Abstract Number: 2043 • 2018 ACR/ARHP Annual Meeting
Monocytes and Macrophages of Patients with Rheumatoid Arthritis Respond to Pathologically Increased Ionized Calcium with Proinflammatory Cytokine Production
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis and periarticular bone erosion. Bony erosions and cell necrosis might lead to a local…Abstract Number: 1015 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Peripheral CD14+ Monocytes Are Hyper-Inflammatory, Hyper-Glycolytic and Retain a Memory Bias Toward M1 Macrophages
Background/Purpose: Myeloid cells with a monocyte/macrophages phenotype are present in large numbers in the rheumatoid arthritis (RA) joint, significantly contributing to disease. This study aimed…Abstract Number: 960 • 2017 ACR/ARHP Annual Meeting
ADAM-17 Is Expressed on Rheumatoid Arthritis Synovial Fibroblasts and Mediates Monocyte Migration and Adhesion
Background/Purpose: A disintegrin and metalloproteinase 17 (ADAM-17), also known as tumor necrosis factor-α converting enzyme (TACE), have been reported to be involved in a number…Abstract Number: 1569 • 2016 ACR/ARHP Annual Meeting
Increased Circulating CD14brightCD16+ Intermediate Monocytes Are Regulated By Interleukin-10 in Patients with Rheumatoid Arthritis
Background/Purpose: The study enrolled 35 untreated RA patients and 14 healthy volunteers. DAS28-ESR was evaluated and peripheral blood samples were obtained at baseline and following…Abstract Number: 1624 • 2015 ACR/ARHP Annual Meeting
Epigenetic Profiling of CD14+ and CD16+ Monocyte Subtypes in Rheumatoid Arthritis. Alterations Related to Cardiovascular Disease and Endothelial Dysfunction
Background/Purpose: Monocytes play a key role in the pathogenesis of the cardiovascular disease (CVD). Three monocyte subsets have been described based on their CD14 and…Abstract Number: 2548 • 2015 ACR/ARHP Annual Meeting
M-CSF-R Is a Critical Determinant for the Differentiation of Classical to Non-Classical Monocytes
Background/Purpose: Colony-stimulating factors (CSF) are simply defined as haemotopoitec growth factors. However, CSFs have been implicated to have additional functions in various autoimmune diseases. Specifically…Abstract Number: 2611 • 2015 ACR/ARHP Annual Meeting
Circulating Monocyte Count Is Significantly Associated with Interstitial Pneumonia in Biologic-Naive Patients with Rheumatoid Arthritis: A Single-Center Prospective Cohort Study (Keio First-Bio Cohort Study)
Background/Purpose : Interstitial pneumonia (IP) is one of the most critical complications in rheumatoid arthritis (RA). Severe IP is developed in zymosan-treated SKG mice, and…Abstract Number: 2972 • 2014 ACR/ARHP Annual Meeting
Elevations of Certain Memory-Effector T Cell and Inflammatory Monocyte Subpopulations in Rheumatoid Arthritis Are Associated with the Presence of Subclinical Coronary Artery Atherosclerosis
Background/Purpose: Factors that identify cardiovascular disease (CVD) fully in RA are lacking. Peripheral blood mononuclear cell (PBMC) subsets in RA patients differ markedly, on average,…Abstract Number: 2451 • 2014 ACR/ARHP Annual Meeting
Mir-155 Expression Correlates with Clinical Disease Activity and Has Effector Function in Rheumatoid Arthritis
Background/Purpose: MicroRNAs are fine tuners of biological pathways that function via post-transcriptional regulation of target mRNA life span. MicroRNA 155 (miR155) is particularly implicated in…Abstract Number: 1472 • 2014 ACR/ARHP Annual Meeting
Synovial Fluid from Rheumatoid Arthritis Patients Modulates the Immunophenotype and Viability of Monocytes
Background/Purpose Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by infiltration of the synovium by inflammatory cells that destroys the cartilage and the…Abstract Number: 1469 • 2014 ACR/ARHP Annual Meeting
Methotrexate Treatment Reduces Serum IL-6 Level By Decreasing a CD14brightCD16+ Intermediate Non-Classical Subset of Monocytes in RA Patients
Background/Purpose It is well known that circulating monocytes are the source of inflammatory cytokines, such as IL-6 and TNFα and newly divided into three subsets…Abstract Number: 1458 • 2014 ACR/ARHP Annual Meeting
Functional Phenotype of Synovial Monocytes Modulating Inflammatory T-Cell Response in Rheumatoid Arthritis
Background/Purpose Monocytes function as crucial innate effectors during inflammation. Human monocytes can be divided into three distinct subsets based on CD14 and CD16 expression. Accumulating…Abstract Number: 2431 • 2013 ACR/ARHP Annual Meeting
Association Of T Follicular Helper / Th17 T Cell and Memory B Cell Populations In Rheumatoid Arthritis With Disease Activity and Therapy With TNF Antagonists
Background/Purpose: Autoreactive memory B cells and T cells contribute to the pathogenesis of rheumatoid arthritis (RA) through production of antibodies and cytokines that activate monocytes…Abstract Number: 1151 • 2013 ACR/ARHP Annual Meeting
Snapin Is Required For Functional Autophagy and Is Critical For Monocyte To Macrophage Differentiation
Background/Purpose: Our recent data indicate that Snapin, a SNAP associated protein, is significantly increased in macrophages (MΦs) in rheumatoid arthritis (RA) synovial tissue and its…Abstract Number: 774 • 2013 ACR/ARHP Annual Meeting
Citrullination Of ENA-78/CXCL5 Changes Its Receptor Affinity From CXCR2 To CXCR1 and Induces Monocyte Migration
Background/Purpose: We previously showed that citrullinated epithelial-derived neutrophil-activating peptide 78/CXCL5 (citENA-78/CXCL5) was significantly higher in rheumatoid arthritis (RA) synovial fluids (SFs) compared to osteoarthritis (OA)…