Abstracts tagged "obesity and osteoarthritis"

Abstract Number: 1139 • 2018 ACR/ARHP Annual Meeting
Can Body Composition Explain the Sex Disparity in Risk of Osteoarthritis?
Shanshan Li¹, Tuhina Neogi², Devyani Misra³, Ann Schwartz⁴, Michael C. Nevitt⁵, Cora E. Lewis⁶, James Torner⁷ and David T. Felson², ¹Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Cambridge, MA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³School of Medicine, Boston University School of Medicine, Boston, MA, ⁴University of California San Francisco, San Francisco, CA, ⁵Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁶University of Alabama Birmingham, Birmingham, AL, ⁷University of Iowa, Iowa City, IA
Background/Purpose: Obesity is a major risk factor for knee osteoarthritis (OA), but the mechanisms by which obesity confers OA risk remains unclear. There is a…
Abstract Number: 1950 • 2017 ACR/ARHP Annual Meeting
Cross-Sectional Analysis of Foot Osteoarthritis Frequency and Associated Factors: The Johnston County Osteoarthritis Project
Portia Flowers¹, Amanda Nelson², Howard J. Hillstrom³, Jordan B. Renner⁴, Joanne M. Jordan⁵ and Yvonne M. Golightly⁶, ¹Thurston Arthritis Research Center, University of North Carolina - Chapel Hill, Chapel Hill, NC, ²Division of Rheumatology, Allergy, and Immunology and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Rehabilitation, Hospital Special Surgery (HSS), New York, NY, ⁴UNC School of Medicine, University of North Carolina, Chapel Hill, NC, ⁵Thurston Arthritis Research Center, University of North CArolina at Chapel Hill, Chapel Hill, NC, ⁶Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: The rising number of adults with arthritis and associated activity limitations present a serious public health problem. Although studies have explored lower limb…
Abstract Number: 2180 • 2017 ACR/ARHP Annual Meeting
Metabolic Syndrome Does Not Modify the Association between Obesity and Hip Osteoarthritis
Karen Cheng¹, Scott Ball¹, Simon Schenk¹, Elsa Strotmeyer², John Schousboe³, Marcia Stefanick⁴, Elizabeth Barrett-Connor⁵, Deborah Kado⁵, Michael Nevitt⁶, Nancy E. Lane⁷, Eric Orwoll⁸ and Jan M. Hughes-Austin⁹, ¹Orthopaedic Surgery, University of California, San Diego, San Diego, CA, ²Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, ³University of Minnesota, Minneapolis, MN, ⁴Stanford University, Stanford, CA, ⁵University of California, San Diego, San Diego, CA, ⁶Department of Epidemiology & Biostatistics, University of California San Francisco School of Medicine, San Francisco, CA, ⁷Center for Musculoskeletal Health, University of California at Davis, Hillsborough, CA, ⁸OHSU, Portland, OR, ⁹Orthopaedic Surgery, University of California, San Diego, La Jolla, CA
Background/Purpose: Obesity and metabolic syndrome (MetS) are the strongest modifiable risk factors of knee OA, and frequently affect the same individual. The reported associations in…
Abstract Number: 2209 • 2017 ACR/ARHP Annual Meeting
Leptin and Adiponectin Mediate the Association between Body Mass Index and Hand and Knee Osteoarthritis
F.P.B. Kroon¹, A. Veenbrink¹, R. de Mutsert², A.W. Visser¹, Saskia le Cessie³, F.R. Rosendaal² and M. Kloppenburg^1,2, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Associations between obesity and osteoarthritis (OA) in non-weight bearing joints suggest that systemic influences also contribute to OA. Systemically active substances secreted by adipose…
Abstract Number: 313 • 2017 ACR/ARHP Annual Meeting
The Effect of Obesity on Walking; Comparison of the Spatiotemporal, Kinematic and Kinetic Parameters of Young Obese and Non-Obese Healthy Women
Erkan Kilic¹, Gamze Kilic² and Fatma Inanici³, ¹Rheumatology Clinic, Afyonkarahisar State Hospital, Afyon, Turkey, ²Pyhsical Medicine and Rehabilitation, Afyon Kocatepe University, Faculty of Medicine, Afyon, Turkey, ³Pyhsical Medicine and Rehabilitation, Hacettepe University, Faculty of Medicine, Ankara, Turkey
Background/Purpose: Obesity is a risk factor for development of knee osteoarthritis due to altered gait biomechanics. Gait analysis was performed mostly on older obese adults…
Abstract Number: 2264 • 2016 ACR/ARHP Annual Meeting
Lack of Obesity-Related Changes in Adipocytes and Inflammatory Cells in the Infrapatellar Fat Pad (IFP): A Different Type of Fat?
Anja de Jong¹, I.R. klein-Wieringa¹, Stefan Andersen², Joanneke Kwekkeboom¹, Linda van Toorn¹, Badelog de Lange¹, Danny van Delft³, John Garcia⁴, Wu Wei⁵, Huub van der Heide³, Yvonne Bastiaansen-Jenniskens⁴, Gerjo van Osch⁴, Anne-Marie Zuurmond⁶, Vedrana Stojanovic-Susulic⁷, Rob Nelissen³, René Toes¹, Margreet Kloppenburg¹ and Andreea Ioan-Facsinay¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Charles River Nederland B.V., Leiden, Netherlands, ³Orthopaedics, Leiden University Medical Center, Leiden, Netherlands, ⁴Orthopaedics, Erasmus MC, Rotterdam, Netherlands, ⁵Orthopaedics, Erasmus MC, rotterdam, Netherlands, ⁶TNO, Leiden, Netherlands, ⁷Janssen, Pharmaceutical Companies Johnson & Johnson, Springhouse, PA
Background/Purpose: Obesity is associated with the development and progression of osteoarthritis (OA). Although the mechanisms involved in this association are poorly understood, it is well…
Abstract Number: 3054 • 2016 ACR/ARHP Annual Meeting
The Impact of Obesity on Knee Osteoarthritis Symptoms and Related Biomarker Profiles in a Bariatric Surgery Cohort
Thayer Mukherjee¹, Fernando Bomfim², Evan Wilder¹, Lauren Browne³, Kayleigh Toth⁴, Shira Aharon⁴, Janice Lin⁴, Renata La Rocca Vieira⁵, Christine Ren-Fielding⁶, Manish Parikh⁷, Steven B. Abramson⁸, Mukundan Attur⁹ and Jonathan Samuels², ¹NYU Langone Medical Center, New York, NY, ²Rheumatology, NYU Langone Medical Center, New York, NY, ³NYU Langone Medical Center, Rheumat, New York, NY, ⁴NYU Langone Medical Center, Rheumatology, New York, NY, ⁵Department of Radiology, NYU Langone Medical Center, New York, NY, ⁶Department of Surgery, New York University School of Medicine, New York, NY, ⁷Department of Surgery, NYU Langone Medical Center, New York, NY, ⁸Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY, ⁹Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY
Background/Purpose: Obesity is a common risk factor for knee osteoarthritis (KOA). While it is intuitive that bariatric weight loss improves knee pain, it is not…
Abstract Number: 326 • 2015 ACR/ARHP Annual Meeting
Older Adults without Extreme Obesity Are at Highest Risk for Accelerated Knee Osteoarthritis
Jeffrey Driban¹, Grace H. Lo², Charles B. Eaton³, Lori Lyn Price⁴, Bing Lu⁵, Mary Barbe⁶ and Timothy E. McAlindon⁷, ¹Tufts Medical Center, Boston, MA, ²VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ³Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁴Clinical Care Research, Tufts Medical Center, Boston, MA, ⁵Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁶Temple University School of Medicine, Philadelphia, PA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Accelerated knee osteoarthritis (AKOA) may be a unique subset of knee osteoarthritis (KOA). AKOA is more common among those who are older, overweight, or…
Abstract Number: 328 • 2015 ACR/ARHP Annual Meeting
Associations Between Body Composition Measures of Obesity and Radiographic Osteoarthritis in Older Adults: Data from the Dong-Gu Study
Kyung-Eun Lee¹, Lihui Wen¹, Yi-Rang Yim¹, Ji-Eun Kim¹, Jeong-Won Lee¹, Dong-Jin Park² and Shin-Seok Lee¹, ¹Chonnam National University Medical School and Hospital, Gwangju, South Korea, ²Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea
Background/Purpose: We examined the effects of fat deposition on radiographic osteoarthritis (OA) to determine the role of obesity in the pathology of radiographic OA.Methods: Data…
Abstract Number: 2093 • 2015 ACR/ARHP Annual Meeting
Are General and Central Adiposity Associated with MRI-Assessed Structural Changes in the Knees of Older Adults?
Tomoko Fujii¹, Iva Miljkovic¹, Robert M. Boudreau², Ali Guermazi³, Sara R. Piva⁴, Elsa S. Strotmeyer², Laura Carbone⁵, Tamara B. Harris⁶, Elisa A. Marques⁶, M Kyla Shea⁷, Michael C. Nevitt⁸, Anne B. Newman² and C Kent Kwoh⁹, ¹University of Pittsburgh, Pittsburgh, PA, ²Epidemiology, University of Pittsburgh, Pittsburgh, PA, ³Department of Radiology, Boston University School of Medicine, Boston, MA, ⁴Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ⁵Rheumatology, Georgia Regents University, Augusta, GA, ⁶National Institute on Aging, Bethesda, MD, ⁷Tuffs University, Boston, MA, ⁸Epidemiology and Biostatistics, UCSF, San Francisco, CA, ⁹University of Arizona, Tucson, AZ
Background/Purpose: Obesity is one of the few modifiable risk factors of knee osteoarthritis (OA). However, it is not established whether a mechanical or metabolic mechanism…
Abstract Number: 2246 • 2014 ACR/ARHP Annual Meeting
Reduction of Knee Osteoarthritis Symptoms in a Cohort of Bariatric Surgery Patients
Andrea Leyton-Mange¹, Janice Lin¹, Ryan Flanagan¹, Evan Wilder¹, Jay Bhatia¹, Farah Taufiq¹, Lauren Browne¹, Mukundan Attur¹, Renata La Rocca Vieira², Manish Parikh³, Christine Ren-Fielding³, Steven B. Abramson⁴ and Jonathan Samuels¹, ¹Rheumatology, NYU Langone Medical Center, New York, NY, ²Department of Radiology, NYU Langone Medical Center, New York, NY, ³Department of Surgery, NYU Langone Medical Center, New York, NY, ⁴Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY
Background/Purpose: Obesity is a modifiable risk factor of knee osteoarthritis (KOA). While medical treatments can have limited beneficial effects, an alternative strategy would target weight…
Abstract Number: 1275 • 2014 ACR/ARHP Annual Meeting
Association Between Cardiometabolic Disorders and Hand Osteoarthritis Severity: A Cross-Sectional and Longitudinal Study
Alice Courties¹, Jérémie Sellam¹, Francis Berenbaum¹, Emmanuel Maheu¹, Yoann Barthe², Fabrice Carrat² and Christian Cadet³, ¹AP-HP, Saint-Antoine Hospital, Rheumatology Department and DHU i2B, Paris, France, ²Public Health, Saint-Antoine Hospital, Inserm UMRS_1136, UPMC Univ Paris 06, AP-HP, Paris, France, ³Rheumatology, Private office, Paris, France
Background/Purpose Obesity and metabolic disorders increase the risk of hand osteoarthritis (HOA). This study aimed to determine i) clinical and radiographic features associated with HOA…
Abstract Number: 258 • 2013 ACR/ARHP Annual Meeting
Underdiagnosis and Undertreatment Of Knee Osteoarthritis In The Obese Population: The Need For Physician Education and Advocacy
Janice Lin¹, Ryan Flanagan², Jay Bhatia², Manish Parikh³, Christine Ren-Fielding³, Renata La Rocca Vieira⁴, Steven B. Abramson⁵ and Jonathan Samuels⁶, ¹Medicine-rheumatology, NYU Langone Medical Center, New York, NY, ²Department of Rheumatology, NYU Langone Medical Center, New York, NY, ³Department of Surgery, NYU Langone Medical Center, New York, NY, ⁴Department of Radiology, NYU Langone Medical Center, New York, NY, ⁵Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY, ⁶Division of Rheumatology, Department of Medicine, NYU Langone Medical Center, New York, NY
Background/Purpose: Obesity is a modifiable risk factor of knee osteoarthritis (KOA) . While medical treatments for KOA can have a limited effect, an alternative strategy…
Abstract Number: 58 • 2013 ACR/ARHP Annual Meeting
Saturated Fatty Acids Act Synergistically With Interleukin 1 Beta To Increase Inflammation, Endoplasmic Reticulum Stress and Cell Death In Human Articular Chondrocytes
Oscar Alvarez-Garcia¹, Nicole H Rogers², Roy G Smith³ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²California Institute for Biomedical Research (Calibr), La Jolla, CA, ³Department of Metabolism and Aging, Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL
Background/Purpose: Obesity is a major risk factor for the development of osteoarthritis (OA). Altered biomechanics have been postulated as the main causative mechanism, but recent…
Abstract Number: 44 • 2013 ACR/ARHP Annual Meeting
Suppressor Of Cytokine Signaling 3 Negatively Modulates Leptin-Mediated Catabolic and Proinflammatory Effects In Cartilage – New Potential Mechanism To Target Obesity-Induced Osteoarthritis
Anna Koskinen¹, Katriina Vuolteenaho¹, Riku Korhonen¹, Teemu Moilanen^1,2 and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: Adipocytokine leptin has been suggested to link obesity and osteoarthritis (OA). Initially leptin was found to regulate energy metabolism through central nervous system. More…

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