Abstracts tagged "Osteoarthritis"

Abstract Number: L04 • ACR Convergence 2024
Performance of an Artificial Intelligence Model Compared to Multiple Human Experts in Scoring Synovitis Severity and Osteophyte Severity on Joint Ultrasound Images
Anders Weber¹, Mads Ammitzbøll Danielsen², Bill Aplin Frederiksen³, Hilde Berner Hammer⁴, Benjamin Schultz Overgaard³, Lene Terslev², Thiusius Rajeeth Savarimuthu⁵ and Soren Andreas Just³, ¹ROPCA, Odense, Denmark, ²Center for Rheumatology and Spine Disease, Rigshospitalet, Glostrup, Denmark, ³Section of Rheumatology, Department of Medicine, Svendborg Sygehus OUH, Svendborg, Denmark, ⁴Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, Faculty of Medicine, University of Oslo, Oslo, Norway, ⁵Mærsk Mc-Kinney Møller Institute, University of Southern Denmark, Odense, Denmark
Background/Purpose: To evaluate the agreement of an artificial intelligence (AI) model designed to assess greyscale and Doppler synovitis severity and osteophyte severity in hand joints…
Abstract Number: L08 • ACR Convergence 2024
A Phase 2b, Randomized, Double-blind, Placebo-controlled, Dose-ranging and Parallel-group Study to Evaluate the Safety and Efficacy of XG005 in Subjects with Painful Osteoarthritis of the Knee
Limin Ren¹, Wenjie Zheng², Zhenpeng Guan³, Yang Zhang⁴, Zeyu Huang⁵, Tong Li⁶, Yuwei Peng⁷, Qiuli Wu⁸, Wei Gou⁹, Wei Zhao¹⁰, Pengyan Qiao¹¹, Xiaoli Pan¹² and Guang-Liang Jiang¹³, ¹Peking University, People’s Hospital, Rheumatology and Immunology Department, Beijing, China, ²Yantai Yuhuangding Hospital of Qingdao University, Department of Orthopedics, Yantai, China, ³Peking University, Shougang Hospital, Department of Orthopedics, Beijing, China, ⁴Division of Orthopaedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁵West China Hospital of Sichuan University, Department of Orthopedics, Chengdu, China, ⁶Xiangya Hospital of Central South University, Rheumatology and Immunology Department, Changsha, China, ⁷PingXiang People’s Hospital, Rheumatology and Immunology Department, Pingxiang, China, ⁸Tianjin Medical University General Hospital, Department of Orthopedics, Tianjin, China, ⁹Hebei Petrochina Central Hospital, Rheumatology and Immunology Department, Langfang, China, ¹⁰Central Hospital Affiliated to Shenyang Medical College, Department of Orthopedics, Shenyang, China, ¹¹Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Rheumatology and Immunology Department, Taiyuan, China, ¹²Affiliated Hospital of Zunyi Medical University, Rheumatology and Immunology Department, Zunyi, China, ¹³Xgene Pharmaceutical, Lexington, MA
Background/Purpose: Osteoarthritis (OA) affects 595 million people globally; cases are projected to increase 49-95% for various joints by 2050 as populations age (GBD 2023). OA…
Abstract Number: L15 • ACR Convergence 2024
LEVI-04, a Novel neurotrophin-3 Inhibitor, Substantially Improves Pain and Function Without Deleterious Effects on Joint Structure in People with Knee Osteoarthritis: A Randomized Controlled Phase II Trial
Philip Conaghan¹, Ali Guermazi², Nathaniel Katz³, Asger Bihlet⁴, Dror Rom⁵, Michael Perkins⁶, Bernadette Hughes⁶, Claire Herholdt⁶, Iwona Bombelka⁶ and Simon Westbrook⁶, ¹University of Leeds, Leeds, United Kingdom, ²Boston University, West Roxbury, MA, ³Rin Sof Innovation, Ltd, Boston, MA, ⁴NBCD A/S, Soeborg, Denmark, ⁵Prosoft Clinical, Chesterbrook, ⁶Levicept Ltd, Ramsgate, United Kingdom
Background/Purpose: There is an urgent need for new therapies to treat OA. Excess neurotrophins (NT) are implicated in OA and other painful conditions. Previous OA…
Abstract Number: 0864 • ACR Convergence 2024
Obesity Subtypes and Trajectories of Functional Change After 7-years of Follow-up: The Multicenter Osteoarthritis (MOST) Study
Kristine Godziuk¹, Sarah Tilley², mike LaValley³, Michael Nevitt⁴, C.E. Lewis⁵, James Torner⁶ and Tuhina Neogi², ¹University of Alberta, Edmonton, AB, Canada, ²Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ³Boston University School of Public Health, Arlington, MA, ⁴UCSF, Orinda, CA, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶University of Iowa, Iowa City
Background/Purpose: People with knee osteoarthritis (OA) and obesity (i.e. BMI ≥30kg/m2) have poorer function than those without obesity. However, function is not uniform among people…
Abstract Number: 1186 • ACR Convergence 2024
Intra-articular Corticosteroid Injections for Knee Osteoarthritis: Does the Dose Matter?
Neenu Sukumaran¹ and John Waterman², ¹University of Connecticut, Avon, CT, ²Veterans Administration, Simsbury, CT
Background/Purpose: Intra-articular(IA) corticosteroid injections for knee osteoarthritis (OA) have been performed for over 60 years. However, the appropriate dose of IA corticosteroids has not been determined. To…
Abstract Number: 1202 • ACR Convergence 2024
Harnessing MicroRNA and Machine/Deep Learning for Early Prediction of Knee Osteoarthritis Structural Progression
Afshin Jamshidi¹, Osvaldo Espin-Garcia², Thomas G. Wilson³, Ian Loveless³, Jean-Pierre Pelletier¹, Amanda Ali⁴ and Johanne Martel-Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Department of Epidemiology and Biostatistics, University of Western Ontario; Dalla Lana School of Public Health and Department of Statistical Sciences, University of Toronto; Department of Biostatistics, Schroeder Arthritis Institute; Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Henry Ford Health + Michigan State University Health Sciences, Detroit, MI, ⁴Henry Ford Health + Michigan State University Health Sciences; Center for Molecular Medicine and Genetics, Wayne State University, Montreal, QC, Canada
Background/Purpose: The development of knee osteoarthritis (OA) is generally characterized by a slow evolution. However, its progression and severity may occur rapidly in some individuals.…
Abstract Number: 1447 • ACR Convergence 2024
The Frequency of Diffuse Idiopathic Skeletal Hyperostosis (DISH) in Spondyloarthritis in Comparison to Age and Sex-matched Controls and Impact of SpA on Onset Age of DISH
Ummugulsum Gazel¹, Nicole Hryciw², Baljot Chahal³, Seyyid Bilal Acikgoz⁴, Gizem Ayan⁵, Zaid Jibri³, Marcos Loreto Sampaio³ and Sibel Aydin⁶, ¹University of Ottawa, Ottawa, ON, Canada, ²University of Ottawa, Ottawa, Canada, ³University of Ottawa, Radiology, Ottawa, Canada, ⁴University of Ottawa, Rheumatology, Ottawa, ON, Canada, ⁵University of Ottawa, Rheumatology, Ankara, Turkey, ⁶University of Ottawa - Ottawa, Ottawa, ON, Canada
Background/Purpose: Although diffuse idiopathic skeletal hyperostosis (DISH) is classically defined in the thoracic spine and the elderly population, there are case reports on the overlap…
Abstract Number: 1950 • ACR Convergence 2024
Telehealth Physical Therapy Intervention to Increase Physical Activity in Adults with Knee OA: The Delaware PEAK Randomized Controlled Trial
Daniel White¹, Rana Hinman², Thomas Videtich Bye¹, Sydney Liles³, Dana Voinier⁴, Jennifer Copson⁵, Laura Schmitt¹, Barry Bodt¹ and Jason Jakiela⁶, ¹University of Delaware, Newark, DE, ²University of Melbourne, Melbourne, Victoria, Australia, ³University of Delaware, Elkton, MD, ⁴OSHA, Newark, DE, ⁵University of Delaware, Wilmington, DE, ⁶Winston-Salem State University, Winston-Salem, NC
Background/Purpose: Exercise is strongly recommended treatments to address pain and functional limitation for adults with Knee Osteoarthritis (OA) and Physical Therapy (PT) is responsible for…
Abstract Number: 2098 • ACR Convergence 2024
Vitamin D Deficiency Is Associated with Progression of Radiographic Hand Osteoarthritis in a 6-year Follow-up of the Dong-gu Study
Hyemin Jeong¹, Sung-Eun Choi², Dong-Jin Park³, Ji-Hyoun Kang¹, Min-Ho Shin⁴ and Shin-Seok Lee⁵, ¹Chonnam National University Hospital, Gwangju, South Korea, ²Chonnam National University Medical School & Hospital, Gwangju, South Korea, ³Chonnam National University Medical School and Hospital, Gwangju, South Korea, ⁴Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, KR, Gwangju, Republic of Korea
Background/Purpose: Studies on the relationship between serum levels of 25-hydroxyvitamin D [25(OH)D] and prevalent, incident, or progressive osteoarthritis (OA) have yielded inconsistent results. Given the…
Abstract Number: 2557 • ACR Convergence 2024
The Relation of Colchicine to Knee/hip Replacement Among People with Gout in a Population-based Cohort Study
Zhiqiang Wang¹, Sarah Tilley², Christine Peloquin², Eva Petrow³, Margaret Clancy² and Tuhina Neogi², ¹Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China, Guangzhou, Guangdong, China (People's Republic), ²Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ³Boston Medical Center, Boston, MA
Background/Purpose: Colchicine, an anti-inflammatory drug commonly used in gout, has been associated with a lower incidence of total knee/hip replacement compared to placebo among participants…
Abstract Number: 0161 • ACR Convergence 2024
Cross Country Burden of Osteoarthritis in Latin America and Caribbean from 1990-2021: A Comparative and Consistent Benchmarking Analysis for the Global Burden of Disease Study 2022
malay rathod¹, Eva Kalra², Rafael Sanchez-Dopazo,³, Janmay Vala⁴, Saif Syed⁵, Akhilesh Sharma⁶, Ashwinikumar Shandilya⁷, Asmita Gera⁸, Mohit Lakkimsetti⁹, Juhi Patel¹⁰, VISHRANT AMIN¹¹ and Hardik Desai¹², ¹Monmouth Medical Center, Rutgers University, Ewing, NJ, ²Trident Medical Cente, Charleston, SC, ³Larkin Community Hospital Palm Springs Campus, Hialeah, FL, ⁴Terna Medical College, Navi Mumbai, Maharashtra, India, ⁵Royal college of Surgeons,Dublin,Ireland, Dublin, Dublin, Ireland, ⁶Adesh Institute of Medical Sciences and Research, Bhatinda, India, ⁷Rural Medical college. Pravara institute of medical sciences., Ahmednagar, India, ⁸Tianjin medical University, Tianjin, China, Tianjin, Tianjin, China (People's Republic), ⁹Mamata Medical College,Khammam, Khammam, Telangana, India, ¹⁰GMERS MEDICAL COLLEGE VALSAD, 382330, Gujarat, India, ¹¹GMERS MEDICAL COLLEGE VALSAD, Ahmedabad, India, ¹²Gujarat Adani Institute of Medical Sciences, Bhuj, India
Background/Purpose: Osteoarthritis (OA) poses a significant and escalating health challenge across Latin America and the Caribbean (LAC), driven by demographic shifts, lifestyle factors, and varying…
Abstract Number: 0865 • ACR Convergence 2024
Z’s and Knees: Associations of Participant-reported and Objective Sleep Measures with Pain Among US Veterans with Osteoarthritis of the Knee
David Azizi¹, Sarah Wetzel¹, Marianna Olave¹, Rachel Gillcrist², Hannah Brubeck³, Daniel White⁴, Carla Scanzello⁵, Tuhina Neogi⁶, Alexis Ogdie⁷, Bryant England⁸, Mercedes Quinones⁹, Katherine Wysham¹⁰ and Joshua Baker¹¹, ¹Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, ²Corporal Michael J. Crescenz VA Medical Center, Philadelphia, ³VA Puget Sound Health Care System, Seattle, WA, ⁴University of Delaware, Newark, DE, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁷Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁸University of Nebraska Medical Center, Omaha, NE, ⁹Washington DC VA Medical Center, Bethesda, MD, ¹⁰VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, ¹¹Department of Medicine, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA
Background/Purpose: Inadequate sleep is associated with a range of poor health outcomes, including chronic health conditions, mood disorders, and all-cause mortality. There is some evidence…
Abstract Number: 1187 • ACR Convergence 2024
Association of Depressive Symptoms and Multiple Joint Osteoarthritis with Pain Outcomes in the WE-CAN Trial
Natalie Allcott¹, Stephen Messier², Shannon Mihalko², Jeffrey Katz³, Paul DeVita⁴, David Hunter⁵, Sara Quandt⁶, Carolina Alvarez⁷, Leigh Callahan⁸ and Amanda Nelson¹, ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Wake Forest University, Winston Salem, NC, ³Brigham and Women's Hospital, Brookline, MA, ⁴Eastern Carolina University, Greenville, ⁵Sydney Musculoskeletal Health, University of Sydney, St Leonards, New South Wales, Australia, ⁶Wake Forest University, Winston-Salem, ⁷University of North Carolina at Chapel Hill, Miami, FL, ⁸University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC
Background/Purpose: The Weight-loss and Exercise for Communities with Arthritis in North Carolina (WE-CAN) trial was a community-based, pragmatic randomized clinical trial in men and women…
Abstract Number: 1203 • ACR Convergence 2024
My Shoulder Hurts, What Should I Do? A Systematic Review and Bayesian Network Meta-analysis of Different Injectables in Glenohumeral Osteoarthritis
Mohamed Abdelsalam¹, Mona Sajed², Aya Alsaeed³, Heba Abdelrahman⁴, roaa Rafat⁵, Mohamed Tarek⁶ and Asmaa al-Najjar⁷, ¹Rheumatology, Rehabilitation and Physical medicine department - faculty of medicine -Misr University for science and technology, 6th of October, Al Jizah, Egypt, ²Faculty of Pharmacy - Al-Azhar university for girls, Mansoura, Ad Daqahliyah, Egypt, ³Faculty of medicine - Mansoura university, Mansoura, Ad Daqahliyah, Egypt, ⁴Faculty of medicine - Mansora university, Mansoura, Ad Daqahliyah, Egypt, ⁵Faculty of medicine, Ahfad University for Women, Khartoum, Sudan, Cairo, Egypt, ⁶Faculty of medicine - Al-Azhar university Cairo branch, Cairo, Egypt, ⁷Faculty of medicine - Al-Azhar university in Gaza, Gaza, Palestinian Territories
Background/Purpose: Glenohumeral Osteoarthritis (GH OA) significantly impacts joint function and quality of life. Various intraarticular injectable treatments, including hyaluronic acid (HA), corticosteroids (GCs), platelet-rich plasma…
Abstract Number: 1653 • ACR Convergence 2024
Osteoarthritis Drives Inflammatory Imprinting of Synovial Fibroblasts, Exacerbating Gouty Arthritis Through m6A Modification of S100A4
ZIYI CHEN¹, Yinghui Hua² and Wenjuan Wang¹, ¹Department of Sports Medicine, Huashan Hospital,Fudan University, Shanghai, Shanghai, China (People's Republic), ²Department of Sports Medicine, Huashan Hospital,Fudan University, Shanghai, China (People's Republic)
Background/Purpose: Patients with osteoarthritis (OA) face an elevated risk of future gouty arthritis (GA). To delineate the underlying cellular and molecular mechanisms of OA-driven gout…

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