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Abstracts tagged "Neutrophil Extracellular Traps"

  • Abstract Number: 2002 • 2015 ACR/ARHP Annual Meeting

    Dnase Treatment Protects Against DVT Formation in a Mouse Model of Antiphospholipid Syndrome

    He Meng1, Srilakshmi Yalavarthi2, Levi F. Mazza3, Megan A. Elfline1, Catherine E. Luke1, Peter K. Henke1 and Jason S. Knight2, 1University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan, Ann Arbor, MI, 3Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose:  Antiphospholipid antibodies, especially those targeting beta-2-glycoprotein I (β2GPI), have been shown to amplify thrombosis in mice.  However, most published models have relied on endothelial…
  • Abstract Number: 2072 • 2015 ACR/ARHP Annual Meeting

    Mitochondrial Reactive Oxygen Species Modulate Autoimmunity in Systemic Lupus Erythematosus

    Luz P. Blanco1, Christian Lood2, Monica Purmalek3, Suk See DeRavin4, Carolyne K. Smith3, Carmelo Carmona-Rivera3, Harry Malech4, Jeffrey Ledbetter5, Keith B. Elkon6 and Mariana J. Kaplan1, 1Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Internal Medicine, University of Washington, Seattle, WA, 3Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4NIAID/NIH, Bethesda, MD, 5University of Washington, Seattle, WA, 6Department of Medicine & Immunology, University of Washington, Seattle, WA

    Background/Purpose: Dysregulation in the formation of neutrophil extracellular traps (NETs) may contribute to modification and externalization of autoantigens and to organ damage in diverse autoimmune…
  • Abstract Number: 2073 • 2015 ACR/ARHP Annual Meeting

    Mitochondrial ROS Is a Novel Regulator of Sting-Mediated Type I IFN Production By Governing Extrusion of Oxidized Mitochondrial DNA upon Neutrophil Extracellular Trap Formation.

    Christian Lood1, Luz P. Blanco2, Monica Purmalek3, Carolyne K. Smith3, Carmelo Carmona-Rivera3, Jeffrey Ledbetter4, Mariana J. Kaplan2 and Keith B. Elkon5, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4University of Washington, Seattle, WA, 5Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Neutrophil extracellular trap generation (NETosis) is a reactive oxygen species (ROS)-dependent cell death pathway implicated in autoimmune disorders such as systemic lupus erythematosus (SLE).…
  • Abstract Number: 2121 • 2015 ACR/ARHP Annual Meeting

    Placentas of Lupus Pregnancies Are Characterized By Marked Inflammatory Changes Despite Good Disease Control

    Wendy Marder1, Jason S. Knight2, Mariana J. Kaplan3, Emily C. Somers4, Xu Zhang4, Alexander A. O'Dell5, Vasantha Padmanabhan4 and Richard W. Lieberman4, 1Div of Rheumatology, University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan, Ann Arbor, MI, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4University of Michigan, Ann Arbor, MI, 5Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose:   Systemic lupus erythematosus (SLE) is associated with increased risk of adverse pregnancy outcomes (APO), including preeclampsia and intrauterine growth restriction.  While significant placental…
  • Abstract Number: 2598 • 2015 ACR/ARHP Annual Meeting

    Neutrophil Extracellular Trap Levels Measured By Cell Free Nucleosome ELISA in Serum Are Highly Specific and Sensitive for Rheumatoid Arthritis

    Paul Hasler1, Stavros Giaglis1, Ulrich A. Walker2, Erik Deman1, Christoph Hemmeler1, Christina Ryser1, Samuel Kretzschmar1, Guenther Schaefer3, Juliane Franz1 and Sinuhe Hahn4, 1Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, 2Rheumatology, University Hospital, Basel, Basel, Switzerland, 3Dept. of Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, 4Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland

    Background/Purpose: Rheumatoid factor (RF) or anti-citrullinated peptide antibody (ACPA) detection have limited clinical utility for the diagnosis of rheumatoid arthritis (RA), as the specificity and…
  • Abstract Number: 2709 • 2015 ACR/ARHP Annual Meeting

    Immediate  Release of Peripheral Neutrophil Myeloperoxidase and Elastase and Formation of Extracellular Traps to Cigarette Smoking in Rheumatoid Arthritis

    Juliane Franz1, Stavros Giaglis1,2, Guenther Schaefer3, Erik Deman1, Andreas Thueler4, Sinuhe Hahn2 and Paul Hasler1, 1Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, 2Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, 3Dept. of Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, 4Rheumatology, Kantonsspital Baden, Baden, Switzerland

    Background/Purpose: Smoking represents an independent risk factor for rheumatoid arthritis (RA) (1). In response to infectious agents, neutrophil granulocytes can extrude their nuclear contents as…
  • Abstract Number: 3032 • 2015 ACR/ARHP Annual Meeting

    Role of Adenosine and Neutrophils in Inflammation Associated with Mutations in CECR1 Gene

    Kyawt W. Shwin1,2, Carmelo Carmona-Rivera3, Wanxia Tsai4, Chya-chia Richard Lee5,6, Elaine Novakovich7, Deborah L. Stone8, Amanda K. Ombrello8, Raphaela Goldbach-Mansky9, Massimo Gadina10, Daniel Kastner11, Ivona Aksentijevich12,13, Mariana J. Kaplan7 and Peter C. Grayson14,15, 1NIAMS, National Institutes of Health, BETHESDA, MD, 2Translational Autoinflammatory Diseases Section, National Institutes of Health, Bethesda, MD, 3Systemic Autoimmunity Branch/ NIAMS, National Institutes of Health, Bethesda, MD, 4Translational Immunology, Office of Science and Technology, National Institutes of Health, Bethesda, MD, 5National Cancer Institute, National Institutes of Health, Bethesda, MD, 6Laboratory of Pathology, NCI, National Institutes of Health, BETHESDA, MD, 7Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, 8National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 9Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, 10Translational Immunology, Office of Science and Technology, NIAMS, National Institutes of Health, Bethesda, MD, 11Inflammatory Disease Section, NHGRI, National Institutes of Health, Bethesda, MD, 12NIH/NHGRI, Metabolic, Cardiovascular, and Inflammatory Disease Genomics Branch, Bethesda, MD, 13Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, 14National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 15NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD

    Background/Purpose: The phenotype of patients afflicted by deficiency of adenosine deaminase 2 (DADA2) due to mutations in CECR1encoding ADA2 protein shares many features with idiopathic…
  • Abstract Number: 2867 • 2014 ACR/ARHP Annual Meeting

    Antiphospholipid Antibodies Promote the Release of Neutrophil Extracellular Traps:  a New Mechanism of Thrombosis in the Antiphospholipid Syndrome

    Srilakshmi Yalavarthi1, Levi F. Mazza1, Alexandra E. Morris1, Carlos Núñez-Álvarez2, Diego Hernández2, Paula L. Bockenstedt3, Antonio R. Cabral4 and Jason S. Knight1, 1Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, 3Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, 4Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico

    Background/Purpose:  Antiphospholipid antibodies (aPL), especially those targeting beta-2-glycoprotein I, are known to activate endothelial cells, monocytes, and platelets, with prothrombotic implications.  However, the interaction of…
  • Abstract Number: 2183 • 2014 ACR/ARHP Annual Meeting

    Release of Enzymatically Active Peptidyl Arginine Deiminases (PADs) By Neutrophils Allows Generation of Citrullinated Extracellular Autoantigens in the Synovial Fluid of Patients with Rheumatoid Arthritis

    Julia Spengler1, Bozo Lugonja2, Andrew Creese1, Jimmy Ytterberg3, Karin Lundberg4, Michael Milward1, Mark Pearson5, Christopher Buckley6, Andrew Filer1, Karim Raza7, Paul Cooper1, Iain Chapple8 and Dagmar Scheel-Toellner1, 1University of Birmingham, Birmingham, United Kingdom, 2Rheumatology Research Group, University of Birmingham Research Laboratories, University of Birmingham, Birmingham, United Kingdom, 3Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 4Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 5University of Birmihgham, Birmingham, United Kingdom, 6Rheumathology Research Group, University of Birmingham, Birmingham, United Kingdom, 7Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom, 8Periodontology Dept, School of Dentistry, University of Birmingham, Birmingham, United Kingdom

    Background/Purpose Citrullinated proteins are important autoantigens in the inflamed joints of patients with rheumatoid arthritis (RA). Several of these proteins are derived from proteins generally…
  • Abstract Number: 1862 • 2014 ACR/ARHP Annual Meeting

    The Association of Low-Density Granulocytes with Disease Activity and Response to Treatment in ANCA-Associated Vasculitis

    Peter C. Grayson1, Carmelo Carmona-Rivera1, Lijing Xu2, Noha Lim2, Adam Asare2, Deborah J. Phippard2, Mariana J. Kaplan3, Peter A. Merkel4 and Paul A. Monach5, 1NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD, 2Immune Tolerance Network, Bethesda, MD, 3Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4University of Pennsylvania, Philadelphia, PA, 5Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA

    Background/Purpose: To discover new pathways involved in the pathophysiology of ANCA-associated vasculitis (AAV) and identify potential clinical biomarkers through use of whole-genome gene expression profiling.…
  • Abstract Number: 1814 • 2014 ACR/ARHP Annual Meeting

    RNA-Containing Immune Complexes Shift Human Neutrophils from Phagocytosing Cells to Efficient Releasers of Oxidized DNA in a Process Requiring Crosstalk Between Toll-like Receptors and Fc Gamma Receptor IIa

    Christian Lood1, Xizhang Sun2, Lena Tanaka2, Andrew Oberst3, Jeffrey Ledbetter2 and Keith B. Elkon2, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2Division of Rheumatology, University of Washington, Seattle, WA, 3Department of Immunology, University of Washington, Seattle, WA

    Background/Purpose Neutrophil extracellular traps (NETs), the extrusion of chromatin to capture microbes, has recently emerged as a possible mechanism that may increase the autoantigenic burden…
  • Abstract Number: 1208 • 2014 ACR/ARHP Annual Meeting

    Cholesterol Loading Induces Neutrophil Extracellular Traps, and Atorvastatin Attenuates This Effect

    Ming-Lin Liu1,2, Muhammad Bashir1,3, Kevin Williams4 and Victoria Werth5,6, 1Department of Dermatology, University of Pennsylvania, Philadelphia, PA, 2Department of Dermatology,, Philadelphia V.A. Hospital, Philadelphia, PA, 3Department of Dermatology, Philadelphia V.A. Hospital, Philadelphia, PA, 4Department of Medicine, Temple University School of Medicine, Philadelphia, PA, 5Dermatology, University of Pennsylvania, Philadelphia, PA, 6Dermatology, Philadelphia V.A. Hospital, Philadelphia, PA

    Background/Purpose Neutrophils are the most common white blood cell, but their role in autoimmune and cardiovascular diseases has been underestimated. As part of host defense,…
  • Abstract Number: 1201 • 2014 ACR/ARHP Annual Meeting

    Hypoxia Modulates Peptidyl Arginine Deiminase 4 Activity and Neutrophil Extracellular Trap Formation

    Akif A. Khawaja1,2, Charis Pericleous1, Luke W. Thomas3, Margaret Ashcroft3, Joanna C. Porter2 and Ian Giles1, 1Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 2Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 3Centre for Cell Signalling and Molecular Genetics, Centre for Cell Signalling and Molecular Genetics, University College London, London, United Kingdom

    Background/Purpose RA is an autoimmune rheumatic disease characterised by ACPA, endothelial dysfunction, platelet activation, synovial hyperplasia and hypoxia in affected joints. ACPA recognise citrullinated proteins,…
  • Abstract Number: 641 • 2014 ACR/ARHP Annual Meeting

    Peptidylarginine Deiminase Inhibition Mitigates NET Formation and Protects Against Kidney, Skin, and Vascular Disease in Lupus-Prone MRL/Lpr Mice

    Jason S. Knight1, Venkataraman Subramanian2, Alexander A. O'Dell1, Srilakshmi Yalavarthi1, Wenpu Zhao3, Carolyne K. Smith3, Jeffrey B. Hodgin4, Paul Thompson2 and Mariana J. Kaplan3, 1Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2The Scripps Research Institute, Jupiter, FL, 3Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4Department of Pathology, University of Michigan, Ann Arbor, MI

    Background/Purpose:  An imbalance between neutrophil extracellular trap (NET) production and NET degradation has been observed in systemic lupus erythematosus (SLE), potentially contributing to autoantigen externalization,…
  • Abstract Number: 2426 • 2013 ACR/ARHP Annual Meeting

    Signaling Abnormalities In Neutrophil Granulocytes Of Rheumatoid Arthritis Patients Are Associated With Increased Extracellular Trap Formation and Provide a Basis For The Induction Of Anti-Citrullinated Peptide Antibodies

    Chanchal Sur Chowdhury1, Stavros Giaglis2,3, Ulrich A. Walker4, Andreas Buser5, Paul Hasler2 and Sinuhe Hahn6, 1Dept. of Biomedicine, Laboratory of Prenatal Diagnostics, University Hospital Basel, Basel, Switzerland, 2Dept. of Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, 3Dept. of Biomedicine, Laboratory of Prenatal Madicine, University Hospital Basel, Basel, Switzerland, 4Department of Rheumatology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, 5Division of Hematology; Swiss Red Cross Blood Transfusion Centre, University Hospital Basel, Basel, Switzerland, 6Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland

    Background/Purpose: Rheumatoid arthritis (RA) is often associated with anti-citrullinated peptide antibodies (ACPAs) in the serum. While ACPAs have been associated with increased inflammation, joint destruction…
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