Abstract Number: 0942 • ACR Convergence 2024
An Aged K/BxA Arthritis Mouse Model Develops Features of Interstitial Lung Disease with Pulmonary Fibrosis and Bronchus-Associated T-Cell Aggregates Without a Pulmonary Insult, and Correlates with Worsening Arthritis Scores
Background/Purpose: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is a significant extra-articular manifestation of RA with high morbidity/mortality, but the underlying pathogenesis remains poorly understood.…Abstract Number: 0943 • ACR Convergence 2024
Cytosporone B, a Selective Agonist of Nr4a1, Inhibits Th17 Differentiation and Alleviates Experimental Arthritis in SKG Mice
Background/Purpose: NR4A family regulates T cell tolerance mechanisms, including thymic-negative selection, Treg generation and function, and anergy/exhaustion. Among the three NR4A nuclear receptors, Nur77, the…Abstract Number: 0945 • ACR Convergence 2024
Involvement of Cellular Senescence in Rheumatoid Arthritis-associated Interstitial Lung Disease of SKG Mice
Background/Purpose: There has been accumulating evidence that cellular senescence of fibroblasts and alveolar epithelial cells contributes to inflammation and fibrosis through a senescence-associated secretory phenotype…Abstract Number: 0946 • ACR Convergence 2024
Tissue Resident Monocyte-lineage Cells (TR-MC) Exist as Two Different Subpopulations
Background/Purpose: Monocytes are critical for the pathogenesis of rheumatoid arthritis (RA). However, depletion of peripheral monocytes (PM) is not sufficient to rescue disease in RA…Abstract Number: 0947 • ACR Convergence 2024
REX-7117 Is a Highly Potent and Selective Oral STAT3 Inhibitor That Demonstrated Potential Efficacy and Safety Differentiation versus JAK/TYK2 Targeting in Preclinical Models of Inflammatory Arthritis
Background/Purpose: Inhibition of JAK family signaling has translated into clinically meaningful efficacy in rheumatoid arthritis, psoriatic arthritis and other inflammatory diseases. However, small molecule JAK/TYK2…Abstract Number: 0948 • ACR Convergence 2024
Neuronal Intestinal Dysplasia Due to Ncx Gene Deficiency Attenuates the Severity of Experimental Arthritis in Mice
Background/Purpose: Loss of bacterial diversity and increases of specific bacteria in the gut microbiota have been observed in inflammatory arthritis such as rheumatoid arthritis…Abstract Number: 0949 • ACR Convergence 2024
CCN1 Is a Novel Therapeutic Target for Reducing Structural Damage in Rheumatoid Arthritis: Demonstration from 2 Preclinical Models
Background/Purpose: We have previously shown that the matricellular protein CCN1, characterized by angiogenic and immunomodulatory properties, is overexpressed in endothelial cells and synovial tissue of…Abstract Number: 1836 • ACR Convergence 2024
Transcriptional Changes in the Formation of Tissue Resident Memory T Cells in the Joint
Background/Purpose: Rheumatoid arthritis is a chronic autoimmune disease characterized by joint-specific memory, the phenomenon in which arthritis repeatedly flares in the same joints. We previously…Abstract Number: 1849 • ACR Convergence 2024
Selective Targeting of One-Carbon Metabolism to Combat Rheumatoid Arthritis
Background/Purpose: Rapidly proliferating cells fuel their increased nucleotide demand by boosting one-carbon metabolism, associated with the survival of pathogenic proliferative cells and the release of…Abstract Number: 2540 • ACR Convergence 2024
Characterizing the Functional Role of Type I Interferons in Inflammatory Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation due to cellular infiltration and inflammatory mediators. Type I interferons (IFN) have…Abstract Number: 0927 • ACR Convergence 2024
Synovial Macrophage Heterogeneity and Dynamics in Steady Stateand Rheumatoid Arthritis Mouse Model Time Course
Background/Purpose: Macrophages are vital contributors to both pro-inflammatory signaling and tissue repair processes involved in the pathogenesis and remission of Rheumatoid Arthritis (RA). Recent research…Abstract Number: 0938 • ACR Convergence 2024
Group 2 Innate Lymphoid Cells Promote T Cell Activation and Development of Autoimmune Arthritis
Background/Purpose: Innate Lymphoid Cells (ILCs) are the innate counterparts to T cells and can be divided into three functionally distinct subpopulations: Group 1 (ILC1), Group…Abstract Number: 0001 • ACR Convergence 2023
Loss of the Complement Regulator CD55 Alters Marginal Zone B Cell Homeostasis
Background/Purpose: Complement and B cells are implicated in the pathophysiology of rheumatoid arthritis, an autoimmune disease characterized by synovial inflammation. Loss of complement regulator CD55…Abstract Number: 0082 • ACR Convergence 2023
A VAV1-Directed Molecular Glue Degrader, MRT-6160, Reduces Joint Inflammation in a Collagen-Induced Arthritis Autoimmune Disease Model
Background/Purpose: VAV1 is a member of the VAV family of guanine nucleotide exchange factors (GEFs) and plays a critical role in mediating T- and B-cell…Abstract Number: 1715 • ACR Convergence 2023
Androgen Treatment Exhibits a Protective Role Against Focal Erosions in TNF-Induced Inflammatory Arthritis in Mice
Background/Purpose: Rheumatoid arthritis (RA) is characterized by chronic joint inflammation and bone erosion and is female predominant. The TNF-transgenic (TNF-Tg) murine model of RA develops…
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