Abstracts tagged "monocytes and rheumatoid arthritis (RA)"

Abstract Number: 1015 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Peripheral CD14+ Monocytes Are Hyper-Inflammatory, Hyper-Glycolytic and Retain a Memory Bias Toward M1 Macrophages
Trudy McGarry¹, Megan M. Hanlon², Clare C. Cunningham³, Douglas J. Veale⁴ and Ursula Fearon⁵, ¹St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, ²Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ³Molecular Rheumatology, Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ⁴Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ⁵Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
Background/Purpose: Myeloid cells with a monocyte/macrophages phenotype are present in large numbers in the rheumatoid arthritis (RA) joint, significantly contributing to disease. This study aimed…
Abstract Number: 2043 • 2018 ACR/ARHP Annual Meeting
Monocytes and Macrophages of Patients with Rheumatoid Arthritis Respond to Pathologically Increased Ionized Calcium with Proinflammatory Cytokine Production
Supriya Murthy¹, Elisabeth Jaeger¹, Sebastian Jung¹, Kathleen Friedrich², Olga Seifert¹, Christoph Baerwald¹, Matthias Pierer¹ and Manuela Rossol¹, ¹Department of Internal Medicine, Rheumatology, University of Leipzig, Leipzig, Germany, ²Department of Internal Medicine, Rheumatology, University of Leipzig, Germany, Leipzig, Germany
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis and periarticular bone erosion. Bony erosions and cell necrosis might lead to a local…
Abstract Number: 960 • 2017 ACR/ARHP Annual Meeting
ADAM-17 Is Expressed on Rheumatoid Arthritis Synovial Fibroblasts and Mediates Monocyte Migration and Adhesion
Sho Ishii, Takeo Isozaki, Airi Nishimi, Shinichiro Nishimi, Takahiro Tokunaga, Hidekazu Furuya, Kuninobu Wakabayashi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan
Background/Purpose: A disintegrin and metalloproteinase 17 (ADAM-17), also known as tumor necrosis factor-α converting enzyme (TACE), have been reported to be involved in a number…
Abstract Number: 1569 • 2016 ACR/ARHP Annual Meeting
Increased Circulating CD14brightCD16+ Intermediate Monocytes Are Regulated By Interleukin-10 in Patients with Rheumatoid Arthritis
Masako Tsukamoto¹, Noriyuki Seta², Keiko Yoshimoto¹, Katsuya Suzuki¹, Kunihiro Yamaoka¹ and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Department of Internal Medicine, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan
Background/Purpose: The study enrolled 35 untreated RA patients and 14 healthy volunteers. DAS28-ESR was evaluated and peripheral blood samples were obtained at baseline and following…
Abstract Number: 1624 • 2015 ACR/ARHP Annual Meeting
Epigenetic Profiling of CD14+ and CD16+ Monocyte Subtypes in Rheumatoid Arthritis. Alterations Related to Cardiovascular Disease and Endothelial Dysfunction
Nuria Barbarroja^1,2, Patricia Ruiz-Limon¹, Carlos Perez-Sanchez¹, Yolanda Jiménez Gómez¹, MariCarmen Abalos-Aguilera¹, Pedro Segui³, Pilar Font¹, Ángeles Aguirre Zamorano¹, Jerusalem Calvo-Gutierrez¹, Rafaela Ortega¹, M. Carmen Castro Villegas¹, Eduardo Collantes-Estévez¹, Alejandro Escudero-Contreras¹ and Chary Lopez-Pedrera¹, ¹IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain, ²Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, ³IMIBIC-Reina Sofia University Hospital, Radiology Unit, Cordoba, Spain
Background/Purpose: Monocytes play a key role in the pathogenesis of the cardiovascular disease (CVD). Three monocyte subsets have been described based on their CD14 and…
Abstract Number: 2548 • 2015 ACR/ARHP Annual Meeting
M-CSF-R Is a Critical Determinant for the Differentiation of Classical to Non-Classical Monocytes
Philip J. Homan¹, Alexander Misharin¹, Carla Cuda², Salina Dominguez², Rana Saber², Fu-Nien Tsai³ and Harris R. Perlman⁴, ¹Medicine-Rheumatology, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Medicine, Rhuematology, Northwestern University, Chicago, IL, ⁴Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Colony-stimulating factors (CSF) are simply defined as haemotopoitec growth factors. However, CSFs have been implicated to have additional functions in various autoimmune diseases. Specifically…
Abstract Number: 2611 • 2015 ACR/ARHP Annual Meeting
Circulating Monocyte Count Is Significantly Associated with Interstitial Pneumonia in Biologic-Naive Patients with Rheumatoid Arthritis: A Single-Center Prospective Cohort Study (Keio First-Bio Cohort Study)
Keisuke Izumi¹, Misato Hashizume², Yuko Kaneko³, Keiko Yoshimoto¹ and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Product Research Department, Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ³Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose : Interstitial pneumonia (IP) is one of the most critical complications in rheumatoid arthritis (RA). Severe IP is developed in zymosan-treated SKG mice, and…
Abstract Number: 1469 • 2014 ACR/ARHP Annual Meeting
Methotrexate Treatment Reduces Serum IL-6 Level By Decreasing a CD14brightCD16+ Intermediate Non-Classical Subset of Monocytes in RA Patients
Masako Tsukamoto¹, Keiko Yoshimoto², Noriyuki Seta³, Katsuya Suzuki² and Tsutomu Takeuchi², ¹Division of Rheumatology, Department of Internal medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Department of Internal Medicine, Keio university, Tokyo, Japan
Background/Purpose It is well known that circulating monocytes are the source of inflammatory cytokines, such as IL-6 and TNFα and newly divided into three subsets…
Abstract Number: 1458 • 2014 ACR/ARHP Annual Meeting
Functional Phenotype of Synovial Monocytes Modulating Inflammatory T-Cell Response in Rheumatoid Arthritis
Seong-Wook Kang¹, Seung-Cheol Shim¹, Jinhyun Kim¹, In-Seol Yoo², Su-Jin Yoo², Seung-Taek Song¹, Bo-Ruem Yoon³ and Won-Woo Lee³, ¹Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ²Departmen of Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ³Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose Monocytes function as crucial innate effectors during inflammation. Human monocytes can be divided into three distinct subsets based on CD14 and CD16 expression. Accumulating…
Abstract Number: 2972 • 2014 ACR/ARHP Annual Meeting
Elevations of Certain Memory-Effector T Cell and Inflammatory Monocyte Subpopulations in Rheumatoid Arthritis Are Associated with the Presence of Subclinical Coronary Artery Atherosclerosis
Robert Winchester¹, Jon T. Giles², Simona Nativ³, Hui-Zhu Zhang², Kendall Downer² and Joan Bathon², ¹Department of Medicine, Columbia University, New York, NY, ²Medicine, Columbia University, New York, NY, ³Morristown Medical Center, Morristown, NJ
Background/Purpose: Factors that identify cardiovascular disease (CVD) fully in RA are lacking. Peripheral blood mononuclear cell (PBMC) subsets in RA patients differ markedly, on average,…
Abstract Number: 2451 • 2014 ACR/ARHP Annual Meeting
Mir-155 Expression Correlates with Clinical Disease Activity and Has Effector Function in Rheumatoid Arthritis
Aziza Elmesmari¹, Derek G. Gilchrist², Mariola Kurowska-Stolarska³ and Iain B. McInnes⁴, ¹Immunology, Institute of Infection,Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ²Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ³Institute of Infection,Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ⁴Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: MicroRNAs are fine tuners of biological pathways that function via post-transcriptional regulation of target mRNA life span. MicroRNA 155 (miR155) is particularly implicated in…
Abstract Number: 1472 • 2014 ACR/ARHP Annual Meeting
Synovial Fluid from Rheumatoid Arthritis Patients Modulates the Immunophenotype and Viability of Monocytes
Maria Sole Chimenti, Alberto Bergamini, Eleonora Baffari, Eleonora Ballanti, Alessia Musto, Paola Conigliaro and Roberto Perricone, Rheumatology, allergology and clinical immunology, Department of "Medicina dei Sistemi", University of Rome "Tor Vergata", Rome, Italy
Background/Purpose Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by infiltration of the synovium by inflammatory cells that destroys the cartilage and the…
Abstract Number: 2431 • 2013 ACR/ARHP Annual Meeting
Association Of T Follicular Helper / Th17 T Cell and Memory B Cell Populations In Rheumatoid Arthritis With Disease Activity and Therapy With TNF Antagonists
Marc C. Levesque¹, Camilla Macedo², Lisa Boyette², Kevin Hadi³, Erich R Wilkerson⁴, Diana Metes², Larry W. Moreland⁵ and Mandy J. McGeachy⁶, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh Department of Medicine, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Univeristy of Pittsburgh, Pittsburgh, PA, ⁴Medicine, University of Pittsburgh, Pittsburgh, PA, ⁵Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Medicine, Division of Rheumatology and Clinical Immunology, Univeristy of Pittsburgh, Pittsburgh, PA
Background/Purpose: Autoreactive memory B cells and T cells contribute to the pathogenesis of rheumatoid arthritis (RA) through production of antibodies and cytokines that activate monocytes…
Abstract Number: 1151 • 2013 ACR/ARHP Annual Meeting
Snapin Is Required For Functional Autophagy and Is Critical For Monocyte To Macrophage Differentiation
Bo Shi¹, Qiquan Huang², Robert Birkett¹, Renee E. Koessler³, Andrea Dorfleutner⁴, Christian Stehlik⁴ and Richard M. Pope⁵, ¹Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Chicago, IL, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: Our recent data indicate that Snapin, a SNAP associated protein, is significantly increased in macrophages (MΦs) in rheumatoid arthritis (RA) synovial tissue and its…
Abstract Number: 774 • 2013 ACR/ARHP Annual Meeting
Citrullination Of ENA-78/CXCL5 Changes Its Receptor Affinity From CXCR2 To CXCR1 and Induces Monocyte Migration
Ken Yoshida¹, Alisa E. Koch^1,2, Ray A. Ohara³, Phillip L. Campbell¹, M. Asif Amin¹, David A. Fox¹ and Jeffrey H. Ruth⁴, ¹Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²VA Medical Service, Ann Arbor, MI, ³University of Michigan Medical School, Ann Arbor, MI, ⁴Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: We previously showed that citrullinated epithelial-derived neutrophil-activating peptide 78/CXCL5 (citENA-78/CXCL5) was significantly higher in rheumatoid arthritis (RA) synovial fluids (SFs) compared to osteoarthritis (OA)…

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