Abstracts tagged "Osteoarthritis"

Abstract Number: LB07 • ACR Convergence 2025
Adipose-Tissue Derived Mesenchymal Stem Cells vs Hyaluronic Acid in Refractory Knee Osteoarthritis in a low-resource setting: A Phase IIb RCT
Moshiur Rahman Khasru¹, Mohammad Tariqul Islam², AGM Zakaria Nazimuddin Jubery³, Mahbuba Shirin⁴, Fazle Rabbi Chowdhury⁵, Tangila Marzen⁶, Nafi Uzzaman⁷, Md Abu Bakar Siddiq⁸, Md Ashraful Hoque⁹, Masuda Begum¹⁰, Md Moniruzzaman Khan² and Abul Salek¹¹, ¹Musculoskeletal Medicine and Interventional Physiatry Division, Bagladesh Medcial University, Dhaka, Bangladesh, ²Department of Physical Medicine and Rehabilitation, Bangladesh Medical University, Dhaka, Bangladesh, ³Department of Burn and Plastic Surgery, Dhaka Medcial College and Hospital, Dhaka, Bangladesh, ⁴Department of Radiology and Imaging, Bangladesh Medical University, Dhaka, Bangladesh, ⁵Department of Internal Medicine, Bangladesh Medical University, Dhaka, Bangladesh, ⁶Department of Anatomy, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh, ⁷Stem Cell Rearch Group, Department of Physical Medicine and Rehabilitation, Bangladesh Medical University, Dhaka, Bangladesh, ⁸Department of Rheumatology, Royal North Shore Hospital, Faculty of Medicine, University of Sydney, New South Wales, Australia, ⁹Department of Transfusion Medicine, Cumilla Medical College, Cumilla, Bangladesh, ¹⁰Department of Haematology, Banglabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, ¹¹Department of Physical Medicine and Rehabilittaion, Bangladesh Medical University, Dhaka, Bangladesh
Background/Purpose: Knee osteoarthritis (KOA) is a leading cause of disability, with no available disease-modifying treatments. While Hyaluronic Acid (HA) remains widely used, there is little…
Abstract Number: LB12 • ACR Convergence 2025
Randomized, Double-Blind, Placebo-Controlled Phase IIa Trial of an Innovative Intra-Articular Apoptotic Cell Therapy in Knee Osteoarthritis (OA): 3-Month Positive Outcomes and Identification of Responder Population (NCT06233474)
Philip Conaghan¹, Bernt Husøy², Cecilie Rovsing³, Sidsel L Boll⁴, Liliana Groppa⁵, Amir Oron⁶, Asger Bihlet⁷, Ali Mobasheri⁸, Tobias Winkler⁹, Dror Mevorach¹⁰, Einat Galamidi¹¹, Lital Weinfeld-Bergman¹², Lior Binder¹² and Oren Hershkovitz¹¹, ¹University of Leeds, Leeds, United Kingdom, ²Sanos Clinic, Herlev, Denmark, ³Sanos Clinic, Gandrup, Denmark, ⁴Sanos Clinic, Vejle, Denmark, ⁵T. Mosneaga Republican Clinical Hospital, Chisinau, Moldova, ⁶Kaplan MC, Rehovot, Israel, ⁷NBCD A/S, Soeborg, Denmark, ⁸University of Oulu, Oulu, Finland, ⁹Charité - Universitätsmedizin Berlin, Berlin, Germany, ¹⁰Hadassah-University Hospital, Jerusalem, Israel, ¹¹Enlivex Therapeutics, Ness Ziona, Israel, ¹²Enlivex Therapeutics, Nes Ziona, Israel
Background/Purpose: OA is a prevalent disabling disease growing globally due to aging populations and rising obesity. In primary OA, the effects of joint tissue damage accumulate with age,…
Abstract Number: 2104 • ACR Convergence 2025
Pain 0-10 visual analog scale (VAS) and RAPID3 (routine assessment of patient index data) in OA and RA are similar in 2024 to 1979 and 1989
Theodore Pincus¹, Tengfei Li² and Juan Schmukler¹, ¹Rush University Medical Center, Chicago, IL, ²Rush, chicago, IL
Background/Purpose: A 1979 report by Huskisson, who developed the 0-10 pain visual analog scale (VAS) , entitled "Another look at osteoarthritis" indicated mean pain VAS…
Abstract Number: 2087 • ACR Convergence 2025
Does Carbamazepine Impact Risk of Developing Osteoarthritis? Results of a Real-World Data Analysis
Erfan Afshar¹ and Andrew Long², ¹VCUSOM, Richmond, VA, ²Virginia Commonwealth University Health System, Midlothian, VA
Background/Purpose: Carbamazepine has shown chondroprotective effects in OA animal models by modulating Nav1.7 channels. This study aimed to examine the association between Carbamazepine use and…
Abstract Number: 1806 • ACR Convergence 2025
Sex differences in knee joint microbial DNA of C57BL/6 mice and the effect of cross-sex microbiome transplantation
Veera Durga Vaishnavi Kurra¹, Ausitn Lopez², Aleksander Szymczak³, Gabriella Dyson³, Pratibha Dube⁴, Padmaja Mehta-d'Souza² and Matlock Jeffries³, ¹University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Oklahoma Medical Research Foundation, Edmond, OK
Background/Purpose: Recent studies have suggested an association between the gut microbiome and osteoarthritis. We have previously shown that the joint microbiome is derived at least…
Abstract Number: 1786 • ACR Convergence 2025
SEV-101, A Regenerative Exosome Therapeutic for the Treatment of Osteoarthritis
Beth Lindborg¹, Amanda Vegoe², Michael Williams¹, Parthasarathy Rangarajan³, Marc Tompkins⁴, Sabarinathan Ramachandran⁵ and Timothy O'Brien⁶, ¹Sarcio, Inc., St. Paul, ²Department of Veterinary Population Medicine and Stem Cell Institute, University of Minnesota, Sarcio, Inc, St. Paul, ³Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, ⁴Department of Orthopedic Surgery, University of Minnesota, Sarcio, Inc., Minneapolis, ⁵Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN, ⁶Department of Veterinary Population Medicine and Stem Cell Institute, University of Minnesota, Sarcio, Inc, Minneapolis
Background/Purpose: Osteoarthritis (OA) is a chronic, debilitating joint disease affecting 595 million people worldwide, including over 32 million in the United States. It is characterized…
Abstract Number: 1127 • ACR Convergence 2025
The Pathogenetic Role of Calcium Pyrophosphate and Basic Calcium Phosphate Crystals in Osteoarthritis: Associations with Synovial Fluid Cytokines and Clinical Indices
Francesca Oliviero¹, Chiara Baggio², Amelia Damasco², Federico Zorzi³, Mariagrazia Lorenzin², Giacomo Cozzi² and Roberta Ramonda⁴, ¹Rheumatology Unit, Department od Medicine - DIMED, University of Padova, Padova, Veneto, Italy, ²Rheumatology Unit, Department of Medicine - DIMED, University of Padova, Padova, Veneto, Italy, ³Center for Analysis and Certification Services (CEASC), University of Padova, Padova, Veneto, Italy, ⁴Rheumatology Unit-DIMED-University of Padova ITALY, Padova, Padua, Italy
Background/Purpose: Calcium pyrophosphate (CPP) and basic calcium phosphate (BCP) crystals are frequent features of synovial fluid (SF) in patients with osteoarthritis (OA). Although these crystals…
Abstract Number: 0334 • ACR Convergence 2025
Diagnostic Test Accuracy of Ultrasound for Detecting Knee Osteoarthritis: A Systematic Review and Meta-Analysis
Mohamed Abdelsalam¹, Hadeer Hafez², Maryam Lasheen³, Bassant Elaraby Elsayed Badwy⁴, Omar Sameh Nabil El Sedafy¹, Menat Alla Ayman Ali Mahdy⁴, Hazem E. Mohammed⁵ and Mohamed Reda Awad⁶, ¹Misr University For Science and Technology, ⁶ october, Al Jizah, Egypt, ²⁶th October University, ⁶ october, Al Jizah, Egypt, ³Misr University For Science and Technology, Helwan, Al Qahirah, Egypt, ⁴Misr University For Science and Technology, Nasr City, Al Qahirah, Egypt, ⁵Faculty of Medicine, Assiut university, Assiut, Egypt, assyut, Asyut, Egypt, ⁶Al Azhar University, Cairo, Egypt, Giza, Al Jizah, Egypt
Background/Purpose: Ultrasound (US) is an emerging, promising imaging modality offering a safe, radiation-free, and cost-effective option for diagnosing and assessing structural changes in knee osteoarthritis…
Abstract Number: 0318 • ACR Convergence 2025
Plasma Lipoprotein Subclasses and Risk of Incident Knee Osteoarthritis: A Population-Based Cohort Study
Cheng Li¹, Jing wu², Yuqing Zhang³, Hongyi He⁴, Ying Hu⁵, Jie Wei⁶, Guanghua Lei⁶ and Chao Zeng⁶, ¹Xiangya Hospital, Changsha, China (People's Republic), ²Xiangya Hospital, chagnsha, Hunan, China (People's Republic), ³Massachusetts General Hospital, Quincy, MA, ⁴Xiangya Hospital Central South University, Changsha, China (People's Republic), ⁵Xiangya School of Public Health Central South University, changsha, China (People's Republic), ⁶Xiangya Hospital, Central South University, Changsha, Hunan, China (People's Republic)
Background/Purpose: Lipoprotein subclasses play diverse roles in health and disease. Although lipoproteins have been implicated in knee osteoarthritis (KOA), the relationship between lipoprotein subclasses and…
Abstract Number: 2103 • ACR Convergence 2025
PCRX-201 High-Capacity Adenovirus Serotype 5 Gene Therapy Demonstrates Sustained Clinical Efficacy and Safety in Patients With Knee Osteoarthritis
Stanley Cohen¹, Philip Conaghan², Marc C. Hochberg³, Alan Kivitz⁴, MiJeong Kim⁵, Nino Joy⁶, Shoshanna Jiang⁶, Mary DiGiorgi⁷, Jonathan Slonin⁶ and Derek Slonin⁶, ¹Metroplex Clinical Research Center, dallas, TX, ²University of Leeds, Leeds, United Kingdom, ³Marc C. Hochberg University of Maryland School of Medicine, Baltimore, MD, ⁴Altoona Center for Clinical Research, Duncansville, PA, ⁵Pacira BioSciences, Inc., Brisbane, ⁶Pacira BioSciences, Inc., Brisbane, CA, ⁷Pacira BioSciences, Inc, Brisbane, CA
Background/Purpose: Knee OA is a common disease affecting ~15 million people in the United States. There is an urgent unmet need for additional OA treatments…
Abstract Number: 2086 • ACR Convergence 2025
WOMAC Physical Function and 3D MRI Bone Shape: Advancing a “Virtual” Total Knee Replacement Endpoint for Knee Osteoarthritis Clinical Trials
Dawn McGuire¹, Alan Brett², Neil Segal³, Meghan Miller⁴, David Rosen¹ and Yoshi Kumagai⁵, ¹OrthoTrophix, Inc, Foster City, CA, ²Imorphics, Manchester M²⁰ ²HJ, England, United Kingdom, ³KUMC, Kansa City, KS, ⁴OrthoTrophics, Foster City, CA, ⁵OrthoTrophix, Foster City, CA
Background/Purpose: TPX-100, a peptide derived from matrix extracellular phosphoglycoprotein (MEPE), is in development as a potential disease-modifying osteoarthritis drug (DMOAD) for mild to severe knee…
Abstract Number: 1805 • ACR Convergence 2025
Human meniscus histopathological and transcriptomic changes at early and advanced stages of knee osteoarthritis
Takuya Sakamoto¹, Merissa Olmer¹, chelsea Kenvisay¹, Rachel Miller², Anne-Marie Malfait³, Darryl D'Lima⁴, William Bugbee⁵, Hannah Swahn⁶ and Martin Lotz⁷, ¹Scripps Research Institute, La Jolla, CA, ²Rush University Medical Center, Chicago, IL, ³Rush University, Oak Park, IL, ⁴Scripps Clinic, San Diego, CA, ⁵Scripps Clinic, La Jolla, CA, ⁶Scripps Research Institute, Carlsbad, CA, ⁷Scripps Research, La Jolla, CA
Background/Purpose: The knee menisci are essential in joint biomechanics while meniscus damage is a driver of knee osteoarthritis (OA) and an important source of knee…
Abstract Number: 1785 • ACR Convergence 2025
Soluble CD14 Amplifies Chondrocyte Inflammatory Responses to Lipopolysaccharide and Is Targetable by Anti-CD14 Therapy
Anna Rapp¹, Kate Sharp¹, Baofeng Hu² and Carla Scanzello¹, ¹University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Wynnewood, PA
Background/Purpose: Osteoarthritis (OA) is characterized by a pro-inflammatory joint microenvironment, including elevated levels of endogenous pattern recognition receptor ligands in synovial fluid. Notably, both lipopolysaccharide…
Abstract Number: 1101 • ACR Convergence 2025
Distinct Clinical Phenotypes of Immune Checkpoint Inhibitor–Associated Arthritis: Comparative Analysis of Inflammatory Arthritis, Polymyalgia Rheumatica-like, Activated Crystalline, and Activated Osteoarthritis
Heba Altarawneh¹, Gregory Challener², Mazen Nasrallah³, Janeth Yinh⁴, Hyon K. Choi⁵ and Minna Kohler⁶, ¹Mass General Hospital, Boston, MA, ²MGH, Boston, MA, ³MGB-Salem Hospital, Lynn, MA, ⁴Massachusetts General Hospital, Boston, MA, ⁵MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA, ⁶Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Immune checkpoint inhibitor (ICI)–associated arthritis has been classified into distinct phenotypes, including inflammatory arthritis (IA), polymyalgia rheumatica (PMR)-like syndrome, activated crystalline arthritis, and activated…
Abstract Number: 0333 • ACR Convergence 2025
Diagnostic Test Accuracy of Artificial Intelligence in Early Diagnosis of Osteoarthritis: A Systematic Review and Meta-Analysis of 45,588 Knees
Mohamed Abdelsalam¹, Hadeer Hafez², Omar Sameh Nabil El Sedafy¹, Nourhan Abouelella³, Ahmed Abdulhafeez Hamza³, Omnia Samy El-Sayed⁴, Mohamed Reda Awad⁵, Gihan Omar³ and Hazem E. Mohammed⁶, ¹Misr University For Science and Technology, ⁶ october, Al Jizah, Egypt, ²⁶th October University, ⁶ october, Al Jizah, Egypt, ³Faculty of Medicine, Misr University for Science and Technology, ⁶ october, Al Jizah, Egypt, ⁴Misr University For Science and Technology, Nasr City, Al Qahirah, Egypt, ⁵Al Azhar University, Cairo, Egypt, Giza, Al Jizah, Egypt, ⁶Faculty of Medicine, Assiut university, Assiut, Egypt, assyut, Asyut, Egypt
Background/Purpose: Artificial intelligence (AI) rapid advancement opens new opportunities in the field of rheumatology. With better imaging, AI may help find early osteoarthritic changes that…

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