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Abstracts tagged "Myositis"

  • Abstract Number: 0708 • ACR Convergence 2021

    Cardiovascular Risk in Myositis Patients Compared to General Population – Preliminary Data from a Single-centre Cross-sectional Study

    Sabina Oreska1, Hana Storkanova1, Maja Spiritovic2, Barbora Hermankova3, Petr Cesak4, Jaroslav Kudlicka5, Vladimir Tuka6, Ondrej Mikes5, Martin Satny5, Eva Chytilova5, Zdislava Krupickova5, Michal Vrablik5, Karel Pavelka1, Ladislav Senolt1, Herman Mann1, Jiri Vencovsky7 and Michal Tomcik1, 1Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, 3Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, 4Department of Human Movement Laboratory, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, 53rd Department of Internal Medicine, General University Hospital and 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 63rd Department of Internal Medicine, General University Hospital and 1st Faculty of Medicine, Charle, Prague, Czech Republic, 7Institute of Rheumatology, Prague, Czech Republic

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are associated with systemic inflammation, limited mobility, and glucocorticoid treatment, which can have a negative impact on metabolic disease, atherogenesis,…
  • Abstract Number: 1007 • ACR Convergence 2021

    Vascular Deposition of Oxidized LDL Is Increased in Children with Untreated Juvenile Dermatomyositis

    Jacob Spitznagle1, Akadia Kacha-Ochana2, Joan Cook-Mills3, Amer Khojah2, Gabrielle Morgan4 and Lauren Pachman5, 1Hospital for Special Surgery, New York, NY, 2Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 3Indiana University School of Medicine, Departments of Pediatrics and Microbiology & Immunology, Indianapolis, IN, 4Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, 5Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL

    Background/Purpose: Juvenile dermatomyositis (JDM) is a systemic vasculopathy associated with metabolic derangements and possible increased risk for premature atherosclerosis. Oxidation of low-density lipoprotein (LDL) in…
  • Abstract Number: 0683 • ACR Convergence 2021

    Predictors of Rapidly Progressive Interstitial Lung Disease and Mortality in Patients with Autoantibodies Against Melanoma Differentiation-Associated Protein 5 Dermatomyositis

    Jacqueline So1, Lai-Shan Tam2, Priscilla Wong1, Lydia Ho-Pui Tam1, Tsz On Lam1, Chi Chiu Mok3, Chi Hung To4, Yuen Kwan Chung4, Victor Tak Lung Wong5, Tsz Yuen Wu6, Roy Ho7, Wai Ling Li8, Chi Ho9 and Ho So10, 1Prince of Wales Hospital, Hong Kong, Hong Kong, 2Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China (People's Republic), 3Tuen Mun Hospital, Hong Kong, China, 4Pok Oi Hospital, Hong Kong, Hong Kong, 5Kwong Wah Hospital, Hong Kong, Hong Kong, 6Princess Margaret Hospital, Hong Kong, Hong Kong, 7Queen Elizabeth Hospital, Hong Kong, Hong Kong, 8Queen Mary Hospital, Hong Kong, Hong Kong, 9Alice Ho Miu Ling Nethersole Hospital, Hong Kong, Hong Kong, 10CUHK, Hong Kong, China

    Background/Purpose: Anti-melanoma differentiation-associated protein 5 (MDA5) positive dermatomyositis (DM) is associated with rapidly progressive interstitial lung disease (RP-ILD) and high mortality. This multi-centre retrospective study…
  • Abstract Number: 0709 • ACR Convergence 2021

    Lower HDL-associated Apolipoprotein A-I Levels Associate with Presence of Calcinosis in Adult Dermatomyositis

    Sangmee Bae1, Ani Shahbazian2, Jennifer Wang2 and Christina Charles-Schoeman2, 1University of California Los Angeles, Los Angeles, CA, 2Department of Medicine, University of California, Los Angeles, Los Angeles, CA

    Background/Purpose: Calcinosis is a sequelae of juvenile and adult dermatomyositis (DM) associated with significant morbidity and poor quality of life. It is hypothesized that inflammatory…
  • Abstract Number: 1022 • ACR Convergence 2021

    Incidence of Antisynthetase Syndrome and Risk of Malignancy in a Population-based Cohort (1998-2019)

    Caitrin Coffey1, Li Wang1, Stephanie Duong1, Cassondra Hulshizer1, Cynthia Crowson2, Jay Ryu1 and Floranne Ernste1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic, Eyota, MN

    Background/Purpose: The antisynthetase syndrome (ASSD) is a distinct subgroup of the idiopathic inflammatory myopathies characterized by myositis, interstitial lung disease, inflammatory arthritis, Raynaud’s phenomenon and…
  • Abstract Number: 0684 • ACR Convergence 2021

    Extended Report: Successful Treatment anti-MDA5 Antibody-positive Interstitial Lung Disease with Plasma Exchange Therapy

    Yoshiyuki Abe1, Masahiro Kogami2, Makio Kusaoi2, Kurisu Tada3, Ken yamaji4 and Naoto Tamura3, 1Juntendo University School of Medicine, Tokyo, Japan, 2Juntendo University, Tokyo, Japan, 3Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan, 4Juntendo University School of Medicine Internal Medicine and Rheumatology, Tokyo, Japan

    Background/Purpose: This study was extended report from our previous study that “Successful treatment of anti-MDA5 antibody-positive refractory interstitial lung disease with plasma exchange therapy” (Rheumatology…
  • Abstract Number: 0710 • ACR Convergence 2021

    Patients with Recent Onset, Active Polymyositis (PM), Dermatomyositis (DM) and Antisynthetase Syndrome (ASS) Have Reduced Muscle Endurance but Not Reduced Muscle Strength Compared to Patients with Established, Low-active Disease

    Kristofer Andreasson1 and Helene Alexanderson2, 1Karolinska Institute, Stockholm, Sweden, 2Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: To analyze for differences in quadriceps maximal isometric voluntary contraction (MVIC), muscle endurance (ME), muscle mass and fat mass (m. vastus lateralis, mid-thigh) in…
  • Abstract Number: 1025 • ACR Convergence 2021

    Survival of Patients with Idiopathic Inflammatory Myopathy in Slovenia

    Alojzija Hocevar1, Andrej Virscek2, Monika Krosel1, Matija Tomšič3 and Ziga Rotar3, 1UKC Ljubjana, Ljubjana, Slovenia, 2Statistical Office of the Republic of Slovenia, Ljubljana, Slovenia, 3Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of rare systemic diseases associated with significant morbidity and mortality. The aim of our study was to…
  • Abstract Number: 0686 • ACR Convergence 2021

    Is It Useful to Assess Muscle Involvement with Positron Emission Tomography in Patients with Idiopathic Inflammatory Myositis? A Case-Control Study

    Murat Bektaş1, Emine Göknur Işık2, Fatih Kemik3, Emin Oğuz4, Anna ABBASGHOLI ZADEH5, Burak Ince6, Zeynep Gözde Özkan7, Yasemin Yalcinkaya8, Bahar Esen8, Ahmet Gül9 and Murat İnanç4, 1Istanbul Faculty of Medicine, Istanbul, Turkey, 2Istanbul University, Istanbul Faculty of Medicine, Department of Nuclear Medicine, İstanbul, Turkey, 3Istanbul Faculty of Medicine, Istanbul University, Department of Internal Medicine, İstanbul, Turkey, 4Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İstanbul, Turkey, 5Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, İstanbul, Turkey, 6Istanbul Faculty of Medicine, Istanbul University, Division of Rheumatology, İstanbul, Turkey, 7Istanbul Faculty of Medicine, Department of Nuclear Medicine, Istanbul, Turkey, 8Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, 9Division of Rheumatology, Istanbul University Istanbul School of Medicine, Istanbul, Turkey

    Background/Purpose: Multiple diagnostic methods have been used to investigate muscle involvement in patients with idiopathic inflammatory myositis (IIM) such as electromyography (EMG) and muscle MRI.…
  • Abstract Number: 0711 • ACR Convergence 2021

    Suppression of HDL-associated Apolipoprotein A-I (apoA-I) Levels in Patients with Idiopathic Inflammatory Myopathies

    Sangmee Bae1, Ani Shahbazian2, Jennifer Wang2 and Christina Charles-Schoeman2, 1University of California Los Angeles, Los Angeles, CA, 2Department of Medicine, University of California, Los Angeles, Los Angeles, CA

    Background/Purpose: Patients with idiopathic inflammatory myopathies have accelerated vascular disease, which contributes to higher disease morbidity and mortality. Apolipoprotein A-I (apoA-I) is the major protein…
  • Abstract Number: 1090 • ACR Convergence 2021

    Contribution of Scleroderma/Myositis-Related Antibodies Detected by Immunoblot to the Diagnosis of Systemic Autoimmune Rheumatic Diseases in 134 Patients from a Single Referral Center

    Diana Prieto-Peña1, Belén Atienza-Mateo2, Miguel Ángel gonzalez-Gay3, Ricardo Blanco4 and Marcos Lopez-Hoyos5, 1Hospital Universitario Marqués de Valdecilla, santander, Spain, 2Group "Research in genetic epidemiology and atherosclerosis of systemic diseases and in bone metabolic diseases of the locomotor system", IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 3Research group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla; School of Medicine, Universidad de Cantabria, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, 4Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 5Marques de Valdecilla University Hospital-IDIVAL, Santander, Spain

    Background/Purpose: Immunoblot assays are increasingly used in clinical practice as part of the diagnostic armamentarium of systemic autoimmune rheumatic diseases (SARDs). Our aim was to…
  • Abstract Number: 0688 • ACR Convergence 2021

    Standardized Prevalence Ratios of Cancer in Idiopathic Inflammatory Myositis

    Christopher Mecoli1, Takeru Igusa2, Mengkun Chen3, XingYao Wang2, Jemima Albayda2, Julie Paik2, Eleni Tiniakou2, Brittany Adler2, Carrie Richardson4, William Kelly2, Sonye Danoff5, Andrew Mammen6, Elizabeth Platz3, Antony Rosen2, Lisa Christopher-Stine2, Livia Casciola-Rosen7 and Ami Shah8, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins University, Baltimore, MD, 3Johns Hopkins School of Public Health, Baltimore, MD, 4Rush University Medical Center, Chicago, IL, 5Johns Hopkins Medicine, Baltimore, MD, 6National Institutes of Health, Bethesda, MD, 7Johns Hopkins, Baltimore, MD, 8Johns Hopkins Rheumatology, Baltimore, MD

    Background/Purpose: Whether the likelihood of a cancer diagnosis in idiopathic inflammatory myopathy (IIM) patients differs by autoantibody type is not fully characterized. To inform cancer…
  • Abstract Number: 0712 • ACR Convergence 2021

    Immune Checkpoint Inhibitor-related Myotoxicity : Musculoskeletal and/or Neuromuscular Junction Disorder ?

    Hortense Chassepot1, Lotta Plomp2, Dimitri Psimaras3, Thierry Maisonobe3, Sarah Leonard Louis4, Isabelle Plu4, Mehdi Touat3, Celine Anquetil5, Nadege Wesner5, Nicolas Champtiaux5, Aude Rigolet5, Sophie Demeret3, Nicolas Weiss3, Baptiste Abbar6, Marie-Claire Bretagne7, Bruno Pinna7, Capucine Morelot8, Martin Dres8, Thomas Similowski8, Stephane Ederhy9, Joe-Elie Salem7, Olivier Benveniste5 and Yves Allenbach5, 1Universite de Picardie Jules Verne UPJV - Amiens Picardie Hospital, Department of Clinical Immunology and Internal Medicine, Fourqueux, France, 2Amsterdam University Medical Center (AUMC), Amsterdam, Netherlands, 3Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Neurology, Paris, France, 4Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Neuropathology, Paris, France, 5Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Clinical Immunology and Internal Medicine, Paris, France, 6Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Oncology, Paris, France, 7Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Pharmacology, Paris, France, 8Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Pneumology - R3S, Paris, France, 9Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Cardiology, Paris, France

    Background/Purpose: Immune checkpoint inhibitor (ICI)-related adverse events (irAE) recently emerged as new diseases in the field of auto-immunity. Among them, ICI-related myotoxicity has the highest…
  • Abstract Number: 1164 • ACR Convergence 2021

    A Survey of Treatment Satisfaction with Intravenous Immunoglobulin Among Patients with Inflammatory Myositis

    Alan Zhou, Nancy Maltez and Catherine Ivory, University of Ottawa, Ottawa, ON, Canada

    Background/Purpose: Intravenous Immunoglobulin (IVIg) is used to treat rheumatic conditions such as Inflammatory Myositis. Subcutaneous Immunoglobulin (SCIg) is an alternative route of administering Immunoglobulin. Studies…
  • Abstract Number: 0690 • ACR Convergence 2021

    Impact of Achieving 2016 ACR/EULAR Response Criteria on Patient Centered Outcome Measures in Myositis

    Didem Saygin1, Siamak Moghadam-Kia2, Chester Oddis2, Dana Ascherman2, Nicole Neiman2, Diane Koontz2 and Rohit Aggarwal2, 1University of Chicago, Chicago, IL, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: The 2016 ACR/EULAR Myositis Response Criteria represent a composite measure that is increasingly being used as a primary end point in myositis clinical trials.…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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