Abstracts tagged "neuropsychiatric disorders"

Abstract Number: 0835 • ACR Convergence 2020
Pathogenic Effect of Chronic Stress-induced interleukin-12/23p40 on Neuropsychiatric System in Lupus-prone Mouse
Nobuya Abe¹, Kenji Oku¹, Yuichiro Fujieda¹, Nobuhiko Takahashi², Kohei Karino¹, Michihito Kono¹, Masaru Kato¹, Yuki Tanaka³, Rie Hasebe⁴, Olga Amengual¹, Miwako Yamasaki⁵, Masahiko Watanabe⁵, Masaaki Murakami³ and Tatsuya Atsumi⁶, ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, ²Division of Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ³Division of Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, ⁴Biomedical Animal Research Laboratory, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, ⁵Department of Anatomy, Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, ⁶Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine, Hokkaido University, Sapparo, Hokkaido, Japan
Background/Purpose:Neuropsychiatric system is one of the major organs affected in systemic lupus erythematosus (SLE). However, the pathogenesis of neuropsychiatric SLE (NPSLE) has not been fully…
Abstract Number: 0854 • ACR Convergence 2020
Mortality and Adverse Events of Special Interest in Adult Patients with Systemic Lupus Erythematosus Receiving Intravenous Belimumab: A Post Hoc Descriptive Summary of Serious Psychiatric Events
Saira Sheikh¹, Ricardo Acayaba de Toledo², Laura Geraldino-Pardilla³, Julia Harris⁴, Regina Kurrasch⁵, Andrew Liu⁴, Kathleen Maksimowicz-McKinnon⁶, Holly Quasny⁷, David Roth⁵, Lilian Soto⁸ and Rajesh Punwaney⁵, ¹University of North Carolina Thurston Arthritis Research Center, Chapel Hill, ²Faculdade de Medicina de São José do Rio Preto, São Paulo, Brazil, ³Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York, ⁴GlaxoSmithKline, Uxbridge, United Kingdom, ⁵GlaxoSmithKline, Collegeville, ⁶Henry Ford Hospital, Detroit, ⁷GlaxoSmithKline, Research Triangle Park, ⁸Facultad de Medicina, Clinical Hospital of Universidad de Chile, Santiago, Chile
Background/Purpose: Intravenous (IV) belimumab (BEL) is approved in patients ≥5 years of age with active systemic lupus erythematosus (SLE). Results of the BASE study (the…
Abstract Number: 0978 • ACR Convergence 2020
Border-associated Macrophages Drive Recruitment of Immune Cells into the Choroid Plexus in Mice with Neuropsychiatric Lupus
Erica Moore¹ and Chaim Putterman¹, ¹Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Neuropsychiatric manifestations are observed in 20-40% of systemic lupus erythematosus patients, including cognitive deficits and affective behaviors such as anxiety and depression. Neuropsychiatric lupus…
Abstract Number: 1435 • ACR Convergence 2020
Prognostic Factors for Mononeuritis Multiplex Associated with ANCA-associated Vasculitis
Yutaro Hayashi¹, Satoshi Hama², Keisuke Izumi², Mari Ushikubo¹, Misako Konishi³, Yutaka Okano⁴ and Hisaji Ohshima², ¹Tokyo medical center, Tokyo, Japan, ²Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, tokyo, Japan, ³Tokyo medical center, toukyouto Meguroku, Japan, ⁴Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, Kawasaki, Japan
Background/Purpose: ANCA-associated vasculitis (AAV) sometimes presents mononeuritis multiplex which worsens the prognosis and activity of daily living in patients. This study aimed to determine theprognostic factorsand…
Abstract Number: 1508 • ACR Convergence 2020
Blood-Brain Barrier Leakage in Systemic Lupus Erythematosus Is Associated with Gray Matter Loss and Cognitive Impairment
Lyna Kamintsky¹, Steven Beyea², John Fisk², Javeria Hashmi², Antonina Omisade², Cynthia Calkin², Tim Bardouille², Chris Bowen², Maher Quraan², Arnold Mitnitski², Kara Matheson², Alon Friedman² and John Hanly³, ¹Department of Medical Neuroscience, Dalhousie University, Halifax, Canada, ²Dalhousie University, Halifax, Canada, ³Dalhousie University, Halifax, NS, Canada
Background/Purpose: Cognitive impairment is the most frequent manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE), yet the mechanisms underlying it remain poorly understood. The purpose of…
Abstract Number: 1693 • ACR Convergence 2020
Evaluation of B-cell Depletion with Rituximab and IVIG Concurrent Treatment in Pediatric Autoimmune Brain Disease
Alexis Wilsey¹, Laura Cannon², Stephanie Johannes² and Heather Van Mater², ¹Duke University School of Medicine, Durham, ²Duke University, Durham, NC
Background/Purpose: Rituximab is standard therapy for autoimmune brain disease (ABD) including autoimmune encephalitis (AE) and Neuromyelitis Optica Spectrum Disease (NMOSD). Recommendations for continuing concurrent intravenous…
Abstract Number: 075 • 2020 Pediatric Rheumatology Symposium
Pseudotumor Cerebri Syndrome in Children with Systemic Lupus Erythematosus
Taha Moussa¹, Moussa Abdelhak ² and Cuoghi Edens ³, ¹University of Chicago Medicine, Chicago, ²Cambridge GPVTS, Cambridge, United Kingdom, ³University of Chicago, Chicago
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that typically affects multiple organs and can lead to potentially fatal complications. Management of…
Abstract Number: 40 • 2019 ACR/ARP Annual Meeting
Inflammation and Neuronal Growth Factors in Rheumatoid Arthritis
Caroline Wasén¹, Lovisa Leifsdottir ², Roda Abdalla ¹, Lina Juzokaite ¹, Karin Andersson ¹, Malin Erlandsson ¹, Marie Kalm ³ and Maria Bokarewa ¹, ¹Department of Rheumatology and Inflammation Research, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden, ²Department of Rheumatology and Inflammation Research, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Gotheburg, Sweden, ³hDepartment of Pharmacology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden
Background/Purpose: Depression and cognitive impairment are frequently reported in rheumatoid arthritis (RA). We have recently presented that reduced hippocampus volume may be linked to functional…
Abstract Number: 2106 • 2018 ACR/ARHP Annual Meeting
Angiotensin-Converting Enzyme Inhibitors Prevent Spatial Memory Impairment in a Mouse Model of Neuropsychiatric Lupus through LAIR1-Mediated Inhibition of Microglial Activation
Nina Kello¹, Jacquelyn Nestor², Tomas Huerta³, Czeslawa Kowal², Elham Nasiri³, Patricio T. Huerta⁴, Bruce Volpe⁵ and Betty Diamond⁶, ¹Rheumatology, Northwell Health, Donald and Barbara Zucker School of Medicine, Manhasset, NY, ²Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, ³Feinstein Institute for Medical Research, Manhasset, NY, ⁴Feinstein Institue for Medical Research, Manhasset, NY, ⁵Biomedical Sciences, The Feinstein Institute for Medical Research, Manhasset, NY, ⁶The Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Cognitive dysfunction affects up to 90% of patients with systemic lupus erythematosus (SLE), however it is grossly under-recognized, the pathogenesis is poorly understood and…
Abstract Number: 1670 • 2017 ACR/ARHP Annual Meeting
HMGB1-TLR4 Axis in Patients with Neuropsychiatric Systemic Lupus Erythematosus
Qin Huang¹, Chao Yuan², Hao Ren¹ and Min Yang¹, ¹Department of Rheumatology, Nanfang Hospital，Southern Medical University, Guangzhou, China, ²Department of Neurology, Nanfang Hospital，Southern Medical University, Guangzhou, China
Background/Purpose: Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) is a severe complication of SLE, including a variety of neurological and psychiatric features. Previous studies have demonstrated the…
Abstract Number: 3125 • 2015 ACR/ARHP Annual Meeting
White Matter Magnetization Transfer Ratio Histogram Peak Height Helps Identifying Inflammatory Neuropsychiatric Systemic Lupus Erythematosus
César Magro Checa¹, Ece Ercan², Bart J Emmer³, Ron Wolterbeek⁴, Itamar Ronen², Mark A. Van Buchem², T. W. J. Huizinga⁵ and Gerda M. Steup-Beekman⁵, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Magnetization transfer ratio (MTR) can be used to detect microstructural cerebral changes in normal-appearing brain tissue of neuropsychiatric systemic lupus erythematosus (NPSLE) patients. Our…
Abstract Number: 10 • 2014 ACR/ARHP Annual Meeting
Antiphospholipid Antibodies and Neuropsychiatric Events in Pediatric Patients
Mileka Gilbert¹ and Lenore M. Buckley², ¹Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, ²Section of Rheumatology, Yale School of Medicine, New Haven, CT
Background/Purpose: An association between anti-phospholipid antibodies (aPL abs) and non-thrombotic neuropsychiatric events has been reported in pediatric and adult patients, including patients who do not…
Abstract Number: 2656 • 2014 ACR/ARHP Annual Meeting
The Burden of Neuropsychiatric Symptoms in Systemic Lupus Erythematosus: Physician’s and Patient’s Perspectives
Chiara Tani¹, Maria Francisca Moraes-Fontes², Ana Carolina Araújo², Linda Carli³, Manuel Pereira Gonçalves⁴, Francesca Querci⁵, Alexandra Mendes⁶, Viola Signorini⁷, Sabrina Vagnani⁵, Rosaria Talarico⁸, Céu Mateus⁹, Stefano Bombardieri¹⁰, Nuno Riso² and Marta Mosca¹¹, ¹Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ²Serviço de Medicina 2, Hospital de Curry Cabral, Centro Hospitalar Lisboa Central, Lisbon, Portugal, ³GenOMeC PhD, University of Siena, Siena, Italy, ⁴Mental Health Unit, Universidade Nova de Lisboa (UNL), Portugal, Lisboa, Portugal, ⁵Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ⁶Clinical Psychology Unit, CHLC, Portugal, Lisboa, Portugal, ⁷Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ⁸Rheumatology Unit, Pisa, Italy, ⁹Health Economy, National School of Public Health (UNL), Portugal, Lisboa, Portugal, ¹⁰Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ¹¹Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Neuropsychiatric symptoms (NPS) are observed in SLE with a variable prevalence depending on patient selection and assessment methods. In 2010, a 27-item questionnaire was…
Abstract Number: 2651 • 2014 ACR/ARHP Annual Meeting
Predictors of Therapeutic Outcomes in Patients with Neuropsychiatric Systemic Lupus Erythematosus
Kunihiro Ichinose¹, Kazuhiko Arima², Masataka Umeda¹, Shoichi Fukui³, Ayako Nishino¹, Yoshikazu Nakashima¹, Takahisa Suzuki¹, Yoshiro Horai⁴, Tomohiro Koga⁴, Shin-ya Kawashiri², Naoki Iwamoto¹, Mami Tamai¹, Hideki Nakamura¹, Tomoki Origuchi⁵ and Atsushi Kawakami¹, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Departments of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, Nagasaki, Japan, ⁴Departments of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious organ disorder with a variety of symptoms. Despite advances in the understanding of the immunopathogenic and…
Abstract Number: 2831 • 2013 ACR/ARHP Annual Meeting
Increased Risk Of Autism Spectrum Disorders In Children Born To Women With SLE: Preliminary Data From The O S L E R Cohort
Evelyne Vinet¹, Susan Scott², Christian A. Pineau³, Lawrence Joseph⁴, Ann E. Clarke⁵, Eric Fombonne⁶, Robert W. Platt⁴ and Sasha Bernatsky⁷, ¹McGill University Health Center, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada, ³Rheumatology, McGill University Health Center, Montreal, QC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵Division of Rheumatology, University of Calgary, Alberta, Calgary, AB, Canada, ⁶Oregon Health and Sciences University, Portland, OR, ⁷Division of Clinical Epidemiology, McGill University Health Center, Montreal, QC, Canada
Background/Purpose: Recent experimental data suggest in utero exposure to maternal antibodies and cytokines as important risk factors for autism spectrum disorders (ASD). Interestingly, women with…

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