Abstracts tagged "Mesenchymal stem cells"

Abstract Number: 1593 • ACR Convergence 2026
Efficacy of Mesenchymal Stromal Cells in Anti-MDA5+ Dermatomyositis with ILD: A Single-Center Retrospective Study
xiaomin Li¹, ziyi jin² and LINGYU SUN¹ Affiliations: ¹Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China (People's Republic), ²Nanjing Drum Tower Hospital ,Clinical College of Nanjing Medical University, Nanjing, China (People's Republic)
Background/Purpose: Anti-MDA5 antibody-positive dermatomyositis (MDA5+DM) is a high-risk subtype of idiopathic inflammatory myopathies (IIM), frequently complicated by interstitial lung disease (ILD) and associated with an…
Abstract Number: 1852 • ACR Convergence 2026
Developmental Sacral Fusion Defines a Biologically Relevant Model for Studying Pathological Ankylosis in Axial Spondyloarthritis
Yangkang Zheng¹, Matthew Greenblatt² and Kyle Morse³ Affiliations: ¹Hospital for Special Surgery, Elmhurst, NY, ²Weill Cornell Medicine, New York, NY, ³Hospital for Special Surgery, New York, NY
Background/Purpose: Pathological ankylosis is a hallmark of axial spondyloarthritis (axSpA), yet the mechanisms driving new bone formation remain incompletely understood. Structural fusion may continue despite…
Abstract Number: 2049 • ACR Convergence 2026
Chi3L1, A Senescence-Linked Factor And Aging Biomarker, That Drives MSCs Dysfunction Promoting Joint Aging And OA Progression
Georges Maroun¹, Christian Jorgensen², Farida Djouad¹, Dominique De Seny³, Jean-Marc Brondello⁴ and Pers Yves-Marie⁵ Affiliations: ¹Institute for Regenerative Medicine and Biotherapy, Montpellier, France, ²Head of Rheumatology department - CHU lapeyronie, Montpellier, France, ³Head-chef of rheumatology laboratory GIGA - CHU Liège, Montpellier, France, ⁴Institute of Regenerative Medicine and Biptherapy, Montpellier, France, ⁵CHU Lapeyronie-Rheumatology department, Montpellier, France
Background/Purpose: Osteoarthritis is an age-related joint disorder characterized by the accumulation of senescent cells. Evidence suggests that these cells generate a pathological joint microenvironment that…
Abstract Number: 2639 • ACR Convergence 2026
Rationale, Design, and Initial RA Results in Basket Registry Evaluating Umbilical Lining Stem Cells in Autoimmunity
Michael Bubb¹, Chelsea Parr², Rafael Gonzalez³, Alberto Ortiz⁴, Zaira Rivera Valentin² and Keith March⁵ Affiliations: ¹University of Florida, Gainesville, FL, ²KLM Solutions, LLC, Gainesville, FL, ³Restem, LLC, Corona, CA, ⁴Rehealth, Cancun, Mexico, ⁵Restem, LLC, Gainesville, FL
Background/Purpose: Autoimmune diseases affect over 24 million Americans, yet many patients face incomplete disease control or cumulative treatment toxicity. Umbilical cord lining-derived stem cells (ULSC)…
Abstract Number: 0120 • ACR Convergence 2026
Umbilical Cord Lining Stem Cells Suppress Pro-inflammatory and Upregulate Anti-inflammatory Mediators in IIM
Michael Bubb¹, Payel Chaudhuri², Rafael Gonzalez³ and Keith March⁴ Affiliations: ¹UNiversity of Florids, Gainesville, FL, ²Universit of Florida, Gainesville, FL, ³Restem, LLC, Corona, CA, ⁴Restem, LLC, Gainesville, FL
Background/Purpose: Patients with idiopathic inflammatory myopathy (IIM) face a treatment landscape defined by incomplete disease control and cumulative immunosuppressive toxicity. Umbilical cord lining stem cells…
Abstract Number: 0064 • ACR Convergence 2025
Sclerostin from marrow adipogenic precursors is essential for bone and joint homeostasis in mice
Tailin He and Yifang Mei, Shenzhen Third People's Hospital, Shenzhen, China (People's Republic)
Background/Purpose: A novel mesenchymal subpopulation known as 'marrow adipogenic lineage precursors' (MALPs) has been identified, characterized by the expression of various adipocyte markers while lacking…
Abstract Number: 0472 • ACR Convergence 2025
Detrimental Effects of Umbilical Cord Blood-derived Mesenchymal Stem Cells Intra-articular Injections on Pannus Invasiveness
Sung Eun Kim¹, Hye Lim Kang¹, Min Jung Kim², Hyung-Sik Kim³ and Kichul Shin⁴, ¹Division of Rheumatology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea, ²Seoul Metropolitan Government Boramae Medical center, Dongjak-gu, Seoul, South Korea, ³Department of Oral Biochemistry, Pusan National University School of Dentistry, Yangsan, Republic of Korea, ⁴Seoul National University, Seoul, South Korea
Background/Purpose: Studies have shown that mesenchymal stem cell (MSC) infusion ameliorates arthritis in animal models. However, the first-pass effect in the lung has directed attention…
Abstract Number: 0521 • ACR Convergence 2025
Umbilical cord-derived mesenchymal stem cells suppress the pathogenesis of primary Sjögren’s disease by inducing Bach2 expression
Yukitomo Hagiwara¹, Goh Murayama², Taiga Kuga³, Yujin Nishioka⁴, Masaki Nojima¹, Takumi Saito⁵, Yu Yamaji⁶, Tomoko Miyashita⁶, Makio Kusaoi⁷, Ken Yamaji⁵ and Naoto Tamura⁸, ¹Juntendo University, Department of Internal Medicine and Rheumatology, Bunkyo-ku, Tokyo, Japan, ²Department of Internal Medicine and Rheumatology, Juntendo University Graduate School of Medicine, Tokyo, Japan, ³Juntendo University, Tokyo, Japan, ⁴Juntendo University, Department of Internal Medicine and Rheumatology, Shizuoka, Japan, ⁵Juntendo University, Department of Internal Medicine and Rheumatology, Tokyo, Japan, ⁶Juntendo University, Department of Internal Medicine and Rheumatology, Bunkyo-ku, Tokyo, ⁷Juntendo University, Department of Internal Medicine and Rheumatology, Bunkyo, Tokyo, Japan, ⁸Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Primary Sjögren's disease (pSD) is characterized by lymphocytic infiltration of the salivary and lacrimal glands, leading to functional loss and gradually causing dry mouth…
Abstract Number: 0968 • ACR Convergence 2025
Mesenchymal Stromal Cells in Systemic Sclerosis are Dysfunctional and Have a Profibrotic and Senescent Phenotype
Marianela Brizio¹, Benoit Brilland¹, Maximilien Lora², Mathieu Mancini¹, David Langlais¹, Marie Hudson³ and Ines Colmegna⁴, ¹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Research Institute of the McGill University Health Centre, Montreal, ³McGill University, Montréal, QC, Canada, ⁴The Research Institute of the McGill University Health Centre, Montréal, QC, Canada
Background/Purpose: Mesenchymal stromal cells (MSCs) are non-hematopoietic multipotent cells with immunomodulatory, proangiogenic, and antifibrotic properties. MSC functions are mediated by paracrine soluble factors and small…
Abstract Number: 1141 • ACR Convergence 2025
Modulation of Inflammatory Responses by Dental Pulp Stem Cell Extracellular Vesicles in Monosodium Urate-Stimulated Macrophages
Sadiq Umar¹, Kasey Leung² and Sriram Ravindran², ¹University of Illinois at Chicago, Chicago, IL, ²University of Illinois, Chicago, IL
Background/Purpose: Gout is the most prevalent form of inflammatory arthritis, with rising global incidence. It results from the deposition of monosodium urate (MSU) crystals in…
Abstract Number: 1784 • ACR Convergence 2025
Multimodal Preclinical Screening Of Glucocorticoid-Induced Disruption Of Bone Remodeling In Rat
Anik Tuladhar, Caitlyn Carter, Erin Vaughan, martin j.voorbach, Sabyasachi Biswas, Timothy Brayman, Pankaj Kumar, anastasia marinopoulos, Xin Huang, Sjoerd J. Finnema, Romy Christmann, Terry vanVleet, Brian Enright, Magali Guffroy and Stacey Fossey, AbbVie, North Chicago, IL
Background/Purpose: Bone toxicity during drug development can arise from intended pharmacologic mechanisms or off-target effects. Standard histopathological evaluation often fails to detect early skeletal alterations,…
Abstract Number: 1791 • ACR Convergence 2025
Determining the Effect of CD14 Deficiency on Osteoblastogenesis and Subchondral Bone Remodeling In Mice
Kate Sharp¹, Lance Murphy², Vu Nguyen³, Baofeng Hu⁴ and Carla Scanzello⁵, ¹University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ³University of Pennsylvania, Phildealphia, ⁴University of Pennsylvania, Wynnewood, PA, ⁵University of Pennsylvania, Philadelphia
Background/Purpose: Osteoarthritis (OA) is a debilitating disease affecting ~54% of US adults 75 and older. Toll-like receptor 4 (TLR4), and its co-receptor CD14, have been…
Abstract Number: 0277 • ACR Convergence 2024
Mesenchymal Stem Cells Derived from Human Bone Marrow Ameliorate Monosodium Urate Crystal-induced Inflammation
Jennifer Lee¹ and Ah Young Choi², ¹seoul st mary's hospital, Seoul, South Korea, ²The Cactholic University of Korea, Seoul, Republic of Korea
Background/Purpose: Mesenchymal stem cells (MSCs) have anti-inflammatory properties and have been implicated in several inflammatory diseases. Acute gout is initiated by IL-1β produced by monosodium…
Abstract Number: 0534 • ACR Convergence 2024
Patient Reported Outcomes and Disease Activity from a Phase 1 Double-Blind Randomized Clinical Trial of Allogeneic Mesenchymal Stem Cells in Early Rheumatoid Arthritis
Alexandre Matar¹, Maya Breitman², Tracey Bonfield³, Maricela Haghiac⁴, Jane Reese³, Emma Barnboym⁵, Steven Lewis⁶, Hillard Lazarus⁷ and Nora Singer⁸, ¹MetroHealth, Westlake, OH, ²MetroHealth Medical Center,Case Western Reserve University School of Medicine, Cleveland, OH, ³Case Western Reserve University, Cleveland, OH, ⁴Metrohealth Medical Center, Cleveland, OH, ⁵The MetroHealth System, Cleveland, OH, ⁶Case Western University, MetroHealth, Cleveland, OH, ⁷Case Western Reserve University/University Hospitals, Cleveland, OH, ⁸MetroHealth System at Case Western Reserve University School of Medicine, Cleveland, OH
Background/Purpose: Mesenchymal stem (stromal) cells (MSCs) constitute an emerging therapeutic strategy for several human diseases. Small non-randomized studies have shown that MSCs may be a…
Abstract Number: 0861 • ACR Convergence 2024
Stem Cell Function and Capsule Tissue Composition Are Associated with Symptoms, Joint Range of Motion and Radiographic Severity in People with Knee Osteoarthritis
T Mark Campbell¹, Robert Feibel², Jeff Dilworth³, Odette Laneuville⁴ and Guy Trudel⁵, ¹Bruyère Research Institute, Ottawa, ON, Canada, ²The Ottawa Hospital, Ottawa, ON, Canada, ³University of Wisconsin, Madison, WI, ⁴University of Ottawa, Ottawa, ON, Canada, ⁵Ottawa Hospital Research Institute, Ottawa, ON, Canada
Background/Purpose: Osteoarthritis is a common and debilitating condition without cure. Increased OA severity is associated with lost range of motion (ROM) in the affected joint.…