Date: Sunday, November 8, 2015
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: We examined the effects of fat deposition on radiographic osteoarthritis (OA) to determine the role of obesity in the pathology of radiographic OA.
Methods: Data were taken from the Dong-gu cohort, a cross-sectional study of 2,367 subjects. Baseline characteristics, waist circumference (WC), fat mass, and fat percentage were collected, along with X-rays of the knees and hands. Waist-to-hip ratio (WHR) was defined as the ratio of waist and hip circumferences. Diabetes mellitus was defined as fasting glucose > 126 mg/dL or the use of hypoglycemic medication. Hypertension was defined as systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg, or use of antihypertensive medication. Total knee and hand radiographic OA scores were summed using a semi-quantitative grading system, and then stratified by gender using a multiple linear regression model.
Results: After adjusting for confounders, weight was the only factor significantly associated with knee radiographic OA, regardless of gender (p = 0.027 and p < 0.001, for males and females, respectively). Regarding the hand, fat percentage had the largest effect on radiographic OA in males (Eta = 0.007, p = 0.008), while WHR was the most significant factor in females (Eta = 0.009, p = 0.001). For the knee, fat mass was the most important factor for radiographic OA in males (Eta = 0.012, p = 0.001), while in females, body mass index (BMI) was the most important factor (Eta = 0.059, p < 0.001). Among the variables, only fat percentage was significantly related to both hand and knee radiographic OA in both genders (all p < 0.01).
Conclusion: Regardless of gender, mechanical stress was significantly associated with knee radiographic OA. Otherwise, fat deposition correlated with hand and knee radiographic OA in both genders, while the distribution of fat tissue was significantly associated with hand and knee radiographic OA only in females, with the largest effect on hand and knee radiographic OA.
To cite this abstract in AMA style:Lee KE, Wen L, Yim YR, Kim JE, Lee JW, Park DJ, Lee SS. Associations Between Body Composition Measures of Obesity and Radiographic Osteoarthritis in Older Adults: Data from the Dong-Gu Study [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/associations-between-body-composition-measures-of-obesity-and-radiographic-osteoarthritis-in-older-adults-data-from-the-dong-gu-study/. Accessed October 23, 2019.
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