Abstracts tagged "OA"

Abstract Number: 244 • 2014 ACR/ARHP Annual Meeting
Onset, Magnitude, and Durability of Pain Relief in Patients with Knee OA Receiving a Fixed-Dose Combination Tablet of Enteric-Coated (EC) Naproxen Plus Immediate-Release (IR) Esomeprazole Magnesium Versus Celecoxib and Placebo: Pooled Results from Two Randomized Controlled Trials
John Fort¹, Robert Holt², Amy Y. Grahn³, Jana Steinmetz⁴, Ying Zhang⁵ and Jeffery Kent⁶, ¹Pozen, Inc, Chapel Hill, NC, ²College of Pharmacy, University of Illinois-Chicago, Vernon Hill, IL, ³Horizon Pharma, Inc., Deerfield, IL, ⁴Statistics, Premier Research, Naperville, IL, ⁵Biostatistics, Pozen, Inc, Chapel Hill, NC, ⁶Medical Affairs, Horizon Pharma, Inc, Deerfield, IL
Background/Purpose: Over 40% of patients with OA report having significant knee pain every day. (1) Previously published data have demonstrated the overall comparable efficacy of…
Abstract Number: 2025 • 2013 ACR/ARHP Annual Meeting
Distinctive Expression Profiles Of Long Intergenic Non-Coding RNA Between Polymyalgia Rheumatica and Rheumatoid Arthritis Might Contains Helpful Suggestions For Understanding and Discriminating These Diseases
Yoshinobu Koyama¹, Motohiko Tanino², Hirokazu Shiraishi³, Shuji Nagano⁴, Toshiyuki Ota⁴ and Toshie Higuchi⁵, ¹Division of Rheumatology, Okayama Red Cross General Hospital, Okayama, Japan, ²DNA Chip Research Inc., Yokohama, Japan, ³Orthopedics, Iizuka Hospital, Iizuka, Japan, ⁴Center for Rheumatic Diseases, Iizuka Hospital, Iizuka, Japan, ⁵Center for Autoimmune Diseases, Division of Rheumatology, Japan Red Cross Okayama Hospital, Okayama, Japan
Background/Purpose: There are many clinical similarities between polymyalgia rheumatica (PMR) and rheumatoid arthritis (RA). It has been reported that the specificity for discriminating PMR from…
Abstract Number: 1757 • 2013 ACR/ARHP Annual Meeting
Does Foot Pain Mediate The Effect Of Knee Osteoarthritis and Risk Of Indoor and Outdoor Falls In Older Men and Women?
Uyen Sa D.T. Nguyen¹, Yuqing Zhang², Jingbo Niu³, Robert H. Shmerling⁴, Douglas P. Kiel⁵, Suzanne G. Leveille⁶, Carol A. Oatis⁷ and Marian T. Hannan⁸, ¹Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴Beth Israel Deaconess Medical Center, Boston, MA, ⁵Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁶University of Massachusetts-Boston, Boston, MA, ⁷Physical Therapy, Arcadia University, Glenside, PA, ⁸Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: Knee osteoarthritis (OA), foot pain, and falls are common in older adults and limit mobility. We previously showed that knee OA increases the risk…
Abstract Number: 1076 • 2013 ACR/ARHP Annual Meeting
Individuals With Knee Or Hip OA and Low SES Are Likely To Be Physically Active
Rebecca J. Cleveland¹, Kamil E. Barbour², Jordan B. Renner³, Joanne M. Jordan⁴ and Leigh F. Callahan⁵, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Centers for Disease Control and Prevention, Atlanta, GA, ³University of North Carolina Department of Radiology, Chapel Hill, NC, ⁴Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ⁵Thurston Arthritis Res Ctr, University of North Carolina, Chapel Hill, NC
Background/Purpose: Osteoarthritis (OA) is a major cause of disability and pain in adults over the age of 45. It has been shown that physical activity…
Abstract Number: 828 • 2013 ACR/ARHP Annual Meeting
Psychosocial Determinants Of Total Knee Arthroplasty Outcomes 2 Years After Surgery
Aparna Ingleshwar¹, Maria A. Lopez-Olivo², Glenn C. Landon³, Sherwin J. Siff³, Andrea Barbo⁴ and Maria E. Suarez-Almazor⁵, ¹General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ²General Internal Medicine, University of Texas. M.D Anderson Cancer Center, Houston, TX, ³St. Luke's Episcopal Health System, Houston, TX, ⁴Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, ⁵The Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX
Background/Purpose: To explore potential psychosocial and demographic factors that influence Total Knee Arthroplasty (TKA) outcomes and satisfaction at 24 months. Methods: A prospective cohort study…
Abstract Number: 246 • 2013 ACR/ARHP Annual Meeting
Bone Mineral Density and the Risk of Knee Osteoarthritis: The Johnston County Osteoarthritis Project
Kamil E. Barbour¹, Jennifer M. Hootman², Charles G. Helmick³, Louise Murphy⁴, Jordan B. Renner⁵ and Joanne M. Jordan⁶, ¹Centers for Disease Control and Prevention, Atlanta, GA, ²Division of Population Health, Centers for Disease Control and Prevention, Kennesaw, GA, ³National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, ⁴Division of Population Health, CDC, Atlanta, GA, ⁵University of North Carolina Department of Radiology, Chapel Hill, NC, ⁶Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: There is credible evidence that high bone mineral density (BMD) is associated with an increased risk of incident radiographic osteoarthritis (ROA) of the knee.…
Abstract Number: 259 • 2013 ACR/ARHP Annual Meeting
Examining Patient Reported Outcome Measurement Information System Measures In Community Dwelling Adults With Arthritis
Ana-Maria Orbai¹, Leigh F. Callahan², Rebecca J. Cleveland³, Sharon R. Ghazarian⁴, Susan J. Bartlett^5,6 and Clifton O. Bingham III¹, ¹Rheumatology, Johns Hopkins University, Baltimore, MD, ²Thurston Arthritis Res Ctr, University of North Carolina, Chapel Hill, NC, ³Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Bayview Biostatistics, Epidemiology and Data Management (BEAD) Core, Johns Hopkins University, Johns Hopkins University, Baltimore, MD, ⁵Clinical Epidemiology, McGill University, Montreal, QC, Canada, ⁶Division of Rheumatology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Arthritis is the leading cause of disability in the US and impacts on multiple aspects of health-related quality of life (HRQoL). Many multidimensional HRQoL…
Abstract Number: 56 • 2013 ACR/ARHP Annual Meeting
Age-Related Loss Of The Transforming Growth Factor Beta Receptor ALK5 Precedes Osteoarthritis Development In Cartilage
Arjan van Caam¹, Esmeralda N. Blaney Davidson², Eva Thijssen¹, Wim B. van den Berg¹ and Peter M. van der Kraan¹, ¹Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Osteoarthritis (OA) is the most common joint disease and (old) age is its main risk factor. One of OA's main hallmarks is degradation of…
Abstract Number: 2519 • 2012 ACR/ARHP Annual Meeting
IL-1β and TNF-α Regulate the Global and Locus-Specific hydroxymethylation of Genomic DNA by Modulating the Expression and Activity of Tet-1 in Human OA Chondrocytes
Abdul Haseeb¹ and Tariq M. Haqqi², ¹Medicine/Rheumatology, Case Western Reserve University, Cleveland, OH, ²Medicine/Rheumatology/Haman 586, Metro Health Medical Center, Cleveland, OH
Background/Purpose: 5-hydroxymethylcytosine (5-hmC), which is formed by the oxidation of 5-methylcytosine (5-mC), is a recently discovered epigenetic mark and is highest in brain and in…
Abstract Number: 1588 • 2012 ACR/ARHP Annual Meeting
Relationship Over Time Between Beliefs, Motivation, and Worries about Physical Activity and Physical Activity Participation in Persons with Knee Osteoarthritis
Linda S. Ehrlich-Jones¹, Jungwha Lee², Dorothy D. Dunlop³, Pamela A. Semanik², Min-Woong Sohn⁴, Jing Song³ and Rowland W. Chang³, ¹Research CROR, Rehabilitation Institute Chicago, Chicago, IL, ²Northwestern University, Chicago, IL, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Institute for Public Health and Medicine, Northwestern University, Chicago, IL
Background/Purpose: To determine the relationship over time between beliefs, motivation, and worries about physical activity and physical activity participation in persons with knee osteoarthritis…
Abstract Number: 1589 • 2012 ACR/ARHP Annual Meeting
Obesity and Rehabilitation Outcomes After Lower Extremity Arthroplasty
Soham Al Snih, Amol Karmarkar, Timothy A. Reistetter, Jinhyung Lee, Amit Kumar, James E. Graham and Kenneth J. Ottenbacher, University of Texas Medical Branch, Galveston, TX
Background/Purpose: To examine the effect of obesity on inpatient rehabilitation outcomes after lower extremity arthroplasty procedures (hip and knee) among Medicare Beneficiaries aged 65 years…
Abstract Number: 1102 • 2012 ACR/ARHP Annual Meeting
Immunoreactive Collagen Type II Cleavage Products and Their Nitrated Forms in Rheumatoid Arthritis and Osteoarthritis: An Outpatient Cross-Sectional Study
Ruediger Mueller¹, Axel Finckh², Guy Heynen³ and Johannes von Kempis⁴, ¹Division of Rheumatology, Cantonal Hospital, St. Gallen, Switzerland, ²Rheumatology, Geneva University Hospitals, Geneva 14, Switzerland, ³Consulting, CH-6300 Zug, Switzerland, ⁴Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland
Background/Purpose: Catabolism of type II collagen (COLII) involves multiple metalloproteinases, aggrecanases and cathepsin, releasing heterogeneous triple helix cleavage products. The complex regulation of these enzymes and of inducible…
Abstract Number: 29 • 2012 ACR/ARHP Annual Meeting
Level of IL-1â-Induced Epigenetic Modifications Differ in Chondrocytes From Different Histological Zones of Human Cartilage
Nahid Akhtar¹ and Tariq M. Haqqi², ¹Medicine/Rheumatology, Case Western Reserve University/Metrohealth Medical Center, Cleveland, OH, ²Medicine/Rheumatology/Haman 586, Metro Health Medical Center, Cleveland, OH
Background/Purpose: Osteoarthritis (OA) reduces mobility and function of the affected joint and is a leading cause of disability among the elderly. Recent evidence points to…
Abstract Number: 41 • 2012 ACR/ARHP Annual Meeting
Long-Distance Physical Connections Between Chondrocytes; Cell-to-Cell Communication within Articular Cartilage
Maria Dolores Mayan¹, Raquel Gago-Fuentes¹, Paula Carpintero-Fernandez², Patricia Fernandez-Puente², Purificacion Filgueira-Fernandez¹, Virgin Valiunas³, Peter Brink³, Gary Goldberg⁴ and Francisco J. Blanco Garcia⁵, ¹Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, Xubias de Arriba 84, 15006, A Coruña, Spain, ²Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, As Xubias de Arriba 84, 15006, A Coruña, Spain, ³Department of Physiology and Biophysics. State University of New York, Stony Brook, New York, SC, ⁴Department of Molecular Biology. Medical Center Drive, University of Medicine and Dentistry of New Jersey, Stratford, NJ, ⁵Grupo de Bioingeniería Tisular y Terapia Celular (CBTTC-CHUAC). CIBER-BBN/ISCIII. Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de Coruña (CHUAC). SERGAS. Universidade de A Coruña, A Coruña, Spain
Background/Purpose: It is believed that chondrocytes in cartilage do not connect each other, as they are isolated inside their lacunae separated from each other by…
Abstract Number: 44 • 2012 ACR/ARHP Annual Meeting
Inhibition of WNT Signaling Pathway by Sclerostin Maintains Cartilage Homeostasis
Wafa Bouaziz¹, Thomas Funck-Brentano¹, Hilene Lin¹, Eric Hay¹ and Martine Cohen-Solal², ¹INSERM U606 Paris 7 university, Paris, France, ²Rhumatologie A, INSERM U606 Hôpital Lariboisière, Centre Viggo Petersen, Paris, France
Background/Purpose: Cartilage homeostasis is regulated by several mechanisms that influence the anabolic and catabolic tissue balance. Among them, the local activation of Wnt signaling pathway…

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