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Abstracts tagged "MRI"

  • Abstract Number: 1557 • 2018 ACR/ARHP Annual Meeting

    Visualization of Dorsal Root Ganglionitis with Three-Tesla Magnetic Resonance Neurography in Sensory Ataxic Neuropathy Associated with Sjögren’s Syndrome

    Takeshi Yoshida1, Takeshi Sueyoshi2, Mitsuyo Kinjo3, Shugo Suwazono4 and Hiroyuki Nodera5, 1Rheumatology, Chikamori Hospital, Kochi, Japan, 2Radiology, Minei Daiichi Hospital, Urasoe, Japan, 3Rheumatology, Okinawa Chubu Hospital, Uruma, Japan, 4Brain-Nerve-Muscle Research Center, National Hospital Organization Okinawa Hospital, Uruma, Japan, 5Neurology, Tokushima University School of Medicine, Tokushima, Japan

    Background/Purpose: Sjögrenfs syndrome (SS)-associated neuropathy manifests as various forms of neuropathy, including sensory ataxic neuropathy (SAN). Dorsal root ganglionitis, pathologically defined as the lymphocytic infiltration…
  • Abstract Number: 312 • 2018 ACR/ARHP Annual Meeting

    Diagnostic Value of MRI in Non-Radiographic Axial Spondyloarthritis

    Tamara Rusman1, Marie-Luise John2, Mignon van der Weijden2, Bouke Boden3, Joyce van der Bijl2, Stefan Bruijnen4, Conny van der Laken5, Michael T. Nurmohamed6 and Irene van der Horst-Bruinsma7, 1Rheumatology, VU University medical centre, Amsterdam, Netherlands, 2Amsterdam Rheumatology immunology Center |Department of Rheumatology VU University Medical Center, Amsterdam, Netherlands, 3Radiology, VU University Medical Center, Amsterdam, Netherlands, 4Dept. of Rheumatology, Amsterdam Rheumatology and immunology Center - location VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, 5Amsterdam Rheumatology and immunology Center, Location VU University Medical Center, Amsterdam, Netherlands, 6Rheumatology, Amsterdam Rheumatology and immunology Center, VU University Medical Center, Amsterdam, Netherlands, 7Rheumatology, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose: Few studies showed signs of inflammation at the MRI of the sacroiliac joints (SIJ) or spine in only 30% of the non-radiographic axial spondyloarthritis…
  • Abstract Number: 666 • 2018 ACR/ARHP Annual Meeting

    Inflammation on MRI of the Sacroiliac Joints Is Highly Associated with Structural Damage in Axial Spondyloarthritis Patients in Clinical Practice: Data from the ASAS and DESIR Cohorts

    Alexandre Sepriano1, Sofia Ramiro1,2, Robert B.M. Landewé3,4, Maxime Dougados5, Désirée van der Heijde6 and Martin Rudwaleit7, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Zuyderland Medical Center, Heerlen & Leiden University Medical Center, Leiden, Netherlands, 3Zuyderland Medical Center, Heerlen, Netherlands, 4Amsterdam Rheumatology & Immunology Center, Amsterdam, the Netherlands, Amsterdam, Netherlands, 5Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, 6Leiden University Medical Centre, Leiden, Netherlands, 7Internal Medicine and Rheumatology, Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany

    Background/Purpose: The effect of MRI-detected inflammation on the development of radiographic damage at the sacroiliac joints (SIJ) level in patients (pts) with axial SpA (axSpA)…
  • Abstract Number: 1636 • 2018 ACR/ARHP Annual Meeting

    Frequency and Specificity of MRI Lesions in the Sacroiliac Joints of Patients with Axial Spondyloarthritis and Non-Specific Back Pain: First Analysis of MRI Scans from the Assessments in Spondyloarthritis International Society Classification Cohort

    Walter P. Maksymowych1,2, Susanne J Pedersen3, Xenofon Baraliakos4, Pedro Machado5, Ulrich Weber6, Joachim Sieper7, Stephanie Wichuk1, Denis Poddubnyy7, Mikkel Østergaard3, Joel Paschke2 and Robert G. Lambert8, 1Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, 2CaRE Arthritis, Edmonton, AB, Canada, 3COPECARE University of Copenhagen, Copenhagen, Denmark, 4Rheumazentrum Ruhrgebiet Herne, Herne, Germany, 5University College London, London, United Kingdom, 6University of Southern Denmark, Odense, Denmark, 7Charité Universitätsmeidzin Berlin, Berlin, Germany, 8Radiology, Radiology, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: A broad spectrum of MRI lesions has been described in the sacroiliac joint (SIJ) of patients with axial spondyloarthritis and a recent consensus from…
  • Abstract Number: 315 • 2018 ACR/ARHP Annual Meeting

    Assessing the Value of Whole Body Magnetic Resonance Imaging As to Clinical Examination to Predict Remission and Relapse in Early Peripheral Spondyloarthritis

    Thomas Renson1, Ann-Sophie De Craemer1, Philippe Carron1, Simon Krabbe2, Lennart Jans3, Manouk de Hooge4, Peggy Jacques1, Mikkel Østergaard5, Dirk Elewaut1 and Filip van Den Bosch6, 1Department of Rheumatology, Ghent University Hospital, Ghent, 9000, Belgium, 2Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, 3Department of Radiology, Ghent University Hospital, Ghent, Belgium, 4Ghent University Hospital, Ghent, Belgium, 5Center for Rheumatology and Spine Diseases, Copenhagen Center for Arthritis Research, Rigshospitalet, Denmark, Copenhagen, Denmark, 6Department of Rheumatology, Ghent University Hospital, Ghent, Belgium

    Background/Purpose: Evaluation of disease activity and treatment response in peripheral spondyloarthritis (pSpA) is currently based upon clinical findings, laboratory tests and ultrasound examination. Whole-body magnetic…
  • Abstract Number: 822 • 2018 ACR/ARHP Annual Meeting

    Immuno-Inflammatory Markers and MR-Angiographic Imaging to Detect Disease Activity in Takayasu Arteritis

    Andrea D. Gloor1, Daniel Yerly2, Jennifer L. Cullmann3, Sabine Adler1 and Peter M. Villiger1, 1Department of Rheumatology, Immunology and Allergology, Inselspital, University Hospital of Bern, Bern, Switzerland, 2Department of Biomedical Research, University of Bern, Bern, Switzerland, 3Institute of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital of Bern, Bern, Switzerland

    Background/Purpose: There is an unmet need for tools to quantify local disease activity in TAK.Methods: Sera of 21 TAK patients, aged between 18 and 56…
  • Abstract Number: 1942 • 2018 ACR/ARHP Annual Meeting

    Anti-NMDA Receptor Antibodies in Systemic Lupus Erythematosus Associate with Decreased White Matter Integrity and Impaired Spatial Memory

    Erik Anderson1, An Vo2, Elisabeth Ploran3, Betty Diamond2, Bruce Volpe4, Cynthia Aranow2, David Eidelberg2 and Meggan Mackay2, 1Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY, 2The Feinstein Institute for Medical Research, Manhasset, NY, 3Hofstra University, Hempstead, NY, 4Biomedical Sciences, The Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose: Cognitive impairment is common in SLE and impacts quality of life; however, causality is limited by incomplete understanding of neurotoxic mechanisms. Diffusion tensor imaging…
  • Abstract Number: 426 • 2018 ACR/ARHP Annual Meeting

    The Association of Dietary Patterns with Knee Symptoms and MRI Detected Structures in Patients with Knee Osteoarthritis (OA)

    Shuang Zheng1, Feitong Wu1, Flavia Cicuttini2, Anita E Wluka2, Dawn Aitken1, Tania Winzeberg1,3, Leigh Blizzard1, Graeme Jones4 and Changhai Ding1,5, 1Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, 2Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, 3Faculty of Health, University of Tasmania, Hobart, Australia, 4Menzies Institute for Medical Research, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, 5Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China

    The association of dietary patterns with knee symptoms and MRI detected structures in patients with knee osteoarthritis (OA)Abstract Background/Purpose: This study aimed to examine the…
  • Abstract Number: 864 • 2018 ACR/ARHP Annual Meeting

    The Diagnostic Utility of the Relation between MRI Bone Marrow Edema and Other Types of MRI Lesions in the Sacroiliac Joints in Axial Spondyloarthritis

    Sengül Seven1, Pernille Hededal2, Mikkel Østergaard3, Lone Morsel-Carlsen4, Inge Juul Sørensen5, Birthe Bonde6, Gorm Thamborg7, Oliver Hendricks8, Niklas Rye Jørgensen9 and Susanne J Pedersen10, 1Copenhagen Center for Arthritis Research, Dept. of Rheumatology, Rigshospitalet, University of Copenhagen, Glostrup., 2600 Glostrup, Denmark, 2Dept. of Radiology, Rigshospitalet, University of Copenhagen, Glostrup., Glostrup, Denmark, 3Copenhagen Center for Arthritis Research, Dept. of Rheumatology, Rigshospitalet, University of Copenhagen, Glostrup., Glostrup, Denmark, 4Department of Radiology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Copenhagen, Denmark, 5Dept. of Rheumatology, Rigshospitalet, University of Copenhagen, Glostrup, Glostrup, Denmark, 6Birthe Bonde Clinic of Physiotherapy, Copenhagen, Denmark, 7Copenhagen Center for Arthritis Research, Dept. of Rheumatology, Rigshospitalet, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark, 8King Christian 10th Hospital for Rheumatic Diseases, University of Southern Denmark, Institute of Regional Health Research, Graasten, Denmark, 9Dept. of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Glostrup, Glostrup, Denmark, 10Copenhagen Center for Arthritis Research, Dept. of Rheumatology, Rigshospitalet, University of Copenhagen, Glostrup, Glostrup, Denmark

    Background/Purpose: MRI detected bone marrow edema (BME) plays a central role in the ASAS (Assessment of Spondyloarthritis International Society) classification criteria for axial spondyloarthritis (axSpA).…
  • Abstract Number: 2286 • 2018 ACR/ARHP Annual Meeting

    Myositis and Fasciitis By Magnetic Resonance Imaging in Recent-Onset Polymyalgia Rheumatica and Effect of Tocilizumab Therapy

    Jean Patrick Laporte1, Florent Garrigues2, Anais Huwart2, Sandrine Jousse-Joulin3, Thierry Marhadour1, Dewi Guellec3, Divi Cornec4, Valérie Devauchelle-Pensec3 and Alain Saraux3, 1CHU Brest, Brest, France, 2Radiology, CHU Brest, Brest, France, 3Rheumatology, CHU Brest, Brest, France, 4Rheumatology and UMR1227, Lymphocytes B et Autoimmunité, CHU Brest, Brest, France

    Background/Purpose: To assess the prevalence of myofascial inflammatory lesions visible by magnetic resonance imaging (MRI) and their changes after tocilizumab therapy in active polymyalgia rheumatica…
  • Abstract Number: 429 • 2018 ACR/ARHP Annual Meeting

    The Potential Clinical Relevance of Imaging Biomarker Data from Short-Term Interventional Trials in Osteoarthritis: A Comparison of the Cathepsin K Inhibitor Miv-711 Phase 2a MRI Knee Joint Data and KL-Matched 5577 Knee Control Data from the Osteoarthritis Initiative

    Philip G. Conaghan1, Michael A Bowes2, Sarah R. Kingsbury1, Alan Brett2, Gwenael Guillard2, Åsa Jansson3, Cecilia Wadell3, Richard Bethell3 and John Öhd3, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom, Leeds, United Kingdom, 2Imorphics Ltd, Manchester, United Kingdom, 3Medivir AB, Huddinge, Sweden

    Background/Purpose: New imaging biomarkers using supervised machine learning offer opportunities to demonstrate effects of potential DMOADs on joint structure in short, small trials based on…
  • Abstract Number: 867 • 2018 ACR/ARHP Annual Meeting

    An MRI Guided Treat-to-Target Strategy in Rheumatoid Arthritis Patients in Clinical Remission Improved MRI Inflammation but Not Damage Progression – Results from the Imagine-RA Randomized Controlled Trial

    Signe Møller-Bisgaard1, Kim Hørslev-Petersen2, Bo Jannik Ejbjerg3, Daniel Glinatsi4, Merete Lund Hetland1, Lykke Ørnbjerg1, Jakob M. Møller5, Mikael Boesen6, Robin Christensen7, Kristian Stengaard-Pedersen8, Ole Rintek Madsen9, Bente Jensen10, Jan Alexander Villadsen11, Ellen-Margrethe Hauge8, Philip Bennett12, Oliver Hendricks2, Karsten Asmussen13, Marcin Ryszard Kowalski14, Hanne Lindegaard15, Sabrina Mai Nielsen7, Henning Bliddal16, Niels Steen Krogh17, Torkell Ellingsen15, Agente Nielsen18, Lone Balding19, Anne Grethe Jurik20, Henrik S Thomsen19 and Mikkel Østergaard21, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark, 2King Christian 10th Hospital for Rheumatic Diseases, University of Southern Denmark, Institute of Regional Health Research, Graasten, Denmark, 3Department of Rheumatology, Zealand University Hospital, Køge, Denmark, 4Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, 5Dept. of Radiology, Copenhagen University Hospitals, Herlev and Gentofte, Copenhagen, Denmark, 6Department of Radiology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Copenhagen, Denmark, 7Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg, Denmark, 8Department of Rheumatology, Aarhus University Hospital, Department of Clinical Medicine, Aarhus, Denmark, 9Department of Rheumatology, Copenhagen University Hospital, Herlev and Gentofte, Hellerup, Denmark, 10Department of Rheumatology, Frederiksberg Hospital, Copenhagen, Denmark, Copenhagen, Denmark, 11Department of Rheumatology, Silkeborg Hospital, Silkeborg, Denmark, 12Department of Rheumatology, Copenhagen University Hospital, Herlev and Gentofte, Copenhagen, Denmark, 13Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, 14Department of Rheumatology, Sygehus Vendsyssel, Hjørring, Hjørring, Denmark, 15Department of Rheumatology, Odense University Hospital, Odense, Denmark, 16The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, 17The DANBIO Registry, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 18Department of Radiology, Silkeborg Hospital, Silkeborg, Denmark, 19Department of Radiology, Copenhagen University Hospital Herlev and Gentofte, Copenhagen, Denmark, 20Department of Radiology, Aarhus University Hospital, Aarhus, Denmark, 21Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup Copenhagen Center for Arthritis Research, Copenhagen, Denmark

    Background/Purpose: Magnetic Resonance Imaging (MRI) bone marrow edema (BME)/osteitis and MRI synovitis have been identified as predictors of structural damage progression in rheumatoid arthritis RA1,2.…
  • Abstract Number: 2508 • 2018 ACR/ARHP Annual Meeting

    A First-in-Man Bioelectronic Therapy for Biologic-Refractory Rheumatoid Arthritis

    David Chernoff1, Yaakov Levine1, Charles Peterfy2 and Mark C. Genovese3, 1SetPoint Medical, Inc., Valencia, CA, 2Spire Sciences LLC, Boca Raton, FL, 3Department of Medicine, Stanford University, Palo Alto, CA

    Background/Purpose: Rheumatoid arthritis (RA) is a debilitating chronic disease with an unmet need for additional therapeutic approaches. Bioelectronic therapy (BET), such as electrical neurostimulation of…
  • Abstract Number: 436 • 2018 ACR/ARHP Annual Meeting

    Structural Effects of Intra-Articular Sprifermin in Symptomatic Radiographic Knee Osteoarthritis: A Post-Hoc Analysis of Cartilage Morphology over the 2-Year Treatment-Period of a 5-Year Randomized, Placebo-Controlled, Phase II Study

    Ali Guermazi1, Jeffrey Kraines2, Aida Aydemir2, Stephen Wax3, Michel Crema4, Marc C. Hochberg5 and Frank Roemer1,6, 1Radiology, Boston University School of Medicine, Boston, MA, 2EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 3EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), BIllerica, MA, 4Boston University School of Medicine, Boston, MA, 5University of Maryland School of Medicine, Baltimore, MD, 6Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany

    Background/Purpose: Sprifermin, a recombinant human fibroblast growth factor 18, is currently being investigated as a potential disease-modifying OA drug. Sprifermin treatment leads to a dose-dependent…
  • Abstract Number: 897 • 2018 ACR/ARHP Annual Meeting

    Prevalence of Inflammatory and Chronic Changes Suggestive of Axial Spondyloarthritis in Magnetic Resonance Images of the Axial Skeleton in Individuals < 45 Years in the General Populationas Part of a Large Community Study (SHIP)

    Xenofon Baraliakos1, Daniel Feldmann2, Anne Ott2, Carsten Oliver Schmidt3, Martin Albers3, Adrian Richter3 and Jürgen Braun1, 1Ruhr-University Bochum, Herne, Germany, 2Rheumazentrum Ruhrgebiet, Herne, Germany, 3Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

    Background/Purpose: Magnetic resonance imaging (MRI) is crucial for classification and diagnosis of axial spondyloarthritis (axSpA). Characteristic MRI lesions of axSpA are bone marrow edema (BME)…
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