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Abstracts tagged "Neutrophil Extracellular Traps"

  • Abstract Number: 208 • 2015 ACR/ARHP Annual Meeting

    Neutrophil-Mediated Mechanisms of Drug-Induced Autoimmunity

    Jorge Irizarry-Caro1, Carmelo Carmona-Rivera1, Elaine Novakovich1, Venkataraman Subramaniam2, Paul Thompson3, Mariana J. Kaplan4 and Peter C. Grayson5, 1National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 2Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA, 3University of Massachusetts, Worcester, MA, 4Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

    Background/Purpose: Certain medications are known to induce autoimmune disease in humans, triggering clinical features and autoantibody profiles that mirror idiopathic systemic lupus erythematosus (SLE) and/or…
  • Abstract Number: 209 • 2015 ACR/ARHP Annual Meeting

    Different Autoimmune Rheumatic Diease IgG Have Differential Effects upon Neutrophil Binding, Activation and Neutrophil Extracellular Trap Formation

    Akif A. Khawaja1,2, Charis Pericleous3, Vera M. Ripoll2, Joanna C. Porter4 and Ian Giles5, 1Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 2Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 3Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 4Centre for Inflammation and Tissue Repair, Division of Medicine, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 5Rayne Intitiute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom

    Background/Purpose: Dysregulation of neutrophil activation and function is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs). Neutrophil dysfunction is well recognised…
  • Abstract Number: 933 • 2015 ACR/ARHP Annual Meeting

    DEK-Targeting DNA Aptamers As Novel Therapeutics for Inflammatory Arthritis

    Nirit Mor-Vaknin1, Anjan K. Saha2, Maureen Legendre1, Carmelo Carmona-Rivera3, M. Asif Amin4, Bradley J. Rabquer5, Marta J. Gonzalez-Hernandez6, Julie M. Jorns7, Srilakshmi Yalavarthi8, Smriti Mohan9, Dave Pai10, Kristine Angevine11, Barbara Adams12, Jason S. Knight8, Alisa E. Koch13,14,15, David Fox14, Dave Engelke16, Mariana J. Kaplan17 and David Markovitz4, 1Infectious Diseases, University of Michigan, Ann Arbor, MI, 2Medical School, University of Michigan, Ann Arbor, MI, 3Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4Internal Medicine, University of Michigan, Ann Arbor, MI, 5Albion College, Ann Arbor, MI, 6Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, 7Pathology, University of Michigan, Ann Arbor, MI, 8Division of Rheumatology, University of Michigan, Ann Arbor, MI, 9Pediatric Rheumatology, University of Michigan, Ann Arbor, MI, 10Scripps Research Institute, San Diego, CT, 11Appistry, Inc, St. Louis, MO, 12Pediatric Rheum PTD, Univ of Michigan Hlth System, Ann Arbor, MI, 13VA Medical Service, Ann Arbor, MI, 14Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 15Internal Medicine, Veteran's Affairs and University of Michigan, Ann Arbor, MI, 16Biochemistry, University Michigan, Ann Arbor, MI, 17Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD

    Background/Purpose: Aptamers are short single stranded DNA or RNA oligonucleotides that are specifically selected to bind and neutralize a wide range of biomedically relevant proteins.…
  • Abstract Number: 964 • 2015 ACR/ARHP Annual Meeting

    Neutrophil  Extracellular Traps Are Not Only Targets for ACPA-Positive IgG from Rheumatoid Arthritis Patients but Also Directly Trigger Pro- and Anti-Inflammatory Effects Partly Mediated By the C1q Complement Protein

    Matthieu Ribon1, Sarra Seninet1, Katarzyna Matyja1, Mireille Sebbag2, Cyril Clavel2, Julie Mussard1, Guy Serre2, Marie-Christophe Boissier3 and Patrice Decker1, 1Inserm UMR 1125, Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 2University of Toulouse, UMR 5165 CNRS-1056 Inserm, Toulouse, France, 3Rheumatology Department, Avicenne Hospital, AP-HP, Bobigny, France

    Background/Purpose: Activated neutrophils (PMN) form neutrophil extracellular traps (NET). Those structures are expelled chromatin fibers composed of DNA and associated proteins. The process, NETosis, is…
  • Abstract Number: 1085 • 2015 ACR/ARHP Annual Meeting

    Levamisole Triggers Neutrophil Extracellular Trap Formation through Muscarinic Receptors in Patients with Drug-Induced Vasculitis

    Peter C. Grayson1, Carmelo Carmona-Rivera2, Meryl Waldman3, Karran Phillips4, Venkataraman Subramaniam5, Paul Thompson6, Jonathan D. Graf7 and Mariana J. Kaplan1, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Systemic Autoimmunity Branch/ NIAMS, National Institutes of Health, Bethesda, MD, 3NIDDK, National Institutes of Health, Bethesda, MD, 4NIDA, National Institutes of Health, Baltimore, MD, 5Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA, 6Biochemistry and Molecular Pharmacology, University of Masshachussetts, Worcester, MA, 7Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Levamisole, an anti-helminth drug, has been implicated in cases of drug-induced autoimmunity in humans exposed to adulterated cocaine. Clinical manifestations of levamisole-induced autoimmunity include…
  • Abstract Number: 1763 • 2015 ACR/ARHP Annual Meeting

    Neutrophil Netosis Formation during the UVB Induced-Skin Inflammation

    Ming-Lin Liu1,2, Meena Sharma1,3, Shwetapadma Sahu4,5 and Victoria Werth4,6, 1Department of Dermatology, University of Pennsylvania, Philadelphia, PA, 2Department of Dermatology,, Philadelphia V.A. Medical Center, Philadelphia, PA, 3Department of Dermatology, Philadelphia V.A. Medical Center, Philadelphia, PA, 4Dermatology, University of Pennsylvania, Philadelphia, PA, 5Philadelphia V.A. Medical Center, Philadelphia, PA, 6Dermatology, Philadelphia V.A. Medical Center, Philadelphia, PA

    Background/Purpose: Excessive exposure to sunlight, particularly ultraviolet B (UVB), induces autoimmune skin inflammation and other skin diseases. Although UVB mainly causes damage to the epidermis,…
  • Abstract Number: 1769 • 2015 ACR/ARHP Annual Meeting

    Role of Topical Administration of Peptidylarginine Deiminase  Inhibitors in Murine Lupus

    Erica Moore1, Huw Lewis2, Carolyne K. Smith1, Venkataraman Subramaniam3, Victoria Hoffmann4, Paul Thompson5 and Mariana J. Kaplan1, 1Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Immuno Inflammation, GSK, Stevenage, United Kingdom, 3University of Massachusetts, Boston, MA, 4ORS, National Institutes of Health, Bethesda, MD, 5University of Massachusetts, Worcester, MA

    Background/Purpose: Peptidylarginine deiminases (PADs), specifically PAD4,  have recently been implicated in the pathogenesis of systemic lupus erythematosus (SLE) through their role in citrullinating histones in…
  • Abstract Number: 2867 • 2014 ACR/ARHP Annual Meeting

    Antiphospholipid Antibodies Promote the Release of Neutrophil Extracellular Traps:  a New Mechanism of Thrombosis in the Antiphospholipid Syndrome

    Srilakshmi Yalavarthi1, Levi F. Mazza1, Alexandra E. Morris1, Carlos Núñez-Álvarez2, Diego Hernández2, Paula L. Bockenstedt3, Antonio R. Cabral4 and Jason S. Knight1, 1Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, 3Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, 4Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico

    Background/Purpose:  Antiphospholipid antibodies (aPL), especially those targeting beta-2-glycoprotein I, are known to activate endothelial cells, monocytes, and platelets, with prothrombotic implications.  However, the interaction of…
  • Abstract Number: 2183 • 2014 ACR/ARHP Annual Meeting

    Release of Enzymatically Active Peptidyl Arginine Deiminases (PADs) By Neutrophils Allows Generation of Citrullinated Extracellular Autoantigens in the Synovial Fluid of Patients with Rheumatoid Arthritis

    Julia Spengler1, Bozo Lugonja2, Andrew Creese1, Jimmy Ytterberg3, Karin Lundberg4, Michael Milward1, Mark Pearson5, Christopher Buckley6, Andrew Filer1, Karim Raza7, Paul Cooper1, Iain Chapple8 and Dagmar Scheel-Toellner1, 1University of Birmingham, Birmingham, United Kingdom, 2Rheumatology Research Group, University of Birmingham Research Laboratories, University of Birmingham, Birmingham, United Kingdom, 3Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 4Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 5University of Birmihgham, Birmingham, United Kingdom, 6Rheumathology Research Group, University of Birmingham, Birmingham, United Kingdom, 7Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom, 8Periodontology Dept, School of Dentistry, University of Birmingham, Birmingham, United Kingdom

    Background/Purpose Citrullinated proteins are important autoantigens in the inflamed joints of patients with rheumatoid arthritis (RA). Several of these proteins are derived from proteins generally…
  • Abstract Number: 1862 • 2014 ACR/ARHP Annual Meeting

    The Association of Low-Density Granulocytes with Disease Activity and Response to Treatment in ANCA-Associated Vasculitis

    Peter C. Grayson1, Carmelo Carmona-Rivera1, Lijing Xu2, Noha Lim2, Adam Asare2, Deborah J. Phippard2, Mariana J. Kaplan3, Peter A. Merkel4 and Paul A. Monach5, 1NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD, 2Immune Tolerance Network, Bethesda, MD, 3Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4University of Pennsylvania, Philadelphia, PA, 5Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA

    Background/Purpose: To discover new pathways involved in the pathophysiology of ANCA-associated vasculitis (AAV) and identify potential clinical biomarkers through use of whole-genome gene expression profiling.…
  • Abstract Number: 1814 • 2014 ACR/ARHP Annual Meeting

    RNA-Containing Immune Complexes Shift Human Neutrophils from Phagocytosing Cells to Efficient Releasers of Oxidized DNA in a Process Requiring Crosstalk Between Toll-like Receptors and Fc Gamma Receptor IIa

    Christian Lood1, Xizhang Sun2, Lena Tanaka2, Andrew Oberst3, Jeffrey Ledbetter2 and Keith B. Elkon2, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2Division of Rheumatology, University of Washington, Seattle, WA, 3Department of Immunology, University of Washington, Seattle, WA

    Background/Purpose Neutrophil extracellular traps (NETs), the extrusion of chromatin to capture microbes, has recently emerged as a possible mechanism that may increase the autoantigenic burden…
  • Abstract Number: 1208 • 2014 ACR/ARHP Annual Meeting

    Cholesterol Loading Induces Neutrophil Extracellular Traps, and Atorvastatin Attenuates This Effect

    Ming-Lin Liu1,2, Muhammad Bashir1,3, Kevin Williams4 and Victoria Werth5,6, 1Department of Dermatology, University of Pennsylvania, Philadelphia, PA, 2Department of Dermatology,, Philadelphia V.A. Hospital, Philadelphia, PA, 3Department of Dermatology, Philadelphia V.A. Hospital, Philadelphia, PA, 4Department of Medicine, Temple University School of Medicine, Philadelphia, PA, 5Dermatology, University of Pennsylvania, Philadelphia, PA, 6Dermatology, Philadelphia V.A. Hospital, Philadelphia, PA

    Background/Purpose Neutrophils are the most common white blood cell, but their role in autoimmune and cardiovascular diseases has been underestimated. As part of host defense,…
  • Abstract Number: 1201 • 2014 ACR/ARHP Annual Meeting

    Hypoxia Modulates Peptidyl Arginine Deiminase 4 Activity and Neutrophil Extracellular Trap Formation

    Akif A. Khawaja1,2, Charis Pericleous1, Luke W. Thomas3, Margaret Ashcroft3, Joanna C. Porter2 and Ian Giles1, 1Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 2Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 3Centre for Cell Signalling and Molecular Genetics, Centre for Cell Signalling and Molecular Genetics, University College London, London, United Kingdom

    Background/Purpose RA is an autoimmune rheumatic disease characterised by ACPA, endothelial dysfunction, platelet activation, synovial hyperplasia and hypoxia in affected joints. ACPA recognise citrullinated proteins,…
  • Abstract Number: 641 • 2014 ACR/ARHP Annual Meeting

    Peptidylarginine Deiminase Inhibition Mitigates NET Formation and Protects Against Kidney, Skin, and Vascular Disease in Lupus-Prone MRL/Lpr Mice

    Jason S. Knight1, Venkataraman Subramanian2, Alexander A. O'Dell1, Srilakshmi Yalavarthi1, Wenpu Zhao3, Carolyne K. Smith3, Jeffrey B. Hodgin4, Paul Thompson2 and Mariana J. Kaplan3, 1Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2The Scripps Research Institute, Jupiter, FL, 3Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4Department of Pathology, University of Michigan, Ann Arbor, MI

    Background/Purpose:  An imbalance between neutrophil extracellular trap (NET) production and NET degradation has been observed in systemic lupus erythematosus (SLE), potentially contributing to autoantigen externalization,…
  • Abstract Number: L21 • 2013 ACR/ARHP Annual Meeting

    Celastrol, a Triterpene from Tripterygium Wilfordii, Inhibits Neutrophil Extracellular Trap Formation

    Christopher D. Koehn1, Yangsheng Yu2, Yinshi Yue2, Song Li2, Michelene P Hearth-Holmes3, Geoffrey M Thiele3, Ted R. Mikuls4, James R. O'Dell5, Lynell W. Klassen6, Zhixin Zhang2 and Kaihong Su2, 1Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 2Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 3Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 4Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 5Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, 6Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: , Neutrophils provide the frontline of defense against invading pathogens. However, neutrophils also contribute to the development of autoimmune diseases. Recent studies suggest that…
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