Abstracts tagged "mouse model and rheumatoid arthritis (RA)"

Abstract Number: 33 • 2018 ACR/ARHP Annual Meeting
Card9 Is a Critical Regulator of Autoimmune Arthritis in SKG Mice
Ruth Napier¹, Ellen Lee¹, Emily Vance¹, Kimberly Samson², Paige Snow³, Shimon Sakaguchi⁴ and Holly Rosenzweig¹, ¹Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, ²Oregon Health & Science University, Portland, OR, ³Molecular Microbiology and Immunology, VA Portland Health Care System, Portland, OR, ⁴Osaka University, Osaka, Japan
Background/Purpose: Caspase recruitment domain-containing protein 9 (Card9) is a C-type lectin receptor known for its function in protection against fungal infection and association with human diseases…
Abstract Number: 44 • 2018 ACR/ARHP Annual Meeting
Histone Deacetylase 1 (HDAC1): A Novel Therapeutic Target in Patients with Rheumatoid Arthritis
Lisa Goschl¹, Victoria Saferding², Johan Bäcklund³, Clemens Scheinecker⁴, Josef S. Smolen⁵, Günter Steiner⁶, Wilfried Ellmeier¹ and Michael Bonelli⁷, ¹Medical University of Vienna,Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Vienna, Austria, ²Medical University of Vienna, Austria, Vienna, Austria, ³Karolinska Institute,Department of Medical Biochemistry and Biophysics, Stockholm, Sweden, ⁴Medical University of Vienna, Divison of Rheumatology, Vienna, Austria, ⁵Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, ⁶Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Austria, Vienna, Austria, ⁷Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Despite enormous efforts to develop new therapeutic strategies for treatment of rheumatoid arthritis (RA), the large number of non responding patients to currently available…
Abstract Number: 391 • 2017 ACR/ARHP Annual Meeting
Defective Glucose and Lipid Metabolism in Rheumatoid Arthritis Is Determined By Chronic Inflammation in Metabolic Tissues
Nuria Barbarroja¹, Ivan Arias de la Rosa², Sergio Rodriguez-Cuenca³, Yolanda Jiménez-Gómez¹, Patricia Ruiz-Limon², Carlos Perez-Sanchez¹, Maria Carmen Abalos-Aguilera², Irene Cecchi², Rafaela Ortega-Castro¹, Jerusalem Calvo-Gutierrez¹, Rocio Guzman-Ruiz⁴, Maria del Mar Malagon⁵, Eduardo Collantes-Estévez¹, Antonio Vidal-Puig³, Alejandro Escudero-Contreras² and Chary Lopez-Pedrera¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbroke’s Hospital, University of Cambridge, Cambridge, United Kingdom, ⁴Department of Cell Biology, Physiology, and Immunology,, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain, ⁵Department of Cell Biology, Physiology, and Immunology,I, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain
Background/Purpose: Rheumatoid arthritis (RA) patients are at higher risk for insulin resistance (IR). The association between RA and IR, and its role on the different…
Abstract Number: 406 • 2017 ACR/ARHP Annual Meeting
Mapping Changes in Monocyte and Macrophage Populations in the Synovium: An Aging Study in Arthritic KRN Ag7 Mice
Anna B Montgomery¹, Carla Cuda², Philip J. Homan³, Harris Perlman² and Deborah R. WInter², ¹Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease of the joints associated with accelerated aging and increased mortality. Further, RA is linked with a number…
Abstract Number: 1029 • 2016 ACR/ARHP Annual Meeting
Functional Genetics of PTPN2 in Rheumatoid Arthritis: Haploinsufficiency of PTPN2 Promotes Severity of Th17-Cell Mediated Autoimmune Arthritis
Mattias N. D. Svensson^1,2, Karen M. Doody¹, Cristiano Sacchetti^1,2, Dennis J. Wu¹, Gisen Kim³, Annelie Hellvard⁴, Brith Bergum⁴, Piotr Mydel⁴, Mitchell Kronenberg³, Michel L. Tremblay⁵ and Nunzio Bottini^1,2, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²Department of Medicine, University of California, San Diego, La Jolla, CA, ³Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁴Clinical Science, Broegelmann Research Laboratory, Bergen, Norway, ⁵Goodman Cancer Centre, McGill University, Montréal, QC, Canada
Background/Purpose: Genome-wide association studies have linked polymorphisms in the PTPN2 locus to rheumatoid arthritis (RA). PTPN2 encodes the tyrosine phosphatase TC-PTP, an important regulator of…
Abstract Number: 1434 • 2016 ACR/ARHP Annual Meeting
Effect of Systemic and Local Inflammation on the Insulin Resistance and Glucose/Lipid Metabolism in Rheumatoid Arthritis: Humans and CIA Mouse Model
Nuria Barbarroja¹, IVÁN ARIAS DE LA ROSA¹, Manuel Peña¹, Sergio Rodriguez-Cuenca², Yolanda Jiménez-Gómez¹, Patricia Ruiz-Limon³, Carlos Perez-Sanchez¹, Maria Carmen Abalos-Aguilera³, Jerusalem Calvo-Gutierrez¹, Eduardo Collantes-Estévez¹, Antonio Vidal-Puig², Chary Lopez-Pedrera¹ and Alejandro Escudero-Contreras¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbroke’s Hospital, University of Cambridge, Cambridge, United Kingdom, ³Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain
Background/Purpose: Rheumatoid arthritis (RA) patients are at higher risk for insulin resistance (IR). The association between RA and IR, and its role on the different…
Abstract Number: 2145 • 2016 ACR/ARHP Annual Meeting
The Modulation of Macrophage Polarization By SIRT1 Maybe New Target Therapy in Rheumatoid Arthritis
Sang-Yeob Lee¹, Won Tae Chung², Sung Won Lee³, So Youn Park⁴ and Bae Jae Ho⁵, ¹Cell Biology, Dong -A university, South Korea, Pusan, South Korea, ²Rheumatology, Dong-A University Hospital, Busan, South Korea, ³Dong-A university,Busan, South Korea, Pusan, South Korea, ⁴Medical Research Center for Ischemic Tissue Regeneration, Pusan national university, Yong -San, South Korea, ⁵department of biochemistry, medical college, Pusan National University,, MD, PhD, Gyeongsangnam-do, South Korea
Background/Purpose: The polarization of macrophages was the expressed to M1/M2 phenotype by various stimuli or environment signals. The M1 macrophage was pro-inflammatory phenotype and was…
Abstract Number: 1964 • 2014 ACR/ARHP Annual Meeting
Changes in Soluble CD18 Reflect Latency in the Immune System and Predict Radiographic Progression in Early Rheumatoid Arthritis
Tue Wenzel Kragstrup¹, Babak Jalilian¹, Kresten Krarup Keller², Kristian Stengaard-Pedersen³, Merete Lund Hetland⁴, Kim Hørslev-Petersen⁵, Peter Junker⁶, Mikkel Østergaard⁴, Ellen Margrethe Hauge^7,8, Malene Hvid¹, Thomas Vorup-Jensen¹ and Bent Deleuran^1,3, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Aarhus University Hospital, Aarhus, Denmark, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴Glostrup University Hospital, Glostrup, Denmark, ⁵Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, ⁶Odense University Hospital, Odense, Denmark, ⁷Dept. of Anatomi, Aarhus University, Aarhus, Denmark, ⁸Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose In early rheumatoid arthritis (RA), clinical disease characterized by swollen and painful joints is caused by synovitis. However, presence of autoantibodies may precede the…
Abstract Number: 1280 • 2013 ACR/ARHP Annual Meeting
The Role of Sphingosine-1-Phosphate Receptor 3 Signaling in Murine Collagen-Induced Arthiritis
Hidetake Nagahara¹, Masataka Kohno¹, Ken Murakami¹, Aihiro Yamamoto¹, Takahiro Seno¹, Wataru Fujii¹, Kazuki Fujioka¹, Yuji Kukida¹, Ryo Oda², Hiroyoshi Fujiwara² and Yutaka Kawahito¹, ¹Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, ²Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, kyoto, Japan
Background/Purpose: Sphingolipids represent a major class of lipids that are ubiquitously expressed in eukaryotic cell membranes. Through the interaction with a family of five G-protein-coupled…
Abstract Number: 1288 • 2013 ACR/ARHP Annual Meeting
Development Of Antibodies Specific For Carbamylated Protein Precedes Disease Onset In Mice With Collagen-Induced Arthritis
Leendert A. Trouw¹, Bisheng Liu¹, Jing Shi¹, Diahann T.S.L. Jansen¹, Martin Hegen², Tom W.J. Huizinga¹, Jeroen N. Stoop¹ and René E. M. Toes¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Pfizer, Cambridge, MA
Background/Purpose: Antibodies against citrullinated proteins are a characteristic of rheumatoid arthritis (RA). Recently, we demonstrated that autoantibodies recognizing homocitrulline containing proteins are present in sera…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].