ACR Meeting Abstracts

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Abstracts tagged "Mouse"

  • Abstract Number: 0838 • ACR Convergence 2020

    T Cell–Specific CaMKIV Deficiency Protects Mice from Imiquimod-induced Glomerulonephritis

    Milena Vukelic1, Masataka Umeda1, Andrew Ferretti2, Rhea Bhargava1, Nobuya Yoshida1 and George Tsokos3, 1Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, 2Beth Israel Deaconess Medical Center Harvard Medical School, Boston, 3Division of Rheumatology & Clinical Immunology/Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by autoantibody production, immune complex deposition and multisystem involvement.  Calcium/calmodulin-dependent protein kinase type IV…
  • Abstract Number: 0839 • ACR Convergence 2020

    Single-Cell Transcriptomics of Mouse and Human Lupus Nephritis Identifies Conserved Myeloid Populations Across Species

    Paul Hoover1, Michael Peters2, David Lieb3, Rakesh Mishra4, Nir Hacohen2 and Anne Davidson5, 1Brigham and Women's Hospital, Boston, MA, 2Broad Institute, Boston, 3Broad Institute, Boston, MA, 4Feinstein Institute, Manhasset, NY, 5Northwell Health, New York

    Background/Purpose: We recently identified novel immune cell states in the kidneys of lupus nephritis patients (Arazi et al, Nature Immunology 2019). To determine the similarities…
  • Abstract Number: 0979 • ACR Convergence 2020

    The Identification of Shared and Unique Myeloid Cell States in Pre- and Post-nephritic Lupus Mouse Models, Sle.Yaa1 and NZBW

    Paul Hoover1, Michael Peters2, David Lieb3, Heather Geiger4, Rakesh Mishra5, Nir Hacohen2 and Anne Davidson6, 1Brigham and Women's Hospital, Boston, MA, 2Broad Institute, Boston, 3Broad Institute, Boston, MA, 4New York Genome Center, New York, NY, 5Feinstein Institute, Manhasset, NY, 6Northwell Health, New York

    Background/Purpose:Poor renal prognosis in lupus nephritis (LN) is associated with an abundance of renal macrophages and dendritic cells (DCs) but the role of these cells…
  • Abstract Number: 0998 • ACR Convergence 2020

    Differential Roles of TNFRI and TNFRII in the Morphology of Secondary Lymphoid Organs

    Kim Jeucken1, Jan Piet van Hamburg1 and Sander Tas2, 1Amsterdam Rheumatology and Immunology Center (ARC), Department of Rheumatology and Clinical Immunology, Department of Experimental Immunology and Amsterdam Infection and Immunity Institute, Amsterdam UMC; location AMC, University of Amsterdam, Netherlands, Amsterdam, Netherlands, 2Amsterdam Rheumatology and Immunology Center (ARC), Department of Rheumatology and Clinical Immunology, Department of Experimental Immunology and Amsterdam Infection and Immunity Institute, Amsterdam UMC; location AMC, University of Amsterdam, Netherlands, Utrecht, Netherlands

    Background/Purpose: Tumour necrosis factor (TNF) induced signaling events are important in lymphoid organ development and function, both in health and in immune-mediated inflammatory diseases such…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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