Abstracts tagged "microbiome"

Abstract Number: 1576 • 2017 ACR/ARHP Annual Meeting
IL-23 Promotes Fecal Microbiota Dysbiosis Associated with Susceptibility to Spondyloarthritis and Ileitis in ZAP-70 Mutant SKG Mice
Linda Rehaume¹, Nicholas Matigian¹, Kate Ormerod², Alicia Kang¹, Richard Linedale¹, Olga Zbarskaya¹, Kristine Kikly³, Joshua Daly², Nancy Lachner², Philip Hugenholtz², Mark Morrison¹, Kim-Anh Lê Cao⁴ and Ranjeny Thomas¹, ¹The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, ²Australian Centre for Ecogenomics, The University of Queensland, Brisbane, Australia, ³Biotechnology Discovery Research, Eli Lilly and Co, Indianapolis, IN, ⁴School of Mathematics and Statistics, Centre for Systems Genomics, The University of Melbourne, Melbourne, Australia
Background/Purpose: Identification of disease-associated or protective bacteria may elucidate new biomarkers or probiotic supplements for people suffering from SpA, or for people at-risk of disease…
Abstract Number: 1717 • 2017 ACR/ARHP Annual Meeting
Skin Commensal Bacteria Might Affect Wound Repair in SSc By Preventing Fibroblast Activation and By Provoking Chronic Inflammatory Reaction
Masaya Yokota¹, Janine Schniering¹, Oliver Distler² and Britta Maurer³, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Chronic digital ulcers (DU) due to peripheral microangiopathy are a major complication in systemic sclerosis (SSc). Chronic wounds are often enriched in bacteria without…
Abstract Number: 1737 • 2017 ACR/ARHP Annual Meeting
An Abundance of Butyrate-Producing Bacterium in the Intestine and Increased Foxp3 Gene Expression of T Cells in Patients with Relapsing Polychondritis
Jun Shimizu¹, Takao Kubota² and Noboru Suzuki³, ¹Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ²The Japan Self Defense Forces Central Hospital, Tokyo, Japan, ³Department of Immunology and medicine, St. Marianna University School of Medicine, Kawasaki-shi, 216-8511, Japan
Background/Purpose: Helper T cell subsets including Th17 cells and regulatory T (Treg) cells play a role in the adaptive immune response. RORC and Foxp3 are…
Abstract Number: 924 • 2016 ACR/ARHP Annual Meeting
Intestinal Dysbiosis Influences Gut-Joint Lymphocyte Trafficking
Kristine Kuhn^1,2, Hanna Schulz², Jason Hendrickson² and Neha Ohri², ¹Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Intestinal microbiome studies in IBD and AS have shown significant bacterial dysbiosis (i.e., a substantial alteration of the individual species) in similar populations,…
Abstract Number: 1708 • 2016 ACR/ARHP Annual Meeting
Cutaneous Microbiota Features Distinguish Psoriasis from Psoriatic Arthritis
Julia Manasson¹, Soumya M. Reddy¹, Andrea L. Neimann², Leopoldo N. Segal³ and Jose U. Scher¹, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Department of Dermatology, New York University School of Medicine, New York, NY, ³Department of Medicine, Division of Pulmonary and Critical Care, New York University School of Medicine, New York City, NY
Background/Purpose: Psoriasis (PsO) is a chronic immune-mediated skin condition affecting ~3% of adults worldwide. Up to a third of PsO patients go on to…
Abstract Number: 2522 • 2016 ACR/ARHP Annual Meeting
Pharmacomicrobiomics of Methotrexate: Baseline Intestinal Microbiota Correlates with Therapeutic Response
Carles Ubeda¹, Shahla Abdollahi-Roodsaz², Steven B. Abramson³ and Jose U. Scher⁴, ¹Institute for Research in Public Health, Valencia, Spain, ²Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology Research, NYU School of Medicine and NYU Hospital for Joint Diseases, New York, NY, ⁴New York University School of Medicine, New York, NY
Background/Purpose: Despite significant advances in the therapeutics of inflammatory arthritides, methotrexate (MTX) remains the mainstay of treatment for rheumatoid arthritis (RA) and related conditions worldwide.…
Abstract Number: 2694 • 2016 ACR/ARHP Annual Meeting
Treatment of ZAP-70 Mutant SKG Mice with Anti-IL-23 Antibody Alters Fecal Microbiota Composition and Prevents Outgrowth of Bacteria Associated with Susceptibility to Spondyloarthritis and Ileitis
Linda Rehaume¹, Nicholas Matigian¹, Alicia Kang¹, Olga Zbarskaya¹, Kristine Kikly², Nancy Lachner³, Joshua Daly³, Philip Hugenholtz³, Mark Morrison¹, Kim-Anh Lê Cao⁴ and Ranjeny Thomas¹, ¹Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ²Biotechnology Discovery Research, Eli Lilly and Co, Indianapolis, IN, ³The University of Queensland, Australian Centre for Ecogenomics, Brisbane, Australia, ⁴Translational Research Instiute, The University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: Identification of disease-associated or protective bacteria may elucidate new biomarkers or probiotic supplements for people suffering from spondyloarthritis (SpA), or for people at-risk of…
Abstract Number: 187 • 2016 ACR/ARHP Annual Meeting
Commensal Microbiota Tune Systemic Toll-like Receptor-Mediated Inflammatory Responses
Lehn K. Weaver¹, Chhanda Biswas¹ and Edward M. Behrens², ¹Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Although commensal microbiota are thought to contribute to the development of autoimmunity, the cellular and molecular mechanisms connecting changes in gut microbiota to the…
Abstract Number: 466 • 2016 ACR/ARHP Annual Meeting
Sexually Dimorphic Dysbiosis of Gut Microbiota in Tumor Necrosis Factor Transgenic Mice with Inflammatory-Erosive Arthritis
Richard Bell^1,2, Ronald Wood³, Christopher T. Ritchlin⁴, Edward Schwarz⁵ and Homaira Rahimi⁶, ¹Center for Musculoskelatal Research, University of Rochester, Rochester, NY, ²Pathology, University of Rochester, Rochester, NY, ³University of Rochester, Rochester, NY, ⁴Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁵Orthopedeatrics, University of Rochester, Rochester, NY, ⁶Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY
Background/Purpose: Recent studies identify gut microbiota dysbiosis as a possible contributor to rheumatoid arthritis (RA) pathogenesis. RA patients have significantly different microbiomes than healthy controls.…
Abstract Number: 469 • 2016 ACR/ARHP Annual Meeting
Role of Microbiota in Development of Autoimmune Arthritis
Widian Jubair¹, Jason Hendrickson², Sumitra Adhikari³, Nirmal Banda³, Diana Ir⁴, Charles Robertson⁴, Daniel Frank⁴ and Kristine Kuhn², ¹Rheumatology, University of Colorado, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Division of Rheumatology, UC Denver School of Medicine, Denver, CO, ⁴Division of Infectious Disease, University of Colorado, Aurora, CO
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease with an unknown cause. Observations of dysbiosis and mucosal inflammation in patients with RA has raised interest…
Abstract Number: 572 • 2016 ACR/ARHP Annual Meeting
Anti-Periodontal Bacteria Antibody Titers Are Inversely Correlated with ACPA in RA-Free Individuals with Periodontal Disease Compared to Community Controls
Emma Weeding¹, Londyn Robinson², Jeremy Sokolove³, Julie Marchesan⁴, Steven Offenbacher⁴, William H. Robinson³, Ryan Demmer⁵, Bryan Michalowicz⁶ and Jerry A. Molitor⁷, ¹Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ²University of Minnesota, Minneapolis, MN, ³Stanford University School of Medicine, Stanford, CA, ⁴Department of Periodontology, Dental School, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Epidemiology, Columbia University Mailman School of Public Health, New York, NY, ⁶Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, ⁷Rheumatic/Autoimmune Diseases, University of Minnesota, Minneapolis, MN
Background/Purpose: Rheumatoid arthritis (RA) and periodontal disease (PD) are comorbid conditions that share multiple underlying risk factors and pathophysiological features. A dysbiotic periodontal microbiome might…
Abstract Number: 913 • 2016 ACR/ARHP Annual Meeting
Aggregatibacter Actinomycetemcomitans-Induced Hypercitrullination Links Periodontal Infection to Autoimmunity in Rheumatoid Arthritis
Maximilian F. Konig^1,2, Loreto Abusleme³, Jesper Reinholdt⁴, Robert J. Palmer³, Kevon Sampson¹, Ricardo P. Teles⁵, Peter A. Nigrovic⁶, Antony Rosen¹, Jeremy Sokolove⁷, Jon T. Giles⁸, Niki M. Moutsopoulos³ and Felipe Andrade¹, ¹Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, ⁴Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁵Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁷Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁸Columbia University, College of Physicians and Surgeons, Division of Rheumatology, New York, NY
Background/Purpose: A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of modern germ theory. Recent studies implicate mucosal surfaces as sites…
Abstract Number: 1153 • 2015 ACR/ARHP Annual Meeting
Colonic Intraepithelial Lymphocytes Produce IL-6 in Response to Resident Bacteria to Modulate Epithelial Barrier Function
Gaurav Mehta¹, Emilie H. Regner², Neha Ohri², Sean P. Colgan² and Kristine A. Kuhn², ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Dysbiosis of colon bacteria has emerged as a likely contributor to diseases such as rheumatoid arthritis and spondyloarthropathies. Interactions between the microbiota and distal…
Abstract Number: 2701 • 2015 ACR/ARHP Annual Meeting
An Expansion of Rare Lineage Intestinal Microbes Characterize Rheumatoid Arthritis
Jun Chen¹, John M. Davis III², Eric L. Matteson³ and Veena Taneja⁴, ¹Health Sciences Research, Mayo Clinic, Rochesert, MN, ²Division of Rheumatology, Mayo Clinic, Rochester, MN, ³Division of Rheumatology, Department of Internal Medicine and Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ⁴Immunology, Mayo Clinic, Rochester, MN
Background/Purpose: The adaptive immune response in Rheumatoid arthritis (RA) is influenced by an interaction between host genetics and environment, particularly the host microbiome. To define…
Abstract Number: 2711 • 2015 ACR/ARHP Annual Meeting
The Lung Microbiome in Rheumatoid Arthritis and Associated Local/Systemic Autoimmunity
Jose U. Scher¹, Vijay Joshua², Carles Ubeda³, Alejandro Artacho³, Leopoldo Segal⁴ and Anca I Catrina⁵, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Cmm L8:04, Karolinska Institutet, Stockholm, Sweden, ³Institute for Research in Public Health, Valencia, Spain, ⁴Medicine, Pulmonay Division, NYU School of Medicine, New York City, NY, ⁵Department of Medicine, Solna, Unit of Rheumatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is a complex autoimmune disorder in which several genetic and environmental factors play a role. Recent data suggest that the gut…

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