Abstracts tagged "Neuroimaging"

Abstract Number: 1992 • ACR Convergence 2020
Longitudinal Evaluation of Axonal Dysfunction, Neuronal Markers and Serum Cytokines in Childhood-onset Systemic Lupus Erythematosus
Renan Frittoli¹, Danilo Rodrigues¹, Aline Lapa¹, Mariana Postal¹, Roberto Marini¹, Gabriela Castellano¹, Fernando Cendes¹, Leticia Rittner¹ and Simone Appenzeller¹, ¹UNICAMP, Campinas, Brazil
Background/Purpose: To analyze 1H-MRS brain metabolites in a longitudinal study and to determine clinical, laboratory and treatment features associated with its occurrence. To determine, additionally…
Abstract Number: 0709 • ACR Convergence 2020
Anatomical Distribution of Mrgprd-expressing Nonpeptidergic C-fibers in the Mouse Knee
Alia Obeidat¹, Rachel Miller¹ and Anne-Marie Malfait¹, ¹Rush University, CHICAGO, IL
Background/Purpose: The voltage-gated sodium channel, NaV1.8, marks the majority of C-fiber nociceptors. We have used NaV1.8 tdTomato reporter mice to describe the nociceptive innervation of…
Abstract Number: 100 • 2020 Pediatric Rheumatology Symposium
Does Anakinra Dampen Neuronal Damage in Children with Febrile-Infection Related Epilepsy Syndrome (FIRES): A Single Center Review of Neuroimaging
Eyal Muscal¹, Jill Hunter ², Yi-Chen Lai ² and James Riviello ², ¹Section of Rheumatology, Department of Pediatrics, Baylor College of Medicine, houston, ²BCM/TCH, Houston
Background/Purpose: Febrile-illness related epilepsy syndrome (FIRES), characterized by the emergence of super refractory status epilepticus (SRSE) in previously healthy children following a febrile illness, is…
Abstract Number: L03 • 2019 ACR/ARP Annual Meeting
NYX-2925 Impacts Functional and Chemical Neuroimaging Biomarkers and Patient-reported Outcomes of Pain in Patients with Fibromyalgia
Steven Harte ¹, Leslie Arnold ², Eric Ichesco ¹, Christopher Crumb ¹, Mary Suh ³, Laurel Sindelar ³, Chelsea Kaplan ¹, Tony Larkin ¹, Andrew Schrepf ¹, Daniel Clauw ⁴, Stephen Sainati ³ and Richard Harris¹, ¹University of Michigan, Ann Arbor, ²University of Cincinnati College of Medicine, Cincinnati, ³Aptinyx Inc, Evanston, ⁴Division of Rheumatology, Department of Internal Medicine and Division of Anesthesia, Michigan Medicine, Ann Arbor, MI
Background/Purpose: Fibromyalgia (FM) is a chronic, debilitating disease typified by widespread musculoskeletal pain and accompanied by fatigue, sleep disturbance, memory issues, and mood disorders. FM…
Abstract Number: 1738 • 2019 ACR/ARP Annual Meeting
Tracking Whole-Brain Volumetric Trends in Childhood-onset Systemic Lupus Erythematosus Patients in the Clinical Setting by Magnetic Resonance Imaging
Hermine Brunner¹, Arjun Mathur ², William O'Brien ³ and Mark DiFrancesco ³, ¹Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: The course of childhood-onset Systemic Lupus Erythematosus (cSLE) commonly includes neurocognitive dysfunction, a manifestation with poor prognosis. It has been challenging to diagnose and…
Abstract Number: 1883 • 2019 ACR/ARP Annual Meeting
Elucidating Pain Mechanisms in Polyarticular Juvenile Idiopathic Arthritis Patients
Jaymin Upadhyay¹, Diana Sibai ¹, Robert Labadie ², Jordan Lemme ³, Christine Sieberg ², Kirsten Ecklund ⁴, David Borsook ⁴ and Robert Sundel ⁴, ¹Boston Children's Hospital, Harvard Medical School, Boston, MA, ²Boston Children’s Hospital, Harvard Medical School, Boston, MA, ³Boston Children's Hospital, Harvard Medical School, Boston, ⁴Boston Children’s Hospital, Harvard Medical School, Boston
Background/Purpose: Despite a broad range of available therapeutics, pain remains poorly treated in many juvenile idiopathic arthritis (JIA) patients1-2. For some patients, the level of pain…
Abstract Number: 2159 • 2019 ACR/ARP Annual Meeting
Pachymeningitis in Rheumatic Disease
Rachel Kneeland¹, John Berry ², Sydney Brandwein ² and Monika Starosta ², ¹Department of Internal Medicine, Advocate Lutheran General Hospital, Park Ridge, IL, ²Advocate Lutheran General Hospital, Park Ridge, IL
Background/Purpose: Pachymeningitis is a rare complication of rheumatic disease. Patients present with hearing loss or other neurologic complications. Diagnosis is made by thickening of dura…
Abstract Number: 2256 • 2018 ACR/ARHP Annual Meeting
Rheumatic Diseases Associated with Neuromyelitis Optica Spectrum Disorders (NMOSD): Prevalence, Clinical, Laboratory and Imaging Characteristics
Milena Rodriguez Alvarez¹, Su Zhaz Leon¹, Fernando Cuascut², Naureen Kabani³, Joshy Pathiparampil³, Kristaq Koci⁴, Manjeet Bhamra⁵, Latoya Freeman⁴, Alexandra Kreps⁶, Justin Levinson⁶, Sophia Francis⁶, Vinodkumar Velayndhan⁶, Steve Xie⁷, Abhimanyu Amarnani⁶, Helen Valsamis⁸, Yaacov Anziska⁶, Ellen M. Ginzler⁹ and Isabel M. McFarlane⁹, ¹Rheumatology, SUNY Downstate, Brooklyn, NY, ²Neurology, SUNY Downstate, Brooklyn, NY, ³Internal Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ⁴Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ⁵Medicine, SUNY Downstate, Brooklyn, NY, ⁶SUNY Downstate, Brooklyn, NY, ⁷NYC Health + Hospitals Kings County, Brooklyn, NY, ⁸Neurology, NYC Health + Hospitals Kings County, Brooklyn, NY, ⁹Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY
Background/Purpose: NMOSD are autoimmune disorders characterized by optic neuritis (ON), longitudinal extensive transverse myelitis (LETM), and other clinical features. Aquaporin 4 antibodies (AQP4 Ab) have…
Abstract Number: 26 • 2017 Pediatric Rheumatology Symposium
Gray Matter Volume Loss in Youth with SLE
Andrea Knight¹, Michelle Vickery², Arastoo Vossough³, Guray Erus⁴, Jimit Doshi⁵ and Susan Furth⁶, ¹Center for Pediatric Clinical Effectiveness & PolicyLab, Philadelphia, PA, ²PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, ³Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Section on Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, ⁵Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, ⁶Division of Nephrology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Background/Purpose: Neuropsychiatric SLE in children and adolescents presents diagnostic challenge due to limitations of conventional magnetic resonance imaging (MRI) to detect clinically relevant brain changes.…
Abstract Number: 2834 • 2016 ACR/ARHP Annual Meeting
Utility of the Brain Perfusion Single Photon Emission Computed Tomography in Neuropsychiatric Manifestations of Systemic Lupus Erythematosus
Jorge Medina-Rosas¹, Murray Urowitz², Jiandong Su³, Dafna D Gladman⁴ and Zahi Touma², ¹Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada
Background/Purpose: The diagnosis of Neuropsychiatric Events (NPE) in SLE is challenging and it is mainly based on the physician judgment. Structural brain imaging has…
Abstract Number: 761 • 2015 ACR/ARHP Annual Meeting
Neurometabolic Alterations in Korean Lupus Patients with Chronic Daily Headache
Ji-Min Kim¹, Tae-Han Lee¹, Chang-Nam Son¹, Sung Soo Kim², Hyuk Won Chang³ and Sang-Hyon Kim¹, ¹Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Ulsan University School of Medicine, GangNeung Asan Hospital, Gangneung, South Korea, ³Department of Radiology, Keimyung University School of Medicine, Daegu, South Korea
Background/Purpose: Neuropsychiatric systemic lupus erythematosus (SLE) includes a broad spectrum of neurologic and psychiatric manifestations. One of the most commonly observed neuopsychiatric symptoms is headache.…
Abstract Number: 3125 • 2015 ACR/ARHP Annual Meeting
White Matter Magnetization Transfer Ratio Histogram Peak Height Helps Identifying Inflammatory Neuropsychiatric Systemic Lupus Erythematosus
César Magro Checa¹, Ece Ercan², Bart J Emmer³, Ron Wolterbeek⁴, Itamar Ronen², Mark A. Van Buchem², T. W. J. Huizinga⁵ and Gerda M. Steup-Beekman⁵, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Magnetization transfer ratio (MTR) can be used to detect microstructural cerebral changes in normal-appearing brain tissue of neuropsychiatric systemic lupus erythematosus (NPSLE) patients. Our…
Abstract Number: 2146 • 2013 ACR/ARHP Annual Meeting
Effects Of Chondroitin Sulfate On Brain Response To Painful Stimulation In Knee Osteoarthritis Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Jordi Monfort¹, Jesús Pujol², O Contreras-Rodriguez², Jone Llorente-Onaindia², M López-Solà², Laura Blanco-Hinojo², J Deus², H Ortiz², Francisco Montañés³, M Campillo², Pere Benito², Laura Sánchez⁴, Marta Herrero⁵ and Josep Vergés⁶, ¹Reumatologia, Hospital del Mar, Barcelona, Spain, ²Hospital del Mar, Barcelona, Spain, ³Rhaumatology, Hospital del Mar, Barcelona, Spain, ⁴Bioiberica, Barcelona, Spain, ⁵Pharmascience Division, Bioiberica S.A., Barcelona, Spain, ⁶Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain
Background/Purpose: Knee osteoarthritis (OA) is a degenerative joint disease causing symptoms in 12% of people over the age of 65 . A variety of treatments…
Abstract Number: 1431 • 2012 ACR/ARHP Annual Meeting
Single Photon Emission Computed Tomography Contributes to Clinical Assessments in Neuropsychiatric Systemic Lupus Erythematosus Patients
Maasa Hama¹, Mitsuhiro Takeno¹, Atsushi Ihata¹, Daiga Kishimoto¹, Reikou Watanabe¹, Takeaki Uehara², Ryusuke Yoshimi¹, Yukiko Asami¹, Atsuhisa Ueda¹ and Yoshiaki Ishigatsubo¹, ¹Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Rheumatology, Chigasaki Municipal Hospital, Chigasaki, Japan
Background/Purpose: Because the clinical manifestations of NPSLE are diverse, multifaceted approaches are necessary to evaluate the disease activity and therapeutic responses. We investigated contribution of…
Abstract Number: 1397 • 2012 ACR/ARHP Annual Meeting
Risk Factors Associated with Early Central Nervous System Damage Detected Through Perfusion MRI in Patients with Systemic Lupus Erythematosus
Paola Tomietto¹, Federica Casagrande², Maja Ukmar², Luca Weis², Pia Morassi¹, Rita Moretti³, Gianni Biolo³, Carlo Giansante³ and Maria Assunta Cova², ¹Internal Medicine Department, AOU Ospedali Riuniti di Trieste, Trieste, Italy, ²Radiology Department, Radiology Department, University of Trieste, Trieste, Italy, ³Internal Medicine Department, Internal Medicine Department, University of Trieste, Trieste, Italy
Background/Purpose: Antiphospholipid antibodies (aPL), hypertension and accumulated damage (SLICC-DI) have been associated to the severity of cerebral MRI lesions and to cognitive deficits in SLE.…

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