ACR Meeting Abstracts

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Abstracts tagged "Mouse Models, RA"

  • Abstract Number: 1889 • ACR Convergence 2021

    Arthritogenic T Cells Harbor a Transcriptional Program of T Cell Activation and a Repertoire Pruned by Endogenous Superantigen

    JUDITH F ASHOURI, Elizabeth McCarthy, Steven Yu, Noah Perlmutter, Charles Lin, Chun Jimmie Yu and Arthur Weiss, University of California San Francisco, San Francisco, CA

    Background/Purpose: It is widely accepted that activation of specific CD4 T cells through their TCRs by self-antigen (Ag) is necessary for rheumatoid arthritis (RA) onset.…
  • Abstract Number: 1891 • ACR Convergence 2021

    Variable Effects of Testosterone on Male versus Female Derived Macrophages in Inflammatory Arthritis

    Kiana Chen1, Xi Lin1, Lianping Xing2, H. Mark Kenney3, Richard Bell4, Edward Schwarz5 and Homaira Rahimi5, 1University of Rochester School of Medicine and Dentistry, Rochester, NY, 2University of Rochester Medical Center, Webster, NY, 3University of Rochester Medical Center, Rochester, NY, 4Hospital for Special Surgery, New York, NY, 5University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that is female predominant. The TNF-transgenic (TNF-Tg) mouse model of RA also develops a sexually…
  • Abstract Number: 0774 • ACR Convergence 2020

    Nr4a1-high Arthritogenic T Cells from SKG Mice Are Associated with Markers of Recent and Chronic Antigen-stimulation and an Altered T Cell Receptor Repertoire

    Judith Ashouri-Sinha1, Elizabeth McCarthy1, Steven Yu2, Chun Jimmie Ye1 and Arthur Weiss1, 1UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, San Francisco, CA, 2UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, San Francsico, CA

    Background/Purpose: T cells can either be activated through their T cell receptor (TCR) in an antigen-specific manner, or in response to cytokines. Identification of antigen-reactive…
  • Abstract Number: 0778 • ACR Convergence 2020

    Bacterial Families Lachnospiraceae/Ruminococcaceae Are Immunologically Targeted in Individuals At-risk for RA and a Specific Strain Is Arthritogenic in Monocultured Gnotobiotic Mice

    Meagan Chriswell1, Jennifer Seifert2, Lisa Blum3, Michelle Bloom3, Marie Feser4, M Kristen Demoruelle5, Jill Norris6, Kevin D. Deane7, Eddie James8, Jane Buckner8, William Robinson3, V. Michael Holers5 and Kristine Kuhn9, 1UC Denver SOM, Denver, CO, 2UC Denver, Littleton, CO, 3Stanford University, Palo Alto, CA, 4Division of Rheumatology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA, Colorado, 5University of Colorado, Denver, CO, 6Colorado School of Public Health, Aurora, CO, 72 Division of Rheumatology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA, Colorado, 8Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, 9University of Colorado Anschutz Medical Campus, Aurora, CO

    Background/Purpose: Circulating autoantibodies, including anti-CCP and RF, develop years before physical manifestations of rheumatoid arthritis (RA), with several lines of evidence suggesting that these autoantibodies…
  • Abstract Number: 0781 • ACR Convergence 2020

    Phenotypic and Functional Characterisation of Synovial Fluid-derived Fibroblast-like Synoviocytes in Rheumatoid Arthritis

    Ditte Køster1, Johanne Hovgaard Egedal1, Malene Hvid1, Martin Roelsgaard Jakobsen1, Ulf Müller-Ladner2, Bent Deleuran1, Tue Wenzel Kragstrup1, Elena Neumann3 and Morten Aagaard Nielsen1, 1Aarhus University, Aarhus, Denmark, 2Department of Rheumatology, Immunology, Osteology and Physical Medicine, Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, Bad Nauheim, Germany, 3Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus Liebig University Giessen, Bad Nauheim, Germany

    Background/Purpose: Fibroblast-like synoviocytes (FLS) are central cellular components in persistent inflammatory joint diseases such as rheumatoid arthritis (RA). Pathological subsets of FLS have been identified…
  • Abstract Number: 0966 • ACR Convergence 2020

    Decoupling Inflammation and Bone Loss in Rheumatoid Arthritis via Schnurri-3

    Zheni Stavre1, JungMin Kim2, Jae-Hyuck Shim2 and Ellen Gravallese3, 1University of Massachusetts Medical School-Rheumatology Division, Worcester, MA, 2University of Massachusetts Medical School, Worcester, MA, 3Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to local and systemic bone loss. TNF is a key mediator of bone loss,…
  • Abstract Number: 0969 • ACR Convergence 2020

    Investigating Murine Joint-Draining Lymphatics: Lineage Tracing and Single Cell RNA Sequencing Reveal Evidence That Popliteal Lymphatic Muscle Cells and Their Progenitors Represent Distinct Cell Types Divergent from Striated and Vascular Muscle Cells

    H. Mark Kenney1, Richard Bell2, Elysia Masters1, Lianping Xing1, Christopher Ritchlin3 and Edward Schwarz1, 1University of Rochester Medical Center, Rochester, 2Hospital for Special Surgery, New York, 3Department of Medicine, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Previous studies demonstrated that tumor necrosis factor transgenic (TNF-Tg) mice with inflammatory arthritis have damaged lymphatic muscle cells (LMCs) and eventual loss of popliteal…
  • Abstract Number: 1407 • ACR Convergence 2020

    Resolvin D5 Modulates Th17/Treg Cell Differentiation and Suppresses Osteoclastogenesis

    Hirotaka Yamada1, Jun Saegusa2, Sho Sendo3, Yo Ueda4, Takaichi Okano1, Yoshikazu Fujikawa5, Yuzuru Yamamoto6, Takumi Nagamoto1, Yoshihide Ichise1, Ikuko Naka1, Kengo Akashi7, Akira Onishi7, Masakazu Shinohara1 and Akio Morinobu7, 1Kobe University, Kobe, Japan, 2Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan, 3Kobe University, Kobe, 4Kobe UniversityRheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan, 5Kobe University, Kobe city, Japan, 6Kobe University, Kobe-city, Japan, 7Rheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan

    Background/Purpose: Over the last two decades, it has become increasingly clear that resolution of acute inflammation is not a passive process, but requires active modulation.…
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ACR Pediatric Rheumatology Symposium 2020

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