Abstract Number: 1709 • ACR Convergence 2021
Long-term Safety of a Single Infusion of Human Umbilical Cord Blood-derived Mesenchymal Stem Cell Therapy in Rheumatoid Arthritis: The 5-year Follow-up of the Phase I Clinical Trial
Background/Purpose: Mesenchymal stem cell (MSC) therapy represents a promise for the treatment of autoimmune diseases due to its potent immunomodulatory effect. We investigated the long-term…Abstract Number: 0705 • ACR Convergence 2020
lncRNA H19 and Micro RNA 675-3p Are Altered by Visfatin During Osteogenesis
Background/Purpose: Long non-coding (lnc-)RNAs are transcribed from DNA similar to mRNA. lncRNA are able to interact directly with DNA, RNA and proteins. Some lncRNAs contain…Abstract Number: 0706 • ACR Convergence 2020
Adenosine A2A Receptor Activation Reduces Markers of Chondrocyte Senescence and Cartilage Inflammation Associated with Osteoarthritis
Background/Purpose: Osteoarthritis is an aging-associated disorder linked to dysfunctional metabolism, chronic inflammation, oxidative stress, and cellular senescence. Cellular senescence is associated with stable cell cycle…Abstract Number: 0707 • ACR Convergence 2020
Contribution of NOTUM and Glypicans to the Development of Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is a degenerative disease characterized by altered homeostasis of joint cartilage and bone, the functionality of which relies on chondrocytes and osteoblasts,…Abstract Number: 0745 • ACR Convergence 2020
Development of Functional Assays to Pre-qualify Human Mesenchymal Stem Cells for Rheumatoid Arthritis Treatment
Background/Purpose: Sero-positive rheumatoid arthritis (RA) is a chronic autoimmune disease that without effective treatment, leads to joint damage and disability. Not all patients respond to…Abstract Number: 0969 • ACR Convergence 2020
Investigating Murine Joint-Draining Lymphatics: Lineage Tracing and Single Cell RNA Sequencing Reveal Evidence That Popliteal Lymphatic Muscle Cells and Their Progenitors Represent Distinct Cell Types Divergent from Striated and Vascular Muscle Cells
Background/Purpose: Previous studies demonstrated that tumor necrosis factor transgenic (TNF-Tg) mice with inflammatory arthritis have damaged lymphatic muscle cells (LMCs) and eventual loss of popliteal…Abstract Number: 1255 • ACR Convergence 2020
Sjӧgren’s Syndrome Minor Salivary Gland Mesenchymal Stromal Cells Derived Deploy Intact Immune Plasticity and Display Myofibroblast-Like Properties
Background/Purpose: Primary Sjӧgren’s syndrome (pSS) is the second most common systemic autoimmune disease with hallmark features of severe ocular and oral sicca, leading to reduced…Abstract Number: 62 • 2019 ACR/ARP Annual Meeting
Human Gingiva-derived Mesenchymal Stem Cells Are Therapeutic in Lupus Nephritis Through Targeting of CD39-CD73 Signaling Pathway
Background/Purpose: Cell specific and cytokine targeted therapeutics have underperformed in systemic lupus erythematosus (SLE) in spite of numerous targets examined and clinical trials conducted. Mesenchymal…Abstract Number: 1010 • 2019 ACR/ARP Annual Meeting
IL-17A Induces Distinct Functional Differences Between Two Novel Mesenchymal Stem Cell Populations Identified at the Human Enthesis
Background/Purpose: Ankylosing spondylitis (AS) is associated with entheseal inflammation and new bone formation. Resident populations of lymphocytes have been identified at the enthesis that on…Abstract Number: 1971 • 2019 ACR/ARP Annual Meeting
CD39 Produced from Human Gingiva-Derived Mesenchymal Stem Cells Regulates the Balance of Osteoclasts and Osteoblasts Through Wnt / β-catenin Pathway in Osteoporosis
Background/Purpose: Osteoporosis led to severe bone-related diseases and increased mortality and health care costs. Existing treatments failed to reduce the risk of fractures in patients,…Abstract Number: 1995 • 2019 ACR/ARP Annual Meeting
Gingival-Derived Mesenchymal Stem Cells Alleviate Cartilage Damage in Collagen-Induced Arthritis via Suppressing Activities of Inflamed Synovial Fibroblast
Background/Purpose: Dysfunction of immunology and inflammatory responses is crucial in initiating and promoting bone/cartilage destruction in rheumatic arthritis (RA). Inflamed synovial fibroblast cells (ISFs) are…Abstract Number: 1703 • 2017 ACR/ARHP Annual Meeting
A Double-Blind, Randomized, Placebo-Controlled, Dose-Escalation, Multi-Center Study of a Single Intravenous Infusion of Allogeneic Mesenchymal Precursor Cells in Patients with Rheumatoid Arthritis and Incomplete Response to at Least One Tnfα Inhibitor
Background/Purpose: Allogeneic STRO-3 immunoselected mesenchymal precursor cells (MPCs) derived from bone marrow of healthy donors are a potent, homogeneous cell population which can be activated…Abstract Number: 1935 • 2017 ACR/ARHP Annual Meeting
Influence of Adipokines on the Differentiation of Spongiosa-Derived Mesenchymal Stromal Cells from Osteoporosis and Osteoarthritis Patients
Background/Purpose: Osteoporosis predominantly affects elderly people and is characterized by bone loss, increased fracture risk and reduced regeneration ability. An inverse relationship between bone marrow…Abstract Number: 49 • 2017 ACR/ARHP Annual Meeting
G Protein-Coupled Receptor Kinase 3 Modulates Mesenchymal Stem Cell Proliferation and Differentiation through Sphingosine-1-Phosphate Receptor Regulation
Background/Purpose: Mesenchymal stem cells are multipotent stromal cells that can differentiate into tissue-specific lineages, such as osteocytes and chondrocytes. Their multipotency has made them an…Abstract Number: 62 • 2017 ACR/ARHP Annual Meeting
Convergence of Joint Repair and Pain Pathways Via Nerve Growth Factor and p75 Expressing Mesenchymal Stem Cells in Established Osteoarthritis
Background/Purpose: Nerve growth factor (NGF) is a key regulator of pain and anti-NGF therapy reduces osteoarthritis (OA) associated pain. However, anti-NGF therapy is associated with…
ACR Meeting Abstracts