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Abstracts tagged "Neuroimaging"

  • Abstract Number: 1663 • ACR Convergence 2022

    Age-Dependent Expansion and Activation of Disease-Associated Microglia in Neuropsychiatric Symptoms of Systemic Lupus Erythematosus

    Hadijat Makinde1, Caroline Shah1, Miranda Gurra1, Yidan Wang1, Deborah Winter2 and Carla Cuda1, 1Northwestern University, Chicago, IL, 2Northwestern University, Skokie, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multipe end organs, including the brain. Despite a prevalence of over 50% in…
  • Abstract Number: 1972 • ACR Convergence 2022

    Comprehensive Investigation of Pain and Inflammation in Rheumatoid Arthritis from a Multidisciplinary Approach

    Lilla Tóth1, Gergely Orsi2, Krisztina Csókási3, Gábor Sütő4, Gábor Kumánovics5, Noémi Császár-Nagy6, Szabolcs Takács7, Eszter Szigedi8, Zsófia Nagy8, Zsolt Hodovány8, Lili Duzsik8, Zoltán Vidnyánszky9, József Kun10, Péter Urbán10, György Nagy11 and Zsuzsanna Helyes12, 1Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary, 2MTA-PTE Clinical Neuroscience MR Research Group, Eötvös Loránd Research Network (ELKH); Department of Neurology, Medical School, University of Pecs, Pécs, Hungary, 3Institute of Psychology, Faculty of Humanities and Social Sciences, University of Pécs, Pécs, Hungary, 4Second Department of Medicine and Nephrology-Diabetes Centre, University of Pécs, Pécs, Hungary, 5Department of Rheumatology and Immunology, University of Pécs, Pécs, Hungary, 6National University of Public Services; Psychosomatic Outpatient Clinics, Budapest, Hungary, 7Department of Psychology, Karoly Gaspar University, Budapest, Hungary, 8Psychosomatic Outpatient Clinics, Budapest, Hungary, 9Brain Imaging Centre, Research Centre for Natural Sciences, Budapest, Hungary, 10Szentágothai Research Centre, Bioinformatics Research Group, Genomics and Bioinformatics Core Facility, University of Pécs, Pécs, Hungary, 11Department of Rheumatology and Clinical Immunology, Department of Internal Medicine and Oncology, Semmelweis University; Department of Genetics, Cell and Immunobiology, Semmelweis University; Heart and Vascular Centre, Semmelweis University, Budapest, Hungary, 12Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs; Szentágothai Research Centre and Centre for Neuroscience, University of Pécs, Pécs, Hungary

    Background/Purpose: Despite the therapeutic advances of rheumatoid arthritis (RA), optimal disease control cannot be achieved in the difficult-to-treat (D2T) RA population, leading to the persistence…
  • Abstract Number: 2256 • ACR Convergence 2022

    Increased Brain Functional Connectivity to the Insula Is Associated with Nociplastic Pain in Psoriatic Arthritis

    Flavia Sunzini1, Kristian Stefanov1, Salim Al-Wasity1, Steven E Harte2, Richard E Harris2, Daniel J Clauw2, Stefan Siebert3, Carl Goodyear1, Gordon Waiter4 and Neil Basu1, 1University of Glasgow, Glasgow, Scotland, United Kingdom, 2University of Michigan, Ann Arbor, MI, 3Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom, 4University of Aberdeen, Aberdeen, Scotland, United Kingdom

    Background/Purpose: Pain is a hallmark feature of psoriatic arthritis (PsA); however, its apparent multi-factorial nature makes it difficult for rheumatologists to assess and manage. Clinically,…
  • Abstract Number: 0517 • ACR Convergence 2022

    Cortical Surface Area Correlates with Cognitive Efficiency and Disease Measures in Childhood-Onset Systemic Lupus Erythematosus

    Santiago Arciniegas1, Sarah Mossad2, Tala El Tal3, Victoria Lishak4, Stephanie Fevrier5, Ibrahim Mohamed6, Joanna Law2, Lawrence Ng2, Paris Moaf2, Helen Branson2, Adrienne Davis2, Linda Hiraki7, Deborah Levy8, ashley Danguecan2, George Ibrahim5 and Andrea Knight3, 1University of Toronto/Hospital for Sick Children, Toronto, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada, 3The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 4The Hospital for Sick Children, Department of Psychology, University of Toronto, Toronto, ON, Canada, 5The Hospital for Sick Children/University of Toronto, Toronto, ON, Canada, 6The Hospital for Sick Children, Neurosciences and Mental Health, Research Institute, ON, Canada 3Institute of Biomedical Engineering, University of Toronto, Brampton, ON, Canada, 7The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada, 8Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Cognitive difficulties are common in children with childhood-onset SLE (cSLE), but neuropsychiatric lupus (NPSLE) remains challenging to diagnose and treat. To increase understanding of…
  • Abstract Number: 0665 • ACR Convergence 2022

    Screening for Neurocognitive Demands in Childhood-onset Systemic Lupus Erythematosus Patients Using Pediatric Automated Neuropsychological Assessment Metrics and Association with Magnetic Resonance Imaging

    Jaqueline De Amorim1, Simone Kishimoto1, Danilo Pereira1, Letícia Rittner1 and Simone Appenzeller2, 1University of Campinas, Campinas, São Paulo, Brazil, 2Unicamp, Campinas, São Paulo, Brazil

    Background/Purpose: Neuropsychiatric manifestations are frequently seen in patients with childhood-onset erythematosus (cSLE) and may include neurocognitive dysfunction. These symptoms are difficult to diagnose and classify…
  • Abstract Number: 1474 • ACR Convergence 2022

    Quinolinic Acid, a Kynurenine/Tryptophan Pathway Metabolite, Correlates with Abnormalities in Brain Structure and Function in SLE

    Erik Anderson, Chris Tang, An Vo, Cynthia Aranow, Bruce Volpe, Betty Diamond and Meggan Mackay, Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Stimulation of the kynurenine/tryptophan pathway by interferons alpha and gamma, both known contributors to SLE pathogenesis, leads to a potentially neurotoxic imbalance of pathway…
  • Abstract Number: 1618 • ACR Convergence 2022

    Combined Orbital and Cranial Vessel Wall MRI for Diagnosis and Longitudinal Monitoring of Giant Cell Arteritis

    Rennie Rhee, Shubhasree Banerjee, Vatsal Bhatt, Madhura Tamhankar, Quy Cao, Naomi Amudala, Sherry Chou, Morgan Burke, Laurie Loevner, Peter Merkel and Jae Song, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: In giant cell arteritis (GCA), there is a critical need to identify patients at risk for vision loss ("ocular GCA"). MRI evaluates neurovascular anatomy…
  • Abstract Number: 0164 • ACR Convergence 2021

    Disrupted Executive Control Network Structural-Functional Integration Is Associated with Inferior Performance of Cognitive Switching Tasks in Patients with Systemic Lupus Erythematosus (SLE)

    Xing Qian1, Danielle S Bassett2, Kwun Kei Ng1, Beatrice RY Loo1, Amelia J Koh1, Juan Helen Zhou1 and Anselm Mak3, 1Center for Sleep and Cognition, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 2Departments of Physics & Astronomy, Bioengineering, Electrical & Systems Engineering, Neurology, and Psychiatry, University of Pennsylvania, Philadelphia, PA, 3National University of Singapore, Singapore, Singapore

    Background/Purpose: Cognitive flexibility, a process that enables goal-oriented cognitive switching between mental function modes, is central to executive function which is impaired in SLE patients.…
  • Abstract Number: 0456 • ACR Convergence 2021

    Functional Connectivity, Enhanced Blood-Brain Barrier Leakage and Cognitive Impairment in Systemic Lupus Erythematosus

    John Hanly1, Jason Robertson1, Lyna Kamintsky1, Alon Friedman1, Steven Beyea1, John Fisk1, Antonina Omisade1, Cindy Calkin1, Tim Bardouille1, Chris Bowen1, Alexandra Legge1, Arnold Mitnitski2, Kara Matheson2 and Javeria Hashmi1, 1Dalhousie University, Halifax, NS, Canada, 2Nova Scotia Health Authority, Halifax, NS, Canada

    Background/Purpose: Cognitive impairment is the most frequent manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE), yet the mechanisms underlying it remain poorly understood. We have previously…
  • Abstract Number: 0703 • ACR Convergence 2021

    CD8 Positron Emission Tomography (PET/CT) Imaging with 89Zr-Df-IAB22M2C in Patients with Inclusion Body Myositis

    Colin Quinn1, Kelsey Moulton1, Ron Korn2, William Le3, Niti Goel4, Michael Farwell5 and Steven Greenberg6, 1Department of Neurology, University of Pennsylvania, Philadelphia, PA, 2ImaginAb, Inglewood, CA, 3ImaginAb, Inc, Inglewood, CA, 4Abcuro, Inc., Newton,, MA, 5Department of Radiology, University of Pennsylvania, Philadelphia, PA, 6Brigham and Women's Hospital Department of Neurology, Boston, MA

    Background/Purpose: Inclusion body myositis (IBM) is a slowly progressive autoimmune skeletal muscle disease for which no effective pharmacological therapy is available. A prominent feature of…
  • Abstract Number: 0777 • ACR Convergence 2021

    Potential Biomarkers of Cognitive Impairment in the Context of Childhood-Onset Systemic Lupus Erythematosus

    Santiago Arciniegas1, Sarah Mossad2, Tala El Tal3, Lawrence Ng4, Paris Moaf4, Helen Branson4, Adrienne Davis4, Linda Hiraki4, Deborah Levy4, Ashley Danguecan2 and Andrea Knight2, 1University of Toronto/The Hospital for Sick Children, Toronto, ON, Canada, 2Hospital for Sick Children, Toronto, ON, Canada, 3University of Toronto/Hospital for Sick Children, Toronto, ON, Canada, 4The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: Cognitive complaints are common in children with childhood-onset systemic lupus erythematosus (cSLE), but neuropsychiatric lupus (NPSLE) remains challenging to diagnose and treat. To increase…
  • Abstract Number: 0870 • ACR Convergence 2021

    Blood Brain Barrier Integrity and Brain Imaging Patterns in Patients with SLE

    Shiran Aharon1, Dafna Ben-Bashat2, Orna Aizenstein3, Moran Artzi4, Mark Berman5, Victoria Furer6, Marina Anouk7, Yael Lahat8, Jonathan Wollman9, Ofir Elalouf9, Ari Polachek10 and Daphna Paran11, 1Wohl Institute of Advanced Imaging, Tel-Aviv Sourasky Medical Center, Sagol School of Neuroscience, Sackler Faculty of Medicine, Tel-Aviv, Israel, 2Wohl Institute of Advanced Imaging, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel, 3Department of Neuroradiology Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel, 4Wohl Institute of Advanced Imaging, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, 5Department of Rheumatology , Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel Aviv, Israel, 6Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 7Department of Rheumatology, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel, 8Department of Rheumatology , Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv, Israel, 9Tel Aviv Medical Center, Herzliya, Israel, 10Sourasky Medical Center, Petah-Tikva, Israel, 11Tel Aviv Sourasky Medical Center-Ichilov Hospital, Even Yehuda, Israel

    Background/Purpose: The pathogenesis of neuropsychiatric SLE (NPSLE) has not been fully elucidated. Recent evidence suggests impaired blood brain barrier (BBB) integrity as a possible mechanism…
  • Abstract Number: 1114 • ACR Convergence 2021

    Pachymeningitis: The Mayo Clinic Experience

    Emily Gilbert1, Mina Al-Awqati2, Tina Gunderson3 and Florentina Berianu1, 1Mayo Clinic, Jacksonville, FL, 2University of Illinois, Chicago, IL, 3Mayo Clinic, Rochester, MN

    Background/Purpose: Pachymeningitis is a rare disorder defined by localized or generalized inflammatory thickening of the dura. It can be associated with infections, malignancy, autoimmune disorders,…
  • Abstract Number: 1646 • ACR Convergence 2021

    Abnormal Cerebrovascular Biomarkers in Patients with Rheumatoid Arthritis: Results from a Prospective Study of Cognitive Aging

    Maria Vassilaki1, Cynthia Crowson2, John Davis1, Stephanie Duong1, Aivi Nguyen1, David Jones1, Michelle Mielke1, Vemuri Prashanthi1 and Elena Myasoedova1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic, Eyota, MN

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk of cognitive impairment compared to the general population. This association might be due to chronic…
  • Abstract Number: 0742 • ACR Convergence 2020

    Effect of IA OnabotulinumtoxinA and Vanilloids on Substance P and Neurokinin 1 Receptor Expression in the Dorsal Root Ganglia of Mice with Monoarthritis

    Hollis Krug1, Nicole Blanshan2, Christopher Dorman2 and Sandra Frizelle2, 1Minneapolis VAHCS and University of Minnesota Medical School, Minneapolis, MN, 2Minneapolis VAHCS, Minneapolis

    Background/Purpose: Neurotoxins are increasingly being proposed as analgesics for arthritis pain. Phase II and III clinical trials have shown efficacy but with potential toxicities such…
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