Abstracts tagged "MicroRNA"

Abstract Number: 3195 • 2015 ACR/ARHP Annual Meeting
Circulating Micro-RNA Profiles in Responders to Adalimumab Plus Methotrexate Versus Methotrexate Alone: A Placebo-Controlled Clinical Trial
Jacob Sode^1,2,3, Sophine B. Krintel⁴, Anting L. Carlsen⁵, Merete Lund Hetland⁶, Julia Johansen^7,8, Kim Hørslev-Petersen⁹, Kristian Stengaard-Pedersen¹⁰, Peter Junker¹¹, Mikkel Østergaard^12,13, Niels H. H. Heegaard^14,15 and OPERA study group, ¹Department of Autoimmunology and Biomarkers, Statens Serum Institut, Copenhagen, Denmark, ²Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark, ³Department of Rheumatology, Frederiksberg Hospital, Frederiksberg, Denmark, ⁴Department of Rheumatology, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ⁵Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark, ⁶The DANBIO Registry, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ⁷Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, ⁸Departments of Medicine and Oncology, Copenhagen University Hospital at Herlev, Copenhagen, Denmark, ⁹Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Graasten, Denmark, ¹⁰Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ¹¹Department of Rheumatology, Odense University Hospital, Odense, Denmark, ¹²Rigshospitalet-Glostrup, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, Glostrup, Denmark, ¹³Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, ¹⁴Department of Autoimmunology & Biomarkers, Statens Serum Institut, Copenhagen, Denmark, ¹⁵Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, Odense C, Denmark
Background/Purpose: The variable response to anti-TNF therapy in patients with rheumatoid arthritis (RA) remains largely unexplained, and biomarkers for treatment response are scarce. We previously…
Abstract Number: 1134 • 2015 ACR/ARHP Annual Meeting
Identification of Novel Micro-RNAs in IL-1β-Stimulated OA Chondrocytes By Next-Generation Sequencing
Mohammad Shahidul Makki¹ and Tariq Haqqi², ¹4209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Osteoarthritis (OA) is a chronic and debilitating disease of articulating joints. Mechanical stress, genetic and environmental factors play critical role in the pathogenesis of…
Abstract Number: 1168 • 2015 ACR/ARHP Annual Meeting
MiR125a-5p Mediates Angiogenic Mechanisms in Inflammatory Arthritis
Mary Connolly¹, Sarah Wade¹, Douglas J. Veale² and Ursula Fearon¹, ¹St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ²St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland
Background/Purpose: MicroRNAs (miRNA) belong to a class of small, evolutionarily conserved, noncoding RNAs that function as post-transcriptional repressors of gene expression. An accumulating body of…
Abstract Number: 1239 • 2015 ACR/ARHP Annual Meeting
Significant Impact of Microrna-Target Gene Networks on the Genetics of Rheumatoid Arthritis
Yukinori Okada^1,2 and Toshihiro Tanaka^3,4, ¹Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ²Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, ³Bioresource Research Center, Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University, Tokyo, Japan, ⁴Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
Background/Purpose: MicroRNA (miRNA), a short endogenous noncoding RNA, has a major role in the degradation and translational repression of a specific gene through its binding…
Abstract Number: 1244 • 2015 ACR/ARHP Annual Meeting
Extracellular MicroRNAs in Synovial Fluid Reveal a Marked Proliferative Signature in Patients with Antibiotic-Refractory Lyme Arthritis
Robert B. Lochhead, Nancy D. Kim, Sheila Arvikar, Klemen Strle and Allen C. Steere, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Lyme arthritis (LA), caused by a tick-borne spirochete Borrelia burgdorferi, usually resolves appropriately with antibiotic treatment, called antibiotic-responsive LA. However, in some patients, arthritis…
Abstract Number: 1854 • 2015 ACR/ARHP Annual Meeting
Identification and Characterization of microRNAs Related to the Pathogenesis of Cardiovascular Disease in Patients with Antiphospholipid Syndrome and Systemic Lupus Erythematosus. Role of Specific Autoantibodies
Chary Lopez-Pedrera¹, Maria Ángeles Aguirre Zamorano¹, Patricia Ruiz-Limon¹, Nuria Barbarroja¹, Yolanda Jiménez Gómez¹, Eduardo Collantes-Estevez¹, Mª Jose Cuadrado², Rocio Gonzalez-Conejero³, Constantino Martinez³ and Carlos Perez-Sanchez¹, ¹IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain, ²Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London, United Kingdom, ³Regional Centre for Blood Donation, University of Murcia, Murcia, Spain
Background/Purpose: 1) To identify and characterize miRNAs related to the pathogenesis of CVD in antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) patients; 2) To…
Abstract Number: 2451 • 2014 ACR/ARHP Annual Meeting
Mir-155 Expression Correlates with Clinical Disease Activity and Has Effector Function in Rheumatoid Arthritis
Aziza Elmesmari¹, Derek G. Gilchrist², Mariola Kurowska-Stolarska³ and Iain B. McInnes⁴, ¹Immunology, Institute of Infection,Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ²Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ³Institute of Infection,Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ⁴Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: MicroRNAs are fine tuners of biological pathways that function via post-transcriptional regulation of target mRNA life span. MicroRNA 155 (miR155) is particularly implicated in…
Abstract Number: 530 • 2014 ACR/ARHP Annual Meeting
Downregulation of Microrna-183 in Sjogren’s Syndrome Minor Salivary Glands. Implications in Control of Ezrin Expression and Salivary Gland Function
Paola Perez Riveros¹, Mayank Tandon¹, Salman Kazmi², Alessia Gallo², Gabor G. Illei³ and Ilias Alevizos⁴, ¹Sjogren's Clinic, NIDCR, Bethesda, MD, ²NIH, Bethesda, MD, ³Sjogren's Clinic, NIDCR/ NIH, Bethesda, MD, ⁴Sjogren's Clinic, NIDCR/ NIH #10 1N110, Bethesda, MD
Background/Purpose Sjogren’s syndrome (SS) is an exocrinopathy, which is mainly characterized by salivary glands (SG) hypofunction. SGs from SS patients present dilated lumen in acini…
Abstract Number: 2174 • 2014 ACR/ARHP Annual Meeting
MicroRNA-146a in Salivary Gland Epithelial Cells Inhibits Co-Stimulatory Molecule CD80 Expression and Increases Autoreactive T Cell Activation in Sjögren’s Syndrome
Adrienne Gauna¹, Jun-O Jin^2,3, Qing Yu², Carol Stewart¹ and Seunghee Cha¹, ¹Oral and Maxillofacial Diagnostic Sciences, University of Florida, Gainesville, FL, ²Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, MA, ³Shanghai Public Health Clinical Center, Fudan University Shanghai Medical College, Shanghai, China
Background/Purpose: Sjögren’s syndrome (SS) causes severe dry mouth and eyes. The presence of immune cell infiltration in the salivary (SG) and lacrimal glands suggests a…
Abstract Number: 310 • 2014 ACR/ARHP Annual Meeting
Differential Expression of microRNA in Monocytes from Children with Systemic Juvenile Idiopathic Arthritis: Implications for Polarized Phenotype
Grant Schulert¹, Ndate Fall², Nan Shen³ and Alexei Grom⁴, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rheumatology, Shanghai Institutes for Biological Sciences Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, OH, China, ⁴Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) is an autoinflammatory disease of childhood, and the predominant effector cells are mononuclear phagocytes rather than lymphocytes as in…
Abstract Number: 2085 • 2014 ACR/ARHP Annual Meeting
Association of Circulating Mirnas with Spinal Involvement in Patients with Axial Spondyloarthritis
Klára Prajzlerová¹, Markéta Fojtíková¹, Šárka Forejtová¹, Astrid Jüngel², Steffen Gay², Karel Pavelka¹, Jiri Vencovsky¹, Ladislav Senolt¹ and Mária Filková¹, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ²Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland
Background/Purpose The altered expression of miRNAs and dysregulation of their target genes has been shown to contribute to the development and maintenance of autoimmune diseases.…
Abstract Number: 89 • 2014 ACR/ARHP Annual Meeting
Global miRNA Expression Profiling in Peripheral Blood and Synovial Fluid Mononuclear Cells of Patients with Enthesitis Related Arthritis
Sushma Singh, Ramnath Misra and Amita Aggarwal, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Enthesitis related arthritis (ERA) is the most common category of JIA in India. MicroRNA dysregulation has been associated with arthritis and autoimmune diseases. In…
Abstract Number: 1967 • 2014 ACR/ARHP Annual Meeting
Transforming Growth Factor Beta Is a Major Regulator of Micro-RNA Synthesis in Rheumatoid Arthritis Synovial Fibroblasts
Anna Engler¹, Emmanuel Karouzakis¹, Christoph Kolling², Renate E. Gay³, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Schulthess Clinic, Zurich, Switzerland, ³Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland
Background/Purpose Transforming growth factor beta (TGFβ) modulates microRNA (miRNA) biogenesis in a variety of cell types. The expression of miRNAs is deregulated in the synovial…
Abstract Number: 1885 • 2014 ACR/ARHP Annual Meeting
Integrative Omics Profiling Reveals Dysregulated Novel Pathways Mediated By microRNAs and DNA Methylation in Osteoarthritis
Kathleen M. Fisch¹, Ryuichiro Akagi², Oscar Alvarez-Garcia¹, Takeshi Teramura¹, Yuta Muramatsu¹, Masahiko Saito³, Stuart Duffy¹, Shawn Grogan⁴, Takahisa Sasho⁵, Darryl D'Lima⁶, Andrew I. Su¹ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²The Scripps Research Institute, San Diego, CA, ³Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan, ⁴The Scripps Research Institute, La Jolla, CA, ⁵Orthopaedic Surgery, Chiba University School of Medicine, Chiba, Japan, ⁶SCORE, The Scripps Research Institute, La Jolla, CA
Background/Purpose: Osteoarthritis (OA) is a prevalent joint disease, with several identified clinical risk factors. However, the search for genetic risk factors by candidate gene and…
Abstract Number: 1615 • 2014 ACR/ARHP Annual Meeting
MiR-127-3p As a Novel Regulator of Type I Interferon Signaling Pathway in SLE
Bo Qu^1,2, Xiao Han² and Nan Shen^1,2,3, ¹Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ²Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China, Shanghai, China, ³The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH
Background/Purpose Type I interferon(IFN) is a critical pathogenic factor in Systemic Lupus Erythematosus(SLE) and its associated nephritis, as elevated IFN inducible genes have been found…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

Copyright Policy

View ACR Policies.