ACR Meeting Abstracts

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Abstracts tagged "Myositis"

  • Abstract Number: 0717 • ACR Convergence 2021

    Association of Fatigue with Disease Activity in Myositis

    Tissa Bijoy George1, Anjana Chandrasekhara Pillai2, Siamak Moghadam-Kia3, Nicole Neiman4, Dana Ascherman3, Chester Oddis3, Dianxu Ren4 and Rohit Aggarwal3, 1UPMC McKeesport, Monroeville, PA, 2UPMC, Pittsburgh, PA, 3University of Pittsburgh, Pittsburgh, PA, 4University of Pittsburgh Medical Center, Pittsburgh, PA

    Background/Purpose: The Idiopathic inflammatory myopathies are a heterogeneous group of rare systemic autoimmune diseases with muscle as the primary target. Fatigue is one of the…
  • Abstract Number: 1527 • ACR Convergence 2021

    Effect of Rituximab on IgG Levels and Associated Infection Risk in Myositis

    Michael Macklin1, Chester Oddis2, Siamak Moghadam-Kia2, Dana Ascherman2 and Rohit Aggarwal2, 1University of Pittsburgh, Pittsburgh, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Rituximab is an anti-CD20 antibody with therapeutic use in myositis. However, given its B cell depleting mechanism, there is concern regarding its association with…
  • Abstract Number: 0697 • ACR Convergence 2021

    Detection of Autoantibodies Against Muscle-Specific Four-and-a-Half-LIM Domain 1 (FHL1) in Inflammatory Myopathies: Results from a Single-Center Cohort

    Angeles Shunashy Galindo-Feria1, Begum Horuluoglu1, Jessica Day2, Catia Cerqueira3, Edvard Wigren4, Susanne Gräslund4, Susanna Proudman5, Ingrid E Lundberg4 and Vidya Limaye6, 1Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 2Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia and Discipline of Medicine, University of Adelaide, Adelaide, Australia, 34Dcell, Montreuil, France, 4Karolinska Institutet, Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, Stockholm, Sweden, 5University of Adelaide, Medindie, Australia, 6Royal Adelaide Hospital, Adelaide, Australia

    Background/Purpose: Autoantibodies targeting a muscle-specific autoantigen, four-and-a-half-LIM-domain 1 (FHL1), have been previously identified in patients with idiopathic inflammatory myopathies (IIM) (1). The aim of this…
  • Abstract Number: 0718 • ACR Convergence 2021

    Pain Severity and Interference in Adult Autoimmune Inflammatory Myopathies

    Harmony Tsui1, Mianbo Wang2, Mathieu Piché3, Alexandra Ladouceur4, Evelyne Vinet5, Alexandra Albert6, Maggie Larche7, Annaliese Tisseverasinghe8, Marie Hudson1 and Valerie Leclair9, 1McGill University, Montréal, QC, Canada, 2Lady Davis institute for Medical Research, Montréal, QC, Canada, 3Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada, 4McGill University Health Center, Montréal, QC, Canada, 5McGill University Health Centre, Mont Royal, QC, Canada, 6CHU de Quebec, Québec City, QC, Canada, 7McMaster University, Hamilton, ON, Canada, 8University of Manitoba, Winnipeg, MB, Canada, 9McGill University, Karolinska Insitutet, Montréal, QC, Canada

    Background/Purpose: Although pain is one of the most common and highest priority symptoms reported by people with autoimmune inflammatory myopathies (AIM), large descriptive studies on…
  • Abstract Number: 1841 • ACR Convergence 2021

    Presence of Autoantibodies to Dense-Fine-Speckled 70 (DFS70) Do Not Necessarily Rule out Connective Tissue Diseases

    Louisa-Marie Mockenhaupt1, Ramona Dolscheid-Pommerich1, Charlotte Behning1, Birgit Stoffel-Wagner2, Peter Brossart1 and Valentin Schäfer1, 1University Hospital Bonn, Bonn, Germany, 2University Hospital Bonn, Bonn

    Background/Purpose: Antinuclear antibodies (ANA) are serological markers for the presence of connective tissue diseases [1]. In some patients, a pattern can be detected in ANA…
  • Abstract Number: 0001 • ACR Convergence 2021

    Autoantigenic Properties Indicated for the Entire Aminoacyl tRNA Synthetase Family in Idiopathic Inflammatory Myopathies

    Charlotta Preger1, Antonella Notarnicola1, Cecilia Hellström2, Edvard Wigren1, Catia Cerqueira3, Peter Nilsson2, Ingrid E Lundberg1, Helena Persson4, Susanne Gräslund1 and Per-Johan Jakobsson5, 1Karolinska Institutet, Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, Stockholm, Sweden, 2Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology & SciLifeLab, Stockholm, Sweden, 34Dcell, Montreuil, France, 4Drug Discovery and Development Platform, SciLifeLab & School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Solna, Sweden, 5Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Autoantibodies are thought to play a key role in the pathogenesis of idiopathic inflammatory myopathies (IIM). However, 40% of IIM patients, even those with…
  • Abstract Number: 0698 • ACR Convergence 2021

    Flow Cytometry and Sorting of Single Antibody Secreting Cells from Frozen Muscle Tissue

    Andrew Zlobin, Peter Pytel and Vladimir Liarski, University of Chicago, Chicago, IL

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) – dermatomyositis (DM), polymyositis, and inclusion body myositis - are poorly understood autoimmune muscle disorders. Isolation of relevant immune cell…
  • Abstract Number: 0719 • ACR Convergence 2021

    Increased Risk of Venous Thromboembolism in Adult Patients with Idiopathic Inflammatory Myopathies

    Gözde Kübra Yardımcı1, Arzu Taghiyeva2, Enes Erul2, Bayram Farisogulları3, Levent Kilic1 and Sule Apraş Bilgen1, 1Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 2HACETTEPE UNIVERSITY, Ankara, Turkey, 3Division of Rheumatology, Department of Internal Medicine Faculty of Medicine, Hacettepe University, Ankara, Turkey

    Background/Purpose: Idiopathic inflammatory myopathies (IIMs) patients have a higher risk of venous thromboembolism (VTE) [1]. We aimed to assess the incidence of thrombosis and associated…
  • Abstract Number: 0008 • ACR Convergence 2021

    Jo-1-Binding and Clonally-Expanded Memory B Cells Express Germline and Somatically-Mutated B Cell Receptors in Anti-tRNA Synthetase Syndrome Patients

    Erin Wilfong, Alberto Cisneros, Jennifer Young-Glazer, Scott Smith, Leslie Crofford and Rachel Bonami, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Anti-tRNA synthetase syndrome (ARS) is a severe systemic autoimmune disease associated with myositis, interstitial lung disease, rash, and arthritis. ARS is associated with autoantibodies…
  • Abstract Number: 0699 • ACR Convergence 2021

    Clinical Characteristics of Idiopathic Inflammatory Myositis Manifesting with Myoglobinuria: A 15 Year Retrospective Review

    Lilian Vilar, William Moore and Ian Ward, Dwight D Eisenhower Army Medical Center, Fort Gordon

    Background/Purpose: The Idiopathic Inflammatory myopathies (IIM) are characterized by muscle damage and progressive weakness. Myoglobin is not typically released in high levels in IIM and…
  • Abstract Number: 0720 • ACR Convergence 2021

    The Clinical Significance of anti-PC4 and SFRS1 Interacting Protein 1 Antibody in Polymyositis and Dermatomyositis Patients

    Yuji Hosono1, Azusa Kojima1, Akira Ishii1, Yuto Izumi1, Kazuki Hirano1, Noriko Sasaki2, Chiho Yamada1 and Shinji Sato3, 1Tokai University School of Medicine, Isehara, Japan, 2tokai university, sagamihara-city, Japan, 3Tokai University, Isehara, Japan

    Background/Purpose: Many kinds of myositis specific autoantibodies are detected in sera from polymyositis (PM) and dermatomyositis (DM). Screening for autoantibodies is essential in the diagnostic…
  • Abstract Number: 0330 • ACR Convergence 2021

    Serologic Phenotypes Distinguish SLE Patients with Myositis And/or Interstitial Lung Disease (ILD)

    Thaisa Cotton1, Marvin Fritzler2, May Choi3, Boyang Zheng4, Omid Zahedi Niaki5, Louis-Pierre Grenier5, Evelyne Vinet6, Christian Pineau1, Luck Lukusa7, Fares Kalache5 and Sasha Bernatsky1, 1McGill University, Montréal, QC, Canada, 2University of Calgary, Calgary, AB, Canada, 3Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 4University of British Columbia, Vancouver, BC, Canada, 5McGill University Health Centre, Montréal, QC, Canada, 6McGill University Health Centre, Mont Royal, QC, Canada, 7Research Institute of the McGill University Health Centre, Montréal, QC, Canada

    Background/Purpose: To determine if a serologic phenotype can be identified in SLE patients with myositis and/or ILD.Methods: Adult SLE patients (without myositis or ILD at…
  • Abstract Number: 0700 • ACR Convergence 2021

    Clinical Outcomes in Idiopathic Inflammatory Myositis Within the Military Health System: A 15 Year Retrospective Review

    David Mecham1, William Moore1 and Ian Ward2, 1Dwight D Eisenhower Army Medical Center, Fort Gordon, 2United States Army, Evans, GA

    Background/Purpose: The Idiopathic Inflammatory Myopathies (IIM) are often difficult to treat, require chronic steroid therapy, and can remain active despite multiple treatment regimens. The objective…
  • Abstract Number: 0721 • ACR Convergence 2021

    Timed Function Tests as Measures of Disease Activity and Functional Outcome in Inflammatory Myositis

    saikumar dunga1, Chengappa Kavadichanda2 and VirSingh Negi3, 1Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India, 2JIPMER, Pondicherry, India, 3Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India

    Background/Purpose: Manual muscle testing (MMT) and Functional index 2(FI-2) are the usual methods in assessing disease activity and functional status in IIM1. Limitations of MMT8…
  • Abstract Number: 0441 • ACR Convergence 2021

    A Randomized, Double-blind, Placebo-controlled Study of Arimoclomol in Patients with Inclusion Body Myositis

    Pedro Machado1, Richard Barohn2, Michael McDermott3, Thomas Blaetter4, Tom Lloyd5, Aziz Shaibani6, Miriam Freimer7, Anthony Amato8, Emma Ciafaloni3, Sarah Jones9, Tahseen Mozaffar10, Summer Gibson11, Matthew Wicklund12, Todd Levine13, Claus Sundgreen4, Tim Carstensen4, Karen Bonefeld4, Anders Jørgensen4, Karina Phonekeo4, Andrew Heim14, Laura Herbelin14, Michael Hanna15 and Mazen Dimachkie14, 1Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, 2University of Missouri - Columbia, Columbia, MO, 3University of Rochester, Rochester, NY, 4Orphazyme A/S, Copenhagen, Denmark, 5Johns Hopkins University, Baltimore, MD, 6Nerve and Musle Center, Houston, TX, 7Ohio State University, Columbus, OH, 8Brigham and Women's Hospital, Boston, MA, 9University of Virginia, Charlottesville, VA, 10University of California Irvine, Irvine, CA, 11University of Utah, Salt Lake City, UT, 12University of Colorado, Denver, CO, 13Phoenix Neurological Associates, Phoenix, AZ, 14University of Kansas Medical Center, Kansas City, KS, 15University College London, London, United Kingdom

    Background/Purpose: Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy occurring in patients over the age of 45 years. Since immune suppression has…
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