Abstracts tagged "Myositis"

Abstract Number: 1152 • ACR Convergence 2024
Nailfold Videocapillaroscopy Abnormalities in Different Autoimmune Inflammatory Myopathy Subsets
Thaisa Cotton¹, Valérie Leclair², Claudie Berger³, Yves Troyanov⁴, marie Hudson² and Geneviève Gyger², and Canadian Inflammatory Myopathy Study (CIMS), ¹Université de Montréal, Montreal, QC, Canada, ²McGill University, Montreal, QC, Canada, ³Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁴Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada
Background/Purpose: Nailfold videocapillaroscopy (NVC) alterations have mostly been described in autoimmune inflammatory myopathies (AIM) classified using Bohan and Peter criteria. The aim of this study…
Abstract Number: 1261 • ACR Convergence 2024
Association of Muscle Biopsies and Functional Recovery Trajectories in Children with Juvenile Dermatomyositis
Shannon O'Connor¹, Ilaria Maccora², Megan Quinlan-Waters¹, hermine brunner³, sheila Angeles-Han⁴, grant schulert¹ and leah kottyan¹, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²?PhD student, in the Area of Drugs and Innovative Treatments, NeuroFARBA Department, University of Florence. Meyer Children's Hospital, Florence Italy, Firenze, Florence, Italy, ³Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, ⁴Cincinnati Children's Hospital, Cincinnati, OH
Background/Purpose: Juvenile dermatomyositis (JDM) is an idiopathic inflammatory myopathy characterized by proximal muscle weakness, a distinct rash, and an increased risk of calcinosis, with long-term…
Abstract Number: 2066 • ACR Convergence 2024
Comparative Diagnostic Efficacy of Quantitative Measurement of Echo Intensity and Texture versus Qualitative Analysis of Ultrasound Images in Myositis
Takeshi Yoshida¹, Hiroki Yamazaki², Naoko Takamatsu², Yoshinori Taniguchi³, Taiki Nozaki⁴, masataka inoue⁵, Yoshitaka Kumon⁶, yuki matsumoto², Yuki Kanazawa², Masafumi Harada², Ichizo Nishino⁷, Jemima Albayda⁸ and Yuishin Izumi², ¹Chikamori Hospital, Kochi, Kochi, Japan, ²Tokushima University School of Medicine, Tokushima, Japan, ³Kochi University School of Medicine, kochi, Japan, ⁴keio University School of Medicine, Tokyo, Japan, ⁵Hyogo Medical University, Nishinomiya, Japan, ⁶Chikamori Hospital, Kochi, Japan, ⁷National Center of Neurology and Psychiatry, Tokyo, Japan, ⁸Johns Hopkins School of Medicine, Baltimore, MD
Background/Purpose: Recently, the role of imaging tests such as magnetic resonance imaging and ultrasound (US) in the diagnosis and classification of myositis has become increasingly…
Abstract Number: 2085 • ACR Convergence 2024
The Effects of Pioglitazone on Metabolic Dysregulation in Inclusion Body Myositis: An Open-Label Pilot Study
Brittany Adler¹, Michael Bene¹, Cissy Zhang², Julie Paik¹, Christopher Mecoli¹, Thomas Lloyd³, Eleni Tiniakou⁴, Erika Darrah¹, Lisa Christopher-Stine¹, Albert Mears¹, Megan McGowan¹, Ruben Pagkatipunan¹, Anne Le² and Jemima Albayda⁵, ¹Johns Hopkins University, Baltimore, MD, ²Gigantest, Baltimore, MD, ³Baylor College of Medicine, Houston, TX, ⁴Johns Hopkins University, Lutherville Timonium, MD, ⁵Johns Hopkins School of Medicine, Baltimore, MD
Background/Purpose: Inclusion body myositis (IBM) is a progressive muscle disease for which there is no effective treatment. Mitochondrial dysregulation is a pathologic hallmark of IBM.…
Abstract Number: 0323 • ACR Convergence 2024
Pain Prevalence and Factors Associated with Pain Levels in Patients with Idiopathic Inflammatory Myopathies
Didem Saygin¹, Anne-Marie Malfait², Kristin Wipfler³, Christopher G McKennan⁴, Jiaxuan Duan⁴, Kaleb Michaud⁵ and Yvonne Lee⁶, ¹Rush University Medical Center, Chicago, IL, ²Rush University Medical Center, Division of Rheumatology, Chicago, IL, ³FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ⁴University of Pittsburgh, Department of Statistics, Pittsburgh, PA, ⁵University of Nebraska Medical Center, Omaha, NE, ⁶Northwestern University, Chicago, IL
Background/Purpose: The cardinal symptom of idiopathic inflammatory myopathies (IIM) is muscle weakness leading to functional limitations in the majority of the patients. With a shift…
Abstract Number: 0348 • ACR Convergence 2024
Upadacitinib in Interstitial Lung Disease Associated with Idiopathic Inflammatory Myopathies
Ting Zhang¹, Qiyuan Wang², Wenjia Sun³, Lei Liu¹ and Jing Xue⁴, ¹Zhejiang University, Hangzhou, China (People's Republic), ²Zhejiang Univerisity, Hangzhou, China (People's Republic), ³The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China (People's Republic), ⁴The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (People's Republic)
Background/Purpose: Interstitial lung disease (ILD) is one of the most severe complications in idiopathic inflammatory myopathies (IIM), substantially contributing to the morbidity and mortality. ILD…
Abstract Number: 1153 • ACR Convergence 2024
Increased Prevalence of Myositis Specific and Associated Autoantibodies in Patients with Interstitial Lung Disease of Unknown Etiology
Vasiliki Koulouri¹, Ilektra Voulgareli², Sofia Flouda³, Nikoletta Galanopoulou⁴, Nikolaos Marketos⁵, Charalampos Skarlis⁵, Sylvia Raftopoulou⁵, Kyriaki Tavernaraki⁶, Alexia Chronaiou², Georgios Tsoukalas², Nikolaos Zias⁷, Dimitrios Boumpas⁸ and Clio Mavragani⁹, ¹Department of Physiology and Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Greece, Athens, Greece, ²4th Respiratory Medicine Department, Sotiria General and Chest Diseases Hospital, Athens, Greece, Athens, Greece, ³4th Department of Internal Medicine, "Attikon" University Hospital, Athens, Greece, ⁴10th Respiratory Medicine Department, Sotiria General and Chest Diseases Hospital, Athens, Greece, ⁵Molecular and Applied Physiology Unit, Department of Physiology, School of Medicine, National and Kapodistrian University of Athens., Athens, Greece, ⁶Imaging and Interventional Radiology, Sotiria General and Chest Diseases Hospital, Athens, Greece, Athens, Greece, ⁷Respiratory Medicine Department, Athens Naval Hospital, Athens, Greece, ⁸4th Department of Internal Medicine, "Attikon" University Hospital, Athens, Greece, Athens, Greece, ⁹Department of Physiology and Pathophysiology, School of Medicine, National and Kapodistrian University of Athens., Athens, Greece
Background/Purpose: In recent years, connective tissue diseases (CTDs) have been increasingly recognized as a significant underlying pathology of interstitial lung diseases (ILDs). Amongst CTDs, idiopathic…
Abstract Number: 1275 • ACR Convergence 2024
Implementing Integrated Mental Health Care in a Juvenile Myositis Clinic: A One-Year Review
Luana Flores Pereira¹, Louise Boulard², Kayla M. Baker³, Audrey Bell-Peter⁴, Vanessa Carbone³, Brian Feldman⁵, Jayne MacMahon⁶, Valerio Maniscalco⁷, Jo-Anne Marcuz⁸, Tanya Slater⁴, Kristi Whitney⁴, Y. Ingrid Goh³ and Andrea Knight⁹, ¹Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, ON, Canada, ²Neurosciences and Mental Health Program, SickKids Research Institute; The Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ³Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Sciences, SickKids Research Institute, Toronto, ON, Canada, ⁴Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Division of Rheumatology, The Hospital for Sick Children; Departments of Pediatrics and Medicine, Faculty of Medicine; The Institute for Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁶Division of Rheumatology, The Hospital for Sick Children; Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto; Child Health Evaluative Sciences, SickKids Research Institute, Toronto, ON, Canada, ⁷Rheumatology Unit, ERN-ReCONNET Center, Meyer Children Hospital IRCCS; Department of Pediatrics, Santo Stefano Hospital, Florence, Italy, ⁸Division on Rheumatology, The Hospital for Sick Children; Department of Rehabilitation Services, The Hospital for Sick Children, Toronto, ON, Canada, ⁹Division of Rheumatology, The Hospital for Sick Children; Neurosciences and Mental Health, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada
Background/Purpose: Juvenile myositis (JM) patients experience a high burden of emotional distress, yet mental health (MH) care is not typically integrated into standard clinical practices.…
Abstract Number: 2068 • ACR Convergence 2024
Poloxamers 188 & 182 Are Effective in Repairing the Membrane Resealing Defect in Myositis
Shane Bruckner¹, Braden Zeno², Gianni Giarrano³, Alexis Tucker³, Hannah Bulgart⁴, Brian Paleo³, Kassidy Banford³, Nicholas Young⁴, Rohit Aggarwal⁵, Chester Oddis⁶, Paula Clemens⁷, Dana Ascherman⁸, Noah Weisleder¹ and Wael Jarjour⁹, ¹Ohio State University, Columbus, OH, ²Ohio State, Upper Arlington, OH, ³Ohio State University, Columbus, ⁴The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA, ⁶Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷University of Pittsburgh, Pittsburgh, ⁸Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁹The Ohio State University, Columbus, OH
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of disorders in which autoimmune responses produce a chronic state of inflammation resulting in degeneration of skeletal…
Abstract Number: 2086 • ACR Convergence 2024
Specific Transcriptomic Profile Associated with Disease Activity in Muscle Biopsies from Patients with Sarcoid Myopathy
Iago Pinal-Fernandez¹, Nikolas Ruffer², Maria Casal-Dominguez³, katherine Pak⁴, Stefania Dell'Orso⁵, Faiza Naz⁵, Shamima Islam⁶, Gusatavo Gutierrez-Cruz⁶, Margherita Milone⁷, Albert selva-O'Callaghan⁸, jose milisenda⁹, Felix Kleefeld¹⁰, Andrew Mammen⁶, Teerin Liewluck¹¹ and Werner Stenzel¹², ¹NIAMS/National Institutes of Health, Bethesda, MD, ²Klinikum Bad Bramstedt, Hamburg, Germany, ³NIAMS, NIH, Bethesda, MD, ⁴National Institutes of Health, Bethesda, MD, ⁵National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, Bethesda, MD, ⁶NIH, Bethesda, MD, ⁷Mayo Clinic-Rochester, Rochester, MN, ⁸Systemic Autoimmune Disease Section, Vall d’Hebron Institute of Research, Barcelona, Spain, ⁹Hospital Clinic de Barcelona, Barcelona, Spain, ¹⁰Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany, Berlin, Germany, ¹¹Mayo Clinic, Rochester, MN, ¹²Charite University, Berlin, Germany
Background/Purpose: Sarcoidosis, a multisystem inflammatory disorder of unknown etiology, exhibits diverse clinical manifestations, with symptomatic musculoskeletal involvement being relatively uncommon but potentially debilitating. We conducted…
Abstract Number: 0300 • ACR Convergence 2023
Nailfold Videocapillaroscopy in Idiopathic Inflammatory Myopathy Compared with Healthy Controls
Megan Sullivan¹, Maximiliano Diaz-Menindez², Colleen T. Ball², Benjamin Wang³ and Florentina Berianu¹, ¹Mayo Clinic Florida, Jacksonville, FL, ²Mayo Clinic Jacksonville, Jacksonville, FL, ³Mayo Clinic, Jacksonville, FL
Background/Purpose: Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune disorders that cause inflammation of the muscle. This includes dermatomyositis and polymyositis. Literature has been…
Abstract Number: 1157 • ACR Convergence 2023
Experience of Pain in Adults with Idiopathic Inflammatory Myopathies, Myositis
Helene Alexanderson¹, Masoumeh Tasaroffi², Henrik Pettersson³ and Malin Regardt³, ¹Karolinska Institutet, Stockholm, Sweden, ²Danderyds Hospital, Stockholm, Sweden, ³Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Knowledge of pain in myositis is limited. Recent research suggest that pain is a common symptom in adults with myositis and deemed as one…
Abstract Number: 1179 • ACR Convergence 2023
Rituximab in the Treatment of Interstitial Lung Disease Associated with the Antisynthetase Syndrome
Javier Narvaez¹, Elena Cañadillas-Sanchez², Ivan Castellvi³, Juan José Alegre⁴, Paola Vidal-Montal⁵ and Joan Miquel Nolla⁵, ¹Hospital Universitario de Bellvitge, Barcelona, Spain, ²Department of Rheumatology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain, ³Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Sant Just Desvern, Spain, ⁴Department of Rheumatology, Hospital Universitario Dr Peset, Valencia, Spain, ⁵Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain
Background/Purpose: To assess the real-world, long-term effectiveness of rituximab (RTX) as a rescue therapy in patients with antisynthetase syndrome and interstitial lung disease (ASS-ILD). Methods:…
Abstract Number: 1956 • ACR Convergence 2023
Rituximab Treatment in Adult Patients with Idiopathic Inflammatory Myositis (IIM): A Systematic Review and Meta-analysis
Lilian Otalora Rojas¹, Karishma Ramsubeik², Luis Sanchez-Ramos², Shastri Motilal³, Jasvinder Singh⁴ and Gurjit S Kaeley⁵, ¹University of Florida, Ponte Vedra Beach, FL, ²University of Florida, Jacksonville, FL, ³The University of the West Indies, St. Augustine, Trinidad and Tobago, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵University of Florida College of Medicine – Jacksonville, Ponte Vedra Beach, FL
Background/Purpose: Autoimmune myositis involves a spectrum of rare autoimmune disorders characterized by inflammation and damage to skeletal muscles. The management of these challenging conditions often…
Abstract Number: 2465 • ACR Convergence 2023
Clonally Expanded B Cells in Anti-Histidyl-tRNA Synthetase Syndrome Patients Exhibit an Autoreactive-Prone Memory Phenotype and Bind Jo-1 Autoantigen
Lindsay Bass¹, Dena Liu¹, Alberto Cisneros², Jennifer Young-Glazer², Leslie Crofford³, Erin Wilfong² and Rachel Bonami², ¹Vanderbilt University, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN, ³Vanderbilt University Medical Center, Melbourne, AR
Background/Purpose: Anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS) is defined by the presence of autoantibodies against histidyl tRNA synthetase (Jo-1). Clinically, Jo-1 ARS can involve multiple tissues…

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