ACR Meeting Abstracts

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Abstracts tagged "monocytes"

  • Abstract Number: 1497 • ACR Convergence 2021

    Kidney Disease in Lupus Patients Is Linked to Monocytes’ Aberrant Spliceosome and Altered Expression of IFN-Response Related Genes

    Chary Lopez-Pedrera1, Alejandra Patiño-Trives2, Alejandro Ibañez-Costa3, Maria Luque-Tevar2, Iván Arias de la Rosa4, Desiree Ruiz5, Pedro Seguí-Azpilicueta5, Mario Espinosa5, Rosa Ortega5, Nuria Barbarroja4, Justo P Cataño3, Raul Luque3, Maria Angeles Aguirre1 and Carlos Pérez-Sánchez6, 1IMIBIC/Reina Sofia Hospital/University of Córdoba, Córdoba, Spain, 2Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, 3IMIBIC, Department of Cell Biology, Physiology and Immunology, University of Cordoba, Córdoba, Spain, 4University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, 5IMIBIC, Reina Sofia Hospital/University of Córdoba, Córdoba, Spain, 6IMIBIC, Córdoba, Spain

    Background/Purpose: The present study aimed at: 1- Identifying altered SLE monocytes transcriptomic signatures linked to the immune response and its association with clinical features. 2-…
  • Abstract Number: 155 • 2020 Pediatric Rheumatology Symposium

    Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) Is Characterized by a Novel Subset of Monocytes with Markers Associated with Crossing the Blood Brain Barrier (BBB)

    Shamma Rahman1, Fabian Gaertner 1, Jessica Houghton 1, Claudia Macaubas 1, Avis Chan 2, Laurie Columbo 1, Jennifer Frankovich 3 and Elizabeth Mellins 1, 1Stanford University, Stanford, 2Stanford University School of Medicine, Palo Alto, 3Stanford

    Background/Purpose: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by abrupt onset of obsessive-compulsive disorder (OCD) and/or food restriction with other specified neuropsychiatric symptoms.  65% of…
  • Abstract Number: 29 • 2019 ACR/ARP Annual Meeting

    Therapeutic Anti-TNF Biologic Agents Exhibit Functional Differences in Blocking TNF-induced Effects on Human Monocytes In Vitro

    Bohdan Harvey1 and Zehra Kaymakcalan 1, 1AbbVie Bioresearch Center, Worcester, MA

    Background/Purpose: Therapeutic anti-TNF biologic agents can be distinct in their structure and/or in their binding to TNF.  Whether these differences affect the functional properties of…
  • Abstract Number: 55 • 2019 ACR/ARP Annual Meeting

    A Novel Subclass of Intravascular Non-classical, Tissue Resident Synovial Monocyte Is Critical for Rheumatoid Arthritis Pathogenesis

    Anna Montgomery 1, Shang-Yang Chen 1, Deborah Winter 2 and Harris Perlman2, 1Northwestern University, Chicago, 2Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago

    Background/Purpose: There are at least three populations of circulating monocytes; classical, intermediate and non-classical. We demonstrated that circulating non-classical monocytes are required for the effector…
  • Abstract Number: 780 • 2019 ACR/ARP Annual Meeting

    Changes in MiR-17-92 Cluster Expression Link Systemic Juvenile Idiopathic Arthritis, Monocyte-to-Macrophage Differentiation, and Interferon Regulation

    Divya Takellapti1, Xiaoling Niu 2, Thuy Do 3 and Grant Schulert 3, 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Fudan University, Shanghai, Shanghai, China (People's Republic), 3Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: MicroRNAs (miRNAs) are small noncoding RNAs which post-transcriptionally regulate gene expression. The miR-17-92 cluster is well characterized; its overexpression has been found to serve…
  • Abstract Number: 1073 • 2019 ACR/ARP Annual Meeting

    Identification of Distinct Pro-Fibrotic Monocyte and Macrophage Subsets in Systemic Sclerosis

    Angela Tam1, Lauren Reinke-Breen 2, Glenda Trujillo 2, Shiwen Xu 1, Christopher Denton 3, David Abraham 1, Gabor Jarai 2 and Voon Ong 4, 1University College London, London, United Kingdom, 2Bristol-Myers Squibb, Pennington, 3University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom, 4UCL Medical School, Royal Free Campus, London

    Background/Purpose: Chronic inflammation may modulate the balance of classical, intermediate and non-classical monocyte subsets (defined by CD14/CD16 expression)1.  Monocytes are heterogeneous and subsets can be…
  • Abstract Number: 1969 • 2019 ACR/ARP Annual Meeting

    FOXO1 Is Required for Human Osteoclast Differentiation

    Sabarinadh Chilaka 1, Yannick Degboe 1, Iain McInnes 2 and Carl Goodyear3, 1Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Glasgow, Scotland, United Kingdom, 2Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, 3University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Dysregulation of osteoclast differentiation and function is a feature of inflammatory arthropathies (IA). Multiple genes and signalling pathways have been associated with regulation of…
  • Abstract Number: 1466 • 2018 ACR/ARHP Annual Meeting

    Altered Count of NK Cells and Non-Classical Monocyte Subpopulation in the Pre-Clinical Phase of Rheumatoid Arthritis

    Klára Prajzlerová1, Olga Kryštůfková2, Petra Hánová1, Hana Hulejová3, Monika Gregová4, Karel Pavelka4, Jiri Vencovsky1, Ladislav Šenolt5 and Mária Filková1, 1Department of Rheumatology, First Faculty of Medicine, Charles University and Rheumatology Institute, Prague, Czech Republic, Prague, Czech Republic, 2Department of Rheumatology, First Faculty of Medicine, Charles University and Rheumatology Institute, Prague, Czech Republic, prague, Czech Republic, 3Rheumatology Institute, Prague, Czech Republic, Prague, Czech Republic, 4Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 5First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are detectable long before the manifestation of rheumatoid arthritis (RA). EULAR provided a clinical definition of individuals with arthralgia suspicious…
  • Abstract Number: 2090 • 2018 ACR/ARHP Annual Meeting

    Identification of a Role for Monocytes in Murine Lupus Associated Diffuse Alveolar Hemorrhage By Mass Cytometry

    Nathan Nelson-Maney1, Pui Lee2, Anais Levescot3, Yuelong Huang4 and Peter Nigrovic5, 1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, 2Harvard Medical School, Boston, MA, 3Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, boston, MA, 4Brigham and Women's Hospital, Boston, MA, 5Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication of systemic lupus erythematosus. The inciting pathology is thought to be pulmonary capillaritis but the…
  • Abstract Number: 1008 • 2018 ACR/ARHP Annual Meeting

    Presence of a Specific Defect in M2 Polarization of Blood Monocytes from Patients with Rheumatoid Arthritis, Associated with Increased microRNA-155

    Audrey Paoletti1, Julien Rohmer2, Juliette Pascaud3, Bineta Oumouly1, Elodie Rivière3, Samuel Bitoun4, Gaetane Nocturne5 and Xavier Mariette6, 1U1184 IMVA, INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, 2National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Internal medicine, France, Paris, France, 3Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre & Fontenay aux Roses, France, 4INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, 5INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, 6Rheumatology department, Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique- Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, Paris, France

    Background/Purpose: Macrophages contribute in situ to the RA pathogenesis. Two distinct states of polarization for macrophages have been recognized: the classically activated macrophage phenotype (M1),…
  • Abstract Number: 1100 • 2018 ACR/ARHP Annual Meeting

    The Frequencies and Molecular Profiles of CD16+ Monocyte Subsets in Patients with Systemic Lupus Erythematosus, Primary Antiphospholipid Syndrome, and Antiphospholipid Syndrome with Lupus, Identify Specific Clinical Features of These Diseases

    Chary Lopez-Pedrera1, Maria Ángeles Aguirre Zamorano1, Nuria Barbarroja2, Patricia Ruiz-Limon3, Maria Carmen Abalos-Aguilera4, Yolanda Jiménez-Gómez2, Ivan Arias de la Rosa4, Pedro Segui5, Rafaela Ortega-Castro2, Eduardo Collantes Estevez1, Alejandro Escudero-Contreras4, Lucas Le Lann6, Christophe Jamin6, Concepcion Marañón7, Marta Alarcón-Riquelme8, Jacques-Olivier Pers6 and Carlos Perez-Sanchez2, 1IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, MA, Spain, 4Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 5Radiology, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 6U1227, Université de Brest, Inserm, Labex IGO, CHU de Brest, Brest, France, 7GENYO, Centre for Genomics and Oncological Research Pfizer, University of Granada, Andalusian Regional Government, Granada, Spain, 8Medical Genomics, Center for Genomics and Oncological Research (GENYO), Granada, Spain

    Background/Purpose: This study, developed within the IMI-JU project PRECISESADS framework, aimed to determine the enrichment on CD14+ and CD16+ monocyte subpopulations in SLE, APS and…
  • Abstract Number: 1567 • 2017 ACR/ARHP Annual Meeting

    A Mitogen-Associated Protein Kinase (MAPK) Associated Kinase 2 Inhibitor Decreases in Vitro Th17 and Monocyte Inflammatory Responses in Spondyloarthritis

    Davide Simone, Hui Shi, Nuha Ansar, Alison Davies, Karen Doig and Paul Bowness, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom

    Background/Purpose: The current biologic treatment for Ankylosing Spondylitis (AS) and Psoriatic Arthritis (PsA) are limited to TNF-a inhibitors (TNFi) and, more recently, IL-17A monoclonal antibodies.…
  • Abstract Number: 1680 • 2017 ACR/ARHP Annual Meeting

    Higher Baseline Monocyte Count Is Associated with More Extensive Skin Involvement and Higher Mortality in Systemic Sclerosis

    Vishnu Mohan1, Purvesh Khatri2, Samuel Theodore1, Julio Charles1, Hau Pham1, Deepthi Nair1, Madeleine Scott2, John D. Reveille1, Maureen D. Mayes1 and Shervin Assassi1, 1University of Texas McGovern Medical School, Houston, TX, 2Stanford University, Stanford, CA

    Background/Purpose: Macrophages are the primary inflammatory cell type present in the systemic sclerosis (SSc) skin. Circulating monocytes can give rise to profibrotic inflammatory cells such…
  • Abstract Number: 1948 • 2017 ACR/ARHP Annual Meeting

    TNF-α Overrides the Ability of RANK Ligand to Induce Osteoclast Differentiation of Classical Circulating Precursors

    Cecilia Ansalone1, Flavia Sunzini1, Caitlin Duncan1, Sabarinadh Chilaka1, Iain B. McInnes2 and Carl S. Goodyear3, 1Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 2University of Glasgow, Glasgow, United Kingdom, 3Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: TNF-α is well known to be involved in inflammatory-induced bone destruction. This is widely supported by clinical studies showing reduced bone pathology after anti-TNF-α…
  • Abstract Number: 135 • 2017 Pediatric Rheumatology Symposium

    Epigenetic Profiling Of Juvenile Idiopathic Arthritis (JIA) Synovial Fluid Monocytes Points Towards a Role For Monocytes In Bone Damage

    Janneke Peeters1, Arjan Boltjes2,3, Stephin Vervoort4, Paul Coffer1, Bas Vastert2,5, Femke van Wijk2,3, Michal Mokry3, Teun de Vries6,7 and Jorg van Loosdregt3, 1Center for Molecular Medicine and Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands, 2Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 3Division of Pediatrics, University Medical Center Utrecht, Utrecht, Netherlands, 4Peter MacCallum Cancer Centre, Melbourne, Australia, 5Division of Pediatric Rheumatology, University Medical Center Utrecht, Utrecht, Netherlands, 6Department of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam, Amsterdam, Netherlands, 7Department of Periodontology, Academic Centre for Dentistry Amsterdam, Amsterdam, Netherlands

    Background/Purpose:  Juvenile Idiopathic Arthritis (JIA) is a multifactorial autoimmune disease characterized by the accumulation of various immune cells, including monocytes, in the joint synovial fluid…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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