ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Neuroimaging"

  • Abstract Number: 0164 • ACR Convergence 2021

    Disrupted Executive Control Network Structural-Functional Integration Is Associated with Inferior Performance of Cognitive Switching Tasks in Patients with Systemic Lupus Erythematosus (SLE)

    Xing Qian1, Danielle S Bassett2, Kwun Kei Ng1, Beatrice RY Loo1, Amelia J Koh1, Juan Helen Zhou1 and Anselm Mak3, 1Center for Sleep and Cognition, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 2Departments of Physics & Astronomy, Bioengineering, Electrical & Systems Engineering, Neurology, and Psychiatry, University of Pennsylvania, Philadelphia, PA, 3National University of Singapore, Singapore, Singapore

    Background/Purpose: Cognitive flexibility, a process that enables goal-oriented cognitive switching between mental function modes, is central to executive function which is impaired in SLE patients.…
  • Abstract Number: 0456 • ACR Convergence 2021

    Functional Connectivity, Enhanced Blood-Brain Barrier Leakage and Cognitive Impairment in Systemic Lupus Erythematosus

    John Hanly1, Jason Robertson1, Lyna Kamintsky1, Alon Friedman1, Steven Beyea1, John Fisk1, Antonina Omisade1, Cindy Calkin1, Tim Bardouille1, Chris Bowen1, Alexandra Legge1, Arnold Mitnitski2, Kara Matheson2 and Javeria Hashmi1, 1Dalhousie University, Halifax, NS, Canada, 2Nova Scotia Health Authority, Halifax, NS, Canada

    Background/Purpose: Cognitive impairment is the most frequent manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE), yet the mechanisms underlying it remain poorly understood. We have previously…
  • Abstract Number: 0703 • ACR Convergence 2021

    CD8 Positron Emission Tomography (PET/CT) Imaging with 89Zr-Df-IAB22M2C in Patients with Inclusion Body Myositis

    Colin Quinn1, Kelsey Moulton1, Ron Korn2, William Le3, Niti Goel4, Michael Farwell5 and Steven Greenberg6, 1Department of Neurology, University of Pennsylvania, Philadelphia, PA, 2ImaginAb, Inglewood, CA, 3ImaginAb, Inc, Inglewood, CA, 4Abcuro, Inc., Newton,, MA, 5Department of Radiology, University of Pennsylvania, Philadelphia, PA, 6Brigham and Women's Hospital Department of Neurology, Boston, MA

    Background/Purpose: Inclusion body myositis (IBM) is a slowly progressive autoimmune skeletal muscle disease for which no effective pharmacological therapy is available. A prominent feature of…
  • Abstract Number: 0777 • ACR Convergence 2021

    Potential Biomarkers of Cognitive Impairment in the Context of Childhood-Onset Systemic Lupus Erythematosus

    Santiago Arciniegas1, Sarah Mossad2, Tala El Tal3, Lawrence Ng4, Paris Moaf4, Helen Branson4, Adrienne Davis4, Linda Hiraki4, Deborah Levy4, Ashley Danguecan2 and Andrea Knight2, 1University of Toronto/The Hospital for Sick Children, Toronto, ON, Canada, 2Hospital for Sick Children, Toronto, ON, Canada, 3University of Toronto/Hospital for Sick Children, Toronto, ON, Canada, 4The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: Cognitive complaints are common in children with childhood-onset systemic lupus erythematosus (cSLE), but neuropsychiatric lupus (NPSLE) remains challenging to diagnose and treat. To increase…
  • Abstract Number: 0870 • ACR Convergence 2021

    Blood Brain Barrier Integrity and Brain Imaging Patterns in Patients with SLE

    Shiran Aharon1, Dafna Ben-Bashat2, Orna Aizenstein3, Moran Artzi4, Mark Berman5, Victoria Furer6, Marina Anouk7, Yael Lahat8, Jonathan Wollman9, Ofir Elalouf9, Ari Polachek10 and Daphna Paran11, 1Wohl Institute of Advanced Imaging, Tel-Aviv Sourasky Medical Center, Sagol School of Neuroscience, Sackler Faculty of Medicine, Tel-Aviv, Israel, 2Wohl Institute of Advanced Imaging, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel, 3Department of Neuroradiology Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel, 4Wohl Institute of Advanced Imaging, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, 5Department of Rheumatology , Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel Aviv, Israel, 6Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 7Department of Rheumatology, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel, 8Department of Rheumatology , Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel, 9Tel Aviv Medical Center, Herzliya, Israel, 10Sourasky Medical Center, Petah-Tikva, Israel, 11Tel Aviv Sourasky Medical Center-Ichilov Hospital, Even Yehuda, Israel

    Background/Purpose: The pathogenesis of neuropsychiatric SLE (NPSLE) has not been fully elucidated. Recent evidence suggests impaired blood brain barrier (BBB) integrity as a possible mechanism…
  • Abstract Number: 1114 • ACR Convergence 2021

    Pachymeningitis: The Mayo Clinic Experience

    Emily Gilbert1, Mina Al-Awqati2, Tina Gunderson3 and Florentina Berianu1, 1Mayo Clinic, Jacksonville, FL, 2University of Illinois, Chicago, IL, 3Mayo Clinic, Rochester, MN

    Background/Purpose: Pachymeningitis is a rare disorder defined by localized or generalized inflammatory thickening of the dura. It can be associated with infections, malignancy, autoimmune disorders,…
  • Abstract Number: 1646 • ACR Convergence 2021

    Abnormal Cerebrovascular Biomarkers in Patients with Rheumatoid Arthritis: Results from a Prospective Study of Cognitive Aging

    Maria Vassilaki1, Cynthia Crowson2, John Davis1, Stephanie Duong1, Aivi Nguyen1, David Jones1, Michelle Mielke1, Vemuri Prashanthi1 and Elena Myasoedova1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic, Eyota, MN

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk of cognitive impairment compared to the general population. This association might be due to chronic…
  • Abstract Number: 0742 • ACR Convergence 2020

    Effect of IA OnabotulinumtoxinA and Vanilloids on Substance P and Neurokinin 1 Receptor Expression in the Dorsal Root Ganglia of Mice with Monoarthritis

    Hollis Krug1, Nicole Blanshan2, Christopher Dorman2 and Sandra Frizelle2, 1Minneapolis VAHCS and University of Minnesota Medical School, Minneapolis, MN, 2Minneapolis VAHCS, Minneapolis

    Background/Purpose: Neurotoxins are increasingly being proposed as analgesics for arthritis pain. Phase II and III clinical trials have shown efficacy but with potential toxicities such…
  • Abstract Number: 1508 • ACR Convergence 2020

    Blood-Brain Barrier Leakage in Systemic Lupus Erythematosus Is Associated with Gray Matter Loss and Cognitive Impairment

    Lyna Kamintsky1, Steven Beyea2, John Fisk2, Javeria Hashmi2, Antonina Omisade2, Cynthia Calkin2, Tim Bardouille2, Chris Bowen2, Maher Quraan2, Arnold Mitnitski2, Kara Matheson2, Alon Friedman2 and John Hanly3, 1Department of Medical Neuroscience, Dalhousie University, Halifax, Canada, 2Dalhousie University, Halifax, Canada, 3Dalhousie University, Halifax, NS, Canada

    Background/Purpose: Cognitive impairment is the most frequent manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE), yet the mechanisms underlying it remain poorly understood. The purpose of…
  • Abstract Number: 1675 • ACR Convergence 2020

    Microstructural Damage Is Associated with Age at Disease-onset and Cognitive Impairment in Systemic Lupus Erythematosus

    Paulo Julio1, Renan Frittoli1, Aline Lapa1, Thais Caldeira1, Leticia Rittner1, Fernando Cendes1, Roberto Marini1, Paula Fernandes1, Lilian Costallat1 and Simone Appenzeller1, 1UNICAMP, Campinas, Brazil

    Background/Purpose: To compare corpus callosum (CC) volume and diffusion tensor imaging in systemic lupus erythematosus according to age of disease-onset. Methods: We selected 75 patients with…
  • Abstract Number: 1819 • ACR Convergence 2020

    Altered Brain Functional Connectivity in Systemic Lupus Erythematosus

    Michelle Barraclough1, Shane McKie2, Benjamin Parker1, Alan Jackson3, Rebecca Elliott4 and Ian Bruce5, 1Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, The University of Manchester; NIHR Manchester Biomedical Research Centre, Manchester University NHS FT, Manchester Academic Health Science Centre, Manchester, United Kingdom, 2FBMH Platform Sciences, Enabling Technologies & Infrastructure, The University of Manchester, Manchester, 3Wolfson Molecular Imaging Centre, Institute of imaging and bioinformatics, The University of Manchester, Manchester, 4Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester; NIHR Manchester Biomedical Research Centre, Manchester University NHS FT, Manchester Academic Health Science Centre, Manchester, United Kingdom, 5Centre for Epidemiology Versus Arthritis, The University of Manchester and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

    Background/Purpose: Cognitive dysfunction (CD) is very prevalent in SLE and significantly affects quality of life. Altered functional brain mechanisms are associated with CD in SLE.…
  • Abstract Number: 1992 • ACR Convergence 2020

    Longitudinal Evaluation of Axonal Dysfunction, Neuronal Markers and Serum Cytokines in Childhood-onset Systemic Lupus Erythematosus

    Renan Frittoli1, Danilo Rodrigues1, Aline Lapa1, Mariana Postal1, Roberto Marini1, Gabriela Castellano1, Fernando Cendes1, Leticia Rittner1 and Simone Appenzeller1, 1UNICAMP, Campinas, Brazil

    Background/Purpose: To analyze 1H-MRS brain metabolites in a longitudinal study and to determine clinical, laboratory and treatment features associated with its occurrence. To determine, additionally…
  • Abstract Number: 0709 • ACR Convergence 2020

    Anatomical Distribution of Mrgprd-expressing Nonpeptidergic C-fibers in the Mouse Knee

    Alia Obeidat1, Rachel Miller1 and Anne-Marie Malfait1, 1Rush University, CHICAGO, IL

    Background/Purpose: The voltage-gated sodium channel, NaV1.8, marks the majority of C-fiber nociceptors. We have used NaV1.8 tdTomato reporter mice to describe the nociceptive innervation of…
  • Abstract Number: 100 • 2020 Pediatric Rheumatology Symposium

    Does Anakinra Dampen Neuronal Damage in Children with Febrile-Infection Related Epilepsy Syndrome (FIRES): A Single Center Review of Neuroimaging

    Eyal Muscal1, Jill Hunter 2, Yi-Chen Lai 2 and James Riviello 2, 1Section of Rheumatology, Department of Pediatrics, Baylor College of Medicine, houston, 2BCM/TCH, Houston

    Background/Purpose: Febrile-illness related epilepsy syndrome (FIRES), characterized by the emergence of super refractory status epilepticus (SRSE) in previously healthy children following a febrile illness, is…
  • Abstract Number: L03 • 2019 ACR/ARP Annual Meeting

    NYX-2925 Impacts Functional and Chemical Neuroimaging Biomarkers and Patient-reported Outcomes of Pain in Patients with Fibromyalgia

    Steven Harte 1, Leslie Arnold 2, Eric Ichesco 1, Christopher Crumb 1, Mary Suh 3, Laurel Sindelar 3, Chelsea Kaplan 1, Tony Larkin 1, Andrew Schrepf 1, Daniel Clauw 4, Stephen Sainati 3 and Richard Harris1, 1University of Michigan, Ann Arbor, 2University of Cincinnati College of Medicine, Cincinnati, 3Aptinyx Inc, Evanston, 4Division of Rheumatology, Department of Internal Medicine and Division of Anesthesia, Michigan Medicine, Ann Arbor, MI

    Background/Purpose: Fibromyalgia (FM) is a chronic, debilitating disease typified by widespread musculoskeletal pain and accompanied by fatigue, sleep disturbance, memory issues, and mood disorders.  FM…
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