Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: To clarify whether MRI bone oedema predicts the development of rapid radiographic progression (RRP) in Nagasaki University Early Arthritis Cohort patients with early-stage rheumatoid arthritis (RA).
Methods: Early-stage RA patients (n=76) were enrolled and underwent Gd-enhanced MRI of both wrists and finger joints. Synovitis, bone oedema and bone erosion were evaluated using the Rheumatoid Arthritis Magnetic Resonance Imaging score (RAMRIS). RRP was defined as an annual increment > 3 at 1 year by plain radiographs and the Genant-modified Sharp score. A multivariate logistic regression analysis was performed to establish the risk factors for RRP, using patients’ characteristics, serum variables, MRI findings, therapeutic responses and regime.
Results: The patients’ median age was 54.5 yrs, and their median disease duration at enrollment was 3 months. RRP was found in 12 of the 76 patients at 1 year. A univariate analysis revealed that matrix metalloproteinase-3, RAMRIS bone oedema score and RAMRIS bone erosion score were associated with RRP. Multivariate logistic regression analyses demonstrated that the RAMRIS bone oedema score at enrollment (5-point increase, OR 2.18, 95%CI 1.32–3.59, p=0.002) is the only independent predictor of the development of RRP at 1 year. An ROC analysis identified the best cut-off value for RAMRIS bone oedema score as 5.
Conclusion: Our findings suggest that MRI bone oedema is closely associated with the development of RRP in early-stage RA patients. Physicians should carefully control the disease activity when MRI bone oedema is observed in early RA patients.
To cite this abstract in AMA style:Nakashima Y, Tamai M, Michitsuji T, Shimizu T, Fukui S, Umeda M, Nishino A, Koga T, Kawashiri SY, Iwamoto N, Ichinose K, Hirai Y, Nakamura H, Origuchi T, Kawakami A. MRI Bone Oedema at Enrollment Predicts the Development of Rapid Radiographic Progression at 1 Year Toward Patients with Early-Stage Rheumatoid Arthritis: Results from Nagasaki University Early Arthritis Cohort [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/mri-bone-oedema-at-enrollment-predicts-the-development-of-rapid-radiographic-progression-at-1-year-toward-patients-with-early-stage-rheumatoid-arthritis-results-from-nagasaki-university-early-arthrit/. Accessed June 6, 2020.
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