Abstracts tagged "metabolomics"

Abstract Number: 0842 • ACR Convergence 2020
mTOR Signaling Pathway Blockade and Rab4 Expression Affects Metabolism of Lupus T Cells
Tamas Faludi¹, Nick Huang¹, Manuel Duarte¹, Joshua Lewis¹ and Andras Perl¹, ¹SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Pro-inflammatory T-cell development underlies the pathogenesis of systemic lupus erythematosus (SLE). Activation of the mechanistic target of rapamycin (mTOR) plays a central role in…
Abstract Number: 0844 • ACR Convergence 2020
Rab4A Regulates Glomerulonephritis and Tryptophan Metabolism in Sle1.2.3. Lupus-prone Mice via Recycling of CD98
Brandon Wyman¹, Nick Huang¹, Zhiwei Lai¹, Mark Haas², Manuel Duarte¹, Joshua Lewis¹ and Andras Perl¹, ¹SUNY Upstate Medical University, Syracuse, NY, ²Cedars-Sinai, Los Angeles, CA
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disease with an incompletely understood etiology. Previous work has identified Rab4A, a small GTPase responsible for endosomal…
Abstract Number: 0970 • ACR Convergence 2020
Oxylipins Profiles During the Earliest Phases of Rheumatoid Arthritis: Associations with Clinical Stage and Treatment Outcomes
Roxana Coras¹, Javier Rodríguez-Carrio², Mercedes Alperi-López³, Patricia López⁴, Catalina Ulloa⁵, Francisco J Ballina-García³, Aaron M Armando⁶, Oswald Quehenberger¹, Monica Guma⁷ and Ana Suárez⁴, ¹University of California San Diego, La Jolla, CA, ²Department of Functional Biology, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Asturias, Spain/Bone and Mineral Research Unit, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Spain, Oviedo, ³Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain, Oviedo, ⁴Department of Functional Biology, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Asturias, Spain, Oviedo, ⁵Bone and Mineral Research Unit, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Spain, Oviedo, ⁶Department of Pharmacology, School of Medicine, University of California, San Diego, USA, San Diego, ⁷Division of Rheumatology, University of California San Diego, Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: Altered eicosanoids have been linked to rheumatoid arthritis (RA), suggesting an enhanced metabolization. Eicosanoid metabolism forms a complex network, involving different pathways and mediators,…
Abstract Number: 0991 • ACR Convergence 2020
Pathogenic, Glycolytic PD-1+ B Cells Accumulate in the Hypoxic RA Joint
Achilleas Floudas¹, Nuno Neto², Viviana Marzaioli³, Kieran Murray⁴, Barry Moran⁵, Michael Monaghan⁶, Candice Low⁷, Ronan Mullan⁸, Navin Rao⁹, Vinod Krishna⁹, Sunil Nagpal¹⁰, Douglas Veale¹¹ and Ursula Fearon³, ¹Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Dublin, Ireland, ²Department of Mechanical and Manufacturing Engineering, Dublin, Dublin, Ireland, ³Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, ⁴Saint Vincent's University Hospital, Dublin 4, Dublin, Ireland, ⁵Trinity Biomedical Sciences Institute, Dublin, Ireland, ⁶Department of Mechanical and Manufacturing Engineering, Dublin, Ireland, ⁷EULAR Centre for Arthritis and Rheumatic diseases, St Vincents University Hospital, UCD, Dublin, Ireland, ⁸Adelaide and Meath Hospital, Dublin, Dublin, Ireland, ⁹Janssen R&D, Spring House, PA, ¹⁰Janssen Research & Development, Collegeville, PA, ¹¹EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland
Background/Purpose: Rheumatoid arthritis (RA) often has a progressive and debilitating course, with significant impact on the patient’s quality of life. Despite the long-known association with…
Abstract Number: 0996 • ACR Convergence 2020
Bacteria-Derived Indole Drives Autoimmune Arthritis by Altering B Cell Glycosylation of Autoantibodies
Brandon Trent¹, Meagan Chriswell², Widian Jubair³ and Kristine Kuhn¹, ¹University of Colorado Anschutz Medical Campus, Aurora, CO, ²UC Denver SOM, Denver, CO, ³University of Colorado Denver, Denver, CO
Background/Purpose: Background: Dysbiosis of gut bacterial communities in rheumatoid arthritis (RA) is a noted phenomenon in both murine models and human patients; however, the mechanisms…
Abstract Number: 1008 • ACR Convergence 2020
Assessing Improved Risk Prediction of Seropositive Rheumatoid Arthritis by Environmental, Genetic, and Preclinical Plasma Metabolite Factors
Karen Costenbader¹, Jeffrey Sparks², Elizabeth Karlson³, Kazuki Yoshida⁴, Jing Cui⁵, Susan Malspeis⁶ and Lilia Bouzit⁷, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁵Brigham Women's Hospital, Boston, MA, ⁶Brigham and Women's Hospital, Boston, ⁷Harvard Chan School of Public Health, Boston, MA
Background/Purpose: Recent research has advanced the understanding of associations between environmental, genetic, and metabolic factors and rheumatoid arthritis (RA), introducing potential to improve risk prediction.…
Abstract Number: 022 • 2020 Pediatric Rheumatology Symposium
Association of Plasma Metabolomic Profiles with Methotrexate Response in Juvenile Idiopathic Arthritis
Ryan Funk¹ and Mara Becker ², ¹University of Kansas, Leawood, Kansas, ²Duke University Medical Center/Duke Clinical Research Institute, Chapel Hill
Background/Purpose: Despite efforts to identify biomarkers to guide therapy in the treatment of juvenile idiopathic arthritis (JIA), drug therapy remains a trial-and-error process. In the…
Abstract Number: 115 • 2020 Pediatric Rheumatology Symposium
Carbohydrate and Sugar Intake Predict Pain in Teens with Active JIA Disease but Not in Teens in Remission or Controls: A Cross-Sectional, Case-Control Metabolomics Pilot Study
Kimberly Lewis¹, Nico Osier ², Patricia Carter ³, Christina Nguyen ⁴, Ruy Carrasco ⁵, Shelby Brooks ², Alexandra Garcia ⁶ and Stefano Tiziani ⁵, ¹The University of Texas at Austin, Austin, Texas, ²The University of Texas at Austin, Austin, ³University of Alabama, Tuscalossa, ⁴Ascension Seton Nursing Research, Austin, ⁵The University of Texas at Austin, Dell Medical School, Austin, ⁶The University of Texas at Austin, Dell Medical School, School of Nursing, Austin
Background/Purpose: The purpose of this study is to define the relationships between pain and carbohydrate metabolism in teens with active juvenile idiopathic arthritis (JIA), teens…
Abstract Number: 156 • 2020 Pediatric Rheumatology Symposium
Metabolic Profiling in Juvenile Dermatomyositis
Jeffrey Dvergsten¹, Olga Ilkayeva ², Lawrence Landerman ², Michael Muehlbauer ³, David Pisetsky ⁴, Ann Reed ³ and Kim Huffman ⁵, ¹Duke University Hospital, Hillsborough, ²Duke University, Durham, NC, ³Duke University, Durham, ⁴Duke University Medical Center, Durham, ⁵Durham
Background/Purpose: Investigators have made significant progress piecing together pathogenic mechanisms of juvenile dermatomyositis (DM). However, this remains an incomplete puzzle, and optimal approaches to diagnosing,…
Abstract Number: 2885 • 2019 ACR/ARP Annual Meeting
An Integrated Gut Microbiomic and Plasma Metabolomic Analysis in Patients with Four Systemic Autoimmune Diseases
Chiara Bellocchi ¹, Álvaro Fernández-Ochoa ², Gaia Montanelli ³, Barbara Vigone ³, Alessandro Santaniello ³, Rosa Quirantes-Piné ⁴, Isabel Borrás-Linares ⁴, Maria Gerosa ⁵, Carolina Artusi ⁶, Roberta Gualtierotti ⁶, Antonio Segura-Carrettero ⁴, Marta E. Alarcón-Riquelme ⁷ and Lorenzo Beretta³, ¹Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, University of Milan, Milan, Italy, Milan, Italy, ². Department of Analytical Chemistry, University of Granada, Granada, Spain, Granda, Spain, ³Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, Milan, Italy, ⁴Department of Analytical Chemistry, University of Granada, Granada, Spain, Granada, Spain, ⁵Istituto Ortopedico Gaetano Pini, University of Milan, Milan, Italy, ⁶Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, Milan, Italy, ⁷Centro de Genómica e Investigaciones Oncológicas Pfizer-Universidad de Granada-Junta de Andalucía (GENYO), Granada, Spain
Background/Purpose: Gut microbiota may be relevant in the regulation of immune processes and in the development of systemic autoimmune diseases (SADs). A reduction of microbiota…
Abstract Number: 1870 • 2019 ACR/ARP Annual Meeting
NMR-Based Serum, Urine and Muscle Metabolomics in Inflammatory Myositis for Diagnosis and Activity Assessment: Serum Metabolomics Can Differentiate Active from Inactive Myositis
Latika Gupta¹, Dinesh Kumar ², Umesh Kumar ³, Anupam Guleria ², Abhishek Zanwar ⁴, Ritu Raj ⁵ and Ramnath Misra ¹, ¹Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, Uttar Pradesh, India, ²Centre for Biomedical Research, Sanjay Gandhi Post Graduate Institute of Medical Science, Lucknow, Uttar Pradesh, India, ³Centre of Biomedical Research SGPGIMS, Raibareli Road, Lucknow-226014, India, Lucknow, Uttar Pradesh, India, ⁴Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, ⁵Centre of Biomedical Research, Lucknow, Uttar Pradesh, India
Background/Purpose: Differentiating smouldering disease activity from weakness due to fatty replacement of atrophied muscle can often be a challenge in Idiopathic Inflammatory Myositis (IIM). There…
Abstract Number: 1947 • 2019 ACR/ARP Annual Meeting
Integrating Genetic Risk Scores and Pre-Diagnostic Metabolomics to Infer Dysregulated Mechanisms in Rheumatoid Arthritis in Women
Su H. Chu¹, Jing Cui ², Jeffrey Sparks ², Bing Lu ², Clary Clish ³, Jessica Lasky-Su ¹, Elizabeth Karlson ² and Karen Costenbader ², ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Broad Institute of MIT and Harvard, Boston, MA
Background/Purpose: Rheumatoid arthritis genetic risk scores (RA-GRS) improve RA risk prediction, but the added predictive value over lifestyle risk factors is modest. Several human leukocyte…
Abstract Number: 2127 • 2019 ACR/ARP Annual Meeting
Diagnosis of Inflammatory Rheumatic Diseases: Preliminary Approach by Urine Metabolomics
Judit Morello ¹, Sara M. Teixeira ¹, João Rodrigues ², Sara Maia ³, Atlas Sardoo ⁴, Rita Pinheiro Torres ⁵, Sofia A. Pereira ⁴, Jaime Branco ⁶, Alexandra Antunes ⁷ and Fernando Pimentel-Santos⁴, ¹Centro de Química Estrutural, Instituto Superior Técnico, Ulisboa, Lisboa, Portugal, ²Clarify Analytical, Évora, Portugal, ³CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon, Lisbon, Portugal, ⁴Centro de Estudos de Doenças Crónicas (CEDOC), Nova Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal, lisboa, Portugal, ⁵Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental; CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon., Lisbon, Portugal, ⁶CEDOC, NOVA-Medical School | Hospital Egas Moniz, CHLO, Lisbon, Lisbon, Portugal, ⁷Centro de Química Estrutural, Instituto Superior Técnico, Ulisboa,, Lisboa, Portugal
Background/Purpose: Early diagnosis of inflammatory rheumatic diseases (IRD), as axial Spondyloarthritis (axSpA), Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) represents in our days a…
Abstract Number: 2496 • 2019 ACR/ARP Annual Meeting
Serum Metabolomic Analysis of Psoriatic Arthritis Using Solid Phase Microextraction – Liquid Chromatography – High-Resolution Mass Spectrometry Identifies Putative Disease Activity Markers
Vinod Chandran¹, Nikita Looby ², Nathaly Reyes-Garces ², Rohan Machhar ³, Miao Yu ², Anna Roszkowska ², Janusz Pawliszyn ² and Vathany Kulasingam ⁴, ¹University Health Network, University of Toronto, Toronto, Canada, ²University of Waterloo, Waterloo, ON, Canada, ³Krembil Research Institute, University Health Network, Toronto, Canada, ⁴University of Toronto, Toronto, ON, Canada
Background/Purpose: Disease activity in psoriatic arthritis (PsA) is often difficult to assess but drives treatment decisions, joint damage and long-term outcomes. We aimed to identify…
Abstract Number: 65 • 2018 ACR/ARHP Annual Meeting
Bacteria-Derived Indole Drives Autoimmune Arthritis By Altering B Cell Glycosylation of Autoantibodies
Widian Jubair¹, Erica Alexeev², Timothy Lemke³, Meagan Chriswell¹, Sean Colgan² and Kristine A Kuhn^1,2, ¹Rheumatology, University of Colorado Denver, Aurora, CO, ²Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO, ³University of Colorado Denver, Aurora, CO
Background/Purpose: Ongoing studies in rheumatoid arthritis (RA) implicate intestinal dysbiosis of bacteria as a contributing factor, though the mechanism(s) by which bacteria influence disease is…

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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