Abstracts tagged "Myositis"

Abstract Number: 1075 • ACR Convergence 2020
Diagnostic Utility of Myositis Antibodies in HyperCKemia: A University Affiliated Single Center Retrospective Study
Sandeepkumar Gupta¹, Debendra Pattanaik², Tulio Bertorini² and Amado Afreire³, ¹Medical College Of Georgia at Augusta University Medical Center, Augusta, GA, ²University of Tennessee Health Science Center, Memphis, TN, ³University of Tennessee Health Science Cente, Memphis, TN
Background/Purpose: Myositis specific and associated autoantibodies are now being used more frequently in the diagnosis of idiopathic inflammatory myositis. However there is a no study…
Abstract Number: 1096 • ACR Convergence 2020
Assessing Interstitial Lung Disease in a Racially Diverse Population with Idiopathic Inflammatory Myositis
Jammie Law¹, Ana Valle², Katherine Mullins³ and Shereen Mahmood⁴, ¹Montefiore Medical Center, Bronx, NY, ²Albert Einstein College of Medicine, New York, NY, ³Montefiore Medical Center, BROOKLYN, NY, ⁴Albert Einstein College of Medicine / Montefiore Medical Center, Wantagh, NY
Background/Purpose: Interstitial lung disease (ILD) is a common extra-muscular manifestation of Idiopathic Inflammatory Myositis (IIM) and increases risk of mortality. Prior studies and registries have focused on either smaller cohorts or predominantly Caucasian/European populations. Our aim was to better characterize the…
Abstract Number: 1055 • ACR Convergence 2020
Myositis and Systemic Sclerosis Spectrum IPAF Patients Are More Likely to Respond Favorably to Immunosuppression
Erin Wilfong¹, Gabriel Schroeder¹, April Barnado¹, Steven Lord¹, Narender Annapureddy¹, Rosemarie Dudenhofer¹ and Leslie J. Crofford¹, ¹Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Classification criteria for interstitial pneumonia with autoimmune features (IPAF) were introduced in 2015 to identify interstitial lung disease (ILD) patients who might benefit from…
Abstract Number: 1076 • ACR Convergence 2020
Anti-Jo1 Antibody Quantification Serve as a Prognostic Factor in Anti-synthetase Syndrom
Lois Bolko¹, Kevin Didier², Jean-Hugues Salmon¹, Makoto Miyara³, Segolene Toquet², Amelie Servettaz², Yves Allenbach³, Olivier Benveniste⁴ and Baptiste Hervier⁵, ¹Maison Blanche Hospital, Reims, Champagne-Ardenne, France, ²Robert Debre Hospital, Reims, Champagne-Ardenne, France, ³Sorbonne Université, Paris, Ile-de-France, France, ⁴Sorbonne Université, paris, France, ⁵Saint-Louis Hospital, Paris, Ile-de-France, France
Background/Purpose: Anti-Synthetase Syndrome (ASyS) is a rare systemic autoimmune disease defined by a combination of pulmonary, muscle, joint, and skin manifestations and the presence of…
Abstract Number: 1098 • ACR Convergence 2020
Anti-cortactin Autoantibodies Are Associated with Key Clinical Features in Adult Myositis but Are Rarely Present in Juvenile Myositis
Iago Pinal-Fernandez¹, Katherine Pak², Albert Gil-Vila³, Andres Baucells⁴, Benjamin Plotz⁵, Maria Casal-Dominguez⁶, Assia Derfoul⁷, Maria Angeles Martinez⁴, Albert Selva-O'Callaghan³, Sara Sabbagh⁸, Frederick W. Miller¹, Lisa G. Rider⁹, Lisa Christopher-Stine¹⁰ and Andrew Mammen⁶, ¹National Institutes of Health, Bethesda, MD, ²NIAMS, NIH, Bethesda, MD, ³Vall d’Hebron Hospital, Barcelona, Spain, ⁴Sant Pau Hospital, Barcelona, Spain, ⁵Division of Rheumatology, New York University Langone Health, New York, NY, ⁶NIH, Bethesda, MD, ⁷NIAMS, NIH, Bethesda, ⁸Division of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Washington, DC, ⁹Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Garrett Park, MD, ¹⁰Johns Hopkins University, Baltimore, MD
Background/Purpose: To define the prevalence and clinical phenotype of anti-cortactin autoantibodies in adult and juvenile myositis.Methods: In this longitudinal cohort study, anti-cortactin autoantibody tiers were…
Abstract Number: 1056 • ACR Convergence 2020
Descriptive Data Analysis of Patients with Anti Jo1 Syndrome (AJS) and Lung Involvement
Mohamed Alalwani¹, Bassam Alhaddad², Basem Zraik³, Christopher O'Rourke³, Ruchi Yadav³, Ali Askari¹, Charles Malemud¹ and Soumya Chatterjee⁴, ¹Case Western Reserve University / University Hospitals Cleveland Medical Center, Cleveland, OH, ²MetroHealth Medical Center, Westlake, OH, ³Cleveland Clinic, Cleveland, OH, ⁴Cleveland Clinic, Richmond Heights, OH
Background/Purpose: To evaluate the patterns, severity and, prognostic parameters of interstitial lung disease (ILD) in Anti Jo1 Syndrome (AJS).Methods: We identified 51 anti-Jo-1 patients with…
Abstract Number: 1077 • ACR Convergence 2020
Glucagon-like Peptide-1 Receptor Agonist Suppresses Muscle Inflammation and Muscle Fiber Death, and Ameliorates Muscle Weakness in Experimental Polymyositis
Mari Kamiya¹, Seon Uk Kim², Jeong Yeon Kim³, Shinsuke Yasuda⁴, Eun Young Lee⁵ and Fumitaka Mizoguchi¹, ¹Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ²Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Jongno-gu, Seoul, Republic of Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, ⁴Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Tokyo, Japan, ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
Background/Purpose: Glucocorticoids (GC) are the cornerstone of the treatment for polymyositis (PM). However, the treatment with GC causes GC-induced myopathy, which further deteriorates the muscle…
Abstract Number: 1099 • ACR Convergence 2020
High Burden of Infections in Indian Patients with Idiopathic Inflammatory Myopathy: Validation of Observations from the MyoCite Dataset
Rudrarpan Chatterjee¹, Pankti Mehta², Vikas Agarwal¹ and Latika Gupta², ¹Sanjay Gandhi Post Graduate Institute of Medical Sciences, lucknow, Lucknow, Uttar Pradesh, India, ²Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Background/Purpose: Infections are a major cause of morbidity and mortality in idiopathic inflammatory myopathy (IIM), more so in India.[1-3] The objective of this study was…
Abstract Number: 1057 • ACR Convergence 2020
Earlier Cancer Diagnosis After Idiopathic Inflammatory Myopathy Onset Is Associated with Improved Long Term Survival – Results from Four European Cohorts
Alexander Oldroyd¹, Paul New², Janine Lamb¹, William Ollier¹, Robert Cooper², Kuberacka Mariampillai³, Olivier Benveniste³, Jiří Vencovský⁴, Heřman Mann⁵, Zoltan Griger⁶, Melinda Nagy-Vincze⁶, Katalin Dankó⁶ and Hector Chinoy⁷, ¹University of Manchester, Manchester, United Kingdom, ²University of Liverpool, Liverpool, United Kingdom, ³Sorbonne Université, Paris, France, ⁴Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁵Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁶University of Debrecen, Debrecen, Hungary, ⁷The University of Manchester, Manchester, United Kingdom
Background/Purpose: The idiopathic inflammatory myopathies (IIMs) are strongly associated with the development of clinically detectable cancer. Cancer screening has therefore been advocated in newly diagnosed…
Abstract Number: 1078 • ACR Convergence 2020
Highly Reactive anti-Jo1 Autoantibodies to Distinct HisRS Variants and Domains Associate with Lung and Joint Involvement in Patients with Myositis
Antonella Notarnicola¹, Charlotta Preger², Susanna L. Lundström², Nuria Renard², Edvard Wigren², Eveline Van Gompel², Angeles S. Galindo-Feria², Helena Persson³, Maryam Fathi⁴, Johan Grunewald², Per-Johan Jakobsson², Susanne Gräslund², Ingrid Lundberg⁵ and Cátia Fernandes-Cerqueira², ¹Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, ²Karolinska Institutet, stockholm, Sweden, ³Science for Life Laboratories, KTH, Stockholm, Sweden, ⁴Karolinska University Hospital, stockholm, Sweden, ⁵Division of Rheumatology, Department of Medicine, Karolinska Institutet,, Stockholm, Sweden
Background/Purpose: To address the reactivity and affinity against histidyl-transfer RNA synthetase (HisRS) autoantigen of anti-Jo1 autoantibodies from serum and bronchoalveolar lavage fluid (BALF) and associations…
Abstract Number: 1457 • ACR Convergence 2020
Two Minute Walking Distance and Other Timed Function Tests Are Superior to MMT-8 in Assessing Outcomes in Polymyositis and Dermatomyositis
Sai kumar Dunga¹, Chengappa G Kavadichanda² and VS Negi², ¹Jawaharlal institute of postgraduate medical education and research, puducherry, India, ²Jawaharlal institute of postgraduate medical education and research, Puducherry, Puducherry, India
Background/Purpose: Inflammatory myositis are heterogenous group of diseases affecting skeletal muscles and multiple different organs. Assessing improvement in disease activity is done by Manual muscle…
Abstract Number: 1059 • ACR Convergence 2020
Anti-mitochondrial Autoantibodies Are Associated with Cardiomyopathy, Dysphagia, and Features of More Severe Disease in Adult-onset Myositis
Sara Sabbagh¹, Iago Pinal-Fernandez², Maria Casal-Dominguez³, Jemima Albayda⁴, Julie Paik⁴, Frederick W. Miller², Lisa G. Rider⁵, Andrew Mammen³ and Lisa Christopher-Stine⁴, ¹Medical College of Wisconsin, Fox Point, WI, ²National Institutes of Health, Bethesda, MD, ³NIH, Bethesda, MD, ⁴Johns Hopkins University, Baltimore, MD, ⁵Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Garrett Park, MD
Background/Purpose: We examined the prevalence of anti-mitochondrial autoantibodies (AMA) in adult- and juvenile-onset myositis longitudinal cohorts and investigated phenotypic differences between myositis patients with or…
Abstract Number: 1079 • ACR Convergence 2020
Sex Differences in Antibody Profile, Phenotype, and Treatment Response in a Racially Diverse Population with Idiopathic Inflammatory Myopathies
Ana Valle¹, Jammie Law², Katherine Mullins³ and Shereen Mahmood⁴, ¹Albert Einstein College of Medicine, New York, NY, ²Montefiore Medical Center, Bronx, NY, ³Montefiore Medical Center, BROOKLYN, NY, ⁴Albert Einstein College of Medicine / Montefiore Medical Center, Wantagh, NY
Background/Purpose: It is established that autoimmune diseases are more common in females than males. Large scale idiopathic inflammatory myopathy (IIM) registries have shown a similar…
Abstract Number: 1556 • ACR Convergence 2020
Assessing Calcinosis in Dermatomyositis with Computed Tomography and Calcium Scoring
Prateek Gowda¹, Briana Cervantes², Lisa G. Rider³, Frederick W. Miller⁴, Marcus Chen⁴ and Adam Schiffenbauer⁴, ¹NIBIB, Baltimore, MD, ²NIEHS, Silver Spring, MD, ³Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Garrett Park, MD, ⁴National Institutes of Health, Bethesda, MD
Background/Purpose: Calcinosis is a condition in which calcium salts are deposited in and around soft tissue and is observed in up to 30% of adult…
Abstract Number: 1060 • ACR Convergence 2020
B-cell-rich Inflammatory Myopathies in Adults: Striking Association with Connective Tissue Diseases
Pat Korathanakhun¹, Océane Landon-Cardinal², Valérie Leclair³, Benjamin Ellezam⁴, Alain Meyer⁵, Josiane Bourré-Tessier², Anne-Marie Mansour⁶, Sandrine Larue⁷, François Grand'Maison⁷, Rami Massie⁸, Matthieu Le Page⁹, Catherine Isabelle⁷, Nathalie Routhier⁶, Flavie Roy¹⁰, Minoru Satoh¹¹, Marvin Fritzler¹², Jean-Luc Senécal², Yves Troyanov¹³, Marie Hudson³, Jason Karamchandani¹⁴ and Erin O'Ferrall⁸, ¹Montreal Neurological Institute and Hospital, Montreal, QC, Canada, ²Division of Rheumatology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, ³Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada, ⁴Division of Pathology, Centre hospitalier universitaire Sainte-Justine, Montréal, QC, Canada, ⁵Service de rhumatologie et Centre de références des maladies autoimmunes rares, Hôpitaux universitaires de Strasbourg, Strasbourg, France, ⁶Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada, ⁷Hôpital Charles-Lemoyne, Longueuil, QC, Canada, ⁸Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, ⁹Centre hospitalier de Lanaudière, Saint-Charles-Borromée, QC, Canada, ¹⁰Uiversité de Montréal, Montreal, QC, Canada, ¹¹Department of Clinical Nursing, University of Occupational and Environmental Health, Kitakyushu, Japan, ¹²Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ¹³Division of Rheumatology, Hôpital du Sacré-Coeur, Montréal, QC, Canada, ¹⁴Department of Pathology, Montreal Neurological Institute and Hospital, Montreal, QC, Canada
Background/Purpose: Myositis with significant B-cell infiltrates on muscle biopsy has scarcely been described in adults. Radke (2018) found B cells in adult dermatomyositis (DM) and…

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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