ACR Meeting Abstracts

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Abstracts tagged "MRI"

  • Abstract Number: 950 • 2015 ACR/ARHP Annual Meeting

    In a Two-Year Double-Blind Randomized Controlled Multicenter Study, Chondroitin Sulfate Was Significantly Superior to Celecoxib at Reducing Cartilage Loss with Similar Efficacy at Reducing Disease Symptoms in Knee Osteoarthritis Patients

    Jean-Pierre Pelletier1, Jean Pierre Raynauld2, André Beaulieu3, Louis Bessette4, Frédéric Morin5, Artur J Fernandes6, François Abram7, Marc Dorais8 and Johanne Martel-Pelletier9, 1Rheumatology, Institut de recherche en rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 2Osteoarthritis Research Unit, CRCHUM, Montreal, Montreal, QC, Canada, 3Centre de rhumatologie St-Louis, St. Louis, QC, Canada, 4Groupe de Recherche en Rhumatologie et Maladies Osseuses, Quebec, Quebec, QC, Canada, 5Centre de Recherche Musculo-squelettique, Trois-Rivières, Trois-Rivières, QC, Canada, 6Centre de Recherche Musculo-squelettique, Trois-Rivières, 6Rheumatology Division, Sherbrooke, Sherbrooke, QC, Canada, 7Medical Imaging Research & Development, ArthroLab Inc, Montreal, QC, Canada, 8StatSciences Inc., Montreal, Canada, Montreal, QC, Canada, 9Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM),, Montreal, QC, Canada

    Background/Purpose: In osteoarthritis (OA) treatment, although chondroitin sulfate (CS) was found in a number of studies using radiography to have a structure modifying effect, to…
  • Abstract Number: 1728 • 2015 ACR/ARHP Annual Meeting

    Diffusion Weighted Imaging Is a Sensitive and Specific MRI Protocol for the Diagnosis and Assessment of Disease Severity in Ankylosing Spondylitis

    Linda A. Bradbury1, Kelly A. Hollis2, Benoit Gautier2, Sateesh Shankaranarayana3, Philip Robinson4, Nivene Saad3, Kim-Anh Lê Cao2 and Matthew A. Brown1, 1The University of Queensland Diamantina Institute, Brisbane, Australia, 2University of Queensland Diamantina Institute, Brisbane, Australia, 3Princess Alexandra Hospital, Brisbane, Australia, 4Human Genetics Group, University of Queensland Diamantina Insititute, Brisbane, Australia

    Background/Purpose: Diffusion weighted imaging (DWI) is an MRI protocol which assesses the random Brownian motion of water molecules in the tissue imaged; this motion is…
  • Abstract Number: 1006 • 2015 ACR/ARHP Annual Meeting

    Incident Frequent Knee Pain Is Associated with Changes in Semi-Quantitative Imaging Biomarkers of Inflammation

    C.Kent Kwoh1, Michael J. Hannon2, Tomoko Fujii3, Frank W Roemer4, Ali Guermazi5, David Hunter6, Felix Eckstein7 and Robert M. Boudreau8, 1Department of Medicine, The University of Arizona Arthritis Center and Division of Rheumatology, Tucson, AZ, 2Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 3University of Pittsburgh, Pittsburgh, PA, 4Department of Radiology, Boston University School of Medicine, Boston, MA, 5Boston University School of Medicine, Boston, MA, 6Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, 7Paracelsus Med Univ, Chondrometrics GmbH, Salzburg, Austria, 8Epidemiology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: The cause of knee pain in osteoarthritis (OA) is multi-factorial, and there is increasing evidence of the role of inflammation in OA. The goal…
  • Abstract Number: 1729 • 2015 ACR/ARHP Annual Meeting

    Predictors and Clinical Factors Associated with Change in Spinal Inflammation Assessed on MRI over 2 Years: Data from Tasmanian Ankylosing Spondylitis Study

    Hussain Ijaz Khan1, Louisa Chou2, Patricia Lewis3, Anitra Wilson3, Janet Millner4 and Jane Zochling3, 1Musculoskeletal Unit, Menzies Institute of Medical Research, Hobart, Australia, 2Menzies Institute of Medical Research, University of Tasmania, Hobart, 7000, Australia, 3Menzies Institute of Medical Research, Hobart, Australia, 4Physiotherapy, Royal Hobart Hospital, Hobart, Australia

    Background/Purpose: Ankylosing Spondylitis (AS) is debilitating disease affecting the axial skeleton which is often  difficult to diagnose in early stages. Magnetic Resonance Imaging (MRI) is…
  • Abstract Number: 1007 • 2015 ACR/ARHP Annual Meeting

    Change in Semi-Quantitative Imaging Biomarkers Predicts Knee Osteoarthritis Progression: Data from the Fnih OA Biomarkers Consortium

    Jamie E. Collins1, Elena Losina2, Michael C. Nevitt3, Frank W. Roemer4, Ali Guermazi4, John A. Lynch5, Jeffrey N. Katz2, C. Kent Kwoh6, Joanne M. Jordan7, Virginia Kraus8 and David Hunter9, 1Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3University of California, San Francisco, San Francisco, CA, 4Boston University School of Medicine, Boston, MA, 5University of California San Francisco, San Francisco, CA, 6University of Arizona, Tucson, AZ, 7Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, 8Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 9University of Sydney, Sydney, Australia

    Background/Purpose: Semi-quantitative scoring of magnetic resonance images (MRIs) is a valuable method for performing multi-feature assessment of the knee joint. The goal of this study…
  • Abstract Number: 1735 • 2015 ACR/ARHP Annual Meeting

    Imaging and Clinical Factors Associated with Subchondral Sacroiliac Fatty Marrow in Axial Spondyloarthritis

    Kavi Devulapalli1, Xenofon Baraliakos2, Daria Motamedi1 and Lianne S. Gensler3, 1Radiology, UCSF, SAN FRANCISCO, CA, 2Rheumazentrum Ruhrgebiet, Herne, Germany, 3Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA

     Background/Purpose: Magnetic resonance imaging (MR) plays an important role in the evaluation of inflammatory and structural changes in axial spondyloarthritis (axSpA) patients. Prior research suggests…
  • Abstract Number: 1011 • 2015 ACR/ARHP Annual Meeting

    Impact of a Musculoskeletal “Mini-Residency” Continuing Professional Education Program on Knee MRI Orders By Primary Care Providers

    Matthew Call1,2, Andrea M. Barker3, Grant W. Cannon4, Phillip Lawrence5 and Michael J. Battistone6, 1Rheumatology, University of Utah, Salt Lake City, UT, 2Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 3General Internal Medicine, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 4Division of Rheumatology, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 5Pharmacology, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 6Rheumatology, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT

    Background/Purpose: The US Department of Veterans Affairs (VA) has developed a national continuing professional development program to train primary care providers (PCPs) in the evaluation…
  • Abstract Number: 1810 • 2015 ACR/ARHP Annual Meeting

    A Five-Year Follow-up of Microvascular Dysfunction and Coronary Artery Disease in SLE: Results from a Community-Based Lupus Cohort

    Vaneet K. Sandhu1, Mariko L. Ishimori1, Janet Wei2, Louise Thomson2, Daniel Berman2, Jay Schapira2, Noel Bairey Merz2, Daniel Wallace3 and Michael Weisman3, 1Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 2Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, 3Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: To investigate serial changes in the prevalence of coronary microvascular dysfunction and coronary artery disease (CAD) by cardiac imaging in a cohort of SLE…
  • Abstract Number: 1304 • 2015 ACR/ARHP Annual Meeting

    Studying MR-Detected Inflammation in Symptom-Free Persons from the General Population to Generate Ramris-Based Reference Values

    L. Mangnus1, H.W. van Steenbergen2, M. Reijnierse3 and A.H.M. van der Helm- van Mil1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Radiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: It is recommended by an EULAR imaging taskforce that MR-detected inflammation is useful in the diagnostic process of Rheumatoid Arthritis. This recommendation is based…
  • Abstract Number: 1817 • 2015 ACR/ARHP Annual Meeting

    Myocardial Tissue Characterization with Native Myocardial T1 Mapping in SLE Patients with Chest Pain

    Jaime Shaw1, Mariko L. Ishimori2, Vaneet K. Sandhu2, Behzad Sharif3, Louise Thomson4, Debiao Li1, Jay Schapira4, Daniel Wallace3, Noel Bairey Merz4, Michael Weisman3 and Daniel Berman4, 1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 2Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 3Cedars-Sinai Medical Center, Los Angeles, CA, 4Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: SLE patients often exhibit signs and symptoms of cardiac ischemia with an overall increased prevalence of coronary artery disease (CAD), microvascular dysfunction and myocarditis…
  • Abstract Number: 1305 • 2015 ACR/ARHP Annual Meeting

    Prevalence of MR-Detected Ramris-Defined Erosions in the General Population

    L. Mangnus1, H.W. van Steenbergen2, M. Reijnierse3 and A.H.M. van der Helm- van Mil1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Radiology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The diagnostic value of Magnetic Resonance (MR) imaging for Rheumatoid Arthritis (RA) is undetermined. The main value of MR is its sensitive depiction of…
  • Abstract Number: 2024 • 2015 ACR/ARHP Annual Meeting

    Replacing Radiographic Sacroiliitis By Structural Lesions on MRI of the Sacroiliac Joints in Two Early Axial Spa Cohorts: What Is the Impact on the Classification of Patients According to the ASAS Axial Spa Criteria?

    Pauline Bakker1, Rosaline van den Berg2, Manouk de Hooge3, Zineb Ez-Zaitouni4, Miranda van Lunteren4, Karen M. Fagerli5, Roberta Ramonda6, Robert B. M. Landewé7, Maikel van Oosterhout8, Monique Reijnierse9, Floris van Gaalen1, Pascal Claudepierre10, Daniel Wendling11, Maxime Dougados12 and Désirée van der Heijde13, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, 4Leiden University Medical Centre, Leiden, Netherlands, 5Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 6Cattedra, Voc Rheumatology, University of Padua, Padova, Italy, 7Rheumatology, University Hospital Maastricht, Maastricht, Netherlands, 8Rheumatology, GHZ Hospital, Gouda, Netherlands, 9Radiology, Leiden University Medical Center, Leiden, Netherlands, 10Hôpital Henri Mondor, Créteil, France, 11Université de Franche-Comté, Besançon, France, 12Paris-Descartes University, Paris, France, 13Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands, Leiden, Netherlands

    Background/Purpose: Conventional radiography of the sacroiliac joints (X-SI) is the most commonly used imaging technique to detect structural lesions in axial SpondyloArthritis (axSpA). However, a…
  • Abstract Number: 1306 • 2015 ACR/ARHP Annual Meeting

    MRI Erosions in Undifferentiated Arthritis. Different Associations with the Collagen IIA N-Terminal Propeptide (PIIANP) and Galectin-3 in Pre-RA and Other Arthritides

    Saida Farah Issa1, Anne Duer2, Mikkel Østergaard3, Hanne Lindegaard1, Kim Hørslev-Petersen4, Merete Lund Hetland5, Jakob M. Møller6, Anne Friesgaard Christensen7 and Peter Junker1, 1Department of Rheumatology, Odense University Hospital, Odense, Denmark, 2Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Hvidovre, Denmark, 3Center for Rheumatology and Spine Diseases, Glostrup Hospital, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, 4Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, 5DANBIO, Center for Rheumatology and Spine Diseases, Glostrup Univ Hospital, Glostrup, Denmark, 6Department of Radiology, Copenhagen University Hospital Herlev, Herlev, Denmark, 7Department of Rheumatology, Vejle Hospital, Vejle, Denmark

    Background/Purpose: Galectin-3 has been implicated as a mediator of inflammation and erosive progression in animal arthritis and rheumatoid arthritis(RA). The type IIA procollagen peptide(PIIANP) is…
  • Abstract Number: 2025 • 2015 ACR/ARHP Annual Meeting

    Modification of Structural Lesions on Magnetic Resonance Imaging By Etanercept: A 12-Week Randomized Placebo-Controlled Trial

    Walter Maksymowych1, Stephanie Wichuk2, Maxime Dougados3, Heather Jones4, Annette Szumski5, Lisa Marshall4, Jack F Bukowski6 and Robert G Lambert7, 1Department of Medicine, University of Alberta, Edmonton, AB, Canada, 2Rheumatology Research Lab, University of Alberta, Edmonton, AB, Canada, 3Rheumatology Department, Hôpital Cochin, Paris, France, 4Inflammation Global Medical Affairs, Pfizer, Collegeville, PA, 5Department of Biostatistics, Pfizer, Collegeville, PA, 6Clinical Affairs, Pfizer, Collegeville, PA, 7Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Modification of structural lesions by anti-TNF therapy has not been demonstrated in a randomized placebo (PBO)-controlled trial. The Spondyloarthritis Research Consortium of Canada (SPARCC)…
  • Abstract Number: 315 • 2015 ACR/ARHP Annual Meeting

    Structural Effects of Sprifermin in Knee Osteoarthritis: A Post-Hoc Analysis on Cartilage and Non-Cartilaginous Tissue Alterations

    Frank Roemer1, Aida Aydemir2, Stefan Lohmander3, Michel Crema4, Monica D. Marra5, Norma Muurahainen2, Felix Eckstein6 and Ali Guermazi7, 1Radiology, Boston University School of Medicine, Boston, MA, 2EMD Serono, Billerica, MA, 3Lund University, Lund, Sweden, 4Department of Radiology, Boston University School of Medicine, Boston, MA, 5Department of Radiology, BUSM, Boston, MA, 6Paracelsus Med Univ, Chondrometrics GmbH, Salzburg, Austria, 7Boston University School of Medicine, Boston, MA

    Background/Purpose: A randomized, double-blind, placebo-controlled phase 1b clinical trial of sprifermin (rhFGF18) in knee OA assessed central medial tibio-femoral compartment cartilage thickness on quantitative MRI…
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