Abstracts tagged "Macrophage"

Abstract Number: 1010 • 2016 ACR/ARHP Annual Meeting
Elucidating the Activation Profile of Systemic Sclerosis Macrophages
Michael S. Ball¹, Emilie P. Shipman¹, Mohamed A. Eltanbouly¹, Viktor Martyanov², Kimberly A. Archambault³, Mary A. Carns⁴, Esperanza Arroyo⁴, Kathleen Aren⁴, Monique Hinchcliff⁵, Michael L. Whitfield^2,3 and Patricia A. Pioli¹, ¹Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: Genome-wide gene expression studies implicate macrophages (MØs) as mediators of fibrosis in systemic sclerosis (SSc) and our data indicate that MØs constitute the dominant…
Abstract Number: 2718 • 2016 ACR/ARHP Annual Meeting
Plasma Levels of the M2 Macrophage Markers, CD163 and CD206, Changes Reversely and Soluble CD163 Is Associated with Disease Activity in Spondyloarthritis
Line Dam Heftdal^1,2, René Østgård^3,4, Malene Hvid^3,5, Bent Deleuran^2,3,5, Holger Jon Møller⁵ and Stinne Greisen^2,3, ¹Department of Biomedicine, Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁴Department of Rheumatology, Regional Hospital Silkeborg, Silkeborg, Denmark, ⁵Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Background/Purpose: Spondyloarthritis (SpA) covers a group of interrelated auto-inflammatory disorders where TNFa is a central mediator of disease. T cells and macrophages are abundant in…
Abstract Number: 1030 • 2016 ACR/ARHP Annual Meeting
Synovial Tissue Resident Macrophages Play the Protective Role in the Development of Inflammatory Arthritis in CD11c-Flip-KO Mice
Qi Quan Huang¹, Renee E. Doyle², Robert Birkett³ and Richard M. Pope², ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Chicago, IL
Synovial Tissue Resident Macrophages Play the protective role in the Development of Inflammatory Arthritis in CD11c-Flip-KO MiceQi-Quan Huang1, Renee Doyle1, Robert Birkett1 and Richard M.…
Abstract Number: 3071 • 2016 ACR/ARHP Annual Meeting
Recombinant Human Proteoglycan-4 (rhPRG4) Inhibits Monosodium Urate (MSU) Crystal Phagocytosis By Human Macrophages and Resultant Inflammatory Response
Marwa Qadri¹, Tannin Schmidt², Khaled Elsaid³ and Gregory Jay⁴, ¹Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences University, Boston, MA, ²Kinesiology and Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, ³Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, ⁴Emergency Medicine, Brown University, Providence, RI
Background/Purpose: Gout is an inflammatory arthritis caused by precipitation of monosodium urate (MSU) crystals in synovial joints. MSU crystals interact with resident macrophages that…
Abstract Number: 1438 • 2016 ACR/ARHP Annual Meeting
Tofacitinib Restores Reverse Cholesterol Transport Inhibition Induced By Inflammation. Understanding the Lipid Paradox
Sandra Pérez-Baos¹, Juan I. Barrasa², Paula Gratal¹, Ane Larrañaga-Vera¹, Iván Prieto-Potin¹, Gabriel Herrero-Beaumont¹ and Raquel Largo¹, ¹Bone and Joint Research Unit, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain, ²Joint and Bone Research Unit, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain
Background/Purpose: Patients with active rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality, paradoxically in association with reduced circulating levels of total cholesterol…
Abstract Number: 1445 • 2016 ACR/ARHP Annual Meeting
Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Ameliorate Rheumatoid Arthritis Via Regulation of Macrophage Activation and Polarization
Tae-Hoon Shin¹, Kichul Shin², Hyung-Sik Kim^3,4 and Kyung-Sun Kang⁵, ¹Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, Korea, The Republic of, ²Kyungnam villa #102, Division of Rheumatology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea, Republic of, ³Busan National University School of Medicine, Busan, Korea, The Republic of, ⁴Biomedical Research Institute, Busan National University Hospital, Busan, Korea, The Republic of, ⁵Institute for Stem cell Regenerative Medicine, Kangstem Biotech, Seoul, Korea, The Republic of
Background/Purpose: Immunomodulatory properties enable mesenchymal stem cells (MSCs) to be a promising alternative for the treatment of a wide range of immune-related diseases including rheumatoid…
Abstract Number: 1844 • 2016 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells Ameliorate the Deficiencies in Immunomodulatory and Phagocytic Capacities of Lupus Macrophages
Wei Deng¹, Weiwei Chen¹, Zhuoya Zhang², Saisai Huang¹, Wei Kong¹, Xuebing Feng¹ and Lingyun Sun¹, ¹Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Evidence has accumulated that umbilical cord (UC)-derived mesenchymal stem cells (MSCs) show therapeutic effects on systemic lupus erythematosus (SLE). Deficiency in SLE macrophages exhibits…
Abstract Number: 1854 • 2016 ACR/ARHP Annual Meeting
Increased Percentage of CD204/CD206 Double Positive Monocytes Correlates with Specific Lung and Skin Involvement Parameters and an “Active” Capillaroscopic Pattern of Microangiopathy in Systemic Sclerosis Patients
Stefano Soldano¹, Paola Contini², Amelia Chiara Trombetta³, Barbara Ruaro⁴, Sabrina Paolino⁴, Carmen Pizzorni⁴, Renata Brizzolara⁴, Paola Montagna⁴, Alberto Sulli⁴ and Maurizio Cutolo⁴, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genoa, Italy, ²Division of Clinical Immunology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genova, Italy, ³Department of Internal Medicine, University of Genova,, Research Laboratory and Academic Division of Clinical Rheumatology, Genova, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genova, Italy
Background/Purpose: Immune cell activation plays a crucial role in the pathogenesis of systemic sclerosis (SSc), and macrophages may be important mediators in this complex pathway…
Abstract Number: 1862 • 2016 ACR/ARHP Annual Meeting
Modelling Healthy and Scleroderma Fibrotic Skin in Vitro: Mechanical Stress Alters Macrophage Cytokine Expression and Triggers Signalling Via the Mechano-Sensing Transcription Factor Myocardin-Related Transcription Factor-a
Angela Tam¹, Shiwen Xu¹, Henry Lopez¹, Korsa Khan², Bahja Ahmed Abdi³, Henrique Rosario⁴, Nikita Arumalla², Mark Gibson², Christopher Denton², David Abraham², Barbara D Smith⁵ and Richard J Stratton², ¹Division of Medicine, Centre for Rheumatology and Connective tissue disease, University College London, London, United Kingdom, ²Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ³Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁴Division of Medicine, Centre of Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁵Boston University School of Medicine, Boston, MA
Background/Purpose: Skin involvement is one of the most prominent clinical features in scleroderma. There is a marked contrast in mechanical stiffness between healthy forearm skin…
Abstract Number: 2060 • 2016 ACR/ARHP Annual Meeting
Bim Suppresses the Development of SLE By Limiting Macrophage Inflammatory Responses
FuNien Tsai¹, Carla Cuda², Harris R. Perlman³, Philip J. Homan⁴, Salina Dominguez², Alexander Shaffer³, George Kenneth Haines III⁵ and Jack Hutcheson⁶, ¹Medicine-Rheumatology, Northwestern University-Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Chicago, IL, ³Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Medicine-Rheumatology, Northwestern University, Chicago, IL, ⁵Mount Sinai, New York, NY, ⁶UT Southwestern, Dallas, TX
Background/Purpose: The Bcl-2 family guards the mitochondrial apoptotic pathway. Among numerous Bcl-2 antagonists, only the loss of Bim in mice leads to the development of…
Abstract Number: 2109 • 2016 ACR/ARHP Annual Meeting
Immunoprofiling of Bruton’s Tyrosine Kinase (Btk)/Tec Family Kinase Inhibitors Indicate Activities Beyond Btk in Immunocyte Function
Jolanta Kosek¹, Lori Capone², Mary Adams¹, Eun Mi Hur¹, Peter H. Schafer³ and Garth Ringheim¹, ¹Inflammation and Immunology Translational Development, Celgene Corporation, Summit, NJ, ²Celgene Corporation, Summit, NJ, ³Department of Translational Development, Celgene Corporation, Summit, NJ
Background/Purpose: CC-292, CC-90008, and ibrutinib are covalent Btk/Tec family kinase inhibitors that block Btk activity by binding with high affinity to the adenosine triphosphate (ATP)…
Abstract Number: 2145 • 2016 ACR/ARHP Annual Meeting
The Modulation of Macrophage Polarization By SIRT1 Maybe New Target Therapy in Rheumatoid Arthritis
Sang-Yeob Lee¹, Won Tae Chung², Sung Won Lee³, So Youn Park⁴ and Bae Jae Ho⁵, ¹Cell Biology, Dong -A university, South Korea, Pusan, South Korea, ²Rheumatology, Dong-A University Hospital, Busan, South Korea, ³Dong-A university,Busan, South Korea, Pusan, South Korea, ⁴Medical Research Center for Ischemic Tissue Regeneration, Pusan national university, Yong -San, South Korea, ⁵department of biochemistry, medical college, Pusan National University,, MD, PhD, Gyeongsangnam-do, South Korea
Background/Purpose: The polarization of macrophages was the expressed to M1/M2 phenotype by various stimuli or environment signals. The M1 macrophage was pro-inflammatory phenotype and was…
Abstract Number: 2267 • 2016 ACR/ARHP Annual Meeting
AMP-Activated Protein Kinase: A Target for Methotrexate in Macrophages
Cornelia Cudrici¹, Martin Pelletier² and Richard M. Siegel³, ¹NIAMS, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, ²Infectious and immune diseases Centre Hospitalier de l'Université Laval (CHUL) Québec, Québec, QC, Canada, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD
Background/Purpose: Methotrexate (MTX) remains a cornerstone of treatment in multiple forms of inflammatory arthritis, lupus and vasculitis. The anti-inflammatory effects of MTX are more likely…
Abstract Number: 2414 • 2016 ACR/ARHP Annual Meeting
Microrna Associated with Active Systemic Juvenile Idiopathic Arthritis Regulate CD163 Expression in Polarized Macrophages through Two Distinct Mechanisms
Thuy Do¹, Rachel Tan², Mark Bennett², Mario Medvedovic², Nan Shen³, Sherry Thornton¹, Alexei Grom¹ and Grant Schulert⁴, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²University of Cincinnati, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: CD163 is a hemoglobin scavenger receptor and innate pattern recognition receptor, and a marker of activated monocytes and macrophages. It is also expressed on…
Abstract Number: 2419 • 2016 ACR/ARHP Annual Meeting
Single-Cell Analysis of CD163 mRNA and Protein Expression By Primeflow™ in Polarized Monocyte and Macrophage Populations
Rachel Tan¹, Sherry Thornton², Alyssa Sproles², Thuy Do³, Jonathan Schick⁴, Monica DeLay⁴ and Grant Schulert⁵, ¹University of Cincinnati, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ³Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Cincinnati Children's Hospital, Cincinnati, OH, ⁵Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: CD163 is involved in the regulation and resolution of innate inflammation and the removal of free hemoglobin from the blood via internalization of the…

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