Abstracts tagged "obesity"

Abstract Number: 0405 • ACR Convergence 2022
Efficacy and Safety of Tofacitinib in Patients with Ankylosing Spondylitis by Baseline BMI: A Post Hoc Analysis of Phase 2 and Phase 3 Trials
Hillary Norton¹, Paula Sliwinska-Stanczyk², Tomas Hala³, Bassel Elzorkany⁴, Lori Stockert⁵, Harry Shi⁵, Cunshan Wang⁶, Jerome Paulissen⁷ and Christopher Ritchlin⁸, ¹Sante Fe Rheumatology, Santa Fe, NM, ²Reumatika Centrum Reumatologii, Warsaw, Poland, ³Center for Clinical and Basic Research, Pardubice, Czech Republic, ⁴Department of Rheumatology, Cairo University, Cairo, Egypt, ⁵Pfizer, Inc, Collegeville, PA, ⁶Pfizer Inc, Groton, CT, ⁷Pfizer Inc, New York, NY, ⁸Allergy, Immunology and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY
Background/Purpose: Higher BMI is associated with reduced response to TNF inhibitors (TNFi) in patients (pts) with AS.1 Tofacitinib is an oral Janus kinase inhibitor for…
Abstract Number: 0178 • ACR Convergence 2021
Abdominal Obesity May Confound Accuracy of Cardiovascular Risk Prediction in Rheumatoid Arthritis; Can Coronary Atherosclerosis Imaging and Biomarkers Help?
George Karpouzas¹, sarah ormseth², Elizabeth Hernandez² and Matthew Budoff³, ¹Harbor-UCLA Medical Center, Torrance, CA, ²The Lundquist Institute, Harbor-UCLA Medical Center, Torrance, CA, ³Division of Cardiology, and the Lundquist Institute ay Harbor-UCLA Medical Center, Torrance, CA
Background/Purpose: Accurate cardiovascular risk stratification is essential in rheumatoid arthritis (RA) care. Previous studies evaluated the impact of obesity (defined as body mass index) on…
Abstract Number: 0295 • ACR Convergence 2021
Weight History and Associations with Cardiovascular Risk in Patients with Rheumatoid Arthritis
Lydia Federico¹, Kaleb Michaud², Kristin Wipfler³, Gulsen Ozen⁴ and Joshua Baker¹, ¹University of Pennsylvania, Philadelphia, PA, ²University of Nebraska Medical Center, Omaha, NE, ³FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ⁴University of Nebraska Medical Center, Bellevue, NE
Background/Purpose: Cardiovascular disease (CVD) is the leading cause of mortality in rheumatoid arthritis (RA), but traditional CVD risk factors may not accurately characterize risk. For…
Abstract Number: 0583 • ACR Convergence 2021
Obesity and Lower Socioeconomic Position Are Independently Associated with Incident Osteoarthritis and Rheumatoid Arthritis: Results from the English Longitudinal Study of Ageing
Rozemarijn Witkam¹, James Gwinnutt¹, Jennifer Humphreys¹, Rachel Cooper², David Selby¹ and Suzanne Verstappen³, ¹University of Manchester, Manchester, United Kingdom, ²Manchester Metropolitan University, Manchester, United Kingdom, ³School of Social Sciences, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Obesity is a known risk factor for OA and hypothesised as a risk factor for RA, although due to different underlying mechanisms. Lower socioeconomic…
Abstract Number: 0789 • ACR Convergence 2021
Adipokine Levels and Associations with Achievement of Low Disease Activity in Rheumatoid Arthritis
Joshua Baker¹, Bryant England², Michael George¹, Katherine Wysham³, Gail Kerr⁴, Andreas Reimold⁵, Paul Monach⁶, Gary Kunkel⁷, Brian Sauer⁷, Bartlett Hamilton⁸, Carlos Hunter², Michael Duryee², Geoffrey Thiele² and Ted Mikuls², ¹University of Pennsylvania, Philadelphia, PA, ²University of Nebraska Medical Center, Omaha, NE, ³VA Puget Sound/University of Washington, Seattle, WA, ⁴Washington D.C., Veterans Affairs Medical Center (VAMC)/Georgetown and Howard Universities, Washington, DC, ⁵University of Texas – Southwestern Medical Center/Dallas Veterans Affairs Medical Center (VAMC), Dallas, TX, ⁶Brigham and Women's Hospital, Boston, MA, ⁷University of Utah, Salt Lake City, UT, ⁸University of Nebraska, Omaha, NE
Background/Purpose: Adipokines are fat-secreted proteins that serve as metabolic regulators. Prior studies have identified associations between adipokines and disease characteristics such as disease activity and…
Abstract Number: 0864 • ACR Convergence 2021
Does Obesity Affect Disease Activity Outcomes in Systemic Lupus Erythematosus?
Konstantinos Tselios¹, Dafna Gladman², Jiandong Su³ and Murray Urowitz⁴, ¹McMaster University, Hamilton, ON, Canada, ²Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ³University Health Network, Toronto, ON, Canada, ⁴Center for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Lupus Clinic, Toronto, ON, Canada
Background/Purpose: Increased Body Mass Index (BMI) affects cardiovascular risk and is related to worse health-related quality of life measures in patients with systemic lupus erythematosus…
Abstract Number: 1126 • ACR Convergence 2021
Synovial Cell Dysfunction in Obese Patients May Contribute to Poor Outcomes in Knee Osteoarthritis
Holly Philpott¹, Trevor Birmingham², Nicole Aye², Benoit Fiset³, Logan Walsh³, Brent Lanting² and Tom Appleton², ¹Western University, London, ON, Canada, ²University of Western Ontario, London, ON, Canada, ³McGill University, Montréal, QC, Canada
Background/Purpose: Obesity is a major risk factor for poor outcomes in knee osteoarthritis (OA) and may involve both mechanical and physiological stresses on joint tissues.…
Abstract Number: 1129 • ACR Convergence 2021
Cost-effectiveness of Weight Loss Interventions Prior to Total Knee Replacement for Patients with Advanced Knee Osteoarthritis and Class III Obesity
Aleksandra Kostic¹, Valia Leifer², Tuhina Neogi³, David Hunter⁴, Lisa Suter⁵, Faith Selzer⁶, Jeffrey Katz¹ and Elena Losina⁷, ¹Brigham and Women's Hospital, Brookline, MA, ²The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA, ³Boston University School of Medicine, Boston, MA, ⁴Institute of Bone and Joint Research, University of Sydney, St Leonards, Australia, ⁵Yale School of Medicine, New Haven, CT, ⁶Brigham and Women's Hospital, Amesbury, MA, ⁷Brigham and Women's Hospital, Boston, MA
Background/Purpose: Class III obesity, defined by BMI >40kg/m2, is linked to increased risk of complications post total knee replacement (TKR). This has led to recommendations…
Abstract Number: 1320 • ACR Convergence 2021
Obesity and Its Associations with Clinical Manifestations and Disease Burden of Patients with Spondyloarthritis: An Ancillary Study from the ASAS-perSpA Project
Mehmet Tuncay Duruoz¹, Sevtap Acer Kasman², Halise Hande Gezer¹, Clementina López Medina³ and Maxime Dougados⁴, ¹Marmara University School of Medicine, PMR Department, Rheumatology Division, Istanbul, Turkey, Istanbul, Turkey, ²Marmara University School of Medicine, PMR Department, Rheumatology Division, Istanbul, Turkey, ³Department of Rheumatology, Reina Sofia Hospital, IMIBIC, University of Cordoba, Cordoba, Spain/ Department of Rheumatology, University of Paris, Cochin Hospital, Paris, France, ⁴Université de Paris . Department of Rheumatology - Hôpital Cochin. Assistance Publique - Hôpitaux de Paris . INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité. Paris, France., Paris, France
Background/Purpose: Obese patients with spondyloarthritis (SpA) had more functional limitations, higher subjective disease activity, fewer benefits of exercise, and showed less response to drug therapy.…
Abstract Number: 1322 • ACR Convergence 2021
Body Mass Index (BMI) Underestimates Obesity in Females with Axial Spondyloarthropathy
Sinead Maguire¹, Wilson Fiona², Phil Gallagher³ and Finbar (Barry) O'Shea¹, ¹St James's Hospital, Dublin, Ireland, ²Discipline of Physiotherapy, Trinity College Dublin, Dublin, Ireland, ³St Vincent's Hospital, Dublin, Ireland
Background/Purpose: Worldwide prevalence of obesity has been steadily increasing, despite public health campaigns to raise awareness. In axial spondyloarthropathy (axSpA) obesity has been shown to…
Abstract Number: 1327 • ACR Convergence 2021
Impact of BMI on Treatment Response Among PsA Patients Initiating TNF Inhibitors, IL17 Inhibitors and Oral Small Molecules
Emily Purcell¹, Soumya Reddy², Jessica Walsh³, Jose Scher⁴, Ethan Craig⁵, Elaine Husni⁶ and Alexis Ogdie¹, ¹University of Pennsylvania, Philadelphia, PA, ²NYU School of Medicine, New York, NY, ³Salt Lake City Veteran Affairs Medical Center (VAMC)/University of Utah Hospital, Salt Lake City, UT, ⁴New York University School of Medicine, New York, NY, ⁵University of Pennsylvania, Wallingford, PA, ⁶Cleveland Clinic, Cleveland, OH
Background/Purpose: Obesity is associated with poor response to treatment in patients with psoriatic arthritis (PsA), however, available data are mostly focused on tumor necrosis factor…
Abstract Number: 1404 • ACR Convergence 2021
Lower Frequency of Comorbidities Prior to Onset of Giant Cell Arteritis; A Population-based Study
jigisha rakholiya¹, Mohanad Elfishawi¹, Tina Gunderson¹, Cynthia Crowson², Eric Matteson³, Carl Turesson⁴, Karin Wadström⁵, Cornelia Weyand¹, Matthew Koster¹ and Kenneth Warrington⁶, ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Eyota, MN, ³Mayo Clinic College of Medicine and Science, Rochester, MN, ⁴Lund University, Malm, Sweden, ⁵Lund University, Malmö, Sweden, ⁶Mayo Clinic, Rochester, Minnesota
Background/Purpose: Advancing age, female sex and white race are well-known risk factors for development of giant cell arteritis (GCA). Recent studies suggest that certain metabolic…
Abstract Number: 1499 • ACR Convergence 2021
Imbalance Between T Follicular Cells and T Regulatory Cells Involved in High Fat-Diet Associated Lupus Development in MRL/lpr Mice
Ronak Patel¹, Therese Posas-Mendoza², Juan Meng³, Xuhua Shi³, Swathi Dhulipala⁴, Chad Hille², Linh Hellmers¹, Robert Quinet⁵, William Davis⁶, Jerald Zakem⁷, Chandana Keshavamurthy¹, Zongbing You³ and Xin Zhang¹, ¹Ochsner, New Orleans, LA, ²Ochsner Clinic Foundation, New Orleans, LA, ³Tulane University, New Orleans, LA, ⁴Ochsner Clinic Foundation, River Ridge, LA, ⁵Ochsner Health, River Ridge, LA, ⁶Ochsner Medical Center, New Orleans, LA, ⁷Ochsner Health Systems, Metairie, LA
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by persistent inflammation and production of autoantibodies, which deposit within numerous tissues leading to…
Abstract Number: 1645 • ACR Convergence 2021
Elevations in Adipocytokines and Mortality in Rheumatoid Arthritis
Joshua Baker¹, Bryant England², Michael George¹, Katherine Wysham³, Gail Kerr⁴, Andreas Reimold⁵, Paul Monach⁶, Gary Kunkel⁷, Brian Sauer⁷, Bartlett Hamilton⁸, Carlos Hunter², Michael Duryee², Geoffrey Thiele² and Ted Mikuls², ¹University of Pennsylvania, Philadelphia, PA, ²University of Nebraska Medical Center, Omaha, NE, ³VA Puget Sound/University of Washington, Seattle, WA, ⁴Washington D.C., Veterans Affairs Medical Center (VAMC)/Georgetown and Howard Universities, Washington, DC, ⁵University of Texas – Southwestern Medical Center/Dallas Veterans Affairs Medical Center (VAMC), Dallas, TX, ⁶Brigham and Women's Hospital, Boston, MA, ⁷University of Utah, Salt Lake City, UT, ⁸University of Nebraska, Omaha, NE
Background/Purpose: Adipokines are metabolic regulators and are associated with adverse outcomes in chronic conditions and among older adults. Elevations in one adipokine, adiponectin, have been…
Abstract Number: 0004 • ACR Convergence 2021
Unappreciated Systemic Metabolic Functions of the Canonical B Cell Cytokines, BAFF and APRIL: Regulation of Lipolysis and Non-shivering Thermogenesis and Protection from Obesogenic Diet Induced Weight Gain
Isaac Harley¹, Calvin Chan², Paul Pfluger³, Trompette Aurelien⁴, Traci Stankiewicz⁵, Jessica Allen⁵, Maria Moreno-Fernandez⁵, Michelle Damen⁵, Jarren Oates⁵, Pablo Alarcon⁵, Jessica Doll⁶, Matthew Flick⁷, Leah Flick⁸, Juan Sanchez-Gurmaches⁹, Rajib Mukherjee⁹, Rebekah Karns¹⁰, Michael Helmrath¹¹, Thomas Inge¹², Stuart Weisberg¹³, Sunje Pamp¹⁴, David Relman¹⁵, Randy Seeley¹⁶, Matthias Tschoep¹⁷, Chris Karp¹⁸ and Senad Divanovic⁸, ¹University of Colorado Anschutz Medical Campus, Aurora, CO, ²University of Cincinnati, Cincinnati, OH, ³Technical University of Munich, Munich, Germany, ⁴Le Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ⁵Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinnati, OH, ⁶Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinn, OH, ⁷Division of Experimental Hematology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁸Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹Division of Endocrinology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹⁰Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹¹Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹²Department of Surgery, Children’s Hospital Colorado, Aurora, CO, ¹³Columbia University Medical Center, New York, NY, USA, New York, NY, ¹⁴Danmarks Tekniske Universitet, Lyngby, Denmark, ¹⁵Department: Medicine - Med/Infectious Diseases - Stanford University, Stanford, ¹⁶Department of Surgery, Internal Medicine and Nutritional Sciences, University of Michigan, Ann Arbor, MI, ¹⁷Division of Metabolic Diseases, Technische Universität München, Munich, Germany, ¹⁸Division of Molecular Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati
Background/Purpose: The impact of immune mediators on weight homeostasis and systemic metabolism remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative…

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