Abstracts tagged "macrophages"

Abstract Number: 2043 • 2018 ACR/ARHP Annual Meeting
Monocytes and Macrophages of Patients with Rheumatoid Arthritis Respond to Pathologically Increased Ionized Calcium with Proinflammatory Cytokine Production
Supriya Murthy¹, Elisabeth Jaeger¹, Sebastian Jung¹, Kathleen Friedrich², Olga Seifert¹, Christoph Baerwald¹, Matthias Pierer¹ and Manuela Rossol¹, ¹Department of Internal Medicine, Rheumatology, University of Leipzig, Leipzig, Germany, ²Department of Internal Medicine, Rheumatology, University of Leipzig, Germany, Leipzig, Germany
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis and periarticular bone erosion. Bony erosions and cell necrosis might lead to a local…
Abstract Number: 174 • 2017 ACR/ARHP Annual Meeting
Transcriptional Profiling of Synovial Macrophages from RA Patients to Capture Disease Heterogeneity
Philip J. Homan¹, Arthur M. Mandelin II², Salina Dominguez¹, Emily Bacalao³, S. Louis Bridges Jr.⁴, Joan M. Bathon⁵, John Atkinson⁶, David Fox⁷, Eric L. Matteson⁸, Chris Buckley⁹, Costantino Pitzalis¹⁰, Deborah Parks¹¹, Laura Hughes¹², Laura Geraldino-Pardilla¹³, Robert Ike¹⁴, Kristine Phillips¹⁵, Kerry Wright¹⁶, Andrew Filer¹⁷, Stephen Kelly¹⁸, Eric M. Ruderman¹⁹, Carla Cuda¹, Hiam Abdala-Valencia³, Alexander Misharin³, G. R. Scott Budinger³, Richard M. Pope¹⁹, Harris Perlman²⁰ and Deborah R. WInter¹, ¹Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rheumatology, Northwestern University, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, ⁵Division of Rheumatology, Columbia University Medical Center, New York, NY, ⁶Washington University in St. Louis, St. Louis, MO, ⁷Department of Medicine [Division of Rheumatology], University of Michigan Medical System, Ann Arbor, MI, ⁸Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁹University of Birmingham, Birmingham, United Kingdom, ¹⁰Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ¹¹Washington University School of Medicine in St. Louis, St. Louis, MO, ¹²University Alabama Birmingham, Birmingham, AL, ¹³Columbia University, New york, NY, ¹⁴Division of Rheumatology, University of Michigan, Ann Arbor, MI, ¹⁵University of Michigan, Ann Arbor, MI, ¹⁶Rheumatology, Mayo Clinic, Rochester, MN, ¹⁷Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, ¹⁸William Harvey Research Institute, London, United Kingdom, ¹⁹Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²⁰Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University Feinberg School of Medicine,, Chicago, IL
Background/Purpose: In a given patient with rheumatoid arthritis (RA), it is difficult to predict disease progression or identify to which treatments they will respond. Macrophages…
Abstract Number: 301 • 2017 ACR/ARHP Annual Meeting
MiR-221-3p Overexpression Impairs Anti-Inflammatory Activity of TLR4-Stimulated M2-Macrophages
Lilian Quero^1,2, Andre Tiaden^1,2 and Diego Kyburz^2,3, ¹Department of Biomedicine, Experimental Rheumatology, University of Basel, Basel, Switzerland, ²Rheumatology, University Hospital Basel, Basel, Switzerland, ³Department of Biomedicine, Experimental Rheumatology, University of Basel, 4051 Basel, Switzerland
Background/Purpose: MicroRNAs (miRNAs) have been shown to contribute to the inflammatory response in rheumatoid arthritis (RA) and several of these miRNAs have been found to…
Abstract Number: 1791 • 2017 ACR/ARHP Annual Meeting
TET1 Is an Important Transcriptional Activator of the Tnfa Locus in Macrophages
Emmanuel Karouzakis¹, Fangfang Sun², Agnieszka Pajak¹, Shuang Ye², Steffen Gay¹, Oliver Distler³ and Michel Neidhart¹, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Activated macrophages are found in the inflamed and hyperplastic synovial RA tissue. Macrophages are the main producers of high levels of pro-inflammatory cytokines such…
Abstract Number: 2570 • 2017 ACR/ARHP Annual Meeting
The Functional Consequence of Human (hu)TLR8 on Macrophage Immunometabolism and Renal Inflammation in Murine Systemic Lupus Erythematosus
Naomi I. Maria¹, Megan Woods², Shani Martinez³, Weiqing Huang⁴ and Anne Davidson⁴, ¹Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ²Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ³Feinstein Institute for Medical Research, Manhasset, NY, ⁴Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Infiltrating macrophages are one of the hallmarks of renal inflammation and kidney damage in lupus nephritis. Increasing evidence suggests the crucial role of cell-specific…
Abstract Number: 172 • 2016 ACR/ARHP Annual Meeting
S100A8/A9 Produced during Experimental Osteoarthritis Induces a Systemic Decrease in BM Monocytes and Increases Ly6C High Monocytes Locally in the Joint
Niels Cremers, Edwin Geven, Arjen Blom, Annet Sloetjes, Irene Di Ceglie, Stephanie van Dalen, Giuliana Ascone, Martijn van den Bosch and Peter van Lent, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: In response to pro-inflammatory cytokines released locally during osteoarthritis (OA), such as the alarmins S100A8/A9, monocytes can be recruited from the bone marrow (BM)…
Abstract Number: 479 • 2016 ACR/ARHP Annual Meeting
Type II Collagen Secreted from Articular Chondrocytes Is Mainly Destroyed By Cathepsin S in RA Mice
Jinjun Zhao¹, Qin Huang², Hao Ren¹, Qingqing Ouyang¹ and Min Yang¹, ¹Nanfang Hospital，Southern Medical University, Guangzhou, China, ²Department of Rheumatology, Nanfang Hospital，Southern Medical University, Guangzhou, China
Background/Purpose: Mast cells have long been recognized to increase strikingly in number in the synovial membrane of rheumatoid arthritis（RA），accounting for 5% of the surface synovial…
Abstract Number: 2140 • 2016 ACR/ARHP Annual Meeting
Phenotypic and Functional Characteristics of Exosomes Isolated from Human Osteoarthritis (OA) Synovial Fluid
Geraldine M. McCarthy¹, Dylan McGagh², Clare C. Cunningham³, Emma M. Corr⁴, Louise Sullivan⁵, Fatima Haji⁶ and Aisling Dunne⁴, ¹Div of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland, ²School of Biochemistry & Immunology and School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ³School of Biochemistry and Immunology, Trinity College Dublin, Dubln, Ireland, ⁴School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland, ⁵Trinity Biomedical Sciences Institute, Trinity College Dublin, School of Biochemistry & Immunology and School of Medicine, Dublin 2, Ireland, ⁶Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland
Background/Purpose: Exosomes are biologically active microvesicles derived from the endosomal membrane system understood to play a significant role in a wide range of inflammatory diseases.…
Abstract Number: 2264 • 2016 ACR/ARHP Annual Meeting
Lack of Obesity-Related Changes in Adipocytes and Inflammatory Cells in the Infrapatellar Fat Pad (IFP): A Different Type of Fat?
Anja de Jong¹, I.R. klein-Wieringa¹, Stefan Andersen², Joanneke Kwekkeboom¹, Linda van Toorn¹, Badelog de Lange¹, Danny van Delft³, John Garcia⁴, Wu Wei⁵, Huub van der Heide³, Yvonne Bastiaansen-Jenniskens⁴, Gerjo van Osch⁴, Anne-Marie Zuurmond⁶, Vedrana Stojanovic-Susulic⁷, Rob Nelissen³, René Toes¹, Margreet Kloppenburg¹ and Andreea Ioan-Facsinay¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Charles River Nederland B.V., Leiden, Netherlands, ³Orthopaedics, Leiden University Medical Center, Leiden, Netherlands, ⁴Orthopaedics, Erasmus MC, Rotterdam, Netherlands, ⁵Orthopaedics, Erasmus MC, rotterdam, Netherlands, ⁶TNO, Leiden, Netherlands, ⁷Janssen, Pharmaceutical Companies Johnson & Johnson, Springhouse, PA
Background/Purpose: Obesity is associated with the development and progression of osteoarthritis (OA). Although the mechanisms involved in this association are poorly understood, it is well…
Abstract Number: 3175 • 2016 ACR/ARHP Annual Meeting
Longitudinal Analysis of MMF Clinical, Molecular, and Immunohistochemistry (IHC) Responses Shows SSc Patients Lose Their Inflammatory Signature and Rebound upon Treatment Cessation
Diana Toledo¹, Monique Hinchcliff², Jaclyn Taroni¹, Tammara A. Wood³, Jennifer Franks³, Sanjiv Shah⁴, Rishi Agrawal⁴, Lauren Beussink-Nelson⁴, Mary A. Carns⁵, Sofia Podlusky⁶, Patricia Pioli⁷ and Michael Whitfield³, ¹Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ³Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Northwestern University, Chicago, IL, ⁵Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁶Rheumatology Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁷Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: We previously showed patients in the inflammatory subset were most likely to demonstrate improvement in modified Rodnan Skin Score (mRSS) during mycophenolate mofetil (MMF)…
Abstract Number: 793 • 2015 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells Promote the Generation of CD206+ Macrophage and Increase Its Phagocytic Activity in Systemic Lupus Erythematosus
Wei Deng, Weiwei Chen, Zhuoya Zhang, Saisai Huang, Wei Kong, Yue Sun, Xuebing Feng, Xiaojun Tang, Genhong Yao and Lingyun Sun, Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Umbilical cord (UC)-derived mesenchymal stem cells (MSCs) have been confirmed to exert therapeutic effects on systemic lupus erythematosus (SLE). Deficiency in SLE macrophages exhibits…
Abstract Number: 1033 • 2015 ACR/ARHP Annual Meeting
Novel Ligand-Independent Peptide Inhibitors of Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) and T Cell Receptor (TCR): Efficacy in a Collagen-Induced Arthritis Model Suggests New Targeted Treatment for Rheumatoid Arthritis
Zu T. Shen and Alexander B. Sigalov, SignaBlok, Inc., Shrewsbury, MA
Background/Purpose: Macrophages and T cells are central to the pathophysiology of autoimmune diseases. Synovial macrophages, synovial fibroblasts and infiltrating T lymphocytes are the most abundant…
Abstract Number: 2151 • 2015 ACR/ARHP Annual Meeting
Inhibition of Myeloid-Associated Gene Expression in Skin Biopsy Samples of Systemic Sclerosis Patients Treated with Tocilizumab
Thierry Sornasse¹, Haiyin Chen¹, Lisa Rice², Giuseppina Stifano², Angelika Jahreis¹, Jeffrey Siegel¹ and Robert Lafyatis², ¹Genentech, South San Francisco, CA, ²Boston University School of Medicine, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is a progressive, debilitating disease with limited treatment options. IL-6 has been implicated in disease pathogenesis. Tocilizumab (TCZ), an IL-6Rα inhibitor,…
Abstract Number: 2875 • 2014 ACR/ARHP Annual Meeting
Macrophage Expression of Hypoxia-Inducible Factor-2 Alpha Promotes Rheumatoid Arthritis Progression
Munitta Muthana^1,2, William Jacob Hardy³, Sarah Hawtree¹, Fiona Wright¹, Ursula Fearon⁴, DJ Veale⁵, Mauro Perretti⁶ and Anthony G. Wilson⁷, ¹Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, ²Medical School, University of Sheffield, Sheffield, United Kingdom, ³University of Sheffield, Sheffield, United Kingdom, ⁴Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ⁵Consultant Rheumatologist, St. Vincent’s University Hospital, Dublin, Ireland, ⁶Biochemical Pharmaology, Barts and the London School of Medicine, London, United Kingdom, ⁷University College Dublin, Dublin, Ireland
Background/Purpose Hypoxia exists in many diseased tissues including arthritic joints, atherosclerotic plaques and malignant tumours. Macrophages accumulate in these hypoxic sites where they possess broad…
Abstract Number: 2175 • 2014 ACR/ARHP Annual Meeting
Macrophages from the Synovium of Active Rheumatoid Arthritis Exhibit an Activin a- Dependent Pro-Inflammatory Profile
Elena Izquierdo¹, Blanca Soler Palacios², Lizbeth Estrada-Capetillo², Gabriel Criado³, Concha Nieto¹, Cristina Municio², Isidoro González-Álvaro⁴, Paloma Sánchez-Mateos², Jose L. Pablos⁵, Ángel L. Corbí¹ and Amaya Puig-Kröger², ¹Microbiología Molecular y Biología de las Infecciones, Centro de Investigaciones Biologicas (CSIC), Madrid, Spain, ²Laboratorio de Inmuno-Metabolismo, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain, ³Servicio de reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ⁴Rheumatology Department, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria Hospital Universitario La Princesa, Madrid, Spain, ⁵Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
Background/Purpose: Synovial macrophages are key effector cells in rheumatoid arthritis (RA), where they are a major source of pro-inflammatory cytokines and contribute to the cartilage…

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