ACR Meeting Abstracts

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Abstracts tagged "Myopathies"

  • Abstract Number: 1965 • ACR Convergence 2024

    Artificial Intelligence Assisted Interpretation of Lung Ultrasound Imaging for the Detection of Interstitial Lung Disease

    Robert Fairchild1, Diane Mar2, Mariani Deluna3, Matthew Baker4, suzanne Tamang5, Henry Guo3, David Fiorentino4 and Lorinda Chung6, 1Stanford University, San Francisco, CA, 2VA Palo Alto / Stanford, Palo Alto, CA, 3Stanford University, Palo Alto, CA, 4Stanford University, Menlo Park, CA, 5Stanford University, Atherton, CA, 6Stanford University, Woodside, CA

    Background/Purpose: Interstitial lung disease (ILD) is a serious complication of SSc and inflammatory myopathy (IM), necessitating accurate and early detection for improved outcomes.  Lung ultrasound…
  • Abstract Number: 1140 • ACR Convergence 2024

    Pulmonary Hypertension in Hospitalized Patients with Dermatomyositis & Polymyositis: A Nationwide Cohort Analysis

    Saman Tanveer1, Daksh Ahluwalia1, Fatima Tanveer2, Abdullah Saeed3, Almurtada Razok4 and Faria Sami5, 1John H. Stroger Jr. Hospital of Cook County, Chicago, IL, 2CMH Lahore Medical and Dental College, Lahore, Pakistan, 3CMH Lahore Medical and Dental College, Lahore, Punjab, Pakistan, 4John H Stroger Jr Hospital of Cook County, Chicago, IL, 5University of Alabama, Chicago, IL

    Background/Purpose: Dermatomyositis (DM) and polymyositis (PM) are idiopathic inflammatory myopathies characterized by muscles inflammation, proximal muscle weakness and extramuscular manifestations. A particularly challenging extramuscular manifestation…
  • Abstract Number: 2052 • ACR Convergence 2024

    Role of Scleroderma/myositis-related Autoantibodies Detected by Immunoblot to the Diagnosis of Systemic Autoimmune Rheumatic Diseases in 410 Patients from a Single Referral Center

    Carmen Secada Gómez1, Diana Prieto-Peña2, Mónica Renuncio-García3, Juan Irure-Ventura4, Marcos Lopez-Hoyos5 and Ricardo Blanco-Alonso6, 1Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 2Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Cantabria, Spain, 3Division of Immunology, Hospital Universitario Marqués de Valdecilla, Immunopathology Group, IDIVAL, Santander, Spain, 4Division of Immunology, Hospital Universitario Marqués de Valdecilla. Immunopathology group, IDIVAL, Santander, Cantabria, Spain, 5Division of Immunology, Hospital Universitario Marqués de Valdecilla. Immunopathology group, IDIVAL, Santander, Spain, 6Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: In clinical practice, immunoblot assays are being used more frequently as a diagnostic tool for systemic autoimmune rheumatic diseases (SARDs).Our aim was to evaluate the…
  • Abstract Number: 1141 • ACR Convergence 2024

    Defining a Novel Type of Myositis: Immune Mediated Megaconial Myopathy (IMMM)

    Teerin Liewluck1, Ashley Santilli2, Oliver Ni3, Margherita Milone2, Duygu Selcen2, Anahit Mehrabyan4, Arjun Seth5, Christine Hsieh5, Wasim Raslan6, Moayd Alkhalifah6, Raed Alenezi6, Stefan Nicolau7 and Pannathat Soontrapa8, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic-Rochester, Rochester, MN, 3Hennepin Healthcare, Minneapolis, MN, 4University of North Carolina, Chapel Hill, NC, 5Northwestern University, Chicago, IL, 6Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia, 7Nationwide Children’s Hospital, Columbus, OH, 8Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Background/Purpose: To describe a novel type of myositis, immune mediated megaconial myopathy (IMMM),  pathologically characterized by giant mitochondria (megaconia).Methods: We reviewed the Mayo Clinic Muscle…
  • Abstract Number: 2058 • ACR Convergence 2024

    Association of Anti-Synthetase Antibody Subtypes with Radiographic Progression of Interstitial Lung Disease in Anti-Synthetase Syndrome: An Analysis of the CLASS Project Database

    Daphne Rivero Gallegos1, Francisca Bozan2, Sangmee Bae3, Giovanni Zanframundo4, Sara Faghihi-Kashani5, Iazsmin Bauer Ventura6, Eduardo Dourado7, Gianluca sambataro8, Akira Yoshida9, Tamera J Corte10, Francesco Bonella11, Tracy J Doyle12, david fiorentino13, Miguel Angel Gonzalez-Gay14, marie Hudson15, Masataka Kuwana16, Antonella Notarnicola17, Andrew Mammen18, Neil McHugh19, Frederick Miller20, Carlomaurizio Montecucco21, Chester Oddis22, Jorge Rojas-Serrano23, Jens Schmidt24, Carlo A. Scire25, Albert Selva-O’Callaghan26, Victoria Werth27, Rohit Aggarwal28 and Lorenzo Cavagna29, and CLASS project participating investigators, 1INER, Ciudad de México, Mexico State, Mexico, 2Hospital Clinico Universidad de Chile, Santiago, Chile, 3UCLA, Los Angeles, CA, 4Università di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Milano, Italy, 5Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, San Francisco, CA, 6University of Chicago, Chicago, IL, 7Unidade Local de Saúde da Região de Aveiro, Aveiro, Portugal, 8University of Catania, Catania, Italy, 9Nippon Medical School Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan, 10Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia, 11Center for interstitial and rare lung diseases, Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany, 12Brigham and Women's Hospital, West Roxbury, MA, 13Department of Dermatology, Stanford University School of Medicine, Stanford, CA, Palo Alto, CA, 14University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain, 15McGill University, Montreal, QC, Canada, 16Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan, Tokyo, Japan, 17Karolinska University Hospital and Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, 18NIH, Bethesda, MD, 19University of Bath, Bath, United Kingdom, 20NIH, NIEHS, Chapel Hill, NC, 21IRCCS policlinico S. Matteo foundation, University of Pavia, Pavia, Italy, 22Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 23National Institute of Respiratory Diseases, Ismael Cosío Villegas, Mexico City, Mexico, 24University Medical Center Goettingen, Göttingen, Germany, 25University of Milano Bicocca, Milan, Italy, 26Systemic Autoimmune Disease Unit, Vall d’Hebron Institute of Research, Barcelona, Spain, 27University of Pennsylvania, Wynnewood, PA, 28Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA, 29University of Pavia and Fondazione IRCCS Policlinico San Matteo Hospital of Pavia, Pavia, Pavia, Italy

    Background/Purpose: In anti-synthetase syndrome (ASSD), clinical presentations vary from isolated interstitial lung disease (ILD) to systemic multi-organ manifestations. Several studies emphasize the crucial role of…
  • Abstract Number: 1144 • ACR Convergence 2024

    Autoantibody and Radiological Profiles as Prognostic Indicators in Idiopathic Inflammatory Myopathies: Insights into Mortality and Interstitial Lung Disease Development

    cristiana sieiro santos1, Miriam Retuerto2, Laura Sierra2, Jose Ordas Martínez3, Paula Pérez García2, Pedro Baenas2, Clara Moriano Morales2 and Elvira Díez Álvarez4, 1Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, 2Complejo Asistencial Universitario de León, León, Spain, 3Complejo Asistencial Universitario de Leon, Leon, 4Complejo Asistencial Universitario de León, Leon, Spain

    Background/Purpose: The idiopathic inflammatory myopathies (IIMs) constitute a diverse group of acquired muscle disorders, often involving multiple organs such as the skin, heart, and lungs.…
  • Abstract Number: 2059 • ACR Convergence 2024

    The Rs35705950 Promoter Variant of Muc5b Is Associated with Usual Interstitial Pneumonia in Antisynthetase Syndrome

    Daphne Rivero Gallegos1, Mayra Mejía2, Karol J. Nava-Quiroz2, Heidegger N. Mateos-Toledo3, Héctor I. Rocha-González4, Juan C. Huerta-Cruz3, Espiridion Ramos-Martínez5, Gloria Pérez-Rubio3, Ingrid Fricke-Galindo3, Jorge Rojas-Serrano6 and Ramcés Falfán-Valencia3, 1INER, Ciudad de México, Mexico State, Mexico, 2INER, Mexico, Distrito Federal, Mexico, 3INER, Mexico City, Distrito Federal, Mexico, 4Instituto Politècnico Nacional, Mexico City, Distrito Federal, Mexico, 5UNAM, Ciudad de Mexico, Distrito Federal, Mexico, 6National Institute of Respiratory Diseases, Ismael Cosío Villegas, Mexico City, Mexico

    Background/Purpose: Rs35705950 variant in the MUC5B gene promoter is a critical genetic risk factor in idiopathic pulmonary fibrosis (IPF). It has been associated with usual…
  • Abstract Number: 1146 • ACR Convergence 2024

    Impact of COVID-19 on Myositis Testing Trends

    Angel Kevin Garza-Elizondo1, Rosa Icela Arvizu-Rivera2, Pablo Gamez-Siller3, Daniela Alejandra Salcedo-Soto4, Jesus Cardenas-de la Garza5, Gisela Garcia-Arellano6, Miguel Angel Villarreal-Alarcon2 and Dionicio Galarza-Delgado7, 1Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, San Nicolás de los Garza, Mexico, 2Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico, 3Facultad de Medicina UANL, Monterrey, Nuevo León, Mexico, 4Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, Mexico, 5Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, 6Hospital Universitario \"Dr. José Eleuterio González\", Monterrey, Nuevo León, Mexico, 7UANL Hospital Universitario, Monterrey, Nuevo León, Mexico

    Background/Purpose: Idiopathic inflammatory myopathies (IIM), also known as myositis, are a group of heterogeneous autoimmune disorders that lead to muscle injury. Autoantibodies help make the…
  • Abstract Number: 2066 • ACR Convergence 2024

    Comparative Diagnostic Efficacy of Quantitative Measurement of Echo Intensity and Texture versus Qualitative Analysis of Ultrasound Images in Myositis

    Takeshi Yoshida1, Hiroki Yamazaki2, Naoko Takamatsu2, Yoshinori Taniguchi3, Taiki Nozaki4, masataka inoue5, Yoshitaka Kumon6, yuki matsumoto2, Yuki Kanazawa2, Masafumi Harada2, Ichizo Nishino7, Jemima Albayda8 and Yuishin Izumi2, 1Chikamori Hospital, Kochi, Kochi, Japan, 2Tokushima University School of Medicine, Tokushima, Japan, 3Kochi University School of Medicine, kochi, Japan, 4keio University School of Medicine, Tokyo, Japan, 5Hyogo Medical University, Nishinomiya, Japan, 6Chikamori Hospital, Kochi, Japan, 7National Center of Neurology and Psychiatry, Tokyo, Japan, 8Johns Hopkins School of Medicine, Baltimore, MD

    Background/Purpose: Recently, the role of imaging tests such as magnetic resonance imaging and ultrasound (US) in the diagnosis and classification of myositis has become increasingly…
  • Abstract Number: 0295 • ACR Convergence 2023

    Pneumocystis Jirovecii Pneumonia in Patients with Inflammatory Myopathies

    Cody Bruggemeyer1, Sanket Shah2, Didem Saygin3 and Mike Putman4, 1Medical College of Wisconsin, Wauwatosa, WI, 2Medical College of Wisconsin, Milwaukee, WI, 3University of Pittsburgh, Pittsburgh, PA, 4Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI

    Background/Purpose: Pneumocystis Jirovecii Pneumonia (PJP) is an opportunistic fungal infection with high morbidity and mortality rates. Few studies to date have assessed the incidence of…
  • Abstract Number: 1771 • ACR Convergence 2023

    Role of Periostin in the Pathophysiology and Accurate Diagnosis of Interstitial Lung Disease Associated with Autoimmune Diseases

    Verónica Pulito-Cueto1, David Iturbe-Fernández2, Victor Mora-Cuesta2, Joao Carlos Batista-Liz1, Belén Atienza-Mateo3, María Sebastián-Mora1, Virginia Portilla1, Alfonso Corrales1, Miguel A Gonzalez-Gay4, Jose Cifrian5, Ricardo Blanco1 and Raquel López-Mejías1, 1Rheumatology Department, Immunopathology Group, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain, 2Immunopathology Group, Marqués de Valdecilla University Hospital-IDIVAL; Department of Pneumology, Marqués de Valdecilla University Hospital, Santander, Spain, 3Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 4IDIVAL and School of Medicine, UC, Santander; Department of Rheumatology, IIS-Fundación Jiménez Díaz, Madrid, Santander, Spain, 5Immunopathology Group, Marqués de Valdecilla University Hospital-IDIVAL; Department of Pneumology, Marqués de Valdecilla University Hospital; School of Medicine, Cantabria University, Santander, Spain

    Background/Purpose: Periostin is an extracellular matrix protein that contributes to the development and repair of lung tissue [1]. Previous works have described periostin as a…
  • Abstract Number: 2575 • ACR Convergence 2023

    Accurate Stratification of Cancer Risk in a Real-World Cohort Using the International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening

    Alexander Oldroyd1, Francisca Bozan1, Xia Lyu2, Patrick Gordon3, David Isenberg4, Neil McHugh5, Harsha Gunawardena6, Patrick Kiely7, Janine Lamb1, Pedro Machado8, James Miller9, Sarah Tansley5 and Hector Chinoy10, 1University of Manchester, Manchester, United Kingdom, 2Department of Rheumatology, Shanghai Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China, 3NHS, London, United Kingdom, 4University College London, London, United Kingdom, 5University of Bath, Bath, United Kingdom, 6North Bristol NHS Trust, Bristol, United Kingdom, 7St George’s University Hospitals NHS Foundation Trust, London, United Kingdom, 8Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, UK. Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS trust, London, UK., London, United Kingdom, 9Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom, 10The University of Manchester, Sale, United Kingdom

    Background/Purpose: Adult-onset idiopathic inflammatory myopathy (IIM) is associated with an increased cancer risk within three years prior to or following IIM onset. The International Guideline…
  • Abstract Number: 0296 • ACR Convergence 2023

    Does Presence of Anti-SSa and Ro52 Influence the Progression of Interstitial Lung Disease (ILD) in Idiopathic Inflammatory Myopathies (IIM)

    Sonali Narain1, Can Hu2, Michael Liu1, Kourosh Shargani3 and Galina Marder1, 1Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 2Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Fort Lee, NJ, 3Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY

    Background/Purpose: Anti-SSa and Ro52 are commonly present in IIM. We previously reported an association of a more severe early course of IIM-ILD with positive Ro52.…
  • Abstract Number: 1914 • ACR Convergence 2023

    Intravenous Immunoglobulins in the Treatment of Idiopathic Inflammatory Myopathies in a Region of Northern Spain: Analysis by Subtypes

    Cristina Corrales Selaya1, David Martínez-Lopez2, Diana Prieto-Peña1, Fabricio Benavides1, Jose Luis Martin-Varillas3 and Ricardo Blanco4, 1Hospital Universitario Marqués de Valdecilla, Santander, Spain, 2Hospital Sierrallana, Torrelavega, Spain, 3Hospital de Laredo, Laredo, Spain, 4Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of diseases characterised mainly by the presence of inflammation and muscle weakness. The main subtypes of…
  • Abstract Number: 2577 • ACR Convergence 2023

    Frequency of Atherosclerotic Cardiovascular Disease Following a Diagnosis of Idiopathic Inflammatory Myopathy: Data from a Large National Registry

    Astia Allenzara1, Carolina Alvarez2, Amanda Nelson3 and Galen Foulke4, 1University of North Carolina, Chapel Hill, NC, 2University of North Carolina at Chapel Hill, Miami, FL, 3University of North Carolina at Chapel Hill, Chapel Hill, NC, 4Penn State MS Hershey Medical Center, Hershey, PA

    Background/Purpose: Idiopathic inflammatory myopathies confer an increased risk of morbidity from cardiovascular disease. Prior work has noted more than double risk of cardiovascular events for…
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