Abstracts tagged "neutrophils"

Abstract Number: 0596 • ACR Convergence 2022
Neutrophil Extracellular Traps (NET) Trigger an Enhanced Pro-inflammatory Response in Macrophage Subpopulations in Rheumatoid Arthritis Patients via the Aryl Hydrocarbon Receptor (AhR) Pathway
Dyhia Melbouci¹, Sarra Seninet¹, Marie-Christophe Boissier², Elodie Segura³ and Patrice Decker¹, ¹University Sorbonne Paris Nord, Inserm UMR 1125, Li2P, Bobigny, France, ²INSERM UMR 1125, Sorbonne Paris Nord University,Rheumatology Dpt, APHP, GHUPSSD, Avicenne Hosp, Bobigny, France, ³U932 Inserm, Curie Institute, Paris, France
Background/Purpose: Activated neutrophils (PMN) form neutrophil extracellular traps (NET), fibers of DNA and associated proteins expelled in the extracellular space. Increased NET formation has been…
Abstract Number: 1689 • ACR Convergence 2022
Oral Ginger Supplementation Counteracts NETosis in Autoimmune Mouse Models and in Healthy Humans
Ramadan Ali¹, Miela Zahavi², Christine Rysenga¹, Cyrus Sarosh³, Claire Hoy¹, Kristen Demoruelle⁴ and Jason S Knight⁵, ¹University of Michigan, Ann Arbor, MI, ²Universtiy of Michigan, Ann Arbor, MI, ³University of Michigan, Temperance, MI, ⁴University of Colorado Anschutz Medical Campus, Aurora, CO, ⁵University of Michigan, Division of Rheumatology, Ann Arbor, MI
Background/Purpose: It has previously been reported that 6-gingerol, the most abundant phytochemical in ginger root, inhibits neutrophil phosphodiesterase activity and thereby counteracts neutrophil hyperactivity in…
Abstract Number: 0611 • ACR Convergence 2022
Proteomics Reveals Dysregulated Molecular Mechanisms of Cell Death in Neutrophils in Rheumatoid Arthritis
Jennifer Amsler¹, Constance Beaudouin², Morgane LeGall³, Géraldine Falgarone⁴, François Rannou⁵, Léa Tourneur³ and Véronique Witko-Sarsat³, ¹Institute Cochin, Schoenenwerd, Switzerland, ²Hôpital Privé de Provence, Aix-en-Provence, France, ³Institute Cochin, Paris, France, ⁴Hôpital Avicenne, Paris, France, ⁵Hôpital Cochin, Paris, France
Background/Purpose: Favoring apoptosis of neutrophils infiltrating the joints of patients suffering from rheumatoid arthritis (RA) and perpetuating inflammation has recently been discussed as an alternative…
Abstract Number: 1694 • ACR Convergence 2022
Skin Exposure to UV Light Triggers Podocyte and Distal Tubular Injury, in the Presence of CD177+ Neutrophil Cell Cluster
Angelique Cortez¹, Lindsay Mendyka¹, Fred Kolling² and Sladjana Skopelja-Gardner¹, ¹Dartmouth Hitchcock Medical Center, Lebanon, NH, ²Geisel School of Medicine at Dartmouth, Lebanon, NH
Background/Purpose: Sensitivity to ultraviolet (UV) light affects ~ 80% of systemic lupus erythematosus (SLE) patients. UV light exposure of lupus skin leads to local and…
Abstract Number: 0687 • ACR Convergence 2022
DNA- and NET-Binding Beta-2 Glycoprotein I in a Large Cohort of Antiphospholipid Antibody-Positive Patients
Katarina Kmetova¹, Srilakshmi Yalavarthi², Claire Hoy², Cyrus Sarosh³, Noah Peters², Tristin Smith², Sherwin Navaz², Yu Zuo² and Jason S Knight⁴, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³University of Michigan, Temperance, MI, ⁴University of Michigan, Division of Rheumatology, Ann Arbor, MI
Background/Purpose: Beta-2 glycoprotein I (β2GPI) is an abundant plasma protein and a critically important autoantigen in APS. While β2GPI has been reported to have antioxidant,…
Abstract Number: 1714 • ACR Convergence 2022
The Circadian Clock Gene Bmal1 Negatively Regulates Autoantibody Production in SLE
Shuichiro Nakabo¹, Donavon Sandoval-Heglund¹, Victoria Hoffmann², Mingzeng Zhang¹, Norio Hanata¹, Zerai Manna¹, Elaine Poncio¹, Sarfaraz Hasni³ and Mariana Kaplan⁴, ¹NIAMS/NIH, Bethesda, MD, ²ORS/ORF/NIH, Bethesda, MD, ³National Institutes of Health, Bethesda, MD, ⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects multiple organs including kidney and skin. While its etiology and pathogenesis are still…
Abstract Number: 0688 • ACR Convergence 2022
Antibodies of the IgA Isotype Target Neutrophil Extracellular Traps in APS
Sherwin Navaz¹, Lyndsay Kluge¹, Katarina Kmetova², Bruna Jacintho³, Srilakshmi Yalavarthi¹, Claire Hoy¹, Cyrus Sarosh⁴, Noah Peters¹, Tristin Smith¹, Gabriel Figueroa Parra⁵, Jacqueline Madison¹, Kristen Demoruelle⁶, Ali Duarte-Garcia⁵, Jason S Knight⁷ and Yu (Ray) Zuo¹, ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³University of Michigan, São Paulo, Brazil, ⁴University of Michigan, Temperance, MI, ⁵Mayo Clinic, Rochester, MN, ⁶University of Colorado Anschutz Medical Campus, Aurora, CO, ⁷University of Michigan, Division of Rheumatology, Ann Arbor, MI
Background/Purpose: Neutrophil extracellular traps (NETs) are prothrombotic and proinflammatory webs of nuclear DNA, histones, and microbicidal proteins extruded by neutrophils into the extracellular space in…
Abstract Number: 1721 • ACR Convergence 2022
Protective Effects of the Natural Antioxidant Taxifolin in Models of Lupus and Antiphospholipid Syndrome
Christine Rysenga¹, Linda May-Zhang², Miela Zahavi³, Jason S Knight⁴ and Ramadan Ali¹, ¹University of Michigan, Ann Arbor, MI, ²Blue California, Rancho Santa Margarita, CA, ³Universtiy of Michigan, Ann Arbor, MI, ⁴University of Michigan, Division of Rheumatology, Ann Arbor, MI
Background/Purpose: Taxifolin, also known as dihydroquercetin, is a bioactive flavonoid commonly found in apples, onions, French maritime bark, and milk thistle. Given its potent anti-inflammatory…
Abstract Number: 0690 • ACR Convergence 2022
The Physiological Ketone Body Beta-Hydroxybutyrate Potently Neutralizes APS-Associated NETosis
Ajay Tambralli¹, Alyssa Harbaugh¹, Christine Rysenga¹, Kaitlyn Sabb¹, Srilakshmi Yalavarthi¹, Claire Hoy¹, Yu (Ray) Zuo¹ and Jason S Knight², ¹University of Michigan, Ann Arbor, MI, ²University of Michigan, Division of Rheumatology, Ann Arbor, MI
Background/Purpose: Malleable metabolic pathways guide both productive and pathological neutrophil functions, including neutrophil extracellular trap release (NETosis). NETosis plays an important role in APS pathophysiology.…
Abstract Number: 2021 • ACR Convergence 2022
Early Histopathological Changes of the Salivary Glands Associated with the Development of Primary Sjögren’s Syndrome
Xiaomei Shan¹, Clara Reichardt¹, Jeeshan Singh¹, Anne Zeitler², Christine Schauer¹, Jasmin Knopf¹, Martin Herrmann¹, Gerhard Grossmayer¹, Georg Schett¹ and Luis Munoz¹, ¹Universitätsklinikum Erlangen, Erlangen, Germany, ²Friedrich-Alexander University Erlangen Nürnberg, Erlangen, Germany
Background/Purpose: Primary Sjögren's syndrome (PSS) is a chronic inflammatory disease affecting exocrine glands including salivary and lacrimal glands that leads to dry eyes and mouth…
Abstract Number: 0692 • ACR Convergence 2022
The Interplay Between Lipid Peroxidation and Neutrophil Extracellular Trap (NET) Formation in APS Pathogenesis
Naveen Kumar S K¹, Claire Hoy¹, Christine Rysenga¹, Srilakshmi Yalavarthi¹, Cyrus Sarosh², Sherwin Navaz¹, Jacqueline Madison¹, Jason S Knight³ and Yu (Ray) Zuo¹, ¹University of Michigan, Ann Arbor, MI, ²University of Michigan, Temperance, MI, ³University of Michigan, Division of Rheumatology, Ann Arbor, MI
Background/Purpose: Lipid peroxidation is the result of disrupted redox homeostasis and functions as a key component in various cell death programs. Neutrophil extracellular trap (NET)…
Abstract Number: 2266 • ACR Convergence 2022
Platelet-selectin Prime Lupus Neutrophils to Produce Mitochondrial ROS and Participate in SLE Pathogenesis
Marc Scherlinger¹, Pierre Vacher², Vivien Guillotin³, Isabelle Douchet⁴, Christophe Richez⁵ and Patrick Blanco⁴, ¹BIDMC Harvard University, Boston, MA, ²INSERM U1218, Bordeaux, France, ³CHU de Bordeaux, Bordeaux, France, ⁴UMR-CNRS 5164 Immunoconcept, Bordeaux, France, ⁵CHRU Bordeaux, Bordeaux, France
Background/Purpose: In patients with active systemic lupus erythematosus (SLE), circulating platelets have an activated phenotype characterized by the expression of P-selectin (CD62P). We have shown…
Abstract Number: 0693 • ACR Convergence 2022
Low Neutrophil Ectonucleotidase Activity Drives Neutrophil-Platelet Aggregation and Platelet Activation in Antiphospholipid Syndrome (APS)
Naveen Kumar S K¹, Claire Hoy¹, Srilakshmi Yalavarthi¹, Cyrus Sarosh², Kaitlyn Sabb¹, Christine Rysenga¹, Jacqueline Madison¹, Yu Zuo¹ and Jason S Knight³, ¹University of Michigan, Ann Arbor, MI, ²University of Michigan, Temperance, MI, ³University of Michigan, Division of Rheumatology, Ann Arbor, MI
Background/Purpose: By converting extracellular ATP into homeostatic adenosine, the ectonucleotidases CD39 (ATP to AMP) and CD73 (AMP to adenosine) dictate extracellular purinergic gradients and as…
Abstract Number: 2269 • ACR Convergence 2022
Anti-NET Antibodies in Antiphospholipid Antibody-positive Patients: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (“Registry”)
Yu (Ray) Zuo¹, Sherwin Navaz¹, Alex Tsodikov¹, Katarina Kmetova², Claire Hoy¹, Srilakshmi Yalavarthi¹, Danieli Castro Oliveira de Andrade³, Maria G. Tektonidou⁴, Savino Sciascia⁵, Vittorio Pengo⁶, Guillermo Ruiz-Irastorza⁷, H Michael Belmont⁸, maria gerosa⁹, Paul fortin¹⁰, Guilherme de Jesús¹¹, D. Ware Branch¹², Laura Andreoli¹³, Esther Rodriguez Almaraz¹⁴, Michelle Petri¹⁵, Ricard Cervera¹⁶, Rohan Willis¹⁷, Doruk Erkan¹⁸ and Jason S Knight¹⁹, ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁴National and Kapodistrian University of Athens, Athens, Greece, ⁵University of Turin, Torino, Italy, ⁶Padova University Hospital, Padova, Italy, ⁷Autoimmune Diseases Research Unit, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, UPV/EHU, Barakaldo, Spain, ⁸NYU School of Medicine, New York, NY, ⁹University of Milan, Milano, Italy, ¹⁰CHU de Québec, Pavillon CHUL, Québec, Canada, ¹¹Universidade do Estado do Rio de Janeiro, Rio De Janeiro, Brazil, ¹²University of Utah, Salt Lake City, UT, ¹³Rheumatology and Clinical Immunology Unit, ASST Spedali Civili and University of Brescia, Brescia, Italy, ¹⁴Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁵Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, ¹⁶Hospital Clínic de Barcelona, Barcelona, Spain, ¹⁷University of Texas Medical Branch, Galveston, TX, ¹⁸Hospital for Special Surgery, New York, NY, ¹⁹University of Michigan, Division of Rheumatology, Ann Arbor, MI
Background/Purpose: The release of neutrophil extracellular traps (NETs) by hyperactive neutrophils plays a role in the thromboinflammatory phenotype of APS. Previous work has demonstrated that…
Abstract Number: 0877 • ACR Convergence 2022
Neutrophils Extracellular Traps Formation May Serve as a Biomarker for Disease Activity in Oligoarticular Juvenile Idiopathic Arthritis
Merav Heshin-Bekenstein¹, Szilvia Baron², Grant Schulert³, Anna Shusterman⁴, Rachel Shukrun⁴, Yoav Binenbaum⁴ and Ronit Elhasid⁵, ¹Dana Dwek Children's Hospital, Tel Aviv Medical Center Israel, Binyamina, Israel, ²Pediatric Hemato-Oncology Research Laboratory, Tel Aviv Medical Center, Tel Aviv, Israel, ³Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Tel Aviv Medical Center, Tel Aviv, Israel, ⁵Dana Children's Hospital, Tel Aviv Medical Center, Tel Aviv, Israel
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children, causing significant morbidity. Despite the dramatic improvement in treatment, many patients…

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