ACR Meeting Abstracts

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Abstracts tagged "Magnetic resonance imaging (MRI)"

  • Abstract Number: 2020 • ACR Convergence 2020

    Preliminary Definition of a Positive MRI for Structural Lesions in the Sacroiliac Joints in Axial Spondyloarthritis

    Walter Maksymowych1, Xenofon Baraliakos2, Ulrich Weber3, Pedro M Machado4, Susanne J Pedersen5, Joachim Sieper6, Stephanie Wichuk1, Denis Poddubnyy7, Martin Rudwaleit8, Désirée van der Heijde9, Robert Landewé10, Joel Paschke11, Robert G Lambert12 and Mikkel Østergaard13, 1University of Alberta, Edmonton, AB, Canada, 2Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, 3University of South Denmark, Odense, Denmark, 4University College London, London, United Kingdom, 5Rigshospitalet University, Copenhagen, Denmark, 6Charité Universitätsmedizin Berlin, Berlin, Germany, 7Charité – Universitätsmedizin Berlin, Berlin, Germany, 8Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Germany, 9Leiden University Medical Center, Leiden, Netherlands, 10Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, 11CARE Arthritis, Edmonton, AB, Canada, 12University of Alberta and CARE Arthritis, Edmonton, AB, Canada, 13Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

    Background/Purpose: There is lack of international consensus as to what defines a structural lesion on MRI of the sacroiliac joints (SIJ) typical of axial spondyloarthritis…
  • Abstract Number: 0481 • ACR Convergence 2020

    Subclinical Synovitis in Arthralgia: How Often Does It Result in Clinical Arthritis? A Longitudinal Study to Reflect on Starting Points for DMARD Treatment

    Cleo Rogier1, Fenne Wouters2, Laurette van Boheemen3, Dirkjan van Schaardenburg4, Pascal de Jong1 and Annette van der Helm - van Mil5, 1Erasmus MC, Rotterdam, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Amsterdam Rheumatology and immunology Center | Reade, Amste, Netherlands, 4Amsterdam Rheumatology and immunology Center | Reade and Amsterdam UMC, Amsterdam, Netherlands, 5Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands

    Background/Purpose: According to guidelines, clinical arthritis is mandatory for diagnosing rheumatoid arthritis (RA). However, in the absence of clinical synovitis, imaging-detected subclinical synovitis is increasingly…
  • Abstract Number: 1470 • ACR Convergence 2020

    Machine Learning-Based Prediction of Knee Replacement in Persons with and Without Radiographic Osteoarthritis Using Clinical and Imaging Features of Osteoarthritis: The Multicenter Osteoarthritis Study

    S. Reza Jafarzadeh1, David Felson1, Michael Nevitt2, James Torner3, Cora Lewis4, Frank Roemer5, Ali Guermazi1 and Tuhina Neogi1, 1Boston University School of Medicine, Boston, MA, 2University of California, San Francisco, San Francisco, CA, 3University of Iowa, Iowa City, IA, 4University of Alabama Birmingham, Birmingham, AL, 5Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany

    Background/Purpose: Prior studies of predictors of knee replacement (KR) have often included only a limited set of risk factors, been conducted primarily in knees with…
  • Abstract Number: 2022 • ACR Convergence 2020

    Effects of Anti-TNF-therapy on Osteoblastic Activity in Ankylosing Spondylitis – Results from a Prospective Study Using PET-MRI of SIJ and Spine

    Xenofon Baraliakos1, Styliani Tsiami2, Christoph Rischpler3, Nils-Martin Bruckmann4, Wolfgang Fendler3, Julian Kirchner5, Ken Herrmann3, Lino Morris Sawicki5 and Juergen Braun6, 1Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany, 2Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 3Department of Nuclear Medicine, University Essen-Duisburg, Essen, Germany, 4Department of Radiology, University Duesseldorf, Düsseldorf, Germany, 5Department of Radiology, University Duesseldorf, Duesseldorf, Germany, 6Rheumazentrum Ruhrgebiet Herne, and Ruhr-University Bochum, 44649 Herne, Germany

    Background/Purpose: The clinical efficacy of TNFi in patients with axSpA is well established but its effect on new bone formation is still unclear. Positron emission…
  • Abstract Number: 0557 • ACR Convergence 2020

    The Joint Association of Steps/day and Typical Sedentary Bout Length with Worsening Knee Cartilage Damage over Two Years: The MOST Study

    Dana Voinier1, Tuhina Neogi2, Joshua Stefanik3, Ali Guermazi2, Frank Roemer4, Hiral Master5, Louise Thoma6, Meredith Christiansen7, Jason Jakiela1, Michael Nevitt8, Cora Lewis9, James Torner10 and Daniel White1, 1University of Delaware, Newark, DE, 2Boston University School of Medicine, Boston, MA, 3Northeastern University, Boston, MA, 4Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, 5Vanderbilt University Medical Center, Nashville, TN, 6University of North Carolina at Chapel Hill, Chapel Hill, NC, 7University of Delaware, New York, NY, 8University of California San Fransisco, Orinda, CA, 9University of Alabama Birmingham, Birmingham, AL, 10University of Iowa, Iowa City, IA

    Background/Purpose: Knee cartilage requires loading, e.g., walking, to remain healthy. When cartilage is deprived of loading, i.e., during bouts of sedentary time, it becomes vulnerable…
  • Abstract Number: 1486 • ACR Convergence 2020

    Long-term Efficacy and Safety of Intra-articular Sprifermin in Patients with Knee Osteoarthritis: Results from the 5-Year Forward Study

    Felix Eckstein1, Marc Hochberg2, Hans Guehring3, Flavie Moreau4, Victor Ona4, Asger Bihlet5, Inger Byrjalsen5, Jeppe Andersen5, Benjamin Daelken3, Oliver Guenther3, Christoph Ladel3, Martin Michaelis3 and Philip G Conaghan6, 1Paracelsus Medical University, Salzburg, Austria, 2University of Maryland School of Medicine, Baltimore, MD, 3Merck KGaA, Darmstadt, Germany, 4EMD Serono (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 5Nordic Bioscience, Herlev, Denmark, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research Leeds Biomedical Research Centre, Leeds, United Kingdom

    Background/Purpose: The 5-year Phase II FORWARD study assessed the efficacy and safety of the potential disease-modifying osteoarthritis drug (DMOAD) sprifermin (recombinant human fibroblast growth factor…
  • Abstract Number: 2024 • ACR Convergence 2020

    Effects of Filgotinib on Spinal Lesions in Patients with Ankylosing Spondylitis: Magnetic Resonance Imaging Data from the Placebo-Controlled, Double‑Blind, Randomized TORTUGA Trial

    Walter Maksymowych1, Mikkel Østergaard2, Robert Landewé3, William Barchuk4, Ke Liu4, Chantal Tasset5, Leen Gilles5, Thijs Hendrikx6, Robin Besuyen6 and Xenofon Baraliakos7, 1University of Alberta, Edmonton, AB, Canada, 2Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 3Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, 4Gilead Sciences, Inc., Foster City, CA, 5Galapagos NV, Mechelen, Belgium, 6Galapagos BV, Leiden, Netherlands, 7Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany

    Background/Purpose: The oral, selective Janus kinase 1 inhibitor filgotinib (FIL) significantly improved Spondyloarthritis Research Consortium of Canada (SPARCC) MRI inflammation scores (bone marrow edema) in…
  • Abstract Number: 0708 • ACR Convergence 2020

    Differences in Treating Knee Osteoarthritis by Clinician Specialty

    Denise Baldock1 and Casey Zhang2, 1Ipsos MORI, London, England, United Kingdom, 2Ipsos Insight, New York, NY

    Background/Purpose: Current treatment of knee osteoarthritis (OA) is focused primarily around pain relief offering sustained mobility and prioritizing symptom relief over disease progression potentially impacts…
  • Abstract Number: 1535 • ACR Convergence 2020

    Frequency and Anatomic Distribution of Magnetic Resonance Imaging Lesions in the Sacro-iliac Joints of Healthy Subjects and Patients with Spondyloarthritis

    Sophie Hecquet1, Jean-Philippe Lustig2, Frank Verhoeven1, Mickaël Chouk1, Sébastien Aubry2, Daniel Wendling3 and Clement Prati1, 1Rheumatology, University Teaching Hospital, Besançon, France, 2Radiology, University Teaching Hospital, Besançon, France, 3CHU Besançon, department of rheumatology, Besancon, France

    Background/Purpose: Lesions detected by magnetic resonance imaging (MRI) of the sacroiliac joints are critical to the diagnosis of non-radiographic axial spondyloarthritis. However, some lesions, such…
  • Abstract Number: 0964 • ACR Convergence 2020

    Is Meniscal Status in the Anterior Cruciate Ligament Injured Knee Associated with Change in Bone Surface Area? An Exploratory Analysis of Data from the KANON Trial

    Barbara Snoeker1, Aleksandra Turkiewicz1, Mike Bowes2, Frank Roemer3, Stefan Lohmander1, Richard Frobell1 and Martin Englund1, 1Lund University, Lund, Sweden, 2Imorphics Ltd, Manchester, United Kingdom, 3Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany

    Background/Purpose: Bone shape changes, which may be an important feature of osteoarthritis (OA) development, have been observed to occur early in the knee after anterior…
  • Abstract Number: 1546 • ACR Convergence 2020

    Ultrasound, Magnetic Resonance Imaging and Radiography of the Fingers’ Joints of Psoriatic Arthritis Patients

    Ari Polachek1, Victoria Furer2, Mirna Zureik3, Sharon Nevo3, Liran Mendel4, David Levartovsky2, Jonathan Wollman4, Valerie Aloush2, Reut Tzemach4, Ofir Elalouf5, Marina Anouk6, Mark Berman2, Ilana Kaufman7, Yael Lahat goldstein2, Hagit Sarbagil-Maman8, Sara Borok Lev-Ran2, Adi Broide3, Lihi Eder9, Daphna Paran2, Moshe Iluz10, Iris Eshed11 and Ori Elkayam3, 1Tel Aviv Sourasky Medical Center, Petah-Tikva, Israel, 2Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 3Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel, 4Souraaky Medical Center, Tel-Aviv, Israel, 5Souraaky Medical Center, Herzliya, Israel, 6Souraaky Medical Center, Tel Aviv, Israel, 7Tel Aviv Sourasky Medical Center, Petah-Tiqwa, Israel, 8Tel-Aviv Sourasky Medical Center, Kiryat Ono, Israel, 9University of Toronto, Toronto, ON, Canada, 10Souraaky Medical Center, Tel-Aviv, 11Sheba Medical Center, Tel-Aviv, Israel

    Background/Purpose: Ultrasound (US), magnetic resonance imaging (MRI) and conventional radiography are the leading imaging modalities for musculoskeletal (MSK) assessment in PsA. However, little is reported…
  • Abstract Number: 1108 • ACR Convergence 2020

    Cartilage Biomarkers s-Coll2-1 and s-Coll2-1NO2 Are Associated with Knee Osteoarthritis MRI Features and Predict Disease Worsening

    Yves Henrotin1, Anne-Christine Hick2, Berenice Costes3, Alain Labasse3, Thierry Conrozier4, Michel Malaise5, Yves Maugars6, Franz Pelousse7, Jean-Marc Lemaire8, Cedric Tits9, Thibault Helleputte9 and Damien Loeuille10, 1University of Liège, Liège, Belgium, 2Artialis SA, Liège, Belgium, 3Artialis SA, Liege, Belgium, 45. Department of Rheumatology, Hôpital Nord Franche-Comté, Belfort, France, 5University of Liège, Liege, Belgium, 6Service de rhumatologie, Hôtel-Dieu, CHU de Nantes, Nantes, France, 7SODIRAY, Solution Diagnostique Radiologique, Liège, Belgium, 8SODIRAY, Solution Diagnostique Radiologique, Liege, Belgium, 9Data-Driven Precision Medicine, DNAlytics, Louvain-la-Neuve, Belgium, 10CHU NANCY Rheumatology, NANCY

    Background/Purpose: To identify if biochemical markers s-Coll2-1, a peptide of type collagen and its nitrated from, s-Coll2-1NO2 are associated to knee osteoarthritis (OA), focusing on…
  • Abstract Number: 1547 • ACR Convergence 2020

    Role of Artificial Intelligence in Assessment of Peripheral Joint MRI in Inflammatory Arthritis: A Systematic Review and Meta-analysis

    Arya Haj-Mirzaian1, Olga Kubassova2, Mikael Boesen3, Paul Bird4 and John Carrino5, 1Johns Hopkins Hospital, Baltimore, MD, 2Image Analysis Group, London, United Kingdom, 3Department of Radiology Copenhagen University hospital Bispebjerg and Frederiksberg; The Parker Institute, Copenhagen, Denmark, 4Optimus Clinical Research, Kogarah, University of New South Wales, Sydney, New South Wales, Australia, 5Hospital for Special Surgery, Hackensack, NJ

    Background/Purpose: To summarize the feasibility, reliability, and validity of computer-aided quantification of joint destruction and synovitis on MRI using artificial intelligence (AI) based methods in…
  • Abstract Number: 1113 • ACR Convergence 2020

    Intrameniscal Signal Alterations Strongly Predict Destabilizing Meniscal Tears and Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative

    Jeffrey Driban1, James MacKay2, Timothy McAlindon1, Matthew Harkey3, Bing Lu4, Charles Eaton5, Grace Lo6, Mary Barbe7 and Robert Ward1, 1Tufts Medical Center, Boston, MA, 2University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital; Norwich Medical School, University of East Anglia, Cambridge, United Kingdom, 3University of Massachusetts, Worcester, MA, 4Brigham and Women's Hospital and Harvard Medical School, Newton, MA, 5Brown University, Pawtucket, RI, 6Michael E. Debakey VA Medical Center, Baylor College of Medicine, Houston, TX, 7Temple University School of Medicine, Philadelphia, PA

    Background/Purpose: It is unknown whether early changes in the menisci (e.g., intrameniscal signal alterations) have long-term consequences. We conducted a study to assess the prognostic…
  • Abstract Number: 1557 • ACR Convergence 2020

    Lymphatics as a Biomarker of Joint Physiology: Near-Infrared Imaging of Indocyanine Green Identifies Novel Routes of Lymphatic Drainage from Metacarpophalangeal Joints in Healthy Human Hands

    H. Mark Kenney1, Gregory Dieudonne1, Ronald Wood1, Edward Schwarz1, Christopher Ritchlin2 and Homaira Rahimi3, 1University of Rochester Medical Center, Rochester, 2Department of Medicine, University of Rochester Medical Center, Rochester, NY, 3University of Rochester Medical Center, Rochester, NY

    Background/Purpose: In our previous work, we discovered that patients with active hand RA have reduced lymphatic drainage of indocyanine green (ICG) from the web spaces…
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