ACR Meeting Abstracts

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Abstracts tagged "neutrophils"

  • Abstract Number: 0515 • ACR Convergence 2024

    Scavenging Isolevuglandins with 2-HOBA Decreases In Vitro Neutrophil Extracellular Traps in Cells from Patients with Rheumatoid Arthritis

    Olivia Posey, Anastasiia Phothisane, Phicharmon Kulapatana and Michelle Ormseth, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Neutrophils contribute to the innate immune response of killing pathogens through the formation of neutrophil extracellular traps (NETs), which is also called NETosis. NETosis…
  • Abstract Number: 2690 • ACR Convergence 2024

    ANCA IgG Promotion of Neutrophil Recruitment, Migration and Vascular Damage in ANCA Associated Vasculitis May Be Enhanced by Hypoxia

    Noelle Pisacano, Amrita Dhutia, Stephen Rothery, Charles Pusey, Edwin Chilvers, Andrew Cowburn, Katharine Lodge and Maria Prendecki, Imperial College London, London, United Kingdom

    Background/Purpose: Neutrophils are main mediators of disease in ANCA associated vasculitis (AAV). Pathogenic ANCA IgG on neutrophils promotes neutrophil adhesion and migration at the endothelium.…
  • Abstract Number: 0766 • ACR Convergence 2024

    Neutrophil Transcriptomics in VEXAS Syndrome

    Chloe Palmer1, Gustaf Wigerblad1, Tom Hill2, Bhavisha Patel3, Emma Groarke4, Neal Young4, Stefania Dell'Orso5 and Peter Grayson6, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, 3National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Beltsville, MD, 4National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, 5National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, Bethesda, MD, 6National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Chevy Chase, MD

    Background/Purpose: Vacuoles, E1 ubiquitin-activating enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is caused by somatic mutations of the ubiquitin-like modifier activating enzyme 1 (UBA1) gene and…
  • Abstract Number: 0773 • ACR Convergence 2024

    Anti-Citrullinated Histone Antibody CIT-013 Targets NETs in Inflamed Joints and Halts NET-mediated Joint Deterioration

    Leonie Middelink1, Annemarie Kip2, Maarten van der Linden3, Sangeeta Kumari2, Stephanie van Dalen2, Josephine Stein4, Tirza Bruurmijn2, Martyn Foster5, Peter van Zandvoort2, Patrick Round2, Eric Meldrum2, Helmuth van Es2 and Renato Chirivi2, 1Citryll, Oss, Noord-Brabant, Netherlands, 2Citryll BV, Oss, Noord-Brabant, Netherlands, 3Citryll BV, Oss, Netherlands, 4Citryll BV, Oss, Noord-Holland, Netherlands, 5Experimental Pathology Consultancy, Benfleet, United Kingdom

    Background/Purpose: Neutrophil extracellular traps (NETs) contribute to the pathophysiology of many immune-mediated inflammatory diseases (IMIDs). Though NETosis-targeting therapeutics have shown potential as effective treatments, currently…
  • Abstract Number: 0801 • ACR Convergence 2024

    Neutrophil Activation as a Novel Marker of Lung Disease in Rheumatoid Arthritis

    Jia Shi1, Yang Wu1, Ting Wang2, Chen Yu3, qian wang4, Xinping Tian5, Mengtao Li4, Kristen Demoruelle6, Joshua Solomon7 and Christian Lood2, 1University of Washington, Seattle, 2University of Washington, Seattle, WA, 3Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Dong Cheng Qu, China (People's Republic), 4Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China 2National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China, 5Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 6University of Colorado Anschutz Medical Campus, Golden, CO, 7National Jewish Health, Denver, CO

    Background/Purpose: Neutrophil activation is seen in rheumatoid arthritis (RA), but its involvement in RA interstitial lung disease (RA-ILD) is not clear. Levels of N-formyl methionine…
  • Abstract Number: 0918 • ACR Convergence 2024

    Anti-VISTA Antibody Suppresses Neutrophil-mediated Inflammation

    Elizabeth Nowak1, Jiannan Li1, Mohamed ElTanbouly1, Lindsay Mendyka2, Louise Lines1, Rodwell Mabaera3, Christopher Burns4, Randolph Noelle1 and Sladjana Skopelja-Gardner1, 1Geisel School of Medicine at Dartmouth, Lebanon, 2Dartmouth Hitchcock Memorial Hospital, Lyme, NH, 3Dartmouth Hitchcock Medical Center, Lebanon, 4Dartmouth Hitchcock Medical Center, Lebanon, NH

    Background/Purpose: A growing body of evidence suggests that VISTA, an immune checkpoint inhibitory receptor, plays a central role in the regulation of innate immunity in…
  • Abstract Number: 0931 • ACR Convergence 2024

    Salivary Granular Convoluted Tubules Contribute to Maintain Tissue-specific Tolerance – Implications for the Development of Murine Sjögren´s Syndrome

    Xiaomei Shan1, Clara Reichardt1, Marco Munoz Becerra1, Aleix Rigau2, Lena Müller3, Anne Zeitler1, Jasmin Knopf4, Gerhard Grossmayer1, Martin Herrmann1, Christine Schauer1, Markus Eckstein5, Georg Schett6 and Luis Munoz7, 1Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany, 2Friedrich-Alexander Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 3Medizin Universität Wien, Vienna, Austria, 4Universitätsklinikum Mannheim, Mannheim, Germany, 5Institute of Pathology and Comprehensive Cancer Center EMN, Friedrich-Alexander- Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, 6Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 7Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen

    Background/Purpose: Primary Sjögren's syndrome (PSS) is a chronic inflammatory disease affecting exocrine glands with an important systemic autoimmune reaction against some nuclear and membrane bound…
  • Abstract Number: 0933 • ACR Convergence 2024

    NLRP3 Inflammasome Promotes Release of Peptidyl Arginine Deiminases2 and 4 from Human Neutrophils

    Teneema Kuriakose, Mingxin Yang, Lacie Scaletta and Gary Sims, Immunology Biosciences, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD

    Background/Purpose: Autoantibodies targeting citrullinated proteins (ACPAs) are a characteristic feature and a diagnostic marker in rheumatoid arthritis (RA). The generation of citrullinated protein autoantigens is…
  • Abstract Number: 0951 • ACR Convergence 2024

    A Feedback Loop Involving mtDNA, Platelets and Neutrophil Extracellular Traps Amplifies Inflammation in Systemic Sclerosis

    Stavros Giaglis1, Diego Kyburz2 and Ulrich Walker3, 1Experimental Rheumatology Laboratory, University of Basel, Basel, Switzerland, 2University Hospital Basel, Basel, Switzerland, 3Basel University Hospital, Basel, Switzerland

    Background/Purpose: Mitochondria are essential eucaryotic cell organelles with several bacterial features, such as a double-stranded circular genome with hypomethylated CpG areas (1). A fundamental role of…
  • Abstract Number: 0046 • ACR Convergence 2024

    Impaired Neutrophil Extracellular Trap (NET) Degradation in Rheumatoid Arthritis (RA) and Pre-clinical RA Is Mediated by Anti-NET Antibodies

    Jeba Atkia Maisha1, Alina Sememenko2, Jun Kim2, Mario Navarrete2, XIAOBO MENG1, Hani El-Gabalawy1 and Liam O'Neil1, 1University of Manitoba, Winnipeg, MB, Canada, 2University of Manitoba, Winnipeg, Canada

    Background/Purpose: Rheumatoid Arthritis (RA) begins after a prolonged preclinical phase which is marked by the development of RA antibodies, typically against citrullinated proteins (ACPA). The…
  • Abstract Number: 1268 • ACR Convergence 2024

    Neutrophil Lymphocyte Ratio as a Novel Marker of Skin Disease Activity in Older Children with Juvenile Dermatomyositis

    Shreya Swaminathan1, Nidhi Naik2, Susan Shenoi3, Sarah Vandenbergen4, Jessica Turnier5, Zilan Zheng6, Jessica Neely6, James Andrews7 and Christian Lood8, 1University of Washington, Seattle, 2Seattle children's hospital, Bothell, WA, 3Seattle Children's Hospital and Research Center, Mercer Island, WA, WA, 4University of Michigan, Ann Arbor, MI, 5University of Michigan, Saline, MI, 6UCSF, San Francisco, CA, 7University of Alabama at Birmingham, Birmingham, AL, 8University of Washington, Seattle, WA

    Background/Purpose: Exaggerated neutrophil activation can lead to inflammation and organ damage in rheumatic diseases, including dermatomyositis (DM). In both juvenile (JDM) and adult DM, markers…
  • Abstract Number: 0063 • ACR Convergence 2024

    Splicing into Action:Investigating the Role of Alternative Splicing in Rheumatoid Arthritis Neutrophils

    Rayan Najjar1, Noga Rogel2 and Tomas Mustelin3, 1University of Washington, Seattle, 2University of Washinton, Seattle, 3University of Washington, Seattle, WA

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by a variable response to therapies, reflecting its complex and incompletely understood pathogenesis. Emerging research suggests…
  • Abstract Number: 1550 • ACR Convergence 2024

    CD19 CAR T Cell Therapy Suppresses the Inflammatory Profile of Neutrophils in Systemic Lupus Erythematosus

    Panagiotis Garantziotis1, Kirill Anoshkin1, Melanie Hagen2, Andreas Wirsching2, Andreas MAckensen3, Georg Schett4 and Ricardo Grieshaber-Bouyer5, 1Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, 2Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Bayern, Germany, 3Department of Medicine 5 - Hematology and Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Uniklinikum Erlangen, Erlangen, Bayern, Germany, 4Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 5Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany

    Background/Purpose: Patients with Systemic Lupus Erythematosus (SLE) exhibit increased formation of Neutrophil Extracellular Traps and production of proinflammatory cytokines, which can perpetuate autoimmunity. Furthermore, NETs…
  • Abstract Number: 0065 • ACR Convergence 2024

    Evidence of Membranolytic Targeting and Intracellular Citrullinationin Neutrophils Isolated from Patients with Rheumatoid Arthritis

    Neela Fatemeh Moadab1, Tal Gazitt2, Rayan Najjar1, Ethan Le1, J Lee Nelson3, Vijay Joshua4, Keith Elkon1, Caroline Grönwall4 and Tomas Mustelin1, 1University of Washington, Seattle, WA, 2Carmel Hospital, Haifa, Israel, 3University of Washington and Fred Hutchinson Cancer Center, Seattle, WA, 4Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Anti-citrullinated protein autoantibodies (ACPA) are diagnostic for rheumatoid arthritis (RA). The antigens recognized by these autoantibodies are produced by protein arginine deiminases (PADs), particularly…
  • Abstract Number: 1577 • ACR Convergence 2024

    Elevated Neutrophil Extracellular Traps in Systemic Sclerosis-associated Vasculopathy and Suppression by a Synthetic Prostacyclin Analog

    Neda Kortam1, Wenying Liang1, Claire Shiple1, Suiyuan Huang1, Rosemary Gedert1, James St. Clair1, Cyrus Sarosh2, Caroline Foster1, Eliza Pei-Suen Tsou1, John Varga1, Jason Knight1, Dinesh Khanna1 and Ramadan Ali1, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Temperance, MI

    Background/Purpose: Neutrophils and neutrophil extracellular traps (NETs) contribute to the vascular complications of multiple diseases, but their role in systemic sclerosis (SSc) is understudied. We…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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