Abstracts tagged "MRI"

Abstract Number: 822 • 2018 ACR/ARHP Annual Meeting
Immuno-Inflammatory Markers and MR-Angiographic Imaging to Detect Disease Activity in Takayasu Arteritis
Andrea D. Gloor¹, Daniel Yerly², Jennifer L. Cullmann³, Sabine Adler¹ and Peter M. Villiger¹, ¹Department of Rheumatology, Immunology and Allergology, Inselspital, University Hospital of Bern, Bern, Switzerland, ²Department of Biomedical Research, University of Bern, Bern, Switzerland, ³Institute of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital of Bern, Bern, Switzerland
Background/Purpose: There is an unmet need for tools to quantify local disease activity in TAK.Methods: Sera of 21 TAK patients, aged between 18 and 56…
Abstract Number: 1942 • 2018 ACR/ARHP Annual Meeting
Anti-NMDA Receptor Antibodies in Systemic Lupus Erythematosus Associate with Decreased White Matter Integrity and Impaired Spatial Memory
Erik Anderson¹, An Vo², Elisabeth Ploran³, Betty Diamond², Bruce Volpe⁴, Cynthia Aranow², David Eidelberg² and Meggan Mackay², ¹Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY, ²The Feinstein Institute for Medical Research, Manhasset, NY, ³Hofstra University, Hempstead, NY, ⁴Biomedical Sciences, The Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Cognitive impairment is common in SLE and impacts quality of life; however, causality is limited by incomplete understanding of neurotoxic mechanisms. Diffusion tensor imaging…
Abstract Number: 426 • 2018 ACR/ARHP Annual Meeting
The Association of Dietary Patterns with Knee Symptoms and MRI Detected Structures in Patients with Knee Osteoarthritis (OA)
Shuang Zheng¹, Feitong Wu¹, Flavia Cicuttini², Anita E Wluka², Dawn Aitken¹, Tania Winzeberg^1,3, Leigh Blizzard¹, Graeme Jones⁴ and Changhai Ding^1,5, ¹Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ²Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, ³Faculty of Health, University of Tasmania, Hobart, Australia, ⁴Menzies Institute for Medical Research, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ⁵Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China
The association of dietary patterns with knee symptoms and MRI detected structures in patients with knee osteoarthritis (OA)Abstract Background/Purpose: This study aimed to examine the…
Abstract Number: 864 • 2018 ACR/ARHP Annual Meeting
The Diagnostic Utility of the Relation between MRI Bone Marrow Edema and Other Types of MRI Lesions in the Sacroiliac Joints in Axial Spondyloarthritis
Sengül Seven¹, Pernille Hededal², Mikkel Østergaard³, Lone Morsel-Carlsen⁴, Inge Juul Sørensen⁵, Birthe Bonde⁶, Gorm Thamborg⁷, Oliver Hendricks⁸, Niklas Rye Jørgensen⁹ and Susanne J Pedersen¹⁰, ¹Copenhagen Center for Arthritis Research, Dept. of Rheumatology, Rigshospitalet, University of Copenhagen, Glostrup., 2600 Glostrup, Denmark, ²Dept. of Radiology, Rigshospitalet, University of Copenhagen, Glostrup., Glostrup, Denmark, ³Copenhagen Center for Arthritis Research, Dept. of Rheumatology, Rigshospitalet, University of Copenhagen, Glostrup., Glostrup, Denmark, ⁴Department of Radiology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Copenhagen, Denmark, ⁵Dept. of Rheumatology, Rigshospitalet, University of Copenhagen, Glostrup, Glostrup, Denmark, ⁶Birthe Bonde Clinic of Physiotherapy, Copenhagen, Denmark, ⁷Copenhagen Center for Arthritis Research, Dept. of Rheumatology, Rigshospitalet, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark, ⁸King Christian 10th Hospital for Rheumatic Diseases, University of Southern Denmark, Institute of Regional Health Research, Graasten, Denmark, ⁹Dept. of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Glostrup, Glostrup, Denmark, ¹⁰Copenhagen Center for Arthritis Research, Dept. of Rheumatology, Rigshospitalet, University of Copenhagen, Glostrup, Glostrup, Denmark
Background/Purpose: MRI detected bone marrow edema (BME) plays a central role in the ASAS (Assessment of Spondyloarthritis International Society) classification criteria for axial spondyloarthritis (axSpA).…
Abstract Number: 2286 • 2018 ACR/ARHP Annual Meeting
Myositis and Fasciitis By Magnetic Resonance Imaging in Recent-Onset Polymyalgia Rheumatica and Effect of Tocilizumab Therapy
Jean Patrick Laporte¹, Florent Garrigues², Anais Huwart², Sandrine Jousse-Joulin³, Thierry Marhadour¹, Dewi Guellec³, Divi Cornec⁴, Valérie Devauchelle-Pensec³ and Alain Saraux³, ¹CHU Brest, Brest, France, ²Radiology, CHU Brest, Brest, France, ³Rheumatology, CHU Brest, Brest, France, ⁴Rheumatology and UMR1227, Lymphocytes B et Autoimmunité, CHU Brest, Brest, France
Background/Purpose: To assess the prevalence of myofascial inflammatory lesions visible by magnetic resonance imaging (MRI) and their changes after tocilizumab therapy in active polymyalgia rheumatica…
Abstract Number: 429 • 2018 ACR/ARHP Annual Meeting
The Potential Clinical Relevance of Imaging Biomarker Data from Short-Term Interventional Trials in Osteoarthritis: A Comparison of the Cathepsin K Inhibitor Miv-711 Phase 2a MRI Knee Joint Data and KL-Matched 5577 Knee Control Data from the Osteoarthritis Initiative
Philip G. Conaghan¹, Michael A Bowes², Sarah R. Kingsbury¹, Alan Brett², Gwenael Guillard², Åsa Jansson³, Cecilia Wadell³, Richard Bethell³ and John Öhd³, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom, Leeds, United Kingdom, ²Imorphics Ltd, Manchester, United Kingdom, ³Medivir AB, Huddinge, Sweden
Background/Purpose: New imaging biomarkers using supervised machine learning offer opportunities to demonstrate effects of potential DMOADs on joint structure in short, small trials based on…
Abstract Number: 867 • 2018 ACR/ARHP Annual Meeting
An MRI Guided Treat-to-Target Strategy in Rheumatoid Arthritis Patients in Clinical Remission Improved MRI Inflammation but Not Damage Progression – Results from the Imagine-RA Randomized Controlled Trial
Signe Møller-Bisgaard¹, Kim Hørslev-Petersen², Bo Jannik Ejbjerg³, Daniel Glinatsi⁴, Merete Lund Hetland¹, Lykke Ørnbjerg¹, Jakob M. Møller⁵, Mikael Boesen⁶, Robin Christensen⁷, Kristian Stengaard-Pedersen⁸, Ole Rintek Madsen⁹, Bente Jensen¹⁰, Jan Alexander Villadsen¹¹, Ellen-Margrethe Hauge⁸, Philip Bennett¹², Oliver Hendricks², Karsten Asmussen¹³, Marcin Ryszard Kowalski¹⁴, Hanne Lindegaard¹⁵, Sabrina Mai Nielsen⁷, Henning Bliddal¹⁶, Niels Steen Krogh¹⁷, Torkell Ellingsen¹⁵, Agente Nielsen¹⁸, Lone Balding¹⁹, Anne Grethe Jurik²⁰, Henrik S Thomsen¹⁹ and Mikkel Østergaard²¹, ¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark, ²King Christian 10th Hospital for Rheumatic Diseases, University of Southern Denmark, Institute of Regional Health Research, Graasten, Denmark, ³Department of Rheumatology, Zealand University Hospital, Køge, Denmark, ⁴Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, ⁵Dept. of Radiology, Copenhagen University Hospitals, Herlev and Gentofte, Copenhagen, Denmark, ⁶Department of Radiology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Copenhagen, Denmark, ⁷Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg, Denmark, ⁸Department of Rheumatology, Aarhus University Hospital, Department of Clinical Medicine, Aarhus, Denmark, ⁹Department of Rheumatology, Copenhagen University Hospital, Herlev and Gentofte, Hellerup, Denmark, ¹⁰Department of Rheumatology, Frederiksberg Hospital, Copenhagen, Denmark, Copenhagen, Denmark, ¹¹Department of Rheumatology, Silkeborg Hospital, Silkeborg, Denmark, ¹²Department of Rheumatology, Copenhagen University Hospital, Herlev and Gentofte, Copenhagen, Denmark, ¹³Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, ¹⁴Department of Rheumatology, Sygehus Vendsyssel, Hjørring, Hjørring, Denmark, ¹⁵Department of Rheumatology, Odense University Hospital, Odense, Denmark, ¹⁶The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, ¹⁷The DANBIO Registry, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, ¹⁸Department of Radiology, Silkeborg Hospital, Silkeborg, Denmark, ¹⁹Department of Radiology, Copenhagen University Hospital Herlev and Gentofte, Copenhagen, Denmark, ²⁰Department of Radiology, Aarhus University Hospital, Aarhus, Denmark, ²¹Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup Copenhagen Center for Arthritis Research, Copenhagen, Denmark
Background/Purpose: Magnetic Resonance Imaging (MRI) bone marrow edema (BME)/osteitis and MRI synovitis have been identified as predictors of structural damage progression in rheumatoid arthritis RA1,2.…
Abstract Number: 2508 • 2018 ACR/ARHP Annual Meeting
A First-in-Man Bioelectronic Therapy for Biologic-Refractory Rheumatoid Arthritis
David Chernoff¹, Yaakov Levine¹, Charles Peterfy² and Mark C. Genovese³, ¹SetPoint Medical, Inc., Valencia, CA, ²Spire Sciences LLC, Boca Raton, FL, ³Department of Medicine, Stanford University, Palo Alto, CA
Background/Purpose: Rheumatoid arthritis (RA) is a debilitating chronic disease with an unmet need for additional therapeutic approaches. Bioelectronic therapy (BET), such as electrical neurostimulation of…
Abstract Number: 436 • 2018 ACR/ARHP Annual Meeting
Structural Effects of Intra-Articular Sprifermin in Symptomatic Radiographic Knee Osteoarthritis: A Post-Hoc Analysis of Cartilage Morphology over the 2-Year Treatment-Period of a 5-Year Randomized, Placebo-Controlled, Phase II Study
Ali Guermazi¹, Jeffrey Kraines², Aida Aydemir², Stephen Wax³, Michel Crema⁴, Marc C. Hochberg⁵ and Frank Roemer^1,6, ¹Radiology, Boston University School of Medicine, Boston, MA, ²EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ³EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), BIllerica, MA, ⁴Boston University School of Medicine, Boston, MA, ⁵University of Maryland School of Medicine, Baltimore, MD, ⁶Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Sprifermin, a recombinant human fibroblast growth factor 18, is currently being investigated as a potential disease-modifying OA drug. Sprifermin treatment leads to a dose-dependent…
Abstract Number: 897 • 2018 ACR/ARHP Annual Meeting
Prevalence of Inflammatory and Chronic Changes Suggestive of Axial Spondyloarthritis in Magnetic Resonance Images of the Axial Skeleton in Individuals < 45 Years in the General Populationas Part of a Large Community Study (SHIP)
Xenofon Baraliakos¹, Daniel Feldmann², Anne Ott², Carsten Oliver Schmidt³, Martin Albers³, Adrian Richter³ and Jürgen Braun¹, ¹Ruhr-University Bochum, Herne, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
Background/Purpose: Magnetic resonance imaging (MRI) is crucial for classification and diagnosis of axial spondyloarthritis (axSpA). Characteristic MRI lesions of axSpA are bone marrow edema (BME)…
Abstract Number: 2601 • 2018 ACR/ARHP Annual Meeting
Nonsteroidal Anti-Inflammatory Drugs Attenuate Active Inflammatory Sacroiliac Joint Lesions in Patients with Early Axial Spondyloarthritis
Hong-Ki Min¹, Hyonjoung Cho² and Sung-Hwan Park³, ¹Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Armed Forces Capital hospital, Armed Forces Medical Command, Seongnam, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
Background/Purpose: The purpose of the present study was to examine the therapeutic effect of NSAIDs on active inflammatory lesions (bone marrow oedema [BMO]) in the…
Abstract Number: 449 • 2018 ACR/ARHP Annual Meeting
Pain Processing in Chronic Low Back Pain Individuals with or without Sick Leave
Aloma Feitosa¹, Liliana Jorge², Liana Sanches², Eduardo Ferreira Borba³, Edson Amaro² and Ari Halpern^1,2, ¹Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, BR, Sao Paulo, Brazil, ²Instituto do Cérebro, Hospital Israelita Albert Einstein, Sao Paulo, Brazil, ³Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Chronic low back pain (LBP) is one of the most common musculoskeletal complaints in industrialized societies. It affects 80% of the adult population at…
Abstract Number: 922 • 2018 ACR/ARHP Annual Meeting
Anakinra Treatment Prevents Myocardial Mechanical Dysfunction and Inhibits Histologic Evidence of Myocardial Inflammation in the Mouse Model of Kawasaki Disease
Mark Gorelik^1,2, Youngho Lee³, Masanori Abe⁴, Thomas Andrews⁵, Jean Patterson¹, Magali Noval Rivas⁴, Gregory Aune⁵ and Moshe Arditi⁴, ¹Immunology and Virology, Texas Biomedical Research Institute, San Antonio, TX, ²Pediatrics, Baylor College of Medicine, Houston, TX, ³Department of Cell Biology, Hospital for Sick Children, Toronto, ON, Canada, ⁴Pediatrics, Cedars Sinai, Beverly Hills, CA, ⁵Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX
Background/Purpose: Kawasaki disease (KD) is an acute, febrile illness of childhood with sequelae of coronary artery aneurysms and cardiac fibrosis, and is the most common…
Abstract Number: 2784 • 2018 ACR/ARHP Annual Meeting
Multi Modal Imaging Algorithm to Improve the Accuracy for the Diagnosis of Giant Cell Arteritis
Augustin Lecler¹, Thomas Sené², Herve Picard³, Tifenn Leturcq², Kevin Zuber³, Frederique Charbonneau¹, Catherine Vignal-Clermont⁴ and Gaelle Clavel², ¹Department of Radiology, Fondation Ophtalmologique A. de Rothschild, Paris, France, ²Internal Medecine, Fondation Ophtalmologique A. de Rothschild, Paris, France, ³Clinical Research Unit, Fondation Ophtalmologique A. de Rothschild, Paris, France, ⁴Ophtalmology, Fondation Ophtalmologique A. de Rothschild, Paris, France
Background/Purpose: Giant Cell Arteritis (GCA) is the most common systemic vasculitis in patient over 50 years of age. It is a medical emergency as it…
Abstract Number: 591 • 2018 ACR/ARHP Annual Meeting
Evaluation of MRI Ramris Score and Clinical Response in Patients with ACPA Positive Undifferentiated Arthritis Treated with Infliximab Versus Placebo
Thomas Kirchgesner¹, Bruno Vande Berg¹, Tatiana Sokolova², Laurent Meric de Bellefon², Adrien Nzeusseu Toukap³, Maria Stoenoiu⁴ and Patrick Durez², ¹Musculoskeletal Imaging Unit, Musculoskeletal Imaging Unit - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ²Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ³Department of Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ⁴Rheumatology department, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium
Background/Purpose: Patients (Pts) with Undifferentiated Arthritis (UA), positive for ACPA antibodies are at high risk of progressing to Rheumatoid Arthritis (RA). TNF play a key…

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