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Abstracts tagged "Myopathies"

  • Abstract Number: LB14 • ACR Convergence 2025

    Promising Early Outcomes With BMS-986353, a CD19-directed Chimeric Antigen Receptor T Cell Therapy in Severe Refractory Idiopathic Inflammatory Myopathies: Safety and Efficacy Findings From the Ongoing Phase 1 Trial

    Rohit Aggarwal1, David Korman2, Margrit Wiesendanger3, Vikas Majithia4, Ellen De Langhe5, Marc Schmalzing6, Melissa Griffith7, Philipp Koehler8, Joanna Schiller8, Dimitrios Mougiakakos9, Mohamad Cherry10, Richard Nash11, Jacques Azzi12, Ernesto Ayala4, Peter Vandenberghe5, Max Topp6, Jonathan Gutman7, Eugen Feist13, Alisha Desai14, Alexis Melton14, Alice Wozniak14, San-San Ou14, Melissa Harnois14, Jerill Thorpe14, Praneeth Jarugula14, Takafumi Ide14, Ashley Koegel14 and Neil Kramer15, 1University of Pittsburgh, Pittsburgh, Pennsylvania, 2Mountain Rheumatology, HCA HealthONE, Denver, Colorado, 3Icahn School of Medicine at Mount Sinai, New York, New York, 4Mayo Clinic Hospital, Jacksonville, Florida, 5University Hospitals Leuven, Leuven, Belgium, 6University Hospital Würzburg, Würzburg, Germany, 7University of Colorado Anschutz Medical Campus, Aurora, Colorado, 8University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Division of Clinical Immunology and Center for Integrated Oncology (CIO) Aachen Bonn Cologne Duesseldorf, Cologne, Germany, 9University Hospital Magdeburg, Magdeburg, Germany, 10Atlantic Health System, Morristown, New Jersey, 11HealthOne Cares and Colorado Blood Cancer Institute, Denver, Colorado, 12Icahn School of Medicine at Mount Sinai Hospital, New York, New York, 13Helios Vogelsang-Gommern Specialist Clinic, Gommern, Germany, 14Bristol Myers Squibb, Princeton, New Jersey, 15Overlook Medical Center and Atlantic Medical Group, Atlantic Health System, Morristown, New Jersey

    Background/Purpose: Idiopathic inflammatory myopathies (IIMs) are systemic autoimmune diseases affecting muscles, skin, lungs, joints, and several other organs; many patients are refractory to available therapy,…
  • Abstract Number: 2071 • ACR Convergence 2025

    Impact of Diagnostic Delay on Disease Activity and Cumulative Damage in Patients with Idiopathic Inflammatory Myopathies in a Third-level Hospital in Mexico

    valeria cantu1, Rebeca L. Polina-Lugo1, Emmanuel Dominguez-Chapa2, Ana Cecilia Bardan Inchaustegui3, Fernanda M. Garcia-Carrillo4, Daniela A. Mejia-Rodriguez4, Ericka S. Reyna-Hernandez4, Rosa Arvizu-Rivera5, Jesus Alberto Cardenas-de la Garza6 and Miguel Villarreal-Alarcón7, 1Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, 2Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, 3Universidad Autónoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, 4Rheumatology Service, Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico, 5Hospital Universitario "Dr. José Eleuterio Gonzalez", Escobedo, Nuevo León, Mexico, 6Rheumatology Service, University Hospital “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, México, Monterrey, Mexico, 7Hospital Universitario UANL, Monterrey, Nuevo León, Mexico

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a rare and heterogeneous group of autoimmune diseases marked by inflammation of muscle tissue and extramuscular manifestations. Their atypical…
  • Abstract Number: 1201 • ACR Convergence 2025

    Prognostic Significance of 1-Year Pulmonary Function Changes in Myositis-Associated Interstitial Lung Disease

    Shiri Keret1, Silvia Martinez Laverde2, Irada Choudhuri2, Raisa Lomanto Silva3, Eugenia Gkiaouraki2, Tanya Chandra2, Nantakarn Pongtarakulpanit4, Shreya Sriram2, Niladri Bhowmick2, Vaidehi Kothari2, Kaushik Sreerama Reddy2, Eaman Alhassan5, Anushka Aggarwal6, Maha Almackenzie7, Daniel Sullivan2, Sara Faghihi-Kashani8, Koichi Yamaguchi2, Daniel Kass2, Kevin Gibson2, Dana Ascherman9, Siamak Moghadam-Kia5, Chester V. Oddis9 and Rohit Aggarwal10, 1Bnai Zion Medical Center, Atlit, Israel, 2University of Pittsburgh Medical Center, Pittsburgh, 3Massachusetts General Hospital, Boston, MA, 4Mahidol University, University of Pittsburgh, Bangkok, Thailand, 5University of Pittsburgh Medical Center, Pittsburgh, PA, 6Indraprastha Apollo Hospital, New Delhi, India, 7Medical Cities of the Ministry of the Interior, Riyadh, Saudi Arabia, 8UCSF, Mountain View, CA, 9University of Pittsburgh, Pittsburgh, PA, 10University of Pittsburgh, Rheumatology and Clinical Immunology, Pittsburgh, United States of America, Pittsburgh, PA

    Background/Purpose: Lung involvement is the most frequent and severe extramuscular complication of Idiopathic Inflammatory Myopathy (IIM). The utility of pulmonary function test (PFT) monitoring for…
  • Abstract Number: 0281 • ACR Convergence 2025

    Anti-IL-6 Autoantibodies and IL-6 Signalling in Idiopathic Inflammatory Myopathies

    Anja Srpcic1, Manca Ogric1, Sasa Cucnik1, Sergej Pirkmajer2, Katja Lakota1 and Katja Perdan Pirkmajer1, 1University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of systemic autoinflammatory diseases that affect muscle tissue, often leading to muscle atrophy, weakness and myalgia.…
  • Abstract Number: 2068 • ACR Convergence 2025

    Comparing characteristics, diagnostics, and treatment in people with different idiopathic inflammatory myopathies using a large representative cohort

    Michael George1, Thomas Riley1, Ellen Romich2, Emily Holladay3, Tim Beukelman4, Shanette Daigle5, Amy Mudano5, Fenglong Xie6, Xiang Guo7, Nicole Kulisek8, Arne Yndestad9, Ashraf Chaudhary8 and Jeffrey Curtis10, 1University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Media, PA, 3University of Alabama at Birmingham, Birmingham, AL, 4Foundation for Advancing Science Technology Education and Research, Hoover, AL, 5Foundation for Advancing Science, Technology, Education and Research (FASTER), Hoover, AL, 6The University of Alabama at Birmingham, Birmingham, AL, 7Pfizer, Inc, New York, NY, 8Pfizer, Inc, Collegeville, PA, 9Pfizer Inc, Oslo, Norway, Oslo, Norway, 10Foundation for Advancing Science, Technology, Education and Research, Birmingham, AL

    Background/Purpose: Studies of idiopathic inflammatory myopathies (IIM) are often based on the analysis of single cohorts at academic centers. We aimed to identify potential gaps…
  • Abstract Number: 1199 • ACR Convergence 2025

    Interstitial Lung Disease in Systemic Autoimmune Rheumatic Diseases (SARDs): Radiologic and Histologic Correlations

    Darya S. Jalaledin1, Aidan pye2, Angela Chang2, Navid Saleh2, Saud AlHajeri3, Beatrice Daviault4, Arusa Shah5, Sabrina Hoa6, Océane Landon-Cardinal7, Alec Yu2, Robert Levy8, Jennifer Wilson9, Charles Poirier4, James Choi2, John Yee2, Hyein Kim2 and Kun Huang10, 1Université de Montréal, Saint-Lambert, QC, Canada, 2University of British Columbia, VANCOUVER, BC, Canada, 3University of British Columbia, Vancouver, Canada, 4University of Montreal, Montreal, QC, Canada, 5University of Montreal, Montreal, BC, Canada, 6University of Montreal, Brossard, QC, Canada, 7Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, 8University of British Columbia, Deerfield, IL, 9UBC, Vancouver, BC, Canada, 10University of British Columbia, Vancouver, Surrey, BC, Canada

    Background/Purpose: Systemic autoimmune rheumatic diseases (SARDs) are a major cause of interstitial lung disease (ILD), with high prevalence in inflammatory idiopathic myopathy (IIM), systemic sclerosis…
  • Abstract Number: 2067 • ACR Convergence 2025

    Patterns of Comorbidity in Idiopathic Inflammatory Myopathies: A Cross-sectional Analysis of Disease Burden and Risk Factors

    Ilke Coskun Benlidayi1, Meghna Lama2, Oladipo Kunle Afolayan2, Meera Shah3, Manali Sarkar4, Tamar Rubinstein5, Aleksandra Opinc-Rosiak6, Rada Miskovic7, Marcin Milchert8, Dimitri Luz Felipe da Silva9, Samuel Katsuyuki Shinjo10, Elena Nikiphorou11, Ioannis Parodis12, Vincenzo Venerito13, Vikas Agarwal14 and Latika Gupta15, 1Cukurova University, Adana, Turkey, 2The University of Texas Health Science Centre at Houston School of Public Health: Houston, Texas, Houston, 3Indraprastha Apollo Hospital, New Delhi, Mumbai, Maharashtra, India, 4Sir H. N. Reliance Foundation Hospital and Research Centre, Mumbai, Maharashtra, India., Mumbai, Maharashtra, India, 5Albert Einstein College of Medicine, White Plains, NY, 6Medical University of Lodz, Zeromskiego 113, 90-549 Lodz, Poland., Lodz, Poland, 7University of Belgrade; Clinic of Allergy and Immunology, University Clinical Centre of Serbia, Belgrade, Serbia, 8Pomeranian Medical University in Szczecin, Szczecin, Poland, 9University Santo Amaro, São Paulo, Brazil, Sao Paulo, Brazil, 10Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, Brazil, 11King's College London, London, United Kingdom, 12Karolinska Institutet and Karolinska University Hospital, Department of Medicine Solna, Division of Rheumatology, Stockholm, Sweden, 13Univeristy of Bari "Aldo Moro", Italy, Bari, Bari, Italy, 14Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, 15School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham; Royal Wolverhampton NHS Trust; Centre for Musculoskeletal Research, School of Biological Sciences, The University of Manchester, Manchester; Francis Crick Institute, London, Birmingham, UK, United Kingdom

    Background/Purpose: Comorbidities contribute to the disease burden in idiopathic inflammatory myopathies (IIMs). Understanding their distribution and predictors across IIM subtypes can guide tailored strategies. This…
  • Abstract Number: 1196 • ACR Convergence 2025

    Prevalence of and Factors Associated with Chronic Opioid Use among Individuals with Inflammatory Myopathies

    Anuya Natu1, Haley Zimmerman2, Kristin Wipfler3, Kaleb Michaud4, Yvonne Lee5 and Didem Saygin2, 1John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, 2Rush University Medical Center, Chicago, IL, 3FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, 4University of Nebraska Medical Center, Omaha, NE, 5Northwestern University, Chicago, IL

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) can be associated with significant pain and functional impairment. While the use of opioids has been documented in other inflammatory…
  • Abstract Number: 2066 • ACR Convergence 2025

    Psychosocial Factors Strongly Influence Subjective Well-being in Patients with Idiopathic Inflammatory Myopathies

    Meera Shah1, Emilia Naseva2, Tsvetelina Velikova3, Tamar Rubinstein4, Manali Sarkar5, Lavanya Mangla6, Oliver Distler7, Ingrid de Groot8, Lisa Christ9, Carlo Vinicio Caballero Uribe10, Ai Lyn Tan11, Abraham Edgar Gracia Ramos12, Vincenzo Venerito13, Vikas Agarwal14 and Latika Gupta15, 1Indraprastha Apollo Hospital, New Delhi, Mumbai, Maharashtra, India, 2Faculty of Public Health, Medical University of Sofia, 15 Acad. Ivan Evstratiev Geshov, 1606 Sofia; Medical Faculty, Sofia University St. Kliment Ohridski, Sofia, Bulgaria, 3Medical Faculty, Sofia University St. Kliment Ohridski, Sofia, Bulgaria, 4Albert Einstein College of Medicine, White Plains, NY, 5Sir H. N. Reliance Foundation Hospital and Research Centre, Mumbai, Maharashtra, India., Mumbai, Maharashtra, India, 6Maulana Azad Medical College, 2-Bahadurshah Zafar Marg, New Delhi, New Delhi, India, 7Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland, Zurich, Switzerland, 8The Myositis Association, Rotterdam, Netherlands, 9Department of Rheumatology and Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Bern, Switzerland, 10Department of Medicine, Hospital Universidad del Norte, Barranquilla, Atlantico, Colombi, Barranquilla, Colombia, 11NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, England, United Kingdom, 12Department of Internal Medicine, General Hospital, National Medical Center “La Raza”, Instituto Mexicano del Seguro Social, Av. Jacaranda S/N, Col. La Raza, Del. Azcapotzalco, C.P. 02990 Mexico City, Mexico., Mexico City, Mexico, 13Univeristy of Bari "Aldo Moro", Italy, Bari, Bari, Italy, 14Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, 15School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham; Royal Wolverhampton NHS Trust; Centre for Musculoskeletal Research, School of Biological Sciences, The University of Manchester, Manchester; Francis Crick Institute, London, Birmingham, UK, United Kingdom

    Background/Purpose: Traditional clinical measures are well established in idiopathic inflammatory myopathies (IIM), yet exploration of subjective well-being (SWB) remains limited. SWB assessment facilitates holistic patient…
  • Abstract Number: 1193 • ACR Convergence 2025

    Lung Transplant Outcomes in Patients with Myositis- and Systemic Sclerosis-Associated Interstitial Lung Disease Compared to Idiopathic Pulmonary Fibrosis: A Multicentric Retrospective Analysis

    Angela Chang1, Navid Saleh1, Alec Yu1, Darya S. Jalaledin2, Sabrina Hoa3, Robert Levy4, Jennifer Wilson5, Charles Poirier6, John Yee1, James Choi1, Océane Landon-Cardinal7, Hyein Kim8 and Kun Huang9, 1University of British Columbia, Vancouver, BC, Canada, 2Université de Montréal, Saint-Lambert, QC, Canada, 3University of Montreal, Brossard, QC, Canada, 4University of British Columbia, Deerfield, IL, 5UBC, Vancouver, BC, Canada, 6University of Montreal, Montreal, QC, Canada, 7Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, 8The University of British Columbia, Vancouver, BC, Canada, 9University of British Columbia, Vancouver, Surrey, BC, Canada

    Background/Purpose: Interstitial lung disease (ILD) is a frequent complication of idiopathic inflammatory myositis (IIM) and systemic sclerosis (SSc), ranging from subclinical ILD to rapidly progressive…
  • Abstract Number: 2064 • ACR Convergence 2025

    Kinematics Underlying IBM-induced Dysphagia

    Kevin Renz Ambrocio1, Vaidehi Kothari1, Rohit Aggarwal2, Anna Miles3, James L. Coyle1, Eaman Alhassan4, Sandra Stinnett1, David Lacomis1, Lea Sayce1 and Kendrea (Focht) Garand1, 1University of Pittsburgh, Pittsburgh, PA, 2University of Pittsburgh, Rheumatology and Clinical Immunology, Pittsburgh, United States of America, Pittsburgh, PA, 3The University of Auckland, Auckland, New Zealand, 4University of Pittsburgh Medical Center, Pittsburgh, PA

    Background/Purpose: Dysphagia remains a key contributor to mortality in IBM due to its connection with aspiration pneumonia and malnutrition (Shelly et al., 2021). Compared to…
  • Abstract Number: 1192 • ACR Convergence 2025

    Idiopathic Inflammatory Myopathies: A Prospective Phase 4 Controlled Trial Of Recombinant Herpes Zoster Vaccine

    Sandra G Pasoto1, Thais B Gorayeb2, Ana Paula Luppino-Assad3, Nadia E Aikawa4, Ana C Medeiros-Ribeiro1, Leonard V Kupa5, Bruno S Borges6, Samuel K Shinjo7, Fernando H De Souza2, Renata Miossi2, Eloisa Bonfa8 and Clovis Artur Silva9, 1Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, Brazil, 2Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, 3Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SAO PAULO, Brazil, 4Pediatric Rheumatology Unit, Instituto da Criança e do Adolescente, Hospital das Clinicas HCFMUSP, Sao Paulo, Brazil., Sao Paulo, Sao Paulo, Brazil, 5Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, Sao Paulo, Brazil, 6Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, 7Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SÃO PAULO, Brazil, 8Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, São Paulo, Brazil, 9University of São Paulo, São Paulo, São Paulo, Brazil

    Background/Purpose: Although herpes zoster vaccination has been evaluated in immunocompromised populations, studies assessing vaccine immunogenicity and safety in idiopathic inflammatory myopathies (IIM) are restricted to…
  • Abstract Number: 2060 • ACR Convergence 2025

    Treatment Patterns And Drug Use In Idiopathic Inflammatory Myopathies. Description Of The First Year After Diagnosis In A Swedish Myositis Cohort.

    Irene Peralta-García1, Naz Haque2, Dag Leonard3, Anna Glasin4, Silva Puksic5, Balsam Hanna6, My Axelhed7, Theodoros Lappas5, Farbicio Espinosa Ortega1, Karin Lodin1, NIls Eckerdal2, Helene Alexanderson8, Elizabeth Hsia9, Federico Zazzetti10, Ingrid Lundberg11 and Marie Holmqvist1, 1Karolinska Institutet, Clinical Epidemiology Division, Department of Medicine Solna. Karolinska University Hospital, Medical Unit of Gastroenterology, Dermatology, Rheumatology. Theme Inflammation and Ageing, Stockholm, Sweden, 2Karolinska Institutet, Clinical Epidemiology Division, Department of Medicine Solna, Stockholm, Sweden, 3Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 4Rheumatology Department, Linköping Hospital, LInköping, Sweden, 5Rheumatology Department, Örebro University Hospital, Örebro, Sweden, 6Rheumatology Department, Sahlgrenska University Hospital, Gothenburg, Sweden, 7Rheumatology Department, Västmanlands Hospital, Västerås, Sweden, 8Karolinska University Hospital, Stockholm, Sweden, 9Johnson & Johnson, Spring House, PA, 10Johnson & Johnson, Horsham, PA, USA, Ambler, PA, 11Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Due to the rarity and heterogeneity of idiopathic inflammatory myopathies (IIM), we lack robust randomized trials to guide treatment decisions. Most of current practice…
  • Abstract Number: 1037 • ACR Convergence 2025

    Risk Factor Identification and Dynamic Individualized Prediction of Muscle Involvement in Systemic Sclerosis

    Zixing Liu1, Adrianne Woods2, Julie Paik2, Laura Hummers2, Scott Zeger1, Ami Shah2 and Ji Soo Kim3, 1Johns Hopkins Biostatistics, Baltimore, MD, 2Johns Hopkins Rheumatology, Baltimore, MD, 3Johns Hopkins, Baltimore, MD

    Background/Purpose: Myopathy in SSc significantly increases disability, reduces quality of life, and elevates mortality risk, yet remains understudied. Most identified risk factors derive from cross-sectional…
  • Abstract Number: 2058 • ACR Convergence 2025

    Organ-specific disease activity and serological patterns in idiopathic inflammatory myopathies: A descriptive study in a Hispanic cohort

    valeria cantu1, Emmanuel Dominguez-Chapa2, Rebeca L. Polina-Lugo1, Ana Cecilia Bardan Inchaustegui3, fernanda m. garcia-Carrillo4, Ericka S. Reyna-Hernandez5, Daniela A. Mejia-Rodriguez5, Rosa Arvizu-Rivera6, Jesus Alberto Cardenas-de la Garza7, Miguel Villarreal-Alarcón8 and Dionicio A. Galarza-Delgado9, 1Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, 2Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, 3Universidad Autónoma de Nuevo Leon, Monterrey, Nuevo León, Mexico, 4Hospital Universitario "Dr. José Eleuterio González" UANL, Monterrey, Nuevo Leon, Mexico, 5Rheumatology Service, Hospital Universitario “Dr. Jose Eleuterio Gonzalez”, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico, 6Hospital Universitario "Dr. José Eleuterio Gonzalez", Escobedo, Nuevo León, Mexico, 7Rheumatology Service, University Hospital “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, México, Monterrey, Mexico, 8Hospital Universitario UANL, Monterrey, Nuevo León, Mexico, 9Rheumatology Service, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are rare diseases that involve chronic muscle inflammation, weakness, and pain. Autoantibodies in IIM play a central role in disease…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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