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Abstracts tagged "Mesenchymal stem cells"

  • Abstract Number: 0030 • ACR Convergence 2022

    Fluidic Shear Stress Reduces TNFα-mediated Cartilage Damage in a 3D Model of Degenerative Joint Disease

    Alexandra Damerau1, Duc Ha Do Nguyen1, Christina Lubahn1, Thomas Leeuw2, Timo Gaber3 and Frank Buttgereit3, 1Charité-Universitätsmedizin Berlin, Berlin, Germany, 2Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany, 3Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany

    Background/Purpose: Degenerative joint diseases such as osteoarthritis (OA) ultimately result in the breakdown of cartilage. The exact underlying mechanisms of cause and progression of OA…
  • Abstract Number: 1369 • ACR Convergence 2021

    Adipose Tissue-Derived Stromal Vascular Fraction Plus Fat Grafts for Hand Therapy in Patients with Systemic Sclerosis. a Randomized Controlled Clinical Trial

    Martín Iglesias1, Iván Torre-Villalvazo1, Armando Tovar-Palacio1, Alejandro Zentella-Dehesa1, Patricia Butrón-Gandarillas1, Marta Durand-Carbajal1, Erik Torre-Anaya2, Martha Guevara2 and Tatiana Rodriguez-Reyna2, 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico

    Background/Purpose: Adipose tissue-derived Stromal Vascular Fraction (ADSVF) has been proposed as regenerative treatment for hand deformities and digital ulcer healing in patients with Systemic Sclerosis…
  • Abstract Number: 1440 • ACR Convergence 2021

    Targeting Endogenous Mesenchymal Stromal Cell Response to Interferong in Sjӧgren’s Syndrome

    Sara McCoy, Ilya Gurevic, Maxwell Parker and Jacques Galipeau, University of Wisconsin, Madison, WI

    Background/Purpose: Sjӧgren’s syndrome (SS) is a systemic autoimmune disease that is associated with a lymphoma risk 14-fold that of the general population. Greater focal lymphocytic…
  • Abstract Number: 1502 • ACR Convergence 2021

    Longitudinal Changes in B Cell Subsets in Patients in the Mesenchymal Stromal Cell Trial in Lupus: Analysis of the First Cohort

    Diane Kamen1, S Sam Lim2, Scott Jenks3, Regina Bugrovosky3, Aisha Hill3, Chungwen Wei3, Cristina Drenkard3, Kenneth Kalunian4, Ummara Shah5, Mariko Ishimori6, Rosalind Ramsey-Goldman7, Saira Sheikh8, Mary Alison Mahieu7, Daniel Wallace9, Ellen Goldmuntz10 and Gary Gilkeson1, 1Medical University of South Carolina, Charleston, SC, 2Department of Medicine, Division of Rheumatology, Emory University School of Medicine, Atlanta, GA, 3Emory University, Atlanta, GA, 4UC San Diego, La Jolla, CA, 5University of Rochester, Rochester, NY, 6Cedars-Sinai Health System, Los Angeles, CA, 7Northwestern University, Chicago, IL, 8University of North Carolina, Chapel Hill, NC, 9Attune Health, Beverly Hills, CA, 10National Institutes of Health, Bethesda, MD

    Background/Purpose: Recent advances allow expanded identification of B cell subtypes of pathogenic potential in lupus. Of particular interest are IgD- CD27- double negative (DN2) B…
  • Abstract Number: 1709 • ACR Convergence 2021

    Long-term Safety of a Single Infusion of Human Umbilical Cord Blood-derived Mesenchymal Stem Cell Therapy in Rheumatoid Arthritis: The 5-year Follow-up of the Phase I Clinical Trial

    Min Jung Kim1, Eun Hye Park2 and Kichul Shin3, 1Seoul Metropolitan Government–Seoul National University Boramae Medical Center, Seoul, Republic of Korea, 2Chung-Ang University Hospital, Seoul, Republic of Korea, 3Seoul Metropolitan Government- Seoul National University Boramae Medical Center, Seoul, Republic of Korea

    Background/Purpose: Mesenchymal stem cell (MSC) therapy represents a promise for the treatment of autoimmune diseases due to its potent immunomodulatory effect. We investigated the long-term…
  • Abstract Number: 1770 • ACR Convergence 2021

    Interim Analysis of Cohort 1 in the Mesenchymal Stromal Cell Trial in Systemic Lupus Erythematosis: Safety and Data Management During the Pandemic

    Gary Gilkeson1, Diane Kamen1, S Sam Lim2, Rosalind Ramsey-Goldman3, Kenneth Kalunian4, Saira Sheikh5, Mariko Ishimori6 and Daniel Wallace7, 1Medical University of South Carolina, Charleston, SC, 2Department of Medicine, Division of Rheumatology, Emory University School of Medicine, Atlanta, GA, 3Northwestern University, Chicago, IL, 4UC San Diego, La Jolla, CA, 5University of North Carolina Thurston Arthritis Research Center, and Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 6Cedars-Sinai Health System, Los Angeles, CA, 7Attune Health, Beverly Hills, CA

    Background/Purpose: There is heightened interest in the use of mesenchymal stromal cells (MSCs) for the treatment of autoimmune diseases. There are a number of reports…
  • Abstract Number: 0705 • ACR Convergence 2020

    lncRNA H19 and Micro RNA 675-3p Are Altered by Visfatin During Osteogenesis

    Dennis Küppers1, Lali Tsiklauri2, Marie-Lisa Hülser1, Klaus Frommer2, Stefan Rehart3, Caroline Ospelt4, Ulf Müller-Ladner5 and Elena Neumann6, 1Justus-Liebig-University Giessen, Campus Kerckhoff, Dept. of Rheumatology and Clinical Immunology, Giessen, Germany, 2Justus-Liebig-University Giessen, Campus Kerckhoff, Dept. of Rheumatology and Clinical Immunology, Bad Nauheim, Germany, 3Department of Orthopaedics and Trauma Surgery, Agaplesion Markus Hospital, Frankfurt, Frankfurt, Germany, 4University Hospital Zürich; University Hospital of Zurich; Center of Experimental Rheumatology, Department of Rheumatology, Zurich, Switzerland, 5Department of Rheumatology, Immunology, Osteology and Physical Medicine, Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, Bad Nauheim, Germany, 6Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus Liebig University Giessen, Bad Nauheim, Germany

    Background/Purpose: Long non-coding (lnc-)RNAs are transcribed from DNA similar to mRNA. lncRNA are able to interact directly with DNA, RNA and proteins. Some lncRNAs contain…
  • Abstract Number: 0706 • ACR Convergence 2020

    Adenosine A2A Receptor Activation Reduces Markers of Chondrocyte Senescence and Cartilage Inflammation Associated with Osteoarthritis

    Benjamin Friedman1 and Bruce Cronstein2, 1NYU Rheumatology, New York, NY, 2NYU Grossman School of Medicine, New York, NY

    Background/Purpose: Osteoarthritis is an aging-associated disorder linked to dysfunctional metabolism, chronic inflammation, oxidative stress, and cellular senescence. Cellular senescence is associated with stable cell cycle…
  • Abstract Number: 0707 • ACR Convergence 2020

    Contribution of NOTUM and Glypicans to the Development of Osteoarthritis

    Arkaitz Mucientes1, Eva Herranz1, Pia Lois2, Gloria Candelas2, Lydia Abasolo1, Luis Rodriguez-Rodriguez1, Jose Ramon Lamas1 and Benjamin Fernandez-Gutierrez3, 1IdISSC, Madrid, Madrid, Spain, 2Hospital Clínico San Carlos, Madrid, Madrid, Spain, 3Hospital Clínico San Carlos / IdISSC, Madrid, Madrid, Spain

    Background/Purpose: Osteoarthritis (OA) is a degenerative disease characterized by altered homeostasis of joint cartilage and bone, the functionality of which relies on chondrocytes and osteoblasts,…
  • Abstract Number: 0745 • ACR Convergence 2020

    Development of Functional Assays to Pre-qualify Human Mesenchymal Stem Cells for Rheumatoid Arthritis Treatment

    Maya Breitman1, Tracey Bonfield2, Arnold Caplan3, Hillard Lazarus4, Maricela Haghiac5, Jane Reese6 and Nora Singer1, 1The MetroHealth System, Case Western Reserve University School of Medicine, Cleveland, OH, 2National Center of Regenerative Medicine Case Western Reserve University School of Medicine, Cleveland, OH, 3Skeletal Research Center Case Western Reserve University School of Medicine, Cleveland, OH, 4Case Western Reserve University School of Medicine, Cleveland, OH, 5The MetroHealth System, Cleveland, OH, 6University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH

    Background/Purpose: Sero-positive rheumatoid arthritis (RA) is a chronic autoimmune disease that without effective treatment, leads to joint damage and disability. Not all patients respond to…
  • Abstract Number: 0969 • ACR Convergence 2020

    Investigating Murine Joint-Draining Lymphatics: Lineage Tracing and Single Cell RNA Sequencing Reveal Evidence That Popliteal Lymphatic Muscle Cells and Their Progenitors Represent Distinct Cell Types Divergent from Striated and Vascular Muscle Cells

    H. Mark Kenney1, Richard Bell2, Elysia Masters1, Lianping Xing1, Christopher Ritchlin3 and Edward Schwarz1, 1University of Rochester Medical Center, Rochester, 2Hospital for Special Surgery, New York, 3Department of Medicine, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Previous studies demonstrated that tumor necrosis factor transgenic (TNF-Tg) mice with inflammatory arthritis have damaged lymphatic muscle cells (LMCs) and eventual loss of popliteal…
  • Abstract Number: 1255 • ACR Convergence 2020

    Sjӧgren’s Syndrome Minor Salivary Gland Mesenchymal Stromal Cells Derived Deploy Intact Immune Plasticity and Display Myofibroblast-Like Properties

    Sara McCoy1, Jayeeta Giri1, Rahul Das1, Pradyut Paul1, Andrea Pennati1, Maxwell Parker1, Yun Liang1 and Jacques Galipeau1, 1University of Wisconsin, Madison

    Background/Purpose: Primary Sjӧgren’s syndrome (pSS) is the second most common systemic autoimmune disease with hallmark features of severe ocular and oral sicca, leading to reduced…
  • Abstract Number: 62 • 2019 ACR/ARP Annual Meeting

    Human Gingiva-derived Mesenchymal Stem Cells Are Therapeutic in Lupus Nephritis Through Targeting of CD39-CD73 Signaling Pathway

    Song Guo Zheng1, Julie Wang 2, Junlong dang 3, Nancy Olsen 4 and Wael Jarjour 1, 1Ohio State College of Medicine, Columbus, OH, 2Ohio State University, columbus, 3Sun Yat-sen University, Guangzhou, 4Penn State University, Hershey, PA

    Background/Purpose: Cell specific and cytokine targeted therapeutics have underperformed in systemic lupus erythematosus (SLE) in spite of numerous targets examined and clinical trials conducted.  Mesenchymal…
  • Abstract Number: 1010 • 2019 ACR/ARP Annual Meeting

    IL-17A Induces Distinct Functional Differences Between Two Novel Mesenchymal Stem Cell Populations Identified at the Human Enthesis

    Tobias Russell1, Abdulla Watad 2, Charlie Bridgewood 3, Almas Khan 4, Abhay S Rao 4, Peter Loughenbury 4, Peter Milner 4, Robert Dunsmuir 4, Thomas Baboolal 3, Elena Jones 5, Richard Cuthbert 1 and Dennis McGonagle 6, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM)University of Leeds, Leeds, England, United Kingdom, 2Department of Medicine “B”, Zabludowicz Center for Autoimmune Diseases Sheba Medical Center, Ramat-Gan, Israel, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM)University of Leeds, Leeds, United Kingdom, 4Leeds Teaching Hospitals NHS Trust, Leeds, 5University of Leeds, Leeds, England, United Kingdom, 6University of Leeds, Leeds, United Kingdom

    Background/Purpose: Ankylosing spondylitis (AS) is associated with entheseal inflammation and new bone formation. Resident populations of lymphocytes have been identified at the enthesis that on…
  • Abstract Number: 1971 • 2019 ACR/ARP Annual Meeting

    CD39 Produced from Human Gingiva-Derived Mesenchymal Stem Cells Regulates the Balance of Osteoclasts and Osteoblasts Through Wnt / β-catenin Pathway in Osteoporosis

    Wenbin Wu1, Julie Wang 2, feng huang 1, limin Rong 1 and Song Guo Zheng 3, 1Sun Yat-sen University, Guangzhou, 2Ohio State University, columbus, 3Ohio State College of Medicine, Columbus, OH

    Background/Purpose: Osteoporosis led to severe bone-related diseases and increased mortality and health care costs. Existing treatments failed to reduce the risk of fractures in patients,…
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