Abstracts tagged "macrophages"

Abstract Number: 0596 • ACR Convergence 2022
Neutrophil Extracellular Traps (NET) Trigger an Enhanced Pro-inflammatory Response in Macrophage Subpopulations in Rheumatoid Arthritis Patients via the Aryl Hydrocarbon Receptor (AhR) Pathway
Dyhia Melbouci¹, Sarra Seninet¹, Marie-Christophe Boissier², Elodie Segura³ and Patrice Decker¹, ¹University Sorbonne Paris Nord, Inserm UMR 1125, Li2P, Bobigny, France, ²INSERM UMR 1125, Sorbonne Paris Nord University,Rheumatology Dpt, APHP, GHUPSSD, Avicenne Hosp, Bobigny, France, ³U932 Inserm, Curie Institute, Paris, France
Background/Purpose: Activated neutrophils (PMN) form neutrophil extracellular traps (NET), fibers of DNA and associated proteins expelled in the extracellular space. Increased NET formation has been…
Abstract Number: 1683 • ACR Convergence 2022
Malondialdehyde-Acetaldehyde (MAA) Modified Matrix Gla Protein (MGP) Increases Citrullination by Human Macrophages
Spencer Jones¹, nozima Aripova¹, Michael Duryee¹, Austin Ragland¹, Bryant England¹, Ted Mikuls² and Geoffrey Thiele¹, ¹University of Nebraska Medical Center, Omaha, NE, ²Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Malondialdehyde and acetaldehyde, by-products of lipid peroxidation, react with free amino groups on proteins to form a stable post-translational modification (PTM), termed MAA. MAA…
Abstract Number: 0600 • ACR Convergence 2022
Correlates Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Phenotypes: Data from the Accelerated Medicines Partnership
Dana Weisenfeld¹, Fan Zhang², Laura Donlin³, Anna Jonsson¹, William Apruzzese¹, Debbie Campbell⁴, Ellen Gravallese⁵, Larry Moreland⁶, Susan Goodman³, Michael Brenner⁵, Soumya Raychaudhuri¹, Andrew Filer⁷, Jennifer Anolik⁸, Vivian Bykerk³ and Katherine Liao¹, ¹Brigham and Women's Hospital, Boston, MA, ²University of Colorado, Aurora, CO, ³Hospital for Special Surgery, New York, NY, ⁴University of Rochester, Rochester, ⁵Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶University of Colorado, Denver, CO, ⁷University of Birmingham, Birmingham, United Kingdom, ⁸University of Rochester Medical Center, Rochester, NY
Background/Purpose: Prior studies have characterized the diverse cell types in the RA synovium through a multi-center consortium incorporating RNA-seq data. Due to the novelty of…
Abstract Number: 0540 • ACR Convergence 2021
Behavioral Deficits May Precede Influx of Brain-Infiltrating Macrophages in Neuropsychiatric Symptoms of Systemic Lupus Erythematosus
Hadijat Makinde, Miranda Gurra, Yidan Wang, Sara Radecki and Carla Cuda, Northwestern University, Chicago, IL
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects many end organs including the brain. Despite a prevalence of over 50% in…
Abstract Number: 0556 • ACR Convergence 2021
Investigating the Heterogeneity of Skin Macrophages in Systemic Scleroderma
Hadijat Makinde¹, Salina Dominguez¹, Monique Hinchcliff², Deborah Winter³ and Harris Perlman¹, ¹Northwestern University, Chicago, IL, ²Yale School of Medicine, Westport, CT, ³Northwestern University Division of Rheumatology, Chicago, IL
Background/Purpose: The etiology and pathogenesis of systemic sclerosis (SSc) are poorly understood; however, an increasing body of evidence supports an early inflammatory phase that precedes…
Abstract Number: 1000 • ACR Convergence 2021
Molecular Mechanism of Inhibition of CD38 in Attenuation of Monosodium Urate Crystal-induced Inflammatory Responses in Macrophages
Huaping Qin¹, Patricia Oliveira¹, Tiffany Yan¹, Robert Terkeltaub² and Ru Liu Bryan³, ¹University of California San Diego, La Jolla, CA, ²VA/UCSD, San Diego, CA, ³University of California San Diego and VASDHS, San Diego, CA
Background/Purpose: CD38 can function as a degrading enzyme of nicotinamide adenine dinucleotide (NAD), a critical metabolic intermediate serving as enzyme cofactor in redox reactions and…
Abstract Number: 1001 • ACR Convergence 2021
Exosomes Mediate a Cooperative Mechanism of Macrophage/Fibroblast Activation in Systemic Sclerosis
Rajan Bhandari¹, Heetaek Yang², Noelle Kosarek³, Michael Whitfield⁴ and Patricia Pioli¹, ¹Geisel School of Medicine at Dartmouth, Lebanon, NH, ²Geisel School of Medicine, Hanover, NH, ³Dartmouth Geisel School of Medicine, Hartford, VT, ⁴Geisel School of Medicine, Lebanon, NH
Background/Purpose: Prior work demonstrates that macrophages (MØs) from patients with Systemic Sclerosis (SSc) produce fibrotic and pro-inflammatory mediators and that cocultured MØs and SSc fibroblasts…
Abstract Number: 1003 • ACR Convergence 2021
Significant Enrichment of Pathogenic CD206+CD163+ Macrophages in Rheumatoid Arthritis Synovial Tissue with Distinct Transcriptional Signatures
Megan Hanlon¹, Mary Canavan², Nuno Neto³, Qingxuan Song⁴, Phil Gallagher⁵, Ronan Mullan⁶, Conor Hurson⁷, Barry Moran³, Michael Monaghan³, Sunil Nagpal⁸, Douglas Veale⁹ and Ursula Fearon³, ¹Molecular Rheumatology, Dublin, Ireland, ²Trinity College, Santry, Ireland, ³Trinity College Dublin, Dublin, Ireland, ⁴Janssen Research & Development LLC, Spring House, PA, ⁵St Vincent's Hospital, Dublin, Ireland, ⁶Tallaght University Hospital, Dublin, Ireland, ⁷St Vincents University Hospital, Dublin, Ireland, ⁸Janssen Research, Collegeville, PA, ⁹University College Dublin, Dublin, Ireland
Background/Purpose: Synovial tissue macrophages are an exquisitely plastic pool of innate cells that play a key role in RA disease progression. However, the precise nature,…
Abstract Number: 1004 • ACR Convergence 2021
Manipulation of B7 Family Member Expression Demonstrates Synovial Macrophage Plasticity and Possible Future Targets for Treatment of Rheumatoid Arthritis
Annabelle Small¹, Katie Williams², Antonio Ferrante³, Malcolm Smith², Susanna Proudman⁴, Helen Weedon¹ and Mihir Wechalekar⁵, ¹Flinders University, Bedford Park, Australia, ²Flinders University, Adelaide, Australia, ³SA Pathology; University of Adelaide, Adelaide, Australia, ⁴University of Adelaide, Medindie, Australia, ⁵Flinders Medical Centre, Southern Adelaide Local Health Network, Bedford Park, Australia
Background/Purpose: Infiltration of monocyte-derived macrophages into the synovial tissue (ST) is a hallmark of rheumatoid arthritis (RA). These infiltrating cells lead to inflammation, local joint…
Abstract Number: 1478 • ACR Convergence 2021
An Orphan Receptor and Osteoarthritis: Mouse Gpr34 Expression in Dorsal Root Ganglia After Partial Meniscectomy
David Thomas¹, Terese Geraghty², Alia Obeidat², Jun Li², Rachel Miller² and Anne-Marie Malfait³, ¹University of Minnesota Internal Medicine Residency, St. Paul, MN, ²Rush University Medical Center, Chicago, IL, ³Rush University, Chicago, IL
Background/Purpose: Osteoarthritis (OA) is one of the leading causes of musculoskeletal pain and disability. Worldwide, an estimated 303 million patients have clinically diagnosed OA, with…
Abstract Number: 1498 • ACR Convergence 2021
Platelet Secreted LGALS3BP Induces a Pro-inflammatory Phenotype in Systemic Lupus Erythematosus
Hanane EL Bannoudi¹, MacIntosh Cornwell², Elliot Luttrell-Williams², Alexis Engel³, Christina Rolling¹, Peter Izmirly⁴, H. Michael Belmont⁵, Kelly Ruggles², Robert Clancy⁶, Jill Buyon⁵ and Jeffrey Berger², ¹NYU Langone Health, New York, NY, ²New York University, New York, NY, ³NYU Langone Health, New Yok, NY, ⁴New York University School of Medicine, New York, NY, ⁵NYU School of Medicine, New York, NY, ⁶NYU Grossman School of Medicine, New York, NY
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex chronic heterogeneous autoimmune disease, which increases the risk of atherothrombosis. In addition to their well described role…
Abstract Number: 1575 • ACR Convergence 2021
Urate Crystals Regulate a Distinct JNK-Dependent Metabolic and Inflammatory Response
Anyan Cheng¹, Isidoro Cobo¹, Jessica Murillo Saich¹, Roxana Coras², Alyssa Torres³, Addison Lana¹, Johannes Schlachetzki¹, Ru Liu Bryan⁴, Robert Terkeltaub⁵, Elsa Sanchez-Lopez³, Christopher Glass¹ and Monica Guma⁶, ¹University of California San Diego, La Jolla, CA, ²University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, ³University of California San Diego, San Diego, CA, ⁴University of California San Diego and VASDHS, San Diego, CA, ⁵VA/UCSD, San Diego, CA, ⁶University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: Although metabolic reprograming and its regulation in macrophages after TLR activation is well established, little is known about the regulation and the role of…
Abstract Number: 1891 • ACR Convergence 2021
Variable Effects of Testosterone on Male versus Female Derived Macrophages in Inflammatory Arthritis
Kiana Chen¹, Xi Lin¹, Lianping Xing², H. Mark Kenney³, Richard Bell⁴, Edward Schwarz⁵ and Homaira Rahimi⁵, ¹University of Rochester School of Medicine and Dentistry, Rochester, NY, ²University of Rochester Medical Center, Webster, NY, ³University of Rochester Medical Center, Rochester, NY, ⁴Hospital for Special Surgery, New York, NY, ⁵University of Rochester, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that is female predominant. The TNF-transgenic (TNF-Tg) mouse model of RA also develops a sexually…
Abstract Number: 0302 • ACR Convergence 2021
Loss of TAM Receptor Mer Contributes to Sjögren’s Syndrome–like Disease in Mice
Richard Witas and Cuong Nguyen, University of Florida, Gainesville, FL
Background/Purpose: Sjögren’s syndrome (SjS) is a chronic autoimmune disease primarily involving the exocrine glands where the involvement of the innate immune system is largely uncharacterized.…
Abstract Number: 0526 • ACR Convergence 2021
Transcriptional Factor Profiling Denotes Specific Synovial Macrophage Heterogeneity
Deborah Winter¹, Carla Cuda², Shang-Yang Chen², Anna Montgomery³, Salina Dominguez², Gaurav Gadhvi² and Harris Perlman², ¹Northwestern University Division of Rheumatology, Chicago, IL, ²Northwestern University, Chicago, IL, ³UCL, Chicago, IL
Background/Purpose: Macrophages are critical to the pathogenesis of rheumatoid arthritis(RA), but several distinct macrophage subpopulations co-exist in the synovium of joints. In steady-state, tissue-resident macrophages…

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