ACR Meeting Abstracts

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Abstracts tagged "neutrophils"

  • Abstract Number: 0099 • ACR Convergence 2024

    Modulating Pentose Phosphate Pathway Metabolism to Temper Neutrophil Hyperactivity in Antiphospholipid Syndrome

    Kaitlyn Sabb1, Ajay Tambralli1, Megan Radyk1, Emily Becker1, Srilakshmi Yalavarthi1, Claire Hoy1, Cyrus Sarosh2, Jacqueline Madison1, Yu Zuo1, Costas Lyssiotis1 and Jason Knight1, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Temperance, MI

    Background/Purpose: Neutrophil hyperactivity and neutrophil extracellular trap (NET) release (NETosis) appear to play important roles in antiphospholipid syndrome (APS) pathogenesis. To kill microbes and propel…
  • Abstract Number: 1638 • ACR Convergence 2024

    Calprotectin, a Mechanistically Informed Biomarker for Clinically Isolated Aortitis

    Katarina Kmetova1, Emily Chong2, NaveenKumar Somanathapura K3, Kavya Sugur2, Lyndsay Kluge2, Srilakshmi Yalavarthi3, Julia Ford3, Ora Singer4 and Yu Zuo3, 1Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, MI, 2Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann arbor, Ann arbor, MI, 3University of Michigan, Ann arbor, MI, 4University of Michigan, Huntington Woods, MI

    Background/Purpose: Clinically isolated aortitis (CIA) is aortitis in patients without evidence of systemic disease, infection, or involvement of other vascular territories. CIA is discovered incidentally…
  • Abstract Number: 0101 • ACR Convergence 2024

    Metabolomic Profiling Reveals a Role for Citric Acid Cycle Dysfunction in Antiphospholipid Syndrome Neutrophils

    Ajay Tambralli1, Megan Radyk1, Kaitlyn Sabb1, Li Zhang1, Harrison Wong1, Emily Becker1, Srilakshmi Yalavarthi1, Claire Hoy1, Cyrus Sarosh2, Jacqueline Madison1, Yu Zuo1, Jason Knight1 and Costas Lyssiotis1, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Temperance, MI

    Background/Purpose: As early effectors of the immune response, neutrophils must access energy rapidly. Neutrophils rely on glycolysis for antimicrobial functions such as phagocytosis and reactive…
  • Abstract Number: 1795 • ACR Convergence 2024

    Immune Complexes-Mediated Activation of Neutrophils in Systemic Lupus Erythematosus Is Dependent on RNA Recognition by TLR8

    Ting Wang1, Runa Kuley2, Payton Hermanson2, Gundula Min-oo3, Natasha Crellin4, Ching Shang3 and Christian Lood1, 1University of Washington, Seattle, WA, 2University of Washington, Seattle, 3Gilead Sciences, Foster City, CA, 4Gilead, Foster City, CA

    Background/Purpose: Neutrophil activation has been implicated to contribute to the systemic lupus erythematosus (SLE) pathogenesis. However, factors and mechanisms promoting neutrophil activation in SLE have…
  • Abstract Number: 0103 • ACR Convergence 2024

    CD10highLow-Density Granulocytes Is a Potential Marker of Disease Activity in Antiphospholipid Syndrome

    chun Li, Peking University People's Hospital, Beijing, China

    Background/Purpose: To investigate the relationship between CD10highLow-Density Granulocytes (LDG) and disease activity in antiphospholipid syndrome(APS).Methods: This study included 99 patients with APS who were treated…
  • Abstract Number: 1802 • ACR Convergence 2024

    Heterogeneous Neutrophil Subsets Infiltrate Glomeruli of Lupus Nephritis Patients and Are Elevated in the Kidneys and Urine of Sunlight-induced Nephritis Flares

    Noelle Kosarek1, Joshua Skydel2, Alecia Roy3, Fred Kolling1, Lucas Salas1, Christopher Burns4, Andrea Fava5 and Sladjana Skopelja-Gardner1, 1Geisel School of Medicine at Dartmouth, Lebanon, 2Dartmouth Hitchcock Medical Center, Lebanon, 3Dartmouth College, Lebanon, NH, 4Dartmouth Hitchcock Medical Center, Lebanon, NH, 5Divison of Rheumatology, Johns Hopkins University, Baltimore, MD

    Background/Purpose: Up to ~60% of SLE patients in North America will develop kidney disease, lupus nephritis (LN), one of the main contributors to disease morbidity…
  • Abstract Number: 0507 • ACR Convergence 2024

    Neutrophil Activation Markers Can Predict Rheumatoid Arthritis Treatment Response to the Janus Kinase 1/2 Inhibitor Baricitinib

    Runa Kuley1, Bhargavi Duvvuri1, Sabeeha Hasnain2, Ernst Dow3, Alisa Koch4, Richard Higgs4, Venkatesh Krishnan4 and Christian Lood5, 1University of Washington, Seattle, 2Mahindra University, Hyderabad, India, 3Eli Lilly and Co, Indianapolis, IN, 4Eli Lilly, Indianapolis, IN, 5University of Washington, Seattle, WA

    Background/Purpose: Neutrophils play an important role in regulating immune and inflammatory responses in rheumatoid arthritis (RA). We assessed whether baricitinib, a JAK1/JAK2 inhibitor, could reduce…
  • Abstract Number: 2601 • ACR Convergence 2024

    Platelets Specifically Interact with Remigrating Neutrophils and Promote Immunogenic Cellular Death in Systemic Lupus

    Marie nansion1, Eloi Schmauch2, Pierre Vacher3, Jean Sibilia4, Nathan Broussaudier1, Adeline Bruchon1, Pierre Grenot1, Anne-Sophie Korganow5, Thierry Martin5, Sophie Caillard6, Anna Duval6, Jacques-Eric Gottenberg7, Raphaël Carapito1, Séiamak Bahram1, Patrick Blanco8 and Marc Scherlinger9, 1UMR_INSERM 1109, Strasbourg, France, 2Broad Institute of MIT and Harvard, Cambridge, MA, USA., Boston, MA, 3Inserm U1045, Bordeaux, France, 4Strasbourg University Hospital, National reference center for autoimmune disease, Rheumatology, Strasbourg, France, 5Strasbourg University Hospital, National reference center for autoimmune disease, Clinical Immunology, Strasbourg, France, 6Nephrology department, HUS, Strasbourg, France, 7Rheumatology Department, Strasbourg University Hospital,, Strasbourg, France, 8UMR_CNRS 5164 Immunoconcept, BORDEAUX CEDEX, France, 9Strasbourg University Hospital; INSERM 1109, Strasbourg, France

    Background/Purpose: In SLE, platelet activation (express P-selectin+) follows the disease activity, which plays a role in thrombosis as well as in inflammation (1). Neutrophils express high levels of PSGL-1,…
  • Abstract Number: 0515 • ACR Convergence 2024

    Scavenging Isolevuglandins with 2-HOBA Decreases In Vitro Neutrophil Extracellular Traps in Cells from Patients with Rheumatoid Arthritis

    Olivia Posey, Anastasiia Phothisane, Phicharmon Kulapatana and Michelle Ormseth, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Neutrophils contribute to the innate immune response of killing pathogens through the formation of neutrophil extracellular traps (NETs), which is also called NETosis. NETosis…
  • Abstract Number: 2690 • ACR Convergence 2024

    ANCA IgG Promotion of Neutrophil Recruitment, Migration and Vascular Damage in ANCA Associated Vasculitis May Be Enhanced by Hypoxia

    Noelle Pisacano, Amrita Dhutia, Stephen Rothery, Charles Pusey, Edwin Chilvers, Andrew Cowburn, Katharine Lodge and Maria Prendecki, Imperial College London, London, United Kingdom

    Background/Purpose: Neutrophils are main mediators of disease in ANCA associated vasculitis (AAV). Pathogenic ANCA IgG on neutrophils promotes neutrophil adhesion and migration at the endothelium.…
  • Abstract Number: 0766 • ACR Convergence 2024

    Neutrophil Transcriptomics in VEXAS Syndrome

    Chloe Palmer1, Gustaf Wigerblad1, Tom Hill2, Bhavisha Patel3, Emma Groarke4, Neal Young4, Stefania Dell'Orso5 and Peter Grayson6, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, 3National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Beltsville, MD, 4National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, 5National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, Bethesda, MD, 6National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Chevy Chase, MD

    Background/Purpose: Vacuoles, E1 ubiquitin-activating enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is caused by somatic mutations of the ubiquitin-like modifier activating enzyme 1 (UBA1) gene and…
  • Abstract Number: 0773 • ACR Convergence 2024

    Anti-Citrullinated Histone Antibody CIT-013 Targets NETs in Inflamed Joints and Halts NET-mediated Joint Deterioration

    Leonie Middelink1, Annemarie Kip2, Maarten van der Linden3, Sangeeta Kumari2, Stephanie van Dalen2, Josephine Stein4, Tirza Bruurmijn2, Martyn Foster5, Peter van Zandvoort2, Patrick Round2, Eric Meldrum2, Helmuth van Es2 and Renato Chirivi2, 1Citryll, Oss, Noord-Brabant, Netherlands, 2Citryll BV, Oss, Noord-Brabant, Netherlands, 3Citryll BV, Oss, Netherlands, 4Citryll BV, Oss, Noord-Holland, Netherlands, 5Experimental Pathology Consultancy, Benfleet, United Kingdom

    Background/Purpose: Neutrophil extracellular traps (NETs) contribute to the pathophysiology of many immune-mediated inflammatory diseases (IMIDs). Though NETosis-targeting therapeutics have shown potential as effective treatments, currently…
  • Abstract Number: 0801 • ACR Convergence 2024

    Neutrophil Activation as a Novel Marker of Lung Disease in Rheumatoid Arthritis

    Jia Shi1, Yang Wu1, Ting Wang2, Chen Yu3, qian wang4, Xinping Tian5, Mengtao Li4, Kristen Demoruelle6, Joshua Solomon7 and Christian Lood2, 1University of Washington, Seattle, 2University of Washington, Seattle, WA, 3Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Dong Cheng Qu, China (People's Republic), 4Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China 2National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China, 5Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 6University of Colorado Anschutz Medical Campus, Golden, CO, 7National Jewish Health, Denver, CO

    Background/Purpose: Neutrophil activation is seen in rheumatoid arthritis (RA), but its involvement in RA interstitial lung disease (RA-ILD) is not clear. Levels of N-formyl methionine…
  • Abstract Number: 0918 • ACR Convergence 2024

    Anti-VISTA Antibody Suppresses Neutrophil-mediated Inflammation

    Elizabeth Nowak1, Jiannan Li1, Mohamed ElTanbouly1, Lindsay Mendyka2, Louise Lines1, Rodwell Mabaera3, Christopher Burns4, Randolph Noelle1 and Sladjana Skopelja-Gardner1, 1Geisel School of Medicine at Dartmouth, Lebanon, 2Dartmouth Hitchcock Memorial Hospital, Lyme, NH, 3Dartmouth Hitchcock Medical Center, Lebanon, 4Dartmouth Hitchcock Medical Center, Lebanon, NH

    Background/Purpose: A growing body of evidence suggests that VISTA, an immune checkpoint inhibitory receptor, plays a central role in the regulation of innate immunity in…
  • Abstract Number: 0931 • ACR Convergence 2024

    Salivary Granular Convoluted Tubules Contribute to Maintain Tissue-specific Tolerance – Implications for the Development of Murine Sjögren´s Syndrome

    Xiaomei Shan1, Clara Reichardt1, Marco Munoz Becerra1, Aleix Rigau2, Lena Müller3, Anne Zeitler1, Jasmin Knopf4, Gerhard Grossmayer1, Martin Herrmann1, Christine Schauer1, Markus Eckstein5, Georg Schett6 and Luis Munoz7, 1Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany, 2Friedrich-Alexander Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 3Medizin Universität Wien, Vienna, Austria, 4Universitätsklinikum Mannheim, Mannheim, Germany, 5Institute of Pathology and Comprehensive Cancer Center EMN, Friedrich-Alexander- Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, 6Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 7Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen

    Background/Purpose: Primary Sjögren's syndrome (PSS) is a chronic inflammatory disease affecting exocrine glands with an important systemic autoimmune reaction against some nuclear and membrane bound…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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