Abstracts tagged "meta-analysis"

Abstract Number: 1384 • ACR Convergence 2024
Disease-modifying Antirheumatic Drugs and Risk of Incident Interstitial Lung Disease Among Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis
Qianru Zhang¹, Gregory McDermott², Sung Hae Chang³, Pierre-Antoine Juge⁴, Kathleen Vanni⁵, Grace Qian⁶, Katarina Bade⁵, Kevin Mueller⁵, Emily Kowalski⁵, Alene Saavedra⁵ and Jeffrey Sparks⁷, ¹Harard Medical School, Cambridge, ²Brigham and Women's Hospital, Brookline, MA, ³Soonchunhyang University College of Medicine, Bongmyeong-dong, Dongnam-gu, Cheonan-si, South Korea, ⁴Service de Rhumatologie, Hôpital Bichat - Claude-Bernard, AP-HP, Paris, Île-de-France, France, PARIS, Germany, ⁵Brigham and Women's Hospital, Boston, MA, ⁶Brigham and Women’s Hospital, Boston, MA, ⁷Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA
Background/Purpose: Interstitial lung disease (ILD) is a serious extra-articular manifestation of RA, affecting 7-12% of patients and associated with three-fold increased mortality compared to RA…
Abstract Number: 1468 • ACR Convergence 2024
Efficacy of bDMARDs in Early versus Established Disease in Axial Spondyloarthritis: A Meta-Analysis of Randomized Trials
Diego Benavent¹, Victoria Navarro Compán², Dafne Capelusnik³ and Sofia Ramiro⁴, ¹Rheumatology Department, Hospital Universitari de Bellvitge, Barcelona, Spain, CAMBRILS, Spain, ²La Paz University Hospital, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain, ³Tel Aviv Sourasky Medical Center, Ramat Gan, Israel, ⁴Leiden University Medical Center, Bunde, Netherlands
Background/Purpose: The ASAS consensus definition of ‘early axial spondyloarthritis (axSpA)’ (axial symptoms ≤ 2 years) was expert-based given the scarcity of evidence1. We conducted a…
Abstract Number: 1471 • ACR Convergence 2024
Sex-related Differences in Efficacy and Safety Outcomes in Axial Spondyloarthritis Randomized Clinical Trials: A Systematic Literature Review and Meta-analysis
Angel Gao¹, Jordi Pardo Pardo², Steven Dang³, Lianne S Gensler⁴, Philip Mease⁵ and Lihi Eder⁶, ¹Queens University, Kingston, Canada, ²University of Ottawa, Ottawa, Canada, ³Women's College Hospital, Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ⁴Department of Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁵Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA, ⁶University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada
Background/Purpose: Limited information exists on sex-related differences in axial spondyloarthritis (axSpA) randomized controlled trials (RCTs). Through a systematic literature review and meta-analysis we aimed to assess…
Abstract Number: 1498 • ACR Convergence 2024
Gender Disparities in Clinical Manifestations and Outcomes of Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis
Mazen Allouni¹, Muhammad Shamim², Krista Topalsky³ and Omer Pamuk⁴, ¹Case Western Reserve, University Hospitals, Cleveland Medical Center, Cleveland, OH, ²University Hospitals/ Case Western Reserve University, Cuyahoga Falls, OH, ³University Hospitals/ Case Western Reserve University, Shaker Heights, OH, ⁴University Hospitals Cleveland Medical Center/ Case Western Reserve University, Cleveland, OH
Background/Purpose: The clinical manifestations and outcomes of systemic lupus erythematosus (SLE) reveal notable gender differences, which may impact treatment strategies and patient outcomes. This meta-analysis…
Abstract Number: 0029 • ACR Convergence 2024
Effect of Metformin on the Incidence of Total Knee Replacement: A Systematic Review and Meta-Analysis
Syed Hasan¹, Aali Furqan², Afia Salman³, hira Khan⁴, Sarah Aslam⁵, Alishba Rizvi⁴, Hafsah Alim Ur Rahman³, Muhammad Ahmed Ali Fahim³, Madiha Salman³, Eman Ali³, Yumna Furqan⁶, Shanta bai⁷, Farah Yasmin⁸ and Muhammad Sohaib Asghar⁹, ¹Dow University of Health Sciences, Karachi, PK., Karachi, Sindh, Pakistan, ²University of North Texas Health Science Center (UNT HSC), Texas, TX, ³Dow University of Health Sciences, Karachi, Pakistan, ⁴dow medical college, Karachi, Pakistan, ⁵Dow International Medical College, Karachi, Pakistan, ⁶Texas A&M School of Medicine, Dallas, TX, ⁷Liaquat National Hospital and Medical College, Karachi, Pakistan, ⁸Yale University School of Medicine, New Haven, CT 06511, U.S.A., New Haven, CT, ⁹AdventHealth, Sebring, FL
Background/Purpose: Osteoarthritis (OA) is among the most common debilitating conditions, causing disability and pain in older adults. For end-stage OA, total knee replacement (TKR) is…
Abstract Number: 1524 • ACR Convergence 2024
Thrombocytopenia and Systemic Lupus Erythematosus: A Meta-analysis of Observational Studies
Alexandre Matar¹ and Omer Pamuk², ¹MetroHealth, Westlake, OH, ²University Hospitals Cleveland Medical Center/ Case Western Reserve University, Cleveland, OH
Background/Purpose: Thrombocytopenia is one of the hematological abnormalities that can occur in patients with systemic lupus erythematosus (SLE), and it has been shown to affect…
Abstract Number: 0228 • ACR Convergence 2024
Do Imaging Tests Have a Role in Predicting Progression to Rheumatoid Arthritis in People with Clinically Suspect Arthralgia? A Systematic Review & Meta-Analysis
Ankita Gupta¹, Sulaiman Anis² and Paola de Pablo², ¹Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom, ²University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Clinically suspect arthralgia (CSA) has been associated with an increased risk of developing inflammatory arthritis (IA). Subclinical inflammation on imaging tests may help to…
Abstract Number: 1525 • ACR Convergence 2024
Early versus Late Lupus Nephritis: A Meta-analysis of Observational Studies
Alexandre Matar¹ and Omer Pamuk², ¹MetroHealth, Westlake, OH, ²University Hospitals Cleveland Medical Center/ Case Western Reserve University, Cleveland, OH
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic systemic autoimmune disorder characterized by a broad range of clinical and immunological manifestations, one of which is…
Abstract Number: 1400 • ACR Convergence 2023
Achieving ASDAS Inactive Disease Status in Axial Spondyloarthritis: A Systematic Review and Meta-analysis
Sarah Abi Doumeth¹, Omer Pamuk² and Marina Nighat Magrey³, ¹Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, ²Division of Rheumatology, Case Western Reserve University/University Hospitals, Cleveland, OH, ³Case Western Reserve University, University Hospitals, Cleveland, OH
Background/Purpose: ASDAS-CRP is a composite score that measures disease activity in axial spondyloarthritis (axSpA) and is based on patient-reported outcomes and objective measures of inflammation.…
Abstract Number: 1464 • ACR Convergence 2023
Lupus Flares More Common in Patients on Dialysis Compared to After Renal Transplant: A Systematic Review and Meta-analysis
Omer Pamuk¹, Ansaam Daoud², Loai Dweik³, Niraj Desai⁴ and sarfaraz Hasni⁵, ¹University Hospitals Cleveland Medical Center, Cleveland, OH, ²University Hospitals, Case Western Reserve University, Akron, OH, ³Cleveland Clinic Akron General, Akron, OH, ⁴Case Western Reserve University / University Hospitals Cleveland Medical Center, Cleveland, OH, ⁵Lupus Clinical Trials Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH), Bethesda, MD
Background/Purpose: End-stage renal disease (ESRD) may develop in up to 20% of patients with lupus nephritis (LN). The SLE disease activity generally declines after the…
Abstract Number: 1465 • ACR Convergence 2023
Blood-dominant Disease in Older-onset Lupus: A Systematic Review and Meta-analysis
Sarah Abi Doumeth¹, Marina Nighat Magrey² and Omer Pamuk³, ¹Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, ²Case Western Reserve University, University Hospitals, Cleveland, OH, ³University Hospitals Cleveland Medical Center, Cleveland, OH
Background/Purpose: Previous studies have shown that the clinical manifestations of systemic lupus erythematosus (SLE) differ based on age of onset. Late onset SLE has been…
Abstract Number: 1467 • ACR Convergence 2023
Antiphospholipid Antibodies and the Risk of Diffuse Alveolar Hemorrhage in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis
Mariana Gonzalez-Trevino¹, Jeffrey Yang², Larry J. Prokop³, Gabriel Figueroa-Parra¹ and Ali Duarte-Garcia⁴, ¹Division of Rheumatology, Mayo Clinic, Rochester, MN, ²Department of Internal Medicine, Mayo Clinic, Rochester, MN, ³Mayo Clinic Libraries, Mayo Clinic, Rochester, MN, ⁴Mayo Clinic, Rochester, MN
Background/Purpose: Diffuse alveolar hemorrhage (DAH) is one of the most devastating complications of SLE. The exact pathogenesis leading to DAH in SLE is not well…
Abstract Number: 1509 • ACR Convergence 2023
Calcineurin Inhibitors for Treatment of Lupus Nephritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Gabriel Figueroa-Parra¹, Maria Cuellar-Gutierrez¹, Mariana Gonzalez-Trevino¹, Larry J. Prokop², M. Hassan Murad³ and Ali Duarte-Garcia⁴, ¹Division of Rheumatology, Mayo Clinic, Rochester, MN, ²Mayo Clinic Libraries, Mayo Clinic, Rochester, MN, ³Evidence-based Practice Center, Mayo Clinic, Rochester, MN, ⁴Mayo Clinic, Rochester, MN
Background/Purpose: The current recommendations for the treatment of LN consider as the standard of care (SoC) the use of MMF or CYC. Considering the expanding…
Abstract Number: 1522 • ACR Convergence 2023
Treatment of Pulmonary Arterial Hypertension in Patients with Connective Tissue Diseases: A Meta-analysis
Mustafa Erdogan¹, Sinem Nihal Esatoglu², Burcak Kilickiran Avci³ and Gulen Hatemi², ¹Marmara University - Pendik Training and Research Hospital, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ²Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ³Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Cardiology, Istanbul, Turkey
Background/Purpose: Treatment options for pulmonary arterial hypertension (PAH) have expanded in the last two decades. However, evidence for the treatment of connective tissue disease-associated PAH…
Abstract Number: 0207 • ACR Convergence 2023
Role of Pneumocystis Jirovecii Pneumonia Prophylaxis with Trimethoprim-Sulfamethoxazole Among Patients with Autoimmune Inflammatory Diseases Receiving High-Dose Glucocorticoids: A Systematic Review and Meta-Analysis
Athanasios Vassilopoulos¹, Stephanos Vassilopoulos¹, Fadi Shehadeh², Markos Kalligeros¹ and Eleftherios Mylonakis³, ¹Division of Internal Medicine, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, ²Houston Methodist Research Institute, Houston, TX, ³Department of Medicine, Houston Methodist Hospital, Houston, TX
Background/Purpose: Available immunosuppressive treatments for autoimmune inflammatory rheumatic diseases (AIRD) might increase the risk for opportunistic infections, such as Pneumocystis jirovecii pneumonia (PJP). Prophylactic trimethoprim-sulfamethoxazole…

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