Abstracts tagged "Magnetic resonance imaging (MRI)"

Abstract Number: 1995 • ACR Convergence 2020
Non-invasive Vagus Nerve Stimulation Improves Signs and Symptoms of Rheumatoid Arthritis: Results of a Pilot Study
Sara Marsal¹, Hector Corominas², Juan Jose De Agustin De Oro³, Carolina Perez Garcia⁴, Maria Lopez Lasanta³, Helena Borrell³, Delia Reina⁵, Raimon Sanmartí⁶, Francisco Javier Narváez⁷, Clara Franco-Jarava⁸, Charles Peterfy⁹, Jose Antonio Narvaez¹⁰, Vivek Sharma¹¹, Konstantinos Alataris¹¹, Mark Genovese¹² and Matthew Baker¹³, ¹Hospital Universitari Vall d'Hebron, Barcelona, Spain, ²Institut Rec. Hospital de la Santa Creu I Sant Pau., Barcelona, Spain, ³Hospital Universitari Vall d’Hebron, Barcelona, Spain, ⁴Hospital Universitari Parc Salut Mar, Barcelona, Spain, ⁵Hospital Moises Broggi, Barcelona, Spain, ⁶Hospital Universitari Clínic de Barcelona, Barcelona, Catalonia, Spain, ⁷Hospital Bellvitge, BARCELONA, Spain, ⁸1Hospital Universitari Vall d’Hebron, Barcelona, Spain, ⁹Spire Sciences, Inc., Boca Raton, FL, ¹⁰Clinica Diagonal, Barcelona, Spain, ¹¹Vorso Corp, Redwood CIty, CA, ¹²Stanford University Medical Center, Palo Alto, CA, ¹³Stanford University, Menlo Park, CA
Background/Purpose: Vagus nerve stimulation (VNS) has been shown to improve rheumatoid arthritis (RA) disease severity in patients with refractory disease (1,2). A multi-center pilot study…
Abstract Number: 1365 • ACR Convergence 2020
Machine Learning-based Berlin Scoring of Magnetic Resonance Images of the Spine in Patients with Ankylosing Spondylitis: Analysis of Data from a Phase 3 Trial with Secukinumab
Amir Jamaludin¹, Rhydian Windsor¹, Sarim Ather¹, Timor Kadir¹, Andrew Zisserman¹, Juergen Braun², Lianne Gensler³, Pedro Machado⁴, Mikkel Østergaard⁵, Denis Poddubnyy⁶, Thibaud Coroller⁷, Brian Porter⁷, Shephard Mpofu⁸ and Aimee Readie⁷, ¹University of Oxford, Oxford, United Kingdom, ²Rheumazentrum Ruhrgebiet and Ruhr-University, 44649 Herne, Germany, ³University of California San Francisco, San Francisco, CA, ⁴University College London, London, United Kingdom, ⁵Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, ⁶Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁸Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Magnetic resonance imaging (MRI) offers a non-invasive and objective method of early diagnosis and classification, monitoring disease burden and treatment response for patients (pts)…
Abstract Number: 2012 • ACR Convergence 2020
A Phase IIb, Randomized, Double-blind Study in Patients with Rheumatoid Arthritis Evaluating the Safety and Efficacy of Evobrutinib Compared with Placebo in Patients with an Inadequate Response to Methotrexate
Charles Peterfy¹, Maya Buch², Ernest Choy³, Georg Schett⁴, Dana Parsons-Rich⁵, Anand Patel⁶, Yulia Zima⁵, Claire Le Bolay⁷ and Mark Genovese⁸, ¹Spire Sciences, Inc., Boca Raton, FL, ²Centre of Musculoskeletal Research, School of Biological Sciences, University of Manchester, Manchester, United Kingdom, ³CREATE Centre, Cardiff University, Cardiff, Wales, United Kingdom, ⁴Friedrich-Alexander-Universität Erlangen- Nuremberg, Erlangen, Germany, ⁵EMD Serono (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁶EMD Serono (a business of Merck KGaA, Darmstadt, Germany), Billerica, ⁷Merck KGaA, Darmstadt, Germany, ⁸Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA
Background/Purpose: Bruton’s tyrosine kinase (BTK) is involved in multiple signalling pathways potentially implicated in rheumatoid arthritis (RA). Evobrutinib is a highly selective, oral BTK inhibitor.…
Abstract Number: 0317 • ACR Convergence 2020
Axial Involvement in Psoriatic Arthritis in a Comprehensive Rapid Diagnosis Program (Reuma-check PsA). Analysis of Its Characteristics
Rodrigo Garcia Salinas¹, Santiago Ruta², Jessica Torres Chichande¹, Einer Sanchez Prado¹, Facundo Salvatori¹ and Sebastian Magri¹, ¹Hospital Italiano La Plata, La Plata, Argentina, ²Hospital Italiano La Plata, Buenos Aires, Argentina
Background/Purpose: To date, there is no consensus that allows an appropriate definition of axial involvement in PsA, that ranges between 25 to 70%. To estimate…
Abstract Number: 1366 • ACR Convergence 2020
Secukinumab Improved Signs and Symptoms in Patients with Non-radiographic Axial Spondyloarthritis: Results from a Randomized Controlled Phase III Study Stratified by Baseline Objective Signs of Inflammation
Juergen Braun¹, Ricardo Blanco², Helena Marzo-Ortega³, Lianne Gensler⁴, Filip Van den Bosch⁵, Hideto Kameda⁶, Denis Poddubnyy⁷, Marleen van de Sande⁸, Anna Wiksten⁹, Brian Porter¹⁰, Santiago Moreno⁹, Abhijit Shete⁹, Hanno Richards⁹, Sibylle Haemmerle⁹ and Atul Deodhar¹¹, ¹Rheumazentrum Ruhrgebiet Herne, and Ruhr-University Bochum, 44649 Herne, Germany, ²Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, ³The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, ⁴University of California San Francisco, San Francisco, CA, ⁵Ghent University Hospital, Ghent, Belgium, ⁶Toho University, Tokyo, Japan, ⁷Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁸Amsterdam UMC, AMC/University of Amsterdam, Department of Rheumatology and Clinical Immunology, Amsterdam Infection & Immunity Institute and Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam, Netherlands, ⁹Novartis Pharma AG, Basel, Switzerland, ¹⁰Novartis Pharmaceuticals Corporation, East Hanover, NJ, ¹¹Oregon Health & Science University, Portland, OR
Background/Purpose: Active non-radiographic axial spondyloarthritis (nr-axSpA) is often determined on the basis of objective signs of inflammation (elevated C-reactive protein [CRP] and/or evidence of sacroiliitis…
Abstract Number: 2019 • ACR Convergence 2020
Preliminary Definition of a Positive MRI for Active Lesions in the Sacroiliac Joints Typical of Axial Spondyloarthritis
Walter Maksymowych¹, Xenofon Baraliakos², Ulrich Weber³, Pedro M Machado⁴, Susanne J Pedersen⁵, Joachim Sieper⁶, Stephanie Wichuk¹, Denis Poddubnyy⁷, Martin Rudwaleit⁸, Désirée van der Heijde⁹, Robert Landewé¹⁰, Joel Paschke¹¹, Mikkel Østergaard¹² and Robert G Lambert¹³, ¹University of Alberta, Edmonton, AB, Canada, ²Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ³University of South Denmark, Odense, Denmark, ⁴University College London, London, United Kingdom, ⁵Rigshospitalet University, Copenhagen, Denmark, ⁶Charité Universitätsmedizin Berlin, Berlin, Germany, ⁷Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁸Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Germany, ⁹Leiden University Medical Center, Leiden, Netherlands, ¹⁰Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, ¹¹CARE Arthritis, Edmonton, AB, Canada, ¹²Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, ¹³University of Alberta and CARE Arthritis, Edmonton, AB, Canada
Background/Purpose: The ASAS definition of a positive MRI for inflammation (ASAS-MRI+) is intended for classification of patients as having axSpA but is often misused for…
Abstract Number: 0444 • ACR Convergence 2020
Chronological Order of Decrease of Synovitis, Osteitis and Tenosynovitis in Early Arthritis Patients Receiving First DMARD-treatment
Xanthe Matthijssen¹, Ellis Niemantsverdriet¹, Saskia le Cessie¹ and Annette van der Helm - van Mil², ¹Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands
Background/Purpose: Advanced imaging modalities have shown that not only joints but also bones and tendon sheaths can be inflamed at diagnosis of rheumatoid arthritis. We…
Abstract Number: 1396 • ACR Convergence 2020
Digital Artery Volume Index (Davix©) Predicts Onset of Future Digital Ulcers in Patients with Systemic Sclerosis
Klodian Gjeloshi¹, Giovanni Lettieri², Fiammetta Danzo¹, Giuseppina Abignano³, Mark Hinton⁴, Anne-Maree Dean⁵, Giovanna Cuomo⁶, Olga Kubassova⁷ and Francesco Del Galdo⁵, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK and Internal Medicine Department, University of Campania Luigi Vanvitelli, Naples, Italy, Leeds, United Kingdom, ²Radiology Department, San Carlo Hospital, Potenza, Italy, Potenza, Italy, ³Rheumatology Institute of Lucania (IReL), Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, England, United Kingdom, ⁴IAG CEO, London, United Kingdom, London, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom, ⁶Internal Medicine Department, University of Campania Luigi Vanvitelli, Naples, Italy, Naples, Italy, ⁷Image Analysis Group, London, United Kingdom
Background/Purpose: Neointima proliferation is a key pathologic feature of Systemic Sclerosis (SSc), causing arterial vessel narrowing. It is a recognised culprit pathological lesion in Digital…
Abstract Number: 2020 • ACR Convergence 2020
Preliminary Definition of a Positive MRI for Structural Lesions in the Sacroiliac Joints in Axial Spondyloarthritis
Walter Maksymowych¹, Xenofon Baraliakos², Ulrich Weber³, Pedro M Machado⁴, Susanne J Pedersen⁵, Joachim Sieper⁶, Stephanie Wichuk¹, Denis Poddubnyy⁷, Martin Rudwaleit⁸, Désirée van der Heijde⁹, Robert Landewé¹⁰, Joel Paschke¹¹, Robert G Lambert¹² and Mikkel Østergaard¹³, ¹University of Alberta, Edmonton, AB, Canada, ²Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ³University of South Denmark, Odense, Denmark, ⁴University College London, London, United Kingdom, ⁵Rigshospitalet University, Copenhagen, Denmark, ⁶Charité Universitätsmedizin Berlin, Berlin, Germany, ⁷Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁸Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Germany, ⁹Leiden University Medical Center, Leiden, Netherlands, ¹⁰Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, ¹¹CARE Arthritis, Edmonton, AB, Canada, ¹²University of Alberta and CARE Arthritis, Edmonton, AB, Canada, ¹³Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Background/Purpose: There is lack of international consensus as to what defines a structural lesion on MRI of the sacroiliac joints (SIJ) typical of axial spondyloarthritis…
Abstract Number: 0481 • ACR Convergence 2020
Subclinical Synovitis in Arthralgia: How Often Does It Result in Clinical Arthritis? A Longitudinal Study to Reflect on Starting Points for DMARD Treatment
Cleo Rogier¹, Fenne Wouters², Laurette van Boheemen³, Dirkjan van Schaardenburg⁴, Pascal de Jong¹ and Annette van der Helm - van Mil⁵, ¹Erasmus MC, Rotterdam, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Amsterdam Rheumatology and immunology Center | Reade, Amste, Netherlands, ⁴Amsterdam Rheumatology and immunology Center | Reade and Amsterdam UMC, Amsterdam, Netherlands, ⁵Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands
Background/Purpose: According to guidelines, clinical arthritis is mandatory for diagnosing rheumatoid arthritis (RA). However, in the absence of clinical synovitis, imaging-detected subclinical synovitis is increasingly…
Abstract Number: 1470 • ACR Convergence 2020
Machine Learning-Based Prediction of Knee Replacement in Persons with and Without Radiographic Osteoarthritis Using Clinical and Imaging Features of Osteoarthritis: The Multicenter Osteoarthritis Study
S. Reza Jafarzadeh¹, David Felson¹, Michael Nevitt², James Torner³, Cora Lewis⁴, Frank Roemer⁵, Ali Guermazi¹ and Tuhina Neogi¹, ¹Boston University School of Medicine, Boston, MA, ²University of California, San Francisco, San Francisco, CA, ³University of Iowa, Iowa City, IA, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Prior studies of predictors of knee replacement (KR) have often included only a limited set of risk factors, been conducted primarily in knees with…
Abstract Number: 2022 • ACR Convergence 2020
Effects of Anti-TNF-therapy on Osteoblastic Activity in Ankylosing Spondylitis – Results from a Prospective Study Using PET-MRI of SIJ and Spine
Xenofon Baraliakos¹, Styliani Tsiami², Christoph Rischpler³, Nils-Martin Bruckmann⁴, Wolfgang Fendler³, Julian Kirchner⁵, Ken Herrmann³, Lino Morris Sawicki⁵ and Juergen Braun⁶, ¹Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany, ²Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ³Department of Nuclear Medicine, University Essen-Duisburg, Essen, Germany, ⁴Department of Radiology, University Duesseldorf, Düsseldorf, Germany, ⁵Department of Radiology, University Duesseldorf, Duesseldorf, Germany, ⁶Rheumazentrum Ruhrgebiet Herne, and Ruhr-University Bochum, 44649 Herne, Germany
Background/Purpose: The clinical efficacy of TNFi in patients with axSpA is well established but its effect on new bone formation is still unclear. Positron emission…
Abstract Number: 0557 • ACR Convergence 2020
The Joint Association of Steps/day and Typical Sedentary Bout Length with Worsening Knee Cartilage Damage over Two Years: The MOST Study
Dana Voinier¹, Tuhina Neogi², Joshua Stefanik³, Ali Guermazi², Frank Roemer⁴, Hiral Master⁵, Louise Thoma⁶, Meredith Christiansen⁷, Jason Jakiela¹, Michael Nevitt⁸, Cora Lewis⁹, James Torner¹⁰ and Daniel White¹, ¹University of Delaware, Newark, DE, ²Boston University School of Medicine, Boston, MA, ³Northeastern University, Boston, MA, ⁴Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, ⁵Vanderbilt University Medical Center, Nashville, TN, ⁶University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁷University of Delaware, New York, NY, ⁸University of California San Fransisco, Orinda, CA, ⁹University of Alabama Birmingham, Birmingham, AL, ¹⁰University of Iowa, Iowa City, IA
Background/Purpose: Knee cartilage requires loading, e.g., walking, to remain healthy. When cartilage is deprived of loading, i.e., during bouts of sedentary time, it becomes vulnerable…
Abstract Number: 1486 • ACR Convergence 2020
Long-term Efficacy and Safety of Intra-articular Sprifermin in Patients with Knee Osteoarthritis: Results from the 5-Year Forward Study
Felix Eckstein¹, Marc Hochberg², Hans Guehring³, Flavie Moreau⁴, Victor Ona⁴, Asger Bihlet⁵, Inger Byrjalsen⁵, Jeppe Andersen⁵, Benjamin Daelken³, Oliver Guenther³, Christoph Ladel³, Martin Michaelis³ and Philip G Conaghan⁶, ¹Paracelsus Medical University, Salzburg, Austria, ²University of Maryland School of Medicine, Baltimore, MD, ³Merck KGaA, Darmstadt, Germany, ⁴EMD Serono (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁵Nordic Bioscience, Herlev, Denmark, ⁶Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research Leeds Biomedical Research Centre, Leeds, United Kingdom
Background/Purpose: The 5-year Phase II FORWARD study assessed the efficacy and safety of the potential disease-modifying osteoarthritis drug (DMOAD) sprifermin (recombinant human fibroblast growth factor…
Abstract Number: 2024 • ACR Convergence 2020
Effects of Filgotinib on Spinal Lesions in Patients with Ankylosing Spondylitis: Magnetic Resonance Imaging Data from the Placebo-Controlled, Double‑Blind, Randomized TORTUGA Trial
Walter Maksymowych¹, Mikkel Østergaard², Robert Landewé³, William Barchuk⁴, Ke Liu⁴, Chantal Tasset⁵, Leen Gilles⁵, Thijs Hendrikx⁶, Robin Besuyen⁶ and Xenofon Baraliakos⁷, ¹University of Alberta, Edmonton, AB, Canada, ²Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, ³Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, ⁴Gilead Sciences, Inc., Foster City, CA, ⁵Galapagos NV, Mechelen, Belgium, ⁶Galapagos BV, Leiden, Netherlands, ⁷Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany
Background/Purpose: The oral, selective Janus kinase 1 inhibitor filgotinib (FIL) significantly improved Spondyloarthritis Research Consortium of Canada (SPARCC) MRI inflammation scores (bone marrow edema) in…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].