Abstracts tagged "Neutrophil Extracellular Traps"

Abstract Number: 2598 • 2015 ACR/ARHP Annual Meeting
Neutrophil Extracellular Trap Levels Measured By Cell Free Nucleosome ELISA in Serum Are Highly Specific and Sensitive for Rheumatoid Arthritis
Paul Hasler¹, Stavros Giaglis¹, Ulrich A. Walker², Erik Deman¹, Christoph Hemmeler¹, Christina Ryser¹, Samuel Kretzschmar¹, Guenther Schaefer³, Juliane Franz¹ and Sinuhe Hahn⁴, ¹Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, ²Rheumatology, University Hospital, Basel, Basel, Switzerland, ³Dept. of Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, ⁴Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland
Background/Purpose: Rheumatoid factor (RF) or anti-citrullinated peptide antibody (ACPA) detection have limited clinical utility for the diagnosis of rheumatoid arthritis (RA), as the specificity and…
Abstract Number: 2709 • 2015 ACR/ARHP Annual Meeting
Immediate Release of Peripheral Neutrophil Myeloperoxidase and Elastase and Formation of Extracellular Traps to Cigarette Smoking in Rheumatoid Arthritis
Juliane Franz¹, Stavros Giaglis^1,2, Guenther Schaefer³, Erik Deman¹, Andreas Thueler⁴, Sinuhe Hahn² and Paul Hasler¹, ¹Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, ²Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, ³Dept. of Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, ⁴Rheumatology, Kantonsspital Baden, Baden, Switzerland
Background/Purpose: Smoking represents an independent risk factor for rheumatoid arthritis (RA) (1). In response to infectious agents, neutrophil granulocytes can extrude their nuclear contents as…
Abstract Number: 3032 • 2015 ACR/ARHP Annual Meeting
Role of Adenosine and Neutrophils in Inflammation Associated with Mutations in CECR1 Gene
Kyawt W. Shwin^1,2, Carmelo Carmona-Rivera³, Wanxia Tsai⁴, Chya-chia Richard Lee^5,6, Elaine Novakovich⁷, Deborah L. Stone⁸, Amanda K. Ombrello⁸, Raphaela Goldbach-Mansky⁹, Massimo Gadina¹⁰, Daniel Kastner¹¹, Ivona Aksentijevich^12,13, Mariana J. Kaplan⁷ and Peter C. Grayson^14,15, ¹NIAMS, National Institutes of Health, BETHESDA, MD, ²Translational Autoinflammatory Diseases Section, National Institutes of Health, Bethesda, MD, ³Systemic Autoimmunity Branch/ NIAMS, National Institutes of Health, Bethesda, MD, ⁴Translational Immunology, Office of Science and Technology, National Institutes of Health, Bethesda, MD, ⁵National Cancer Institute, National Institutes of Health, Bethesda, MD, ⁶Laboratory of Pathology, NCI, National Institutes of Health, BETHESDA, MD, ⁷Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, ⁸National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ⁹Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, ¹⁰Translational Immunology, Office of Science and Technology, NIAMS, National Institutes of Health, Bethesda, MD, ¹¹Inflammatory Disease Section, NHGRI, National Institutes of Health, Bethesda, MD, ¹²NIH/NHGRI, Metabolic, Cardiovascular, and Inflammatory Disease Genomics Branch, Bethesda, MD, ¹³Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, ¹⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ¹⁵NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD
Background/Purpose: The phenotype of patients afflicted by deficiency of adenosine deaminase 2 (DADA2) due to mutations in CECR1encoding ADA2 protein shares many features with idiopathic…
Abstract Number: 205 • 2015 ACR/ARHP Annual Meeting
Mode of Action of Therapeutic Anti-Citrullinated Protein Antibodies Revealed: Inflammation Reduction Due to Inhibition of Netosis
Renato G.S. Chirivi^1,2, Jos W.G. van Rosmalen¹, Gonny Schmets¹, Helmuth van Es² and Jos M.H. Raats^1,2, ¹ModiQuest BV, Oss, Netherlands, ²Citryll BV, Nijmegen, Netherlands
Background/Purpose: Neutrophils together with aberrant Neutrophil Extracellular Trap (NET) formation contribute to the induction and propagation of inflammation. A growing number of studies indicate that…
Abstract Number: 208 • 2015 ACR/ARHP Annual Meeting
Neutrophil-Mediated Mechanisms of Drug-Induced Autoimmunity
Jorge Irizarry-Caro¹, Carmelo Carmona-Rivera¹, Elaine Novakovich¹, Venkataraman Subramaniam², Paul Thompson³, Mariana J. Kaplan⁴ and Peter C. Grayson⁵, ¹National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, ²Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA, ³University of Massachusetts, Worcester, MA, ⁴Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Certain medications are known to induce autoimmune disease in humans, triggering clinical features and autoantibody profiles that mirror idiopathic systemic lupus erythematosus (SLE) and/or…
Abstract Number: 209 • 2015 ACR/ARHP Annual Meeting
Different Autoimmune Rheumatic Diease IgG Have Differential Effects upon Neutrophil Binding, Activation and Neutrophil Extracellular Trap Formation
Akif A. Khawaja^1,2, Charis Pericleous³, Vera M. Ripoll², Joanna C. Porter⁴ and Ian Giles⁵, ¹Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, ²Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ³Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, ⁴Centre for Inflammation and Tissue Repair, Division of Medicine, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, ⁵Rayne Intitiute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom
Background/Purpose: Dysregulation of neutrophil activation and function is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs). Neutrophil dysfunction is well recognised…
Abstract Number: 933 • 2015 ACR/ARHP Annual Meeting
DEK-Targeting DNA Aptamers As Novel Therapeutics for Inflammatory Arthritis
Nirit Mor-Vaknin¹, Anjan K. Saha², Maureen Legendre¹, Carmelo Carmona-Rivera³, M. Asif Amin⁴, Bradley J. Rabquer⁵, Marta J. Gonzalez-Hernandez⁶, Julie M. Jorns⁷, Srilakshmi Yalavarthi⁸, Smriti Mohan⁹, Dave Pai¹⁰, Kristine Angevine¹¹, Barbara Adams¹², Jason S. Knight⁸, Alisa E. Koch^13,14,15, David Fox¹⁴, Dave Engelke¹⁶, Mariana J. Kaplan¹⁷ and David Markovitz⁴, ¹Infectious Diseases, University of Michigan, Ann Arbor, MI, ²Medical School, University of Michigan, Ann Arbor, MI, ³Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Internal Medicine, University of Michigan, Ann Arbor, MI, ⁵Albion College, Ann Arbor, MI, ⁶Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, ⁷Pathology, University of Michigan, Ann Arbor, MI, ⁸Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁹Pediatric Rheumatology, University of Michigan, Ann Arbor, MI, ¹⁰Scripps Research Institute, San Diego, CT, ¹¹Appistry, Inc, St. Louis, MO, ¹²Pediatric Rheum PTD, Univ of Michigan Hlth System, Ann Arbor, MI, ¹³VA Medical Service, Ann Arbor, MI, ¹⁴Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ¹⁵Internal Medicine, Veteran's Affairs and University of Michigan, Ann Arbor, MI, ¹⁶Biochemistry, University Michigan, Ann Arbor, MI, ¹⁷Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD
Background/Purpose: Aptamers are short single stranded DNA or RNA oligonucleotides that are specifically selected to bind and neutralize a wide range of biomedically relevant proteins.…
Abstract Number: 2867 • 2014 ACR/ARHP Annual Meeting
Antiphospholipid Antibodies Promote the Release of Neutrophil Extracellular Traps: a New Mechanism of Thrombosis in the Antiphospholipid Syndrome
Srilakshmi Yalavarthi¹, Levi F. Mazza¹, Alexandra E. Morris¹, Carlos Núñez-Álvarez², Diego Hernández², Paula L. Bockenstedt³, Antonio R. Cabral⁴ and Jason S. Knight¹, ¹Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ³Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, ⁴Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico
Background/Purpose: Antiphospholipid antibodies (aPL), especially those targeting beta-2-glycoprotein I, are known to activate endothelial cells, monocytes, and platelets, with prothrombotic implications. However, the interaction of…
Abstract Number: 2183 • 2014 ACR/ARHP Annual Meeting
Release of Enzymatically Active Peptidyl Arginine Deiminases (PADs) By Neutrophils Allows Generation of Citrullinated Extracellular Autoantigens in the Synovial Fluid of Patients with Rheumatoid Arthritis
Julia Spengler¹, Bozo Lugonja², Andrew Creese¹, Jimmy Ytterberg³, Karin Lundberg⁴, Michael Milward¹, Mark Pearson⁵, Christopher Buckley⁶, Andrew Filer¹, Karim Raza⁷, Paul Cooper¹, Iain Chapple⁸ and Dagmar Scheel-Toellner¹, ¹University of Birmingham, Birmingham, United Kingdom, ²Rheumatology Research Group, University of Birmingham Research Laboratories, University of Birmingham, Birmingham, United Kingdom, ³Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁵University of Birmihgham, Birmingham, United Kingdom, ⁶Rheumathology Research Group, University of Birmingham, Birmingham, United Kingdom, ⁷Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom, ⁸Periodontology Dept, School of Dentistry, University of Birmingham, Birmingham, United Kingdom
Background/Purpose Citrullinated proteins are important autoantigens in the inflamed joints of patients with rheumatoid arthritis (RA). Several of these proteins are derived from proteins generally…
Abstract Number: 1862 • 2014 ACR/ARHP Annual Meeting
The Association of Low-Density Granulocytes with Disease Activity and Response to Treatment in ANCA-Associated Vasculitis
Peter C. Grayson¹, Carmelo Carmona-Rivera¹, Lijing Xu², Noha Lim², Adam Asare², Deborah J. Phippard², Mariana J. Kaplan³, Peter A. Merkel⁴ and Paul A. Monach⁵, ¹NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD, ²Immune Tolerance Network, Bethesda, MD, ³Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA
Background/Purpose: To discover new pathways involved in the pathophysiology of ANCA-associated vasculitis (AAV) and identify potential clinical biomarkers through use of whole-genome gene expression profiling.…
Abstract Number: 1814 • 2014 ACR/ARHP Annual Meeting
RNA-Containing Immune Complexes Shift Human Neutrophils from Phagocytosing Cells to Efficient Releasers of Oxidized DNA in a Process Requiring Crosstalk Between Toll-like Receptors and Fc Gamma Receptor IIa
Christian Lood¹, Xizhang Sun², Lena Tanaka², Andrew Oberst³, Jeffrey Ledbetter² and Keith B. Elkon², ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Division of Rheumatology, University of Washington, Seattle, WA, ³Department of Immunology, University of Washington, Seattle, WA
Background/Purpose Neutrophil extracellular traps (NETs), the extrusion of chromatin to capture microbes, has recently emerged as a possible mechanism that may increase the autoantigenic burden…
Abstract Number: 1208 • 2014 ACR/ARHP Annual Meeting
Cholesterol Loading Induces Neutrophil Extracellular Traps, and Atorvastatin Attenuates This Effect
Ming-Lin Liu^1,2, Muhammad Bashir^1,3, Kevin Williams⁴ and Victoria Werth^5,6, ¹Department of Dermatology, University of Pennsylvania, Philadelphia, PA, ²Department of Dermatology,, Philadelphia V.A. Hospital, Philadelphia, PA, ³Department of Dermatology, Philadelphia V.A. Hospital, Philadelphia, PA, ⁴Department of Medicine, Temple University School of Medicine, Philadelphia, PA, ⁵Dermatology, University of Pennsylvania, Philadelphia, PA, ⁶Dermatology, Philadelphia V.A. Hospital, Philadelphia, PA
Background/Purpose Neutrophils are the most common white blood cell, but their role in autoimmune and cardiovascular diseases has been underestimated. As part of host defense,…
Abstract Number: 1201 • 2014 ACR/ARHP Annual Meeting
Hypoxia Modulates Peptidyl Arginine Deiminase 4 Activity and Neutrophil Extracellular Trap Formation
Akif A. Khawaja^1,2, Charis Pericleous¹, Luke W. Thomas³, Margaret Ashcroft³, Joanna C. Porter² and Ian Giles¹, ¹Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ²Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, ³Centre for Cell Signalling and Molecular Genetics, Centre for Cell Signalling and Molecular Genetics, University College London, London, United Kingdom
Background/Purpose RA is an autoimmune rheumatic disease characterised by ACPA, endothelial dysfunction, platelet activation, synovial hyperplasia and hypoxia in affected joints. ACPA recognise citrullinated proteins,…
Abstract Number: 641 • 2014 ACR/ARHP Annual Meeting
Peptidylarginine Deiminase Inhibition Mitigates NET Formation and Protects Against Kidney, Skin, and Vascular Disease in Lupus-Prone MRL/Lpr Mice
Jason S. Knight¹, Venkataraman Subramanian², Alexander A. O'Dell¹, Srilakshmi Yalavarthi¹, Wenpu Zhao³, Carolyne K. Smith³, Jeffrey B. Hodgin⁴, Paul Thompson² and Mariana J. Kaplan³, ¹Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²The Scripps Research Institute, Jupiter, FL, ³Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Department of Pathology, University of Michigan, Ann Arbor, MI
Background/Purpose: An imbalance between neutrophil extracellular trap (NET) production and NET degradation has been observed in systemic lupus erythematosus (SLE), potentially contributing to autoantigen externalization,…
Abstract Number: 2426 • 2013 ACR/ARHP Annual Meeting
Signaling Abnormalities In Neutrophil Granulocytes Of Rheumatoid Arthritis Patients Are Associated With Increased Extracellular Trap Formation and Provide a Basis For The Induction Of Anti-Citrullinated Peptide Antibodies
Chanchal Sur Chowdhury¹, Stavros Giaglis^2,3, Ulrich A. Walker⁴, Andreas Buser⁵, Paul Hasler² and Sinuhe Hahn⁶, ¹Dept. of Biomedicine, Laboratory of Prenatal Diagnostics, University Hospital Basel, Basel, Switzerland, ²Dept. of Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, ³Dept. of Biomedicine, Laboratory of Prenatal Madicine, University Hospital Basel, Basel, Switzerland, ⁴Department of Rheumatology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, ⁵Division of Hematology; Swiss Red Cross Blood Transfusion Centre, University Hospital Basel, Basel, Switzerland, ⁶Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland
Background/Purpose: Rheumatoid arthritis (RA) is often associated with anti-citrullinated peptide antibodies (ACPAs) in the serum. While ACPAs have been associated with increased inflammation, joint destruction…

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