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Abstracts tagged "macrophages"

  • Abstract Number: 0042 • ACR Convergence 2024

    Modulating Inflammation and Angiogenesis in an Advanced 3D Rheumatoid Arthritis Synovial Tissue Model

    Eva Philippon1, Jan Piet van Hamburg1, Lisanne van Rooijen1, Gary Sims2, Conny Van der Laken3 and Sander Tas4, 1Amsterdam UMC, Amsterdam, Netherlands, 2Immunology Biosciences, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 3Amsterdam UMC - location VUMC, Amsterdam, Netherlands, 4Amsterdam UMC, locatie AMC, Amsterdam, Netherlands

    Background/Purpose: Rheumatoid Arthritis (RA) is a progressive and systemic autoimmune disorder characterized by chronic and destructive joint inflammation. Key features of RA include synovial cell…
  • Abstract Number: 0928 • ACR Convergence 2024

    In Vitro Study of Fibroblast-Like Synoviocytes and Macrophages-Like Synoviocytes Isolated from Rheumatoid Arthritis, Psoriatic Arthritis Patients and Healthy Subjects

    monia Maccaferri1, Francesco Zambianchi2, Carlo Salvarani3 and Elisa Pignatti3, 1Azienda Ospedaliero Universitaria di Modena, Modena, Italy, 2Department of Maternal, Child and Adult Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy, 3Department of Surgery, Medicine Dentistry and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy

    Background/Purpose: Interactions between fibroblast-like synoviocytes (FLSs) and macrophage-like synoviocytes (MLSs) are pivotal in the pathogenesis of RA and PsA. FLSs both activate and are activated…
  • Abstract Number: 2534 • ACR Convergence 2024

    Deciphering Complement-dependent Macrophage Phenotypes in Human Rheumatoid Arthritis Using Combined Computational-experimental Single-cell Omics

    Juan Vargas1, Ian Mantel2, Jun Inamo3, Nirmal Banda1, Anna Helena Jonsson3, Kevin Wei4, Deepak Rao5, Susan Goodman6, Kevin Deane7, Jennifer Seifert8, Jennifer Anolik9, Michael Brenner10, Soumya Raychaudhuri11, Trent Woodruff12, the Accelerating Medicines Partnership (AMP) RA/SLE Network13, Michael Holers14, Laura Donlin15 and Fan Zhang16, 1The University of Colorado, Aurora, CO, 2WEILL CORNELL MEDICINE, New York, NY, 3University of Colorado School of Medicine, Aurora, CO, 4Brigham and Women's Hospital at Harvard Medical School, Boston, MA, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Hospital for Special Surgery, New York 10025, NY, 7University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 8University of Colorado and Oklahoma Medical Research Foundation, Aurora, CO, 9University of Rochester Medical Center, Rochester, NY, 10Brigham Women's Hospital, Boston, MA, 11Brigham and Women's Hospital, Boston, MA, 12University of Queensland, Brisbane, Australia, 13AMP RA/SLE consortium, Aurora, CO, 14Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 15Hospital for Special Surgery, New York, NY, 16University of Colorado, Aurora, CO

    Background/Purpose: The complement system is a major component of innate immunity and plays a vital role in experimental models of autoimmune disease pathogenesis. In patients…
  • Abstract Number: 0049 • ACR Convergence 2024

    Inflammatory Priming by Anti-MAA Antibodies in Rheumatoid Arthritis

    Marcelo Afonso1, Jitong Sun1, Koji Sakuraba1, Alexandra Circiumaru2, Denis Lagutkin1, Masa Filipovic1, Anca Catrina1, Caroline Grönwall1, Aase Hensvold1 and Bence Réthi1, 1Karolinska Institutet, Stockholm, Sweden, 2Division for Rheumatology, Karolinska Institutet; Center for Rheumatology, Academic Specialist Center, Stockholm region, Stockholm, Sweden

    Background/Purpose: We have previously shown that autoantibodies targeting malondialdehyde-acetaldehyde protein adducts (anti-MAA) in rheumatoid arthritis (RA) patients boosted osteoclast differentiation and induced bone erosion in mice…
  • Abstract Number: 0966 • ACR Convergence 2024

    CDDO-Me Attenuates Pro-fibrotic Activation in Macrophages and Fibroblasts in Systemic Sclerosis

    Heetaek Yang1, Chanhyuk Park2, Chen-Yu Wang3, Emily Morris4, Karen Liby5, Michael Whitfield6 and Patricia Pioli2, 1Dartmouth College, West Lebanon, NH, 2Geisel School of Medicine at Dartmouth, Lebanon, NH, 3Dartmouth College, Lebanon, NH, 4Dartmouth College, Enfield, NH, 5Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, 6Geisel School of Medicine at Dartmouth, Hanover, NH

    Background/Purpose: Systemic Sclerosis (SSc) is characterized by dysfunctional immune activation, oxidative stress, and fibrosis. In prior work, we have shown that SSc macrophages (MØs) have…
  • Abstract Number: 2547 • ACR Convergence 2024

    Neurophysiological Phenotypes Are Uncoupled from Toll-like Receptor-Mediated Peripheral Disease in a Mouse Model of Neuropsychiatric Symptoms of Systemic Lupus Erythematosus

    Cecilia Stumpf1, Vanessa Rodriguez1 and Carla Cuda2, 1Northwestern University, Chicago, 2Northwestern University, Chicago, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical presentations, including neuropsychiatric symptoms (NPSLE). Despite being a major cause of morbidity…
  • Abstract Number: 0057 • ACR Convergence 2024

    Flow Cytometry of Cells Within Induced Sputum from Individuals At-Risk for RA Reveals Relative Expansion of Small Macrophages

    Hideto Takada1, Brian Hattel2, Marie Feser3, LauraKay Moss2, Yuko Okamoto4, Mark Gillespie5, Adam Savage5, Troy Torgerson6, V. Michael Holers7, Kevin Deane8 and Kristen Demoruelle9, 1Tokyo Women's Medical University, Denver, CO, 2University of Colorado Anschutz Medical Campus, Denver, CO, 3Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 4Tokyo Women's Medical University Division of Rheumatology, Shinjyuku-ku, Tokyo, Japan, 5Allen Institute for Immunology, Seattle, WA, 6Allen Institute for Immunology, Enumclaw, WA, 7University of Colorado, Denver, CO, 8University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 9University of Colorado Anschutz Medical Campus, Golden, CO

    Background/Purpose: Serum elevations of ACPA in the absence of inflammatory arthritis is a well-established risk factor for the future development of clinical RA. The lung…
  • Abstract Number: 0972 • ACR Convergence 2024

    Downregulated Fli1 in Scleroderma Myeloid Cells Contributes to Cardiac Fibrosis via a Galectin-3/mTOR Dependent Pathway

    Fatima El adili1, Moyo Mudhibadhi2, Giovanni ligresti3, Maria Trojanowska2 and Andreea Bujor3, 1Boston Medical Center, Boston, MA, 2Boston university medical school, Boston, MA, 3Boston University, Boston, MA

    Background/Purpose: Cardiac fibrosis is a common complication in Systemic sclerosis (SSc), but the pathogenesis is largely unknown. We have previously shown that monocytes isolated from…
  • Abstract Number: 2550 • ACR Convergence 2024

    Infiltrating and Resident Macrophages in Lupus Nephritis: Scar Associated Macrophage Phagocytic Dysfunction and Fibroblast Activation

    Chirag Raparia1, Paul Hoover2, Arnon Arazi3, Nir Hacohen4 and Anne Davidson5, 1Donald and Barbara Zucker School of Medicine At Hofstra/Northwell, Shoreham, NY, 2Brigham and Women's Hospital, SWAMPSCOTT, MA, 3Feinstein Institutes for Medical Research, Melrose, MA, 4Broad Institute of MIT and Harvard, Boston, MA, 5Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Lupus nephritis (LN) is driven by a heterogeneous population of renal macrophages. We have previously reported that the renal macrophage subpopulations are similar in…
  • Abstract Number: 0061 • ACR Convergence 2024

    Comparative Transcriptional Profiling of IPF and RA-ILD Lung Tissue Demonstrates Both Overlapping and Distinct Cell-specific Signaling Pathways

    Joshua Sciurba1, Daniel Kass1, Eleanor Valenzi2, John Sembrat2, Robert Lafyatis3 and Dana Ascherman4, 1University of Pittsburgh School of Medicine, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA, 3Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 4Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA

    Background/Purpose: Transcriptional profiling represents a powerful tool for deciphering disease-relevant pathways and deriving functional biomarkers.  Given the shared demographic, genetic, and clinico-epidemiologic features between rheumatoid…
  • Abstract Number: 0973 • ACR Convergence 2024

    Mechano-transduction via MRTF-A Pathway Is Required for Cytokine Release by Scleroderma Macrophages

    Sandra Lopez Garces1, Guan Hui Tricia Lim2, Jorlin Liu3, Maahia Choudhary3, Juno Erin Vimalenthiran,3, Angela Tam1, David Abraham3, Christopher Denton4, Bahja Ahmed Abdi1 and Richard Stratton5, 1University College London, London, United Kingdom, 2Centre for Rheumatology and Connective Tissue Diseases, University College London Medical School, Royal Free Campus, London, United Kingdom, 3UCL, London, United Kingdom, 4University College London, Northwood, United Kingdom, 5UCL, London, England, United Kingdom

    Background/Purpose: In keeping with hallmark clinical evidence of stiffening and fibrotic thickening of the skin, we and others have previously demonstrated a role for the…
  • Abstract Number: 2593 • ACR Convergence 2024

    A Long-term Synovial Tissue 3D Model Incorporating Fibroblasts, Macrophages, Endothelial Cells, and Other Immune Cells Such as Innate Lymphoid Cells Enables Animal Model-Independent Rheumatoid Arthritis Research

    Miriam Bollmann1, Oskar Landberg2, Negar Ayoubzadeh2, Charlotte A. Jonsson2, Inger Gjertsson2 and Mattias Svensson2, 1University of Gothenburg, Göteborg, Sweden, 2University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with multiple tissues contributing to its pathology, including the synovial membrane. The RA synovial membrane…
  • Abstract Number: 0062 • ACR Convergence 2024

    Pro-Fibrotic Effects of Malondialdehyde-Acetaldehyde-Adducted and/or Citrullinated Proteins on Macrophages and Human Lung Fibroblasts

    Lauren Klingemann1, Nozima Aripova1, Nigina Aripova2, Michael Duryee1, Carlos Hunter1, Jill Poole1, Bryant England1, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2WUSTL, St. Louis, MO

    Background/Purpose: Clinically evident rheumatoid arthritis-associated interstitial lung disease (RA-ILD) affects approximately 10-15% of patients with rheumatoid arthritis (RA) and accounts for the most overrepresented cause…
  • Abstract Number: 1396 • ACR Convergence 2024

    Low CD47 Expression on B Cells, Induces High B Cell Phagocytosis by Macrophages and Is a Predictive Biomarker of Anti-rituximab Antibodies and Lower Response in Rheumatoid Arthritis

    Samuel Bitoun1, Bineta Ly2, Audrey Paoletti2, Catherine Menier Menier3, Marc Pallardy4, Bernard Maillere5 and Xavier Mariette6, and ABIRISK consortium, 1Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicetre, France, 2Rheumatology departement, Université Paris Saclay, Inserm UMR 1184,Hopital Bicêtre, APHP, FHU CARE, Le Kremlin Bicêtre, France, 31 CEA, INRAE, Département Médicaments et Technologies pour la Santé, SIMoS, Université de Paris-Saclay, Gif sur Yvette, France, 4Université Paris-Saclay, INSERM, Inflammation Microbiome Immunosurveillance, Orsay, France, 5CEA, INRAE, Département Médicaments et Technologies pour la Santé, SIMoS, Université de Paris-Saclay, Gif sur Yvette, France, 6Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin Bicetre, France

    Background/Purpose: Rituximab (RTX) provides long lasting efficacy in the control of rheumatoid arthritis. Among factors associated with RTX failure are the occurrence of anti-drug antibodies…
  • Abstract Number: 2594 • ACR Convergence 2024

    A Novel Therapeutically Active CSF-1R Agonist Promotes Tissue Macrophages Inflammation Resolution and Induces Tissue Repair Pathways

    Saul Kivimae1, Sandip Mukherjee2, Phi Quach3, Rhoneil Pena4, Olga Zemska3, Michal Olszewski5, Jicai Huang3, Michael Labson6, Donald Walker1, Mekhala Maiti7, Chakrapani Tripathi8, Thomas Chang3, Suresh Adapala9, Damon Hamel3, Katherine Brendza3, Takahiro Miyazaki3 and Jonathan Zalevsky1, 1Nektar Therapeutics, San Francisco, CA, 2Nurix Therapeutics, San Francisco, 3Nektar Therapeutics, San Francisco, 4Sutro Biopharma, South San Francisco, 5Vaxcyte, San Francisco, 6Guardant Health, Palo Alto, 7Alumis, Inc, South San Francisco, 8Theragent Inc, Arcadia, CA, 9Inotiv, Rockville, MD

    Background/Purpose: Current standard of care chronic inflammatory disease therapies are designed to suppress inflammation and are not optimized for inflammation resolution and restoration of tissue…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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