Abstracts tagged "Monocytes/macrophages"

Abstract Number: 2399 • ACR Convergence 2025
Identification of an LN endotype linked to intestinal expansion of Pathogenic Strains of a Pathobiont Bacterium that induces Systemic Thrombo-inflammatory Pathways directly measurable in Urine
Gregg Silverman¹, Abhimanyu Amarnani², Zakia Azad² and Brad Rovin³, ¹NYU Grossman School of Medicine, New York, NY, ²New York University Grossman School of Medicine, New York, NY, ³The Ohio State University, Columbus, OH
Background/Purpose: During disease, ~50% of SLE patients develop lupus nephritis (LN), one of the most serious complication. Despite the best therapy, within 15 years, ~20%…
Abstract Number: 0708 • ACR Convergence 2025
Association Of Choroidal Sub-foveal Thickness With Skin Manifestations And Serum Monocyte HDL Ratio In Patients With Systemic Sclerosis-A Case Control Study
Tejaswini Ramineni¹, Vijaya prasanna Parimi², Radhika M³ and Narsimulu Gumdal³, ¹Esic Medical College And Hospital, Sanathnagar, Hyderabad, Telangana, India, ²ESIC Medical College and Super Specilaity Hospital, hyderabad, Telangana, India, ³ESIC MEDICAL COLLEGE AND HOSPITAL, Hyderabad, Telangana, India
Background/Purpose: The vascular hypothesis in systemic sclerosis (SSc) posits that vasculopathy is the initial inciting event that triggers inflammation and subsequent fibrosis in the progression…
Abstract Number: 2540 • ACR Convergence 2025
Monocyte-to-High-Density Lipoprotein Cholesterol Ratio as a Clinical Marker of Gastrointestinal Involvement in Behçet Syndrome
Hansun Song, Seong-Ryul Kwon and Mie Jin Lim, College of Medicine, Inha University, Incheon, Republic of Korea
Background/Purpose: Behçet syndrome (BS) is a chronic multisystem vasculitis marked by recurrent mucocutaneous and ocular inflammation, and in a subset of patients, gastrointestinal (GI) involvement.…
Abstract Number: 0951 • ACR Convergence 2025
Epidermal IFNκ Increases Circulating and Cutaneous Monocytes in a C57/Bl6 Overexpression Mouse Model
Patrick O'Brien, Benjamin Klein, Deborah Colesa and J. Michelle Kahlenberg, University of Michigan, Ann Arbor, MI
Background/Purpose: Lupus is a heterogeneous inflammatory autoimmune disease affecting a variety of organs, including skin manifestations such as photosensitivity and cutaneous lesions. The skin of…
Abstract Number: 2584 • ACR Convergence 2025
Spatially Resolved Transcriptomics Reveal Macrophage Heterogeneity in Giant Cell Arteritis
Lea Dionet¹, Federica Pallotti², Margot Poux³, Quentin Delcros⁴, Nader Yatim⁵, Brian Soong⁶, Paul Breillat⁷, Kevin Chevalier⁸, claudie Cladière⁹, Patrick Bruneval¹⁰, Benoit Terris⁴, Alexis REGENT¹¹, Xavier Puéchal¹², Luc Mouthon¹³, Miriam Merad⁶, Olivia Lenoir¹⁴, Pierre-Louis Tharaux¹⁵, Maxime Samson¹⁶ and Benjamin Terrier¹⁷, ¹INSERM, Paris, France, ²Internal Medicine and Clinical Immunology, Rennes, France, ³Université de Paris, PARIS ⁰⁴EME, France, ⁴AP-HP, Paris, France, ⁵University of Paris-Cite, New York, NY, ⁶Mount Sinai School of Medicine, New York, ⁷INSERM, PARIS ¹⁷, Ile-de-France, France, ⁸Université Paris Cité, Montrouge, France, ⁹Marie et Louis Pasteur University, EFS, INSERM, UMR RIGHT, Besançon, France, Dijon, France, ¹⁰AP-HP, Paris, ¹¹Hopital Cochin, Paris, France, ¹²Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hospital Cochin, and Université Paris Cité, Paris ( ⁷⁵⁰¹⁴ ), Ile-de-France, France, ¹³Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Cochin University Hospital, Université Paris Cité, AP-HP, Paris, France, ¹⁴Paris Cardiovascular Research Center, Université Paris Cité, INSERM U⁹⁷⁰, Paris, France, PARIS, Ile-de-France, France, ¹⁵Paris Cardiovascular Research Center, Université Paris Cité, INSERM U⁹⁷⁰, Paris, France, PARIS, France, ¹⁶CHU Dijon Bourgogne, Dijon, France, ¹⁷Cochin Hospital, Paris, France
Background/Purpose: Giant cell arteritis (GCA) is a large-vessel vasculitis affecting individuals over 50 years of age. Current models implicate genetic susceptibility, immune senescence, activation of…
Abstract Number: 0957 • ACR Convergence 2025
Multi-Omic Profiling Reveals a Monocyte-Vascular Signature Associated with the Regression of Skin Fibrosis in SSc
Astrid Hofman¹, Pietro Bearzi², Elena Pachera³, Cosimo Bruni⁴, Lumeng Li², Laura Much⁵, Kristina Bürki¹, Mike Becker⁶, Anna-Maria Hoffmann-Vold⁷ and Oliver Distler⁸, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, the LOOP Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, the LOOP Zurich, Zürich, Switzerland, ³University Hospital Zurich, Zurich, Switzerland, ⁴University of Zurich, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁶Dept. of Rheumatology, University Hospital Zurich, Zürich, Switzerland, ⁷Oslo University Hospital, Oslo, Norway, ⁸Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland, Zurich, Switzerland
Background/Purpose: Regression of skin fibrosis is a feature of the natural history of dcSSc. The molecular mechanisms underlying this resolution remain unclear. This study aims…
Abstract Number: 0980 • ACR Convergence 2025
Expansion of Viral-Reactive CD8+ T cell Repertoire Stratified by Pathotype in New-onset ACPA+ Rheumatoid Arthritis
Carl Coyle¹, Wittaya Suwakulsiri², Lukas Andriessen³, Megan Soon⁴, Pascale Wehr⁵, Sumera Qureshi⁶, Christopher Altmann⁷, Annabelle Small⁸, Vincent Wong⁹, Andrew Cope⁶, Kevin Wei¹⁰, Hendrik Nel⁵, Mihir Wechalekar¹¹ and Ranjeny Thomas², ¹Kings College London, London, United Kingdom, ²Frazer Institute, University of Queensland, Brisbane, Queensland, Australia, ³Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia, ⁴Frazer Institute, The University of Queensland, Brisbane, Australia, ⁵University of Queensland, Woolloongabba, Queensland, Australia, ⁶King's College London, London, United Kingdom, ⁷Flinders University, Adelaide, Australia, ⁸Flinders University, Bedford Park, South Australia, Australia, ⁹College of Medicine and Public Health, Bedford Park, South Australia, Australia, ¹⁰Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ¹¹Flinders Medical Centre, Adelaide, Australia
Background/Purpose: Development of Rheumatoid Arthritis (RA) is strongly associated with specific HLA-DRB1 genotypes and the HLA-DR antigen binding groove, the shared epitope. HLA-B*08 also increases…
Abstract Number: 1553 • ACR Convergence 2025
Circulating Monocyte Level Is Associated With Pulmonary Vascular Disease and Right Ventricular Dysfunction in Systemic Sclerosis
Ai Yaku¹, Bong Joon Kim², Hidenori Yaku¹, Carrie Richardson², Michael Cuttica², Ruben Mylvaganam², Vera Rigolin², Matthew Feinstein² and Sanjiv Shah¹, ¹Northwestern University, Chicago, IL, ²Northwestern University, Chicago
Background/Purpose: Pulmonary arterial hypertension associated with systemic sclerosis (SSc-PAH) is a life-threatening condition with obliterative pulmonary vascular remodeling, right ventricular (RV) dysfunction, and poor prognosis.…
Abstract Number: 1651 • ACR Convergence 2025
Compound Heterozygosity for the Ile692del and Val726Ala Pathogenic MEFV Variants and Elevated IL-18 (CHIVE-18 syndrome) Is Distinct from Familial Mediterranean Fever (FMF) and Includes a Pronounced Response to Interferon Stimulation in Myeloid Cell Populations
Mary Maclean¹, Sabrina Helmold Hait², Cindy Phung³, Deborah Stone⁴, Sophie georgin-Lavialle⁵, Scott Canna⁶, Carl Esperanzate⁷, Amanda Ombrello⁸, Daniel Kastner⁹, Ivona Aksentijevich¹⁰ and Massimo Gadina¹¹, ¹NIH-NIAMS, Rockville, MD, ²NIAMS/NIH, Bethesda, MD, ³National Institute of Arthritis, Musculoskeletal, and Skin Diseases (NIAMS), Bethesda, MD, ⁴NIH, Bethesda, MD, ⁵Sorbonne university, Tenon hospital, DMU³ID, CEREMAIA, ERN RITA, Paris, France, ⁶Children's Hospital of Philadelphia, Philadelphia, PA, ⁷National Human Genome research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD, ⁸National Institutes of Health, Rockville, MD, ⁹National Human Genome Research Institute, Bethesda, MD, ¹⁰¹⁰⁰, Bethesda, MD, ¹¹National Institute of Arthritis Musculoskeletal and Skin diseases, Bethesda, MD
Background/Purpose: Familial Mediterranean fever (FMF) is an autoinflammatory disease associated with biallelic pathogenic variants in the MEFV gene encoding the myeloid-restricted inflammasome sensor pyrin. The…
Abstract Number: 1682 • ACR Convergence 2025
Sjögren’s Disease Salivary Gland Fibroblast Subsets are Proinflammatory and Aberrantly Promote Pain
Sara McCoy¹, Rachael Bogle², michele larsen³, Li Chen⁴, thomas pranzatelli⁵, Paola Perez⁶, john chiorini⁷, Alan Baer⁸, A. Darise Farris⁹, Christopher Lessard⁹, Astrid Rasmussen⁹, Caroline Shiboski¹⁰, Stephen Shiboski¹⁰, Alexander Mikesell³, Zachary Campbell³, Alex Tsoi², Johann Gudjonsson¹¹ and Blake M. Warner¹², ¹University of Wisconsin–Madison, Madison, WI, ²University of Michigan, Holland, OH, ³University of Wisconsin, Madison, ⁴University of Michigan, Ann Arbor, ⁵NIH, Bethesda, ⁶NIDCR, Bethesda, MD, ⁷NIH, bethesda, MD, ⁸Johns Hopkins University School of Medicine, Baltimore, MD, ⁹Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁰University of California San Francisco, San Francisco, CA, ¹¹University of Michigan, Ann Arbor, MI, ¹²National Institutes of Health, Bethesda, MD
Background/Purpose: Fibroblasts (fb) are increasingly recognized as dynamic signaling hubs in rheumatic disease, yet their contribution to Sjögren Disease (SjD) remains poorly defined. We dissect…
Abstract Number: 1757 • ACR Convergence 2025
Skin-to-Joint Immune Cell Migration and Synovial Reprogramming in Psoriatic Arthritis Onset
Maria Gabriella Raimondo¹, Hashem Mohammadian², Mario Angeli², Vladyslav Fedorchenko², Kaiyue Huang³, Yi-Nan Li⁴, Raphael Micheroli⁵, Jörg Distler⁶, Ursula Fearon⁷, Juergen Rech², Francesco Ciccia⁸, Juan Cañete⁹, Adam Croft¹⁰, Mariola Kurowska-Stolarska¹¹, Stefano Alivernini¹², Maria Antonietta D'Agostino¹³, Georg Schett², Simon Rauber¹⁴ and Andreas Ramming¹⁵, ¹Department of Medicine ³ - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, ²Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Germany, ³Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, ⁴University Hospital of Düsseldorf, Düsseldorf, Germany, ⁵University Hospital Zurich, Zurich, Switzerland, ⁶University Hospital Duesseldorf and HHU, Duesseldorf, Germany, ⁷Trinity College Dublin, Dublin, Dublin, Ireland, ⁸Rheumatology Section, University of Campania L. Vanvitelli, Naples, Italy, Naples, Italy, ⁹Rheumatology Department, Hospital Clínic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, ¹⁰University of Birmingham, Hagley, Stourbridge, United Kingdom, ¹¹University of Glasgow, Glasgow, ¹²Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ¹³Division of Rheumatology and Clinical Immunology - Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ¹⁴Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Bayern, Germany, ¹⁵Department of Internal Medicine ³, Rheumatology & Immunology, Friedrich-Alexander-University (FAU) & Universitätsklinikum Erlangen, Erlangen, Germany
Background/Purpose: Psoriatic arthritis (PsA) develops in about 30% of individuals with psoriasis (PsO), highlighting a critical connection between skin and joint inflammation. However, the mechanisms…
Abstract Number: 0944 • ACR Convergence 2024
Targeting Defective Macrophages to Restore Resolution of Inflammation in Rheumatoid Arthritis -Perspectives for an Autologous Secretome Therapy
Melanie Couturier¹, Francis Bonnefoy², emilie Gaiffe³, Charline Vauchy⁴, Suzanne Behlke², ERIC TOUSSIROT⁵ and Sylvain Perruche², ¹1MED’INN’Pharma, F-25000 Besançon, France, Besançon, France, ²MED’INN’Pharma, F-25000 Besançon, France, Besançon, France, ³INSERM CIC -1431 CHU Besançon, France, Besançon, France, ⁴INSERM CIC-1431, CHU de Besançon, Besancon, France, Besançon, France, ⁵university hospital of BESANCON, besancon, France
Background/Purpose: Impaired macrophage efferocytosis, a key hallmark of failed inflammation resolution, is reported in many immune-mediated inflammatory diseases, including in Rheumatoid Arthritis (RA). Hence the…
Abstract Number: 0946 • ACR Convergence 2024
Tissue Resident Monocyte-lineage Cells (TR-MC) Exist as Two Different Subpopulations
Yidan Wang¹, Jessica Maciuch², Tyler Therron³, Carla Cuda², Deborah Winter⁴ and Harris Perlman², ¹Northwestern University, Hanover Park, IL, ²Northwestern University, Chicago, IL, ³Northwestern University, Chicago, ⁴Northwestern University, Skokie, IL
Background/Purpose: Monocytes are critical for the pathogenesis of rheumatoid arthritis (RA). However, depletion of peripheral monocytes (PM) is not sufficient to rescue disease in RA…
Abstract Number: 0962 • ACR Convergence 2024
Characterizing the Contribution of Myeloid Cells to Limited and Diffuse Cutaneous Systemic Sclerosis
Parker Jones¹, Salina Dominguez², Miranda Gurra³, Gaurav Gadhvi⁴, Tyler Therron², Kathleen Aren⁵, Carla Cuda³, Monique Hinchcliff⁶, Harris Perlman³, Hadijat Makinde³ and Deborah Winter⁷, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Chicago, ³Northwestern University, Chicago, IL, ⁴University of Michigan, Ann Arbor, MI, ⁵Northwestern University Division of Rheumatology, Chicago, IL, ⁶Yale School of Medicine, Westport, CT, ⁷Northwestern University, Skokie, IL
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by multiorgan fibrosis. The two main subtypes are diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc…
Abstract Number: 0970 • ACR Convergence 2024
Deubiquitylase (DUB) BRCC36 Isopeptidase Complex (BRISC) Inhibitors Prevent IFNAR1 Deubiquitination to Restore Natural Type I IFN Response in Autoimmunity
Rebecca Ross¹, Poli Adi Narayanna Reddy², Joseph Salvino², Elton Zeqiraj³ and Francesco Del Galdo³, ¹Medicine and Health, University of Leeds, Leeds, United Kingdom, ²The Wistar Institute, Philadelphia, PA, ³University of Leeds, Leeds, United Kingdom
Background/Purpose: Increased Type I IFN activation plays a key role in Scleroderma (SSc), Systemic Lupus Erythematosus and Inflammatory Myositis. Deubiquitylase (DUB) BRCC36 isopeptidase complex (BRISC)…

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