ACR Meeting Abstracts

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Abstracts tagged "meta-analysis"

  • Abstract Number: 1206 • 2016 ACR/ARHP Annual Meeting

    A Replication Study and Meta-Analysis Demonstrate the Influence of the mtDNA Haplogroups in the Rate of Incident Knee Osteoarthritis. Functional Explanation of This Association Using Transmitochondrial Cybrids

    Ignacio Rego-Pérez1, Mercedes Fernandez Moreno1, Angel Soto-Hermida1, Maria Eugenia Vazquez Mosquera1, Estefanía Cortés-Pereira1, Sara Relaño-Fernandez2, Tamara Hermida-Gómez3, Sonia Pertega4, Rafael Garesse5, Natividad Oreiro3, Carlos Fernandez-Lopez1 and Francisco J. Blanco1,6, 1Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo HospitalarioUniversitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 2Plataforma de Genómica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 3Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 4Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 5Departamento de Bioquímica, Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC y Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Universidad Autónoma de Madrid 28029, Madrid, Spain, Madrid, Spain, 6Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain

    Background/Purpose: The study of the mitochondria in the context of osteoarthritis (OA) attracted much attention. In this study we aimed to evaluate the influence of…
  • Abstract Number: 1212 • 2016 ACR/ARHP Annual Meeting

    A Combined Large Scale Meta-Analysis Identifies COG6 As a Novel Shared Risk Locus for Rheumatoid Arthritis and Systemic Lupus Erythematosus

    Ana Márquez1, Laura Vidal-Bralo2, Luis Rodriguez-Rodriguez3, Miguel Angel González-Gay4, Alejandro Balsa5, Isidoro Gonzalez-Alvaro6, Patricia Carreira7, Norberto Ortego Centeno8, Maria del Mar Ayala Gutierrez9, Francisco José García-Hernández10, Francisca González Escribano11, José Mario Sabio12, Carles Tolosa13, Ana Suárez14, Antonio Gonzalez15, Leonid Padyukov16, Jane Worthington17, Timothy J. Vyse18,19, Marta E. Alarcon Riquelme20,21 and Javier Martín1, 1Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, 2Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, 3Rheumatology Department and Heath Research Institute (IdISSC), Hospital Clinico San Carlos, Madrid, Spain, 4Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain, 5Department of Rheumatology and Institute for Health Research (IdiPAZ), University Hospital La Paz, Madrid, Spain, 6Rheumatology, Rheumatology Service, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, 7Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 8Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, 9Department of Internal Medicine, Hospital Carlos Haya, Málaga, Spain, 10Department of Internal Medicine, Hospital Universitario Virgen del Rocío, Sevilla, Spain, 11Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), Sevilla, Spain, 12Department of Internal Medicine, Hospital Virgen de las Nieves, Granada, Spain, 13Department of Internal Medicine, Hospital Parc Taulí, Sabadell, Spain, 14Department of Functional Biology, Immunology Area, Faculty of Medicine, University of Oviedo, Oviedo, Spain, 15Laboratorio de Investigación 10 and Rheumatology Unit, Instituto de Investigación Sanitaria - Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, 16Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 17Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 18Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, 19Division of Immunology, Infection and Inflammatory Disease, King’s College London, London, United Kingdom, 20Centro de Genómica e Investigación Oncológica (GENYO), Pfizer-Universidad de Granada-Junta de Andalucía, Granada, Spain, 21Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: One of the main limitations of the association studies in autoimmunity is the difficulty in identifying genetic risk variants with modest effects, given the…
  • Abstract Number: 1593 • 2016 ACR/ARHP Annual Meeting

    Baricitinib for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

    Natalia V. Zamora1, Jean Tayar2, Maria A. Lopez-Olivo3, Robin Christensen4 and Maria Suarez-Almazor5, 1Section of Rheumatology and Clinical Immunology, The University of Texas, MD Anderson Cancer Center, Houston, TX, 2Department of Gentic Internal Medicine-AT & EC, The University of Texas, MD Anderson Cancer Center, Houston, TX, 3General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, 4Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, 5Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Houston, TX

    Background/Purpose:  Baricitinib is a small molecule inhibitor of the Janus kinase (JAK) pathways that reduce and modulate the production of inflammatory mediators and cytokines. We…
  • Abstract Number: 1780 • 2016 ACR/ARHP Annual Meeting

    Pulmonary Disease in Late Versus Early Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis

    Jennifer Medlin1, Karen Hansen2, Sara McCoy3 and Christie M. Bartels4, 1Internal Medicine, University of Wisconsin Hospitals and Clinics, Madison, WI, 2Department of Medicine, Division of Rheumatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, 3Department of Medicine, Rheumatology Division, University of Wisconsin School of Medicine and Public Health, Madison, WI, 4Medicine, Rheumatology, University of Wisconsin School of Medicine and Public Health, Madison, WI

    Background/Purpose: Phenotypes often differ in late-onset systemic lupus erythematosus (SLE) compared to SLE features in early-onset patients. Prior studies have suggested that there may be…
  • Abstract Number: 1796 • 2016 ACR/ARHP Annual Meeting

    Osteoporosis and Vertebral Fractures in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis

    Mario García-Carrasco1,2, Pamela Soto-Santillan3, Samanda Adriana Rojas villarraga4, Nicolás Molano-González5 and Claudia Mendoza Pinto6, 1Systemic Autoimmune Diseases Research Unit, HGR 36-CIBIOR Instituto Mexicano del Seguro Social, Puebla, Mexico, 2Inmunología y Reumatología, Universidad Autónoma de Puebla, Puebla, Mexico, 3Internal Medicine, Systemic Autoimmune Diseases Research Unit, IMSS, Puebla, México, Puebla, Mexico, 4Novartis de Colombia, Bogota, Colombia, 5Center for Autoimmune Diseases Research (CREA). School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia., Bogota, Colombia, 6Systemic Autoimmune Diseases Research Unit, HGR 36-CIBIOR, IMSS, Puebla, Mexico

    Background/Purpose: Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (FV) in patients with systemic lupus…
  • Abstract Number: 2939 • 2016 ACR/ARHP Annual Meeting

    Risk of Venous Thromboembolism in Patients with Systemic Vasculitides: A Systematic Review and Meta-Analysis

    Patompong Ungprasert1, Matthew J. Koster2 and Kenneth J. Warrington3, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Rheumatology, University of California Los Angeles, CA, USA Mayo Clinic, Rochester, MN, 3Rheumatology, University of California Los Angeles, CA, USA Mayo, Rochester, MN

    Risk of Venous Thromboembolism in Patients with Systemic Vasculitides: A Systematic Review and Meta-analysis Background/Purpose: Venous thromboembolism (VTE) is a common medical problem with a…
  • Abstract Number: 1389 • 2015 ACR/ARHP Annual Meeting

    A Meta-Analysis of the Prevalence of the Ocular Manifestations in All Inflammatory Rheumatic Diseases

    Jacqueline Hayworth1 and Janet E. Pope2, 1Medicine, University of Western Ontario and U of Toronto, Toronto, ON, Canada, 2University of Western Ontario, London, ON, Canada

    Background/Purpose: Many inflammatory rheumatic diseases (IRD) are associated with ocular involvement. The prevalence of these complications is not fully known.  This meta-analysis was performed to…
  • Abstract Number: 1781 • 2015 ACR/ARHP Annual Meeting

    Comparative Efficacy and Safety of Tacrolimus, Mycophenolate Mofetil, and Cyclophosphamide As Induction Therapy for Lupus Nephritis: A Bayesian Network Meta-Analysis of Randomized Controlled Trials

    Young Ho Lee and Gwan Gyu Song, Rheumatology, Korea University Medical Center, Seoul, South Korea

    Background/Purpose: Cyclophosphamide (CYC) regimens improved renal outcomes, and have long been considered the gold standard for inducing renal remission and preventing renal flares in proliferative…
  • Abstract Number: 1833 • 2015 ACR/ARHP Annual Meeting

    Musculoskeletal Complications of Systemic Lupus Erythematosus: Risk Factors for and Prevalence of Avascular Necrosis and Osteoporosis

    Maeve Gamble1 and Janet E. Pope2, 1Medicine, University of Western Ontario, London, ON, Canada, 2University of Western Ontario, London, ON, Canada

    Background/Purpose: Osteoporosis (OP) and avascular necrosis (AVN) are well-recognized musculoskeletal complications of systemic lupus erythematosus (SLE) and cause morbidity.  Steroid therapy and the underlying disease…
  • Abstract Number: 2475 • 2015 ACR/ARHP Annual Meeting

    Association Between Fibromyalgia and Suicidal Risk: A Systematic Review and Meta-Analysis

    Sikarin Upala1 and Anawin Sanguankeo2, 1Internal Medicine, Bassett Medical Center, Cooperstown, NY, 2Bassett Medical Center, Cooperstown, NY

    Background/Purpose: Chronic pain conditions are related poor overall health, economic burden, and mental disorders including suicidal ideation (SI), suicide attempts (SA), and completed suicides. Fibromyalgia…
  • Abstract Number: 2858 • 2015 ACR/ARHP Annual Meeting

    A Phosphodiesterase 4 Inhibitor for Psoriatic Arthritis: Systematic Review and Meta-Analysis

    Ignacio-Alfredo Valerio-Morales1, Maria A. Lopez-Olivo2, Xin Pan3 and Maria E. Suarez-Almazor4, 1Rheumatology, National Institute of Rehablitation, Mexico, Mexico, 2Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, 3Department of Rheumatology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, 4General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX

    Background/Purpose: Inhibition of phosphodiesterase (PDE) family enzymes is now recognized as target to develop new psoriatic arthritis (PsA) drugs. We conducted a systematic review to…
  • Abstract Number: 2873 • 2015 ACR/ARHP Annual Meeting

    Pharmacological Treatment of Psoriatic Arthritis (PSA): Systematic Literature Review for the Update of the EULAR Recommendations for the Management of PSA

    Sofia Ramiro1, Josef S. Smolen2, Robert B.M. Landewé3, Désirée van der Heijde1, Maxime Dougados4, Paul Emery5, Maarten de Wit6, Maurizio Cutolo7, Susan Oliver8 and Laure Gossec9, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, 4Rheumatology Department, Cochin hospital, Paris-Descartes University, Paris, France, 5Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom, 6EULAR Social Leagues, Zurich, Switzerland, 7Division of Clinical Immunology, Dept Internal Medicine, University of Genova, Genova, Italy, 8Independent Nurse Consultant, North Devon, United Kingdom, 9Rheumatology, Pitié Salpetriere Hospital, Paris, France

    Background/Purpose: As part of the update of the EULAR recommendations for the management of PsA, we performed a systematic literature review to assess the efficacy…
  • Abstract Number: 2908 • 2015 ACR/ARHP Annual Meeting

    Diagnostic and Screening Accuracy of Spot Urinary Protein-Creatinine Ratio Compared to Protein Content in a 24 Hour-Urine Collection in Systemic Lupus Erythematosus: Systematic Review and Meta-Analysis

    Jorge Medina-Rosas1, Kristy Yap2, Melanie Anderson3, Jiandong Su2 and Zahi Touma2, 1Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3Library and Information Services, University Health Network, University Health Network, Toronto, ON, Canada

    Background/Purpose: To systematically review literature on the utility of spot urinary protein-creatinine ratio (PCR) as a screening test for proteinuria and its ability to accurately…
  • Abstract Number: 38 • 2015 ACR/ARHP Annual Meeting

    Impact of Obesity on the Disease Course of Rheumatoid Arthritis

    Yang (Linda) Liu1, Gilaad Kaplan2, Bertus Eksteen3 and Cheryl Barnabe1, 1Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 2Division of Gastroenterology, University of Calgary, Calgary, AB, Canada, 3Division of Hepatology, University of Calgary, Calgary, AB, Canada

    Background/Purpose: Obesity results in a higher risk for the development of rheumatoid arthritis (RA) but is associated with less radiographic damage. The evidence for the…
  • Abstract Number: 111 • 2015 ACR/ARHP Annual Meeting

    The Mitochondrial DNA (mtDNA) Haplogroups Influence the Risk of Radiographic OA Progression. a Meta-Analysis

    Angel Soto-Hermida1, Ignacio Rego-Pérez1, Juan Fernandez-Tajes1, Mercedes Fernandez Moreno1, Maria Eugenia Vazquez Mosquera1, Estefanía Cortés-Pereira1, Sara Relaño-Fernandez1, Sonia Pertega2, Natividad Oreiro1, Carlos Fernandez-Lopez1 and Francisco J. Blanco1, 1Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 2Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain

    Background/Purpose: In the last years the role played by the mtDNA haplogroups in the pathogenesis of OA attracted much attention. The aim of this study…
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