ACR Meeting Abstracts

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Abstracts tagged "MicroRNA"

  • Abstract Number: 1854 • 2015 ACR/ARHP Annual Meeting

    Identification and Characterization of microRNAs Related to the Pathogenesis of Cardiovascular Disease in Patients with Antiphospholipid Syndrome and Systemic Lupus Erythematosus. Role of Specific Autoantibodies

    Chary Lopez-Pedrera1, Maria Ángeles Aguirre Zamorano1, Patricia Ruiz-Limon1, Nuria Barbarroja1, Yolanda Jiménez Gómez1, Eduardo Collantes-Estevez1, Mª Jose Cuadrado2, Rocio Gonzalez-Conejero3, Constantino Martinez3 and Carlos Perez-Sanchez1, 1IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain, 2Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London, United Kingdom, 3Regional Centre for Blood Donation, University of Murcia, Murcia, Spain

    Background/Purpose: 1) To identify and characterize miRNAs related to the pathogenesis of CVD in antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) patients; 2) To…
  • Abstract Number: 1866 • 2015 ACR/ARHP Annual Meeting

    Fall in Dicer1 Gene Expression Flags Abnormal Lymphocyte Activation in Lupus

    Olga Sanchez-Pernaute1, Fredeswinda Romero2, Maria Perez-Ferro1, Cristina Serrano3, María J Martinez-Becerra4, F Javier de la Hera5 and Rosario Haro6, 1Section for Autoimmune Diseases, Rheumatology, Jiménez Díaz Foundation University Hospital, Madrid, Spain, 2Section for Autoimmune Diseases. Rheumatology., Jiménez Díaz Foundation University Hospital, Madrid, Spain, 3Section for Autoimmune Diseases. Immunology, Jiménez Díaz Foundation University Hospital, Madrid, Spain, 4Immunology, Jiménez Díaz Foundation University Hospital, Madrid, Spain, 5Section for Autoimmune Diseases, Internal Medicine, Jiménez Díaz Foundation University Hospital, Madrid, Spain, 6Section for Autoimmune Diseases. Dermatology, Jiménez Díaz Foundation University Hospital, Madrid, Spain

    Background/Purpose: The integrity of the microRNA machinery is required for the normal reactivity of the immune system both during differentiation and upon antigen engagement. Dicer1…
  • Abstract Number: 1945 • 2015 ACR/ARHP Annual Meeting

    microRNA-30a Promotes the Inflammatory Response of Rheumatoid Arthritis By Regulating Th1 Cell Differentiation

    Jing Zhang1, HUA YE2, Jianping Guo1, Yan Du3, Mengru Liu1 and Zhanguo Li4, 1Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 2No.11 XIZHIMENG SOUTH STREET,, Peking University People's Hospital, Beijing, China, 3Department of Rheumatology and Immunology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China, 4Peking University People's Hospital, Beijing, China

    Background/Purpose:  In our previous study, the transcriptome profiles of CD4+T cells from 13 active RA cases and 9 healthy controls were accessed by microarrays. a…
  • Abstract Number: 2005 • 2015 ACR/ARHP Annual Meeting

    Circulating Mirnas As Potential Disease Biomarkers in Antiphospholipid Syndrome Patients

    Carlos Perez-Sanchez1, Mihaela Diana Ivanoiu1, Maria Ángeles Aguirre Zamorano1, Patricia Ruiz-Limon1, Nuria Barbarroja1, Yolanda Jiménez Gómez1, Maria Carmen Abalos-Aguilera1, Rocio Gonzalez-Conejero2, Constantino Martinez2, Eduardo Collantes-Estevez1, Mª Jose Cuadrado3 and Chary Lopez-Pedrera1, 1IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain, 2Regional Centre for Blood Donation, University of Murcia, Murcia, Spain, 3Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London, United Kingdom

    Background/Purpose: Epigenetic anomalies are emerging as striking pathogenic features of autoimmune disorders. MicroRNAs (miRNAs) are small non-coding RNAs with a key role in regulatory networks that…
  • Abstract Number: 23 • 2015 ACR/ARHP Annual Meeting

    Microvesicle-Associated Hsa-Mir-223-3p Is Elevated in Rheumatoid Synovial Fluid Compared with Osteoarthritis Synovial Fluid

    Nancy D. Kim1, Robert B. Lochhead1, Pauline Schmit2, Minna J. Kohler3 and Andrew D. Luster4, 1Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Massachusetts General Hospital, Charlestown, MA, 3Rheumatology, Allergy, and Immunology, Massachusetts General Hospital / Harvard Medical School, Boston, MA, 4Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Microvesicles (MVs) (100-1000 nm diameter) are subcellular particles that are enriched in nucleic acid, including microRNA (miR), which may be transferred from cell to…
  • Abstract Number: 2135 • 2015 ACR/ARHP Annual Meeting

    miRNA-223 Delivery to Synovial Fibroblasts Via Monocyte-Derived Extracellular Vesicles Promotes Their Proliferation

    Florian M.P. Meier1, Derek S. Gilchrist1, Derek Baxter2, Diane Vaughan1, Margaret Mullin3, David W. McCarey4, Pawel Herzyk5, Julie Galbraith5, Donna McIntyre1, Russka Shumnalieva6, Ulf Müller-Ladner7, Iain B. McInnes8 and Mariola Kurowska-Stolarska1, 1Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 2Department of Rheumatology, University Hospital Ayr, Ayr, United Kingdom, 3School of Life Sciences, University of Glasgow, Glasgow, United Kingdom, 4Glasgow Royal Infirmary, Glasgow, United Kingdom, 5Polyomics Facility, Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow, United Kingdom, 6Department of Internal Medicine, Clinic of Rheumatology, Sofia, Bulgaria, 7Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 8Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Recently, it was shown that extracellular vesicles (EV) convey microRNAs (miR) from platelets to endothelial cells1and regulate recipient cell gene expression. Interaction of synovial…
  • Abstract Number: 1885 • 2014 ACR/ARHP Annual Meeting

    Integrative Omics Profiling Reveals Dysregulated Novel Pathways Mediated By microRNAs and DNA Methylation in Osteoarthritis

    Kathleen M. Fisch1, Ryuichiro Akagi2, Oscar Alvarez-Garcia1, Takeshi Teramura1, Yuta Muramatsu1, Masahiko Saito3, Stuart Duffy1, Shawn Grogan4, Takahisa Sasho5, Darryl D'Lima6, Andrew I. Su1 and Martin K. Lotz1, 1Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 2The Scripps Research Institute, San Diego, CA, 3Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan, 4The Scripps Research Institute, La Jolla, CA, 5Orthopaedic Surgery, Chiba University School of Medicine, Chiba, Japan, 6SCORE, The Scripps Research Institute, La Jolla, CA

    Background/Purpose: Osteoarthritis (OA) is a prevalent joint disease, with several identified clinical risk factors. However, the search for genetic risk factors by candidate gene and…
  • Abstract Number: 1615 • 2014 ACR/ARHP Annual Meeting

    MiR-127-3p As a Novel Regulator of Type I Interferon Signaling Pathway in SLE

    Bo Qu1,2, Xiao Han2 and Nan Shen1,2,3, 1Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, 2Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China, Shanghai, China, 3The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH

    Background/Purpose Type I interferon(IFN) is a critical pathogenic factor in Systemic Lupus Erythematosus(SLE) and its associated nephritis, as elevated IFN inducible genes have been found…
  • Abstract Number: 1613 • 2014 ACR/ARHP Annual Meeting

    Circulating microRNAs As Candidate Biomarkers of Diagnosis in Systemic Lupus Erythematosus

    Juyang Jung1, Ja-Young Jeon2, Bong-Sik Kim3, Hyoun-Ah Kim2 and Chang-Hee Suh4, 1Ajou university of medical school, Suwon, South Korea, 2Department of Rheumatology, Ajou University School of Medicine, Suwon, South Korea, 3Rheumatology, Ajou University School of Medicine, Suwon, South Korea, 4Rheumatology, Ajou University School of Med, Suwon, South Korea

    Background/Purpose : Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by polyclonal B-cell activation and elevated production of pathogenic autoantibodies. MicroRNAs (miRNAs) are short,…
  • Abstract Number: 1202 • 2014 ACR/ARHP Annual Meeting

    Type I Interferon Promotes Inflammatory Cytokine Production By Inhibiting Mir-146a Maturation in SLE

    Bo Qu1, Jianchang Cao2, Feifei Zhang2 and Nan Shen1,2,3, 1Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, 2Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China, Shanghai, China, 3The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH

    Background/Purpose Systemic lupus erythematosus (SLE) is characterized by the uncontrolled inflammation along with over produced inflammatory cytokines, among which type I interferon (IFN) is recognized…
  • Abstract Number: 1049 • 2014 ACR/ARHP Annual Meeting

    Bioactive TGF-β Is Present on Bovine Milk-Derived Exosomes: Consequences for Patients?

    Bartijn C.H. Pieters, Onno J. Arntz, Mathijs G.A. Broeren, Arjan van Caam, Peter M. van der Kraan, Marieke de Vries and Fons A.J. van de Loo, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: Development of rheumatoid arthritis (RA) is associated with different genetic and environmental factors. We postulate that cow milk could be such an environmental trigger…
  • Abstract Number: 2907 • 2014 ACR/ARHP Annual Meeting

    Loss of microRNA-146a Exacerbates Inflammatory Arthritis

    Victoria Saferding1, Antonia Puchner2, Eliana Goncalvesalves3, Birgit Niederreiter4, Silvia Hayer4, Gernot Schabbauer5, Marije Koenders6, Josef Smolen1, Kurt Redlich3 and Stephan Blueml3, 1Rheumatology, Medical University of Vienna, Vienna, Austria, 2Department of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 4Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 5Vascular Biology and Thrombosis research, Medical University Vienna, Vienna, Austria, 6Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands

    Background/Purpose: MicroRNA (MiR-) 146a is a key regulator of the innate immune response and has also been shown to suppress cancer development in myeloid cells.…
  • Abstract Number: 1015 • 2014 ACR/ARHP Annual Meeting

    Mir-9/MCPIP1 Axis Mediated Regulation of IL-6 Expression in Osteoarthritis Chondrocytes

    Tariq Haqqi1, Abdul Haseeb2 and Mohammad Shahidul Makki2, 1Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, 2Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH

    Background/Purpose Post-transcriptional regulation of cytokine expression is important for maintaining tissue integrity. MCPIP1 was identified as a novel protein, which destabilizes inflammatory cytokines mRNAs via…
  • Abstract Number: 2850 • 2014 ACR/ARHP Annual Meeting

    MiR-125a Is Critical Regulator for Controlling Autoimmunity in Multiple Autoimmune Diseases through Stabilizing Treg Mediated Immune Homeostasis

    Wan Pan1,2, Shu Zhu2, Dai Dai2, John Harley3 and Nan Shen1,2,3, 1Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, 2Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China, 3The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH

    Background/Purpose Although different autoimmune diseases show distinct clinical phenotypes, common cellular and molecular immune pathways have been shown to be intimately involved in the autoimmune…
  • Abstract Number: 967 • 2014 ACR/ARHP Annual Meeting

    Mir-145 Protects Against Skin Fibrosis in Vivo by targeting TGF-β Signaling

    Serena Vettori1,2, Christian Beyer3, Matthias Brock1, Naoki Iwamoto1, Britta Maurer1, Michelle Trenkmann1, Astrid Jüngel1, Renate E. Gay1, Maurizio Calcagni4, Gabriele Valentini5, Steffen Gay1, Joerg H. W. Distler3 and Oliver Distler1, 1Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, 2Internal and Experimental Medicine, Second University of Naples, Naples, Italy, 3Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 4Division of Plastic Surgery and Hand Surgery, University Hospital Zurich, Zurich, Switzerland, 5Internal and Experimental Medicine, Second University of Naples, Napoli, Italy

    Background/Purpose In vitro, miR-145 exerts anti-fibrotic effects in systemic sclerosis (SSc) by downregulating TGF-β signaling. In turn, ectopic TGF-β downregulates miR-145 thereby optimizing TGF-β signaling…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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