Abstracts tagged "Myositis"

Abstract Number: 1874 • ACR Convergence 2022
Autoantibodies Are Common in Patients with Idiopathic Interstitial Lung Disease Suggesting a High Prevalence of Undiagnosed Autoimmune Connective Tissue Disease
Sarah Tansley¹, Caroline Cotton², Fionnuala McMorrow¹, Hui Lu¹, Aravinthan Loganathan¹, Zoe Betteridge¹, Robert New³, Lisa Spencer⁴, Neil McHugh¹ and Robert Cooper⁴, ¹University of Bath, Bath, United Kingdom, ²Liverpool University Hospital, Liverpool, United Kingdom, ³NCA, Manchester, ⁴University of Liverpool, Liverpool
Background/Purpose: In some patients, interstitial lung disease (ILD) may be the dominant or even sole overt manifestation of an otherwise unrecognised autoimmune connective tissue disease…
Abstract Number: 0164 • ACR Convergence 2022
Anti-SSa/SSb and Ro52 Status and Pulmonary Function Tests in Patients with Interstitial Lung Disease and Idiopathic Inflammatory Myopathies
Abdullah Ahmed¹, Sonali Narain², Ivana Ilic¹, Can Hu³, Jaspreet Bhatti⁴ and Galina Marder⁵, ¹Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, ²Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, ³Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Fort Lee, NJ, ⁴Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, ⁵Donald and Barbara Zucker School of Medicine at Hofstra/ Northwell, Great Neck, NY
Background/Purpose: Interstitial lung disease (ILD) is a major cause of morbidity and mortality in patients with idiopathic inflammatory myositis (IIM). Anti-SSa/SSb and Ro52 are frequently…
Abstract Number: 1377 • ACR Convergence 2022
Mental Health Screening in Juvenile Myositis: Preliminary Analysis of a Multicenter Pilot Study
Kaveh Ardalan¹, Lindsay Olson¹, Jeffrey Dvergsten², Ann Reed¹, Alison Manning¹, Gary Maslow¹, Aruna Rikhi¹, Brian Feldman³, ashley Danguecan⁴, Sarah Mossad⁴, Luana Flores Pereira⁴, Susan Shenoi⁵, Stacey Haynes⁵, Joanna Patten⁵ and Andrea Knight⁶, ¹Duke University School of Medicine, Durham, NC, ²Duke University Hospital, Durham, NC, ³Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁴The Hospital for Sick Children, Toronto, ON, Canada, ⁵Seattle Children's Hospital and Research Center / University of Washington, Seattle, WA, ⁶The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada
Background/Purpose: Qualitative studies in juvenile myositis (JM) suggest high rates of emotional distress but the prevalence of mental health comorbidities is not well described. We…
Abstract Number: 1875 • ACR Convergence 2022
Assessment of Antibody Levels to Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) in Patients with Idiopathic Inflammatory Myopathies Receiving Treatment with Intravenous Immunoglobulin
Sangmee Bae¹, emmanuelle Faure-Kumar¹, Jennifer Wang², Ani Shahbazian², linh Truong², Howard Yang², Maureen McMahon¹, John FitzGerald¹ and Christina Charles-Schoeman³, ¹University of California Los Angeles, Los Angeles, CA, ²UCLA Medical Center, Los Angeles, CA, ³Division of Rheumatology, University of California, Los Angeles, Santa Monica, CA
Background/Purpose: Antibodies to Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) have been reported in pooled donor plasma and intravenous immunoglobulin products (IVIG) since May 2020 (C…
Abstract Number: 0002 • ACR Convergence 2022
Cancer Screening Recommendations for Patients with Idiopathic Inflammatory Myopathy
Alexander Oldroyd¹, Jeffrey Callen², Hector Chinoy³, Lorinda Chung⁴, David Fiorentino⁵, Patrick Gordon⁶, Pedro Machado⁷, Neil McHugh⁸, Albert Selva O’Callaghan⁹, Jens Schmidt¹⁰, Sarah Tansley⁸, Ruth Ann Vleugels¹¹, Victoria Werth¹² and Rohit Aggarwal¹³, ¹University of Manchester, Manchester, United Kingdom, ²University of Louisville, Louisville, KY, ³The University of Manchester, Sale, United Kingdom, ⁴Stanford University, Palo Alto, ⁵Stanford University, Stanford, CA, ⁶King’s College Hospital NHS Foundation Trust, London, United Kingdom, ⁷University College London, London, United Kingdom, ⁸University of Bath, Bath, United Kingdom, ⁹Hospital Universitari Vall d'Hebron, Barcelona, Spain, ¹⁰University Medical Centre Göttingen, Göttingen, Germany, ¹¹Harvard Medical School, Boston, MA, ¹²Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, ¹³Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Adult-onset idiopathic inflammatory myopathy (IIM) is associated with increased cancer risk (lung, ovarian, colorectal, lymphoma, breast, and naso-pharyngeal among the most common) within the…
Abstract Number: 0165 • ACR Convergence 2022
Low Paraoxonase-1 Enzyme Activity in Patients with Idiopathic Inflammatory Myopathies Associates with Cancer Diagnosis
Sangmee Bae¹, Ani Shahbazian², Jennifer Wang² and Christina Charles-Schoeman³, ¹University of California Los Angeles, Los Angeles, CA, ²UCLA Medical Center, Los Angeles, CA, ³Division of Rheumatology, University of California, Los Angeles, Santa Monica, CA
Background/Purpose: Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)- associated enzyme with antioxidative properties, which is low in activity in patients with idiopathic inflammatory myopathies…
Abstract Number: 1385 • ACR Convergence 2022
Clinical and Serologic Characterization of Juvenile Systemic Sclerosis Overlap Disease
Amanda Robinson and Kathryn Torok, Pediatric Rheumatology, Children's Hospital of UPMC, Pittsburgh, PA
Background/Purpose: Juvenile systemic sclerosis (jSSc) is a systemic fibroinflammatory autoimmune disease characterized by skin fibrosis and multiple extracutaneous manifestations. A proportion of children with jSSc…
Abstract Number: 1876 • ACR Convergence 2022
Efficacy of JAK Inhibitors in Idiopathic Inflammatory Myopathies (other Than Dermatomyositis)
Ana Campar¹, Ana Sá², Bárbara Oliveira² and António Marinho¹, ¹CENTRO HOSPITALAR UNIVERSITÁRIO DO PORTO, PORTO, Portugal, ²Centro Hospitalar Universitário do Porto, Porto, Portugal
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a rare and heterogeneous group of systemic autoimmune disorders, comprising dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM), polymyositis (PM), inclusion…
Abstract Number: 0003 • ACR Convergence 2022
Rituximab versus Cyclophosphamide for the Treatment of Connective Tissue Disease Associated Interstitial Lung Disease (RECITAL): A Sub-group Analysis of a Multi-centre Randomised Controlled Trial
Toby Maher¹, Veronica Tudor², Peter Saunders³, Michael Gibbons⁴, Sophie Fletcher⁵, Helen Parfrey⁶, Chris Denton⁷, Rachel Hoyles³, Elizabeth Renzoni², Maria Kokosi², Athol Wells², Deborah Ashby⁸, Matyas Szigeti⁸ and Philip Molyneaux⁸, ¹University of Southern California, Los Angeles, CA, ²Royal Brompton Hospital, London, United Kingdom, ³Oxford University Hospitals, Oxford, United Kingdom, ⁴Royal Devon and Exeter Hospital, Exeter, United Kingdom, ⁵Southampton University Hospitals, Southampton, United Kingdom, ⁶Addenbrookes Hospital, Cambridge, United Kingdom, ⁷University College London, London, United Kingdom, ⁸Imperial College London, London, United Kingdom
Background/Purpose: The RECITAL trial (NCT01862926) compared rituximab to cyclophosphamide as first line therapy for patients with severe or progressive interstitial lung disease due to idiopathic…
Abstract Number: 0166 • ACR Convergence 2022
Detection of the Novel Autoantibodies Against Transcription Factor Sp4 Is Related with Low Risk of Cancer in Idiopathic Inflammatory Myopathy Patients
Yuji Hosono¹, Azusa Kojima¹, Akira Ishii¹, Mai Sugiyama¹, Yuto Izumi¹, Noriko Sasaki², Chiho Yamada¹ and Shinji Sato¹, ¹Tokai University School of Medicine, Isehara Kanagawa, Japan, ²Tokai University School of Medicine, sagamihara-city, Japan
Background/Purpose: In idiopathic inflammatory myopathy (IIM), many kinds of autoantibodies are often detected and associated with each clinical phenotype. Recently, autoantibody against transcription factor Sp4…
Abstract Number: 1453 • ACR Convergence 2022
Prevalence and Associations of Myositis in an Indian Inception Cohort of Lupus
Liza Rajasekhar¹, Vineetha Shobha², Meenakshi Ponnana³, Chengappa Kavadichanda⁴, Ashish J Mathew⁵, Saumya Ranjan Tripathy⁶, Manish Rathi⁷, Parasar Ghosh⁸, Ranjan Gupta⁹, Avinash Jain¹⁰ and Amita Aggarwal¹¹, ¹Nizam's Institute of Medical Sciences, Madhapur, India, ²St. John’s Medical College Hospital, Bangalore, India, ³Nizam's Institute of Medical Sciences, Hyderabad, India, ⁴JIPMER, Pondicherry, Puducherry, India, ⁵Rigshospitalet, Copenhagen, Denmark, ⁶SCB medical college, Cuttack, India, ⁷PGIMER Chandigarh, Chandigarh, India, ⁸Govt of West Bengal, Kolkata, India, Kolkata, West Bengal, India, ⁹All India Institute of Medical Sciences, New Delhi, India, ¹⁰SMS Medical College, Lucknow, India, ¹¹Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Muscle inflammation in systemic lupus erythematosus (SLE) usually presents as generalised myalgia in the presence of active disease elsewhere and responds well to treatment.…
Abstract Number: 1878 • ACR Convergence 2022
Identification of Serum Biomarkers Associated with Muscle Inflammation Detected on MRI in Polymyositis/dermatomyositis
Haruna Matsuo¹, Toshimasa Shimizu¹, Tomohiro Koga¹, Nozomi Oki², Masataka Uetani² and Atsushi Kawakami³, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Background/Purpose: Muscle inflammation is a major clinical manifestation in patients with polymyositis/dermatomyositis (PM/DM). Phenotypes of PM/DM patients, especially those with interstitial lung diseases, are known…
Abstract Number: 0035 • ACR Convergence 2022
Anti-Peroxiredoxin 6 and Anti- Myosin Light Polypeptide 6 Autoantibodies with Interstitial Lung Disease and Severe Disease in Juvenile Dermatomyositis
Rie Karasawa¹, James Jarvis², Toshiko Sato¹, Megumi Tanaka¹, Terrance P O'Hanlon³, Payam Noroozi-Farhadi⁴, Willy A. Flegel⁵, Kazuo Yudoh¹ and Lisa G Rider³, ¹Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, ²Department of Pediatrics, University at Buffalo Clinical and Translational Research Center, Buffalo, NY, ³Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD, ⁴NIEHS, NIH, Garrett Park, MD, ⁵NIH, Garrett Park, MD
Background/Purpose: Juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM) are among the most common forms of inflammatory rheumatic diseases in children. Anti-endothelial cell antibodies (AECA)…
Abstract Number: 0167 • ACR Convergence 2022
Accuracy of Multi-Centric Local Determination of Anti-Synthetase Autoantibodies in Patients with Anti-Synthetase Syndrome and Other Autoimmune Diseases
Giovanni Zanframundo¹, Angela Ceribelli², Sara Faghihi Kashani³, Monica Morosini⁴, Sara Bozzini⁵, Natasa Isailovic⁶, Carlo Selmi⁷, Lorenzo Cavagna⁸ and Rohit Aggarwal⁹, ¹Università di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Milano, Italy, ²Humanitas Research Hospital, Humanitas University, Rozzano (MI) Italy, Borgo San Giacomo, Italy, ³Stanford University, Stanford, CA, ⁴Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Pavia, Italy, ⁵Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Pavia, ⁶IRCCS Humanitas Research Hospital, Rozzano (MI), Italy, Rozzano, Italy, ⁷IRCCS Humanitas Research Hospital, Humanitas University, Rozzano (MI), Italy, Rozzano, Italy, ⁸Università di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Pavia, Italy, ⁹Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: RNA-immunoprecipitation (RNA-IP) is considered the gold standard method for anti-tRNA synthetase antibodies (ARS-Ab) detection. This technique, however, is not widely available, unlike commercial kits,…
Abstract Number: 1660 • ACR Convergence 2022
Skeletal Myopathy in Systemic Sclerosis Associates with Higher Disease Burden and Mortality
Julie Paik¹, Caoilfhionn Connolly¹, Fredrick Wigley¹ and Laura Hummers², ¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins Univerisity, Baltimore, MD
Background/Purpose: Skeletal myopathy in systemic sclerosis (SSc) is poorly understood. The etiology of myopathy in SSc is heterogeneous and can result from an inflammation, disuse,…

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