Abstracts tagged "Neuroimaging"

Abstract Number: 1663 • ACR Convergence 2022
Age-Dependent Expansion and Activation of Disease-Associated Microglia in Neuropsychiatric Symptoms of Systemic Lupus Erythematosus
Hadijat Makinde¹, Caroline Shah¹, Miranda Gurra¹, Yidan Wang¹, Deborah Winter² and Carla Cuda¹, ¹Northwestern University, Chicago, IL, ²Northwestern University, Skokie, IL
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multipe end organs, including the brain. Despite a prevalence of over 50% in…
Abstract Number: 1972 • ACR Convergence 2022
Comprehensive Investigation of Pain and Inflammation in Rheumatoid Arthritis from a Multidisciplinary Approach
Lilla Tóth¹, Gergely Orsi², Krisztina Csókási³, Gábor Sütő⁴, Gábor Kumánovics⁵, Noémi Császár-Nagy⁶, Szabolcs Takács⁷, Eszter Szigedi⁸, Zsófia Nagy⁸, Zsolt Hodovány⁸, Lili Duzsik⁸, Zoltán Vidnyánszky⁹, József Kun¹⁰, Péter Urbán¹⁰, György Nagy¹¹ and Zsuzsanna Helyes¹², ¹Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary, ²MTA-PTE Clinical Neuroscience MR Research Group, Eötvös Loránd Research Network (ELKH); Department of Neurology, Medical School, University of Pecs, Pécs, Hungary, ³Institute of Psychology, Faculty of Humanities and Social Sciences, University of Pécs, Pécs, Hungary, ⁴Second Department of Medicine and Nephrology-Diabetes Centre, University of Pécs, Pécs, Hungary, ⁵Department of Rheumatology and Immunology, University of Pécs, Pécs, Hungary, ⁶National University of Public Services; Psychosomatic Outpatient Clinics, Budapest, Hungary, ⁷Department of Psychology, Karoly Gaspar University, Budapest, Hungary, ⁸Psychosomatic Outpatient Clinics, Budapest, Hungary, ⁹Brain Imaging Centre, Research Centre for Natural Sciences, Budapest, Hungary, ¹⁰Szentágothai Research Centre, Bioinformatics Research Group, Genomics and Bioinformatics Core Facility, University of Pécs, Pécs, Hungary, ¹¹Department of Rheumatology and Clinical Immunology, Department of Internal Medicine and Oncology, Semmelweis University; Department of Genetics, Cell and Immunobiology, Semmelweis University; Heart and Vascular Centre, Semmelweis University, Budapest, Hungary, ¹²Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs; Szentágothai Research Centre and Centre for Neuroscience, University of Pécs, Pécs, Hungary
Background/Purpose: Despite the therapeutic advances of rheumatoid arthritis (RA), optimal disease control cannot be achieved in the difficult-to-treat (D2T) RA population, leading to the persistence…
Abstract Number: 2256 • ACR Convergence 2022
Increased Brain Functional Connectivity to the Insula Is Associated with Nociplastic Pain in Psoriatic Arthritis
Flavia Sunzini¹, Kristian Stefanov¹, Salim Al-Wasity¹, Steven E Harte², Richard E Harris², Daniel J Clauw², Stefan Siebert³, Carl Goodyear¹, Gordon Waiter⁴ and Neil Basu¹, ¹University of Glasgow, Glasgow, Scotland, United Kingdom, ²University of Michigan, Ann Arbor, MI, ³Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom, ⁴University of Aberdeen, Aberdeen, Scotland, United Kingdom
Background/Purpose: Pain is a hallmark feature of psoriatic arthritis (PsA); however, its apparent multi-factorial nature makes it difficult for rheumatologists to assess and manage. Clinically,…
Abstract Number: 0517 • ACR Convergence 2022
Cortical Surface Area Correlates with Cognitive Efficiency and Disease Measures in Childhood-Onset Systemic Lupus Erythematosus
Santiago Arciniegas¹, Sarah Mossad², Tala El Tal³, Victoria Lishak⁴, Stephanie Fevrier⁵, Ibrahim Mohamed⁶, Joanna Law², Lawrence Ng², Paris Moaf², Helen Branson², Adrienne Davis², Linda Hiraki⁷, Deborah Levy⁸, ashley Danguecan², George Ibrahim⁵ and Andrea Knight³, ¹University of Toronto/Hospital for Sick Children, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada, ³The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁴The Hospital for Sick Children, Department of Psychology, University of Toronto, Toronto, ON, Canada, ⁵The Hospital for Sick Children/University of Toronto, Toronto, ON, Canada, ⁶The Hospital for Sick Children, Neurosciences and Mental Health, Research Institute, ON, Canada 3Institute of Biomedical Engineering, University of Toronto, Brampton, ON, Canada, ⁷The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada, ⁸Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada
Background/Purpose: Cognitive difficulties are common in children with childhood-onset SLE (cSLE), but neuropsychiatric lupus (NPSLE) remains challenging to diagnose and treat. To increase understanding of…
Abstract Number: 0665 • ACR Convergence 2022
Screening for Neurocognitive Demands in Childhood-onset Systemic Lupus Erythematosus Patients Using Pediatric Automated Neuropsychological Assessment Metrics and Association with Magnetic Resonance Imaging
Jaqueline De Amorim¹, Simone Kishimoto¹, Danilo Pereira¹, Letícia Rittner¹ and Simone Appenzeller², ¹University of Campinas, Campinas, São Paulo, Brazil, ²Unicamp, Campinas, São Paulo, Brazil
Background/Purpose: Neuropsychiatric manifestations are frequently seen in patients with childhood-onset erythematosus (cSLE) and may include neurocognitive dysfunction. These symptoms are difficult to diagnose and classify…
Abstract Number: 1474 • ACR Convergence 2022
Quinolinic Acid, a Kynurenine/Tryptophan Pathway Metabolite, Correlates with Abnormalities in Brain Structure and Function in SLE
Erik Anderson, Chris Tang, An Vo, Cynthia Aranow, Bruce Volpe, Betty Diamond and Meggan Mackay, Feinstein Institutes for Medical Research, Manhasset, NY
Background/Purpose: Stimulation of the kynurenine/tryptophan pathway by interferons alpha and gamma, both known contributors to SLE pathogenesis, leads to a potentially neurotoxic imbalance of pathway…
Abstract Number: 1618 • ACR Convergence 2022
Combined Orbital and Cranial Vessel Wall MRI for Diagnosis and Longitudinal Monitoring of Giant Cell Arteritis
Rennie Rhee, Shubhasree Banerjee, Vatsal Bhatt, Madhura Tamhankar, Quy Cao, Naomi Amudala, Sherry Chou, Morgan Burke, Laurie Loevner, Peter Merkel and Jae Song, University of Pennsylvania, Philadelphia, PA
Background/Purpose: In giant cell arteritis (GCA), there is a critical need to identify patients at risk for vision loss ("ocular GCA"). MRI evaluates neurovascular anatomy…
Abstract Number: 0164 • ACR Convergence 2021
Disrupted Executive Control Network Structural-Functional Integration Is Associated with Inferior Performance of Cognitive Switching Tasks in Patients with Systemic Lupus Erythematosus (SLE)
Xing Qian¹, Danielle S Bassett², Kwun Kei Ng¹, Beatrice RY Loo¹, Amelia J Koh¹, Juan Helen Zhou¹ and Anselm Mak³, ¹Center for Sleep and Cognition, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, ²Departments of Physics & Astronomy, Bioengineering, Electrical & Systems Engineering, Neurology, and Psychiatry, University of Pennsylvania, Philadelphia, PA, ³National University of Singapore, Singapore, Singapore
Background/Purpose: Cognitive flexibility, a process that enables goal-oriented cognitive switching between mental function modes, is central to executive function which is impaired in SLE patients.…
Abstract Number: 0456 • ACR Convergence 2021
Functional Connectivity, Enhanced Blood-Brain Barrier Leakage and Cognitive Impairment in Systemic Lupus Erythematosus
John Hanly¹, Jason Robertson¹, Lyna Kamintsky¹, Alon Friedman¹, Steven Beyea¹, John Fisk¹, Antonina Omisade¹, Cindy Calkin¹, Tim Bardouille¹, Chris Bowen¹, Alexandra Legge¹, Arnold Mitnitski², Kara Matheson² and Javeria Hashmi¹, ¹Dalhousie University, Halifax, NS, Canada, ²Nova Scotia Health Authority, Halifax, NS, Canada
Background/Purpose: Cognitive impairment is the most frequent manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE), yet the mechanisms underlying it remain poorly understood. We have previously…
Abstract Number: 0703 • ACR Convergence 2021
CD8 Positron Emission Tomography (PET/CT) Imaging with 89Zr-Df-IAB22M2C in Patients with Inclusion Body Myositis
Colin Quinn¹, Kelsey Moulton¹, Ron Korn², William Le³, Niti Goel⁴, Michael Farwell⁵ and Steven Greenberg⁶, ¹Department of Neurology, University of Pennsylvania, Philadelphia, PA, ²ImaginAb, Inglewood, CA, ³ImaginAb, Inc, Inglewood, CA, ⁴Abcuro, Inc., Newton,, MA, ⁵Department of Radiology, University of Pennsylvania, Philadelphia, PA, ⁶Brigham and Women's Hospital Department of Neurology, Boston, MA
Background/Purpose: Inclusion body myositis (IBM) is a slowly progressive autoimmune skeletal muscle disease for which no effective pharmacological therapy is available. A prominent feature of…
Abstract Number: 0777 • ACR Convergence 2021
Potential Biomarkers of Cognitive Impairment in the Context of Childhood-Onset Systemic Lupus Erythematosus
Santiago Arciniegas¹, Sarah Mossad², Tala El Tal³, Lawrence Ng⁴, Paris Moaf⁴, Helen Branson⁴, Adrienne Davis⁴, Linda Hiraki⁴, Deborah Levy⁴, Ashley Danguecan² and Andrea Knight², ¹University of Toronto/The Hospital for Sick Children, Toronto, ON, Canada, ²Hospital for Sick Children, Toronto, ON, Canada, ³University of Toronto/Hospital for Sick Children, Toronto, ON, Canada, ⁴The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Cognitive complaints are common in children with childhood-onset systemic lupus erythematosus (cSLE), but neuropsychiatric lupus (NPSLE) remains challenging to diagnose and treat. To increase…
Abstract Number: 0870 • ACR Convergence 2021
Blood Brain Barrier Integrity and Brain Imaging Patterns in Patients with SLE
Shiran Aharon¹, Dafna Ben-Bashat², Orna Aizenstein³, Moran Artzi⁴, Mark Berman⁵, Victoria Furer⁶, Marina Anouk⁷, Yael Lahat⁸, Jonathan Wollman⁹, Ofir Elalouf⁹, Ari Polachek¹⁰ and Daphna Paran¹¹, ¹Wohl Institute of Advanced Imaging, Tel-Aviv Sourasky Medical Center, Sagol School of Neuroscience, Sackler Faculty of Medicine, Tel-Aviv, Israel, ²Wohl Institute of Advanced Imaging, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel, ³Department of Neuroradiology Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel, ⁴Wohl Institute of Advanced Imaging, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, ⁵Department of Rheumatology , Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel Aviv, Israel, ⁶Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁷Department of Rheumatology, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel, ⁸Department of Rheumatology , Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel, ⁹Tel Aviv Medical Center, Herzliya, Israel, ¹⁰Sourasky Medical Center, Petah-Tikva, Israel, ¹¹Tel Aviv Sourasky Medical Center-Ichilov Hospital, Even Yehuda, Israel
Background/Purpose: The pathogenesis of neuropsychiatric SLE (NPSLE) has not been fully elucidated. Recent evidence suggests impaired blood brain barrier (BBB) integrity as a possible mechanism…
Abstract Number: 1114 • ACR Convergence 2021
Pachymeningitis: The Mayo Clinic Experience
Emily Gilbert¹, Mina Al-Awqati², Tina Gunderson³ and Florentina Berianu¹, ¹Mayo Clinic, Jacksonville, FL, ²University of Illinois, Chicago, IL, ³Mayo Clinic, Rochester, MN
Background/Purpose: Pachymeningitis is a rare disorder defined by localized or generalized inflammatory thickening of the dura. It can be associated with infections, malignancy, autoimmune disorders,…
Abstract Number: 1646 • ACR Convergence 2021
Abnormal Cerebrovascular Biomarkers in Patients with Rheumatoid Arthritis: Results from a Prospective Study of Cognitive Aging
Maria Vassilaki¹, Cynthia Crowson², John Davis¹, Stephanie Duong¹, Aivi Nguyen¹, David Jones¹, Michelle Mielke¹, Vemuri Prashanthi¹ and Elena Myasoedova¹, ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Eyota, MN
Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk of cognitive impairment compared to the general population. This association might be due to chronic…
Abstract Number: 0742 • ACR Convergence 2020
Effect of IA OnabotulinumtoxinA and Vanilloids on Substance P and Neurokinin 1 Receptor Expression in the Dorsal Root Ganglia of Mice with Monoarthritis
Hollis Krug¹, Nicole Blanshan², Christopher Dorman² and Sandra Frizelle², ¹Minneapolis VAHCS and University of Minnesota Medical School, Minneapolis, MN, ²Minneapolis VAHCS, Minneapolis
Background/Purpose: Neurotoxins are increasingly being proposed as analgesics for arthritis pain. Phase II and III clinical trials have shown efficacy but with potential toxicities such…