christina Stevens4, Milja Koskinen4, Tracey Cole4, Savannah Aker4, Connor Thonen-Fleck4, Richard Loeser5, Jordan Renner2, Duncan Lascelles6, Yvonne Golightly7 and Amanda Nelson8, 1University of North Carolina, Chapel Hill, Carrboro, NC, 2Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill,, Chapel Hill, NC, 4Translational Research in Pain and Comparative Pain Research and Education Center, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 5University of North Carolina, Chapel Hill, NC, 6North Carolina State University, Raleigh, NC, 7University of Nebraska Medical Center, Omaha, NE, 8University of North Carolina at Chapel Hill, Chapel Hill, NC

    Background/Purpose: Multiple joint osteoarthritis (MJOA) is a progressive, highly prevalent disease affecting millions of Americans and as well as pet dogs. This preliminary analysis sought…
  • Abstract Number: 2110 • ACR Convergence 2024

    Association Between Symptomatic Knee Osteoarthritis and Blood Glucose Control in Persons with Type 2 Diabetes

    Lauren King1, Alanna Weisman1, Baiju Shah1, Robert Goldberg1, Amish Parikh2, Ian Stanaitis3, Rosane Nisenbaum4, Esther Waugh1, Lorraine Lipscombe1 and Gillian Hawker1, 1University of Toronto, Toronto, ON, Canada, 2Trillium Health Partners, Toronto, ON, Canada, 3Women's College Hospital, Toronto, ON, Canada, 4Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON, Canada

    Background/Purpose: There is a high prevalence of knee osteoarthritis (OA) in people with type 2 diabetes (T2D), and knee OA increases risk for diabetes complications…
  • Abstract Number: 0029 • ACR Convergence 2024

    Effect of Metformin on the Incidence of Total Knee Replacement: A Systematic Review and Meta-Analysis

    Syed Hasan1, Aali Furqan2, Afia Salman3, hira Khan4, Sarah Aslam5, Alishba Rizvi4, Hafsah Alim Ur Rahman3, Muhammad Ahmed Ali Fahim3, Madiha Salman3, Eman Ali3, Yumna Furqan6, Shanta bai7, Farah Yasmin8 and Muhammad Sohaib Asghar9, 1Dow University of Health Sciences, Karachi, PK., Karachi, Sindh, Pakistan, 2University of North Texas Health Science Center (UNT HSC), Texas, TX, 3Dow University of Health Sciences, Karachi, Pakistan, 4dow medical college, Karachi, Pakistan, 5Dow International Medical College, Karachi, Pakistan, 6Texas A&M School of Medicine, Dallas, TX, 7Liaquat National Hospital and Medical College, Karachi, Pakistan, 8Yale University School of Medicine, New Haven, CT 06511, U.S.A., New Haven, CT, 9AdventHealth, Sebring, FL

    Background/Purpose: Osteoarthritis (OA) is among the most common debilitating conditions, causing disability and pain in older adults. For end-stage OA, total knee replacement (TKR) is…
  • Abstract Number: 0861 • ACR Convergence 2024

    Stem Cell Function and Capsule Tissue Composition Are Associated with Symptoms, Joint Range of Motion and Radiographic Severity in People with Knee Osteoarthritis

    T Mark Campbell1, Robert Feibel2, Jeff Dilworth3, Odette Laneuville4 and Guy Trudel5, 1Bruyère Research Institute, Ottawa, ON, Canada, 2The Ottawa Hospital, Ottawa, ON, Canada, 3University of Wisconsin, Madison, WI, 4University of Ottawa, Ottawa, ON, Canada, 5Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Background/Purpose: Osteoarthritis is a common and debilitating condition without cure. Increased OA severity is associated with lost range of motion (ROM) in the affected joint.…
  • Abstract Number: 1183 • ACR Convergence 2024

    The Effectiveness of Orthosis for the Management of Hand Osteoarthritis-a Systemic Review and Meta-analysis

    Nouf Alhammadi1, Hanan Alqahtani2 and Bagrat Hakobyan3, 1HMG - Dr.Sulaiman Al Habib Medical Group, Riyadh, Saudi Arabia, 2University of toronto, Toronto, Canada, 3Independent researcher, Yerevan, Armenia

    Background/Purpose: Hand osteoarthritis (OA) affects  11-33% of men and women in their 50s and 60s, significantly affecting the quality of life of those afflicted.Orthoses are…
  • Abstract Number: 1199 • ACR Convergence 2024

    Diclofenac Sodium 1% Gel Improves Physical Function in the Performance of Important Activities of Daily Living in Patients with Hand or Knee Osteoarthritis

    Karin Nicholson, Edwin Sanchez, Nadine Maybaum and Richard Petruschke, Haleon, Warren, NJ

    Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, with hand and knee being among the most afflicted joints.  Symptoms of OA include joint…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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