ACR Meeting Abstracts

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Abstracts tagged "Neuroimaging"

  • Abstract Number: 0742 • ACR Convergence 2020

    Effect of IA OnabotulinumtoxinA and Vanilloids on Substance P and Neurokinin 1 Receptor Expression in the Dorsal Root Ganglia of Mice with Monoarthritis

    Hollis Krug1, Nicole Blanshan2, Christopher Dorman2 and Sandra Frizelle2, 1Minneapolis VAHCS and University of Minnesota Medical School, Minneapolis, MN, 2Minneapolis VAHCS, Minneapolis

    Background/Purpose: Neurotoxins are increasingly being proposed as analgesics for arthritis pain. Phase II and III clinical trials have shown efficacy but with potential toxicities such…
  • Abstract Number: 1508 • ACR Convergence 2020

    Blood-Brain Barrier Leakage in Systemic Lupus Erythematosus Is Associated with Gray Matter Loss and Cognitive Impairment

    Lyna Kamintsky1, Steven Beyea2, John Fisk2, Javeria Hashmi2, Antonina Omisade2, Cynthia Calkin2, Tim Bardouille2, Chris Bowen2, Maher Quraan2, Arnold Mitnitski2, Kara Matheson2, Alon Friedman2 and John Hanly3, 1Department of Medical Neuroscience, Dalhousie University, Halifax, Canada, 2Dalhousie University, Halifax, Canada, 3Dalhousie University, Halifax, NS, Canada

    Background/Purpose: Cognitive impairment is the most frequent manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE), yet the mechanisms underlying it remain poorly understood. The purpose of…
  • Abstract Number: 1675 • ACR Convergence 2020

    Microstructural Damage Is Associated with Age at Disease-onset and Cognitive Impairment in Systemic Lupus Erythematosus

    Paulo Julio1, Renan Frittoli1, Aline Lapa1, Thais Caldeira1, Leticia Rittner1, Fernando Cendes1, Roberto Marini1, Paula Fernandes1, Lilian Costallat1 and Simone Appenzeller1, 1UNICAMP, Campinas, Brazil

    Background/Purpose: To compare corpus callosum (CC) volume and diffusion tensor imaging in systemic lupus erythematosus according to age of disease-onset. Methods: We selected 75 patients with…
  • Abstract Number: 1819 • ACR Convergence 2020

    Altered Brain Functional Connectivity in Systemic Lupus Erythematosus

    Michelle Barraclough1, Shane McKie2, Benjamin Parker1, Alan Jackson3, Rebecca Elliott4 and Ian Bruce5, 1Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, The University of Manchester; NIHR Manchester Biomedical Research Centre, Manchester University NHS FT, Manchester Academic Health Science Centre, Manchester, United Kingdom, 2FBMH Platform Sciences, Enabling Technologies & Infrastructure, The University of Manchester, Manchester, 3Wolfson Molecular Imaging Centre, Institute of imaging and bioinformatics, The University of Manchester, Manchester, 4Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester; NIHR Manchester Biomedical Research Centre, Manchester University NHS FT, Manchester Academic Health Science Centre, Manchester, United Kingdom, 5Centre for Epidemiology Versus Arthritis, The University of Manchester and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

    Background/Purpose: Cognitive dysfunction (CD) is very prevalent in SLE and significantly affects quality of life. Altered functional brain mechanisms are associated with CD in SLE.…
  • Abstract Number: 1992 • ACR Convergence 2020

    Longitudinal Evaluation of Axonal Dysfunction, Neuronal Markers and Serum Cytokines in Childhood-onset Systemic Lupus Erythematosus

    Renan Frittoli1, Danilo Rodrigues1, Aline Lapa1, Mariana Postal1, Roberto Marini1, Gabriela Castellano1, Fernando Cendes1, Leticia Rittner1 and Simone Appenzeller1, 1UNICAMP, Campinas, Brazil

    Background/Purpose: To analyze 1H-MRS brain metabolites in a longitudinal study and to determine clinical, laboratory and treatment features associated with its occurrence. To determine, additionally…
  • Abstract Number: 0709 • ACR Convergence 2020

    Anatomical Distribution of Mrgprd-expressing Nonpeptidergic C-fibers in the Mouse Knee

    Alia Obeidat1, Rachel Miller1 and Anne-Marie Malfait1, 1Rush University, CHICAGO, IL

    Background/Purpose: The voltage-gated sodium channel, NaV1.8, marks the majority of C-fiber nociceptors. We have used NaV1.8 tdTomato reporter mice to describe the nociceptive innervation of…
  • Abstract Number: 100 • 2020 Pediatric Rheumatology Symposium

    Does Anakinra Dampen Neuronal Damage in Children with Febrile-Infection Related Epilepsy Syndrome (FIRES): A Single Center Review of Neuroimaging

    Eyal Muscal1, Jill Hunter 2, Yi-Chen Lai 2 and James Riviello 2, 1Section of Rheumatology, Department of Pediatrics, Baylor College of Medicine, houston, 2BCM/TCH, Houston

    Background/Purpose: Febrile-illness related epilepsy syndrome (FIRES), characterized by the emergence of super refractory status epilepticus (SRSE) in previously healthy children following a febrile illness, is…
  • Abstract Number: L03 • 2019 ACR/ARP Annual Meeting

    NYX-2925 Impacts Functional and Chemical Neuroimaging Biomarkers and Patient-reported Outcomes of Pain in Patients with Fibromyalgia

    Steven Harte 1, Leslie Arnold 2, Eric Ichesco 1, Christopher Crumb 1, Mary Suh 3, Laurel Sindelar 3, Chelsea Kaplan 1, Tony Larkin 1, Andrew Schrepf 1, Daniel Clauw 4, Stephen Sainati 3 and Richard Harris1, 1University of Michigan, Ann Arbor, 2University of Cincinnati College of Medicine, Cincinnati, 3Aptinyx Inc, Evanston, 4Division of Rheumatology, Department of Internal Medicine and Division of Anesthesia, Michigan Medicine, Ann Arbor, MI

    Background/Purpose: Fibromyalgia (FM) is a chronic, debilitating disease typified by widespread musculoskeletal pain and accompanied by fatigue, sleep disturbance, memory issues, and mood disorders.  FM…
  • Abstract Number: 1738 • 2019 ACR/ARP Annual Meeting

    Tracking Whole-Brain Volumetric Trends in Childhood-onset Systemic Lupus Erythematosus Patients in the Clinical Setting by Magnetic Resonance Imaging

    Hermine Brunner1, Arjun Mathur 2, William O'Brien 3 and Mark DiFrancesco 3, 1Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: The course of childhood-onset Systemic Lupus Erythematosus (cSLE) commonly includes neurocognitive dysfunction, a manifestation with poor prognosis. It has been challenging to diagnose and…
  • Abstract Number: 1883 • 2019 ACR/ARP Annual Meeting

    Elucidating Pain Mechanisms in Polyarticular Juvenile Idiopathic Arthritis Patients

    Jaymin Upadhyay1, Diana Sibai 1, Robert Labadie 2, Jordan Lemme 3, Christine Sieberg 2, Kirsten Ecklund 4, David Borsook 4 and Robert Sundel 4, 1Boston Children's Hospital, Harvard Medical School, Boston, MA, 2Boston Children’s Hospital, Harvard Medical School, Boston, MA, 3Boston Children's Hospital, Harvard Medical School, Boston, 4Boston Children’s Hospital, Harvard Medical School, Boston

    Background/Purpose: Despite a broad range of available therapeutics, pain remains poorly treated in many juvenile idiopathic arthritis (JIA) patients1-2. For some patients, the level of pain…
  • Abstract Number: 2159 • 2019 ACR/ARP Annual Meeting

    Pachymeningitis in Rheumatic Disease

    Rachel Kneeland1, John Berry 2, Sydney Brandwein 2 and Monika Starosta 2, 1Department of Internal Medicine, Advocate Lutheran General Hospital, Park Ridge, IL, 2Advocate Lutheran General Hospital, Park Ridge, IL

    Background/Purpose: Pachymeningitis is a rare complication of rheumatic disease. Patients present with hearing loss or other neurologic complications. Diagnosis is made by thickening of dura…
  • Abstract Number: 2256 • 2018 ACR/ARHP Annual Meeting

    Rheumatic Diseases Associated with Neuromyelitis Optica Spectrum Disorders (NMOSD): Prevalence, Clinical, Laboratory and Imaging Characteristics

    Milena Rodriguez Alvarez1, Su Zhaz Leon1, Fernando Cuascut2, Naureen Kabani3, Joshy Pathiparampil3, Kristaq Koci4, Manjeet Bhamra5, Latoya Freeman4, Alexandra Kreps6, Justin Levinson6, Sophia Francis6, Vinodkumar Velayndhan6, Steve Xie7, Abhimanyu Amarnani6, Helen Valsamis8, Yaacov Anziska6, Ellen M. Ginzler9 and Isabel M. McFarlane9, 1Rheumatology, SUNY Downstate, Brooklyn, NY, 2Neurology, SUNY Downstate, Brooklyn, NY, 3Internal Medicine, SUNY Downstate Medical Center, Brooklyn, NY, 4Medicine, SUNY Downstate Medical Center, Brooklyn, NY, 5Medicine, SUNY Downstate, Brooklyn, NY, 6SUNY Downstate, Brooklyn, NY, 7NYC Health + Hospitals Kings County, Brooklyn, NY, 8Neurology, NYC Health + Hospitals Kings County, Brooklyn, NY, 9Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY

     Background/Purpose: NMOSD are autoimmune disorders characterized by optic neuritis (ON), longitudinal extensive transverse myelitis (LETM), and other clinical features. Aquaporin 4 antibodies (AQP4 Ab) have…
  • Abstract Number: 26 • 2017 Pediatric Rheumatology Symposium

    Gray Matter Volume Loss in Youth with SLE

    Andrea Knight1, Michelle Vickery2, Arastoo Vossough3, Guray Erus4, Jimit Doshi5 and Susan Furth6, 1Center for Pediatric Clinical Effectiveness & PolicyLab, Philadelphia, PA, 2PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, 3Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 4Section on Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, 5Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, 6Division of Nephrology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Neuropsychiatric SLE in children and adolescents presents diagnostic challenge due to limitations of conventional magnetic resonance imaging (MRI) to detect clinically relevant brain changes.…
  • Abstract Number: 2834 • 2016 ACR/ARHP Annual Meeting

    Utility of the Brain Perfusion Single Photon Emission Computed Tomography in Neuropsychiatric Manifestations of Systemic Lupus Erythematosus

    Jorge Medina-Rosas1, Murray Urowitz2, Jiandong Su3, Dafna D Gladman4 and Zahi Touma2, 1Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 4University of Toronto, Toronto, ON, Canada

    Background/Purpose:   The diagnosis of Neuropsychiatric Events (NPE) in SLE is challenging and it is mainly based on the physician judgment. Structural brain imaging has…
  • Abstract Number: 3125 • 2015 ACR/ARHP Annual Meeting

    White Matter Magnetization Transfer Ratio Histogram Peak Height Helps Identifying Inflammatory Neuropsychiatric Systemic Lupus Erythematosus

    César Magro Checa1, Ece Ercan2, Bart J Emmer3, Ron Wolterbeek4, Itamar Ronen2, Mark A. Van Buchem2, T. W. J. Huizinga5 and Gerda M. Steup-Beekman5, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Radiology, C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands, 4Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, Netherlands, 5Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Magnetization transfer ratio (MTR) can be used to detect microstructural cerebral changes in normal-appearing brain tissue of neuropsychiatric systemic lupus erythematosus (NPSLE) patients. Our…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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