Abstracts tagged "Macrophage"

Abstract Number: 2145 • 2016 ACR/ARHP Annual Meeting
The Modulation of Macrophage Polarization By SIRT1 Maybe New Target Therapy in Rheumatoid Arthritis
Sang-Yeob Lee¹, Won Tae Chung², Sung Won Lee³, So Youn Park⁴ and Bae Jae Ho⁵, ¹Cell Biology, Dong -A university, South Korea, Pusan, South Korea, ²Rheumatology, Dong-A University Hospital, Busan, South Korea, ³Dong-A university,Busan, South Korea, Pusan, South Korea, ⁴Medical Research Center for Ischemic Tissue Regeneration, Pusan national university, Yong -San, South Korea, ⁵department of biochemistry, medical college, Pusan National University,, MD, PhD, Gyeongsangnam-do, South Korea
Background/Purpose: The polarization of macrophages was the expressed to M1/M2 phenotype by various stimuli or environment signals. The M1 macrophage was pro-inflammatory phenotype and was…
Abstract Number: 2267 • 2016 ACR/ARHP Annual Meeting
AMP-Activated Protein Kinase: A Target for Methotrexate in Macrophages
Cornelia Cudrici¹, Martin Pelletier² and Richard M. Siegel³, ¹NIAMS, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, ²Infectious and immune diseases Centre Hospitalier de l'Université Laval (CHUL) Québec, Québec, QC, Canada, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD
Background/Purpose: Methotrexate (MTX) remains a cornerstone of treatment in multiple forms of inflammatory arthritis, lupus and vasculitis. The anti-inflammatory effects of MTX are more likely…
Abstract Number: 2414 • 2016 ACR/ARHP Annual Meeting
Microrna Associated with Active Systemic Juvenile Idiopathic Arthritis Regulate CD163 Expression in Polarized Macrophages through Two Distinct Mechanisms
Thuy Do¹, Rachel Tan², Mark Bennett², Mario Medvedovic², Nan Shen³, Sherry Thornton¹, Alexei Grom¹ and Grant Schulert⁴, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²University of Cincinnati, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: CD163 is a hemoglobin scavenger receptor and innate pattern recognition receptor, and a marker of activated monocytes and macrophages. It is also expressed on…
Abstract Number: 2419 • 2016 ACR/ARHP Annual Meeting
Single-Cell Analysis of CD163 mRNA and Protein Expression By Primeflow™ in Polarized Monocyte and Macrophage Populations
Rachel Tan¹, Sherry Thornton², Alyssa Sproles², Thuy Do³, Jonathan Schick⁴, Monica DeLay⁴ and Grant Schulert⁵, ¹University of Cincinnati, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ³Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Cincinnati Children's Hospital, Cincinnati, OH, ⁵Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: CD163 is involved in the regulation and resolution of innate inflammation and the removal of free hemoglobin from the blood via internalization of the…
Abstract Number: 186 • 2016 ACR/ARHP Annual Meeting
Impact of TLR Stimulation on Cytokine Production in Macrophage Subsets: TLR2 Stimulation Impairs Anti-Inflammatory Activity of M2 Macrophages
Lilian Quero, Anke Gehringer and Diego Kyburz, Department of Biomedicine, Experimental Rheumatology, University of Basel, 4051 Basel, Switzerland
Background/Purpose: Toll-like receptors (TLRs) have been shown to contribute to the inflammatory response in rheumatoid arthritis (RA). A number of TLRs have been found to…
Abstract Number: 2619 • 2016 ACR/ARHP Annual Meeting
Sustained Suppression of Peripheral Biomarkers By Mavrilimumab but Not Golimumab in Anti-Tumor Necrosis Factor-Inadequate Responders: An Exploratory Analysis in the Phase IIb Earth Explorer 2 Clinical Trial
Xiang Guo¹, Shiliang Wang¹, Anne C. Bay-Jensen², Morten Asser Karsdal², A Godwood³, Marius Albulescu³, D Close³, Patricia C. Ryan¹, Lorin Roskos⁴ and Wendy White¹, ¹Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ²Rheumatology, Nordic Bioscience, Herlev, Denmark, ³MedImmune, Cambridge, United Kingdom, ⁴MedImmune, LLC, Mountain View, CA
Background/Purpose: Treatment of rheumatoid arthritis (RA) patients by anti-tumour necrosis factors (anti-TNFs), such as golimumab, has improved patient outcomes. However, unmet therapeutic needs exist for…
Abstract Number: 461 • 2016 ACR/ARHP Annual Meeting
Involvement of CD163-Positive Macrophages in the Pathogenesis of Arthritis Via Modulation of Inflammatory Cytokine and Chemokine Expression in the Synovium of a Murine Model
Shinjiro Kaieda¹, Hiroaki Ida² and Tomoaki Hoshino³, ¹Department of Medicine, *Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, kurume, Japan, ²Respiorogy, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan, ³Department of Medicine, Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan
Background/Purpose: Synovial-lining macrophages play a crucial role in the onset and maintenance of joint inflammation in arthritis. CD68 and CD163 are commonly used markers of…
Abstract Number: 2626 • 2016 ACR/ARHP Annual Meeting
Soluble CD206 Plasma Levels Decreases with Treatment and Reflects Anti-Tnfa Discontinuation in Rheumatoid Arthritis
Line Dam Heftdal^1,2, Kristian Stengaard-Pedersen², Merete Lund Hetland^3,4, Kim Hørslev-Petersen⁵, Peter Junker⁶, Mikkel Østergaard^4,7, Malene Hvid^8,9, Bent Deleuran^2,8,9, Holger Jon Møller^8,10 and Stinne Greisen^2,9, ¹Department of Biomedicine, Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, ⁴Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, Copenhagen, Denmark, ⁵King Christian X's Hospital for Rheumatic Diseases,, University of Southern Denmark, Graasten, Denmark, ⁶Department of Rheumatology, Odense University Hospital, Odense, Denmark, ⁷Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ⁸Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ¹⁰Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints and infiltration by activated macrophages. TNFa is a central…
Abstract Number: 580 • 2016 ACR/ARHP Annual Meeting
Preferential Distribution of M1 Monocytes in Anti-Cyclic Citrullinated Peptide Antibody Positive Patients with Rheumatoid Arthritis
Shoichi Fukui¹, Naoki Iwamoto², Toshimasa Shimizu², Masataka Umeda², Ayako Nishino³, Yoshiro Horai², Tomohiro Koga⁴, Shin-ya Kawashiri⁵, Kunihiro Ichinose⁶, Yasuko Hirai², Mami Tamai⁶, Hideki Nakamura⁵, Tomoki Origuchi⁷ and Atsushi Kawakami⁴, ¹Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, ³Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki Universit, Nagasaki, Japan, ⁴Unit of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁶Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁷Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan
Background/Purpose: In rheumatoid arthritis (RA), bone erosions are caused mainly by osteoclasts. Osteoclasts are derived from monocytes and macrophages (MoMa). MoMa consists of different subtypes…
Abstract Number: 2703 • 2016 ACR/ARHP Annual Meeting
Apremilast May Improve Atherosclerosis By Promoting Cholesterol Efflux and Inhibiting Foam Cell Formation in Atherosclerotic Plaques
Hailing Liu¹, Tuere Wilder², Aranzazu Mediero³, Zhimin Wei¹, Carmen Corciulo² and Bruce Cronstein³, ¹Medicine, NYU School of Medicine, New York, NY, ²Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ³Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Atherosclerosis is characterized by the accumulation of lipid-laden macrophages in the arterial walls. Patients with inflammatory arthritis and psoriasis are at greater risk of…
Abstract Number: 1010 • 2016 ACR/ARHP Annual Meeting
Elucidating the Activation Profile of Systemic Sclerosis Macrophages
Michael S. Ball¹, Emilie P. Shipman¹, Mohamed A. Eltanbouly¹, Viktor Martyanov², Kimberly A. Archambault³, Mary A. Carns⁴, Esperanza Arroyo⁴, Kathleen Aren⁴, Monique Hinchcliff⁵, Michael L. Whitfield^2,3 and Patricia A. Pioli¹, ¹Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, ²Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: Genome-wide gene expression studies implicate macrophages (MØs) as mediators of fibrosis in systemic sclerosis (SSc) and our data indicate that MØs constitute the dominant…
Abstract Number: 2718 • 2016 ACR/ARHP Annual Meeting
Plasma Levels of the M2 Macrophage Markers, CD163 and CD206, Changes Reversely and Soluble CD163 Is Associated with Disease Activity in Spondyloarthritis
Line Dam Heftdal^1,2, René Østgård^3,4, Malene Hvid^3,5, Bent Deleuran^2,3,5, Holger Jon Møller⁵ and Stinne Greisen^2,3, ¹Department of Biomedicine, Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁴Department of Rheumatology, Regional Hospital Silkeborg, Silkeborg, Denmark, ⁵Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Background/Purpose: Spondyloarthritis (SpA) covers a group of interrelated auto-inflammatory disorders where TNFa is a central mediator of disease. T cells and macrophages are abundant in…
Abstract Number: 1030 • 2016 ACR/ARHP Annual Meeting
Synovial Tissue Resident Macrophages Play the Protective Role in the Development of Inflammatory Arthritis in CD11c-Flip-KO Mice
Qi Quan Huang¹, Renee E. Doyle², Robert Birkett³ and Richard M. Pope², ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Chicago, IL
Synovial Tissue Resident Macrophages Play the protective role in the Development of Inflammatory Arthritis in CD11c-Flip-KO MiceQi-Quan Huang1, Renee Doyle1, Robert Birkett1 and Richard M.…
Abstract Number: 3071 • 2016 ACR/ARHP Annual Meeting
Recombinant Human Proteoglycan-4 (rhPRG4) Inhibits Monosodium Urate (MSU) Crystal Phagocytosis By Human Macrophages and Resultant Inflammatory Response
Marwa Qadri¹, Tannin Schmidt², Khaled Elsaid³ and Gregory Jay⁴, ¹Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences University, Boston, MA, ²Kinesiology and Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, ³Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA, ⁴Emergency Medicine, Brown University, Providence, RI
Background/Purpose: Gout is an inflammatory arthritis caused by precipitation of monosodium urate (MSU) crystals in synovial joints. MSU crystals interact with resident macrophages that…
Abstract Number: 1438 • 2016 ACR/ARHP Annual Meeting
Tofacitinib Restores Reverse Cholesterol Transport Inhibition Induced By Inflammation. Understanding the Lipid Paradox
Sandra Pérez-Baos¹, Juan I. Barrasa², Paula Gratal¹, Ane Larrañaga-Vera¹, Iván Prieto-Potin¹, Gabriel Herrero-Beaumont¹ and Raquel Largo¹, ¹Bone and Joint Research Unit, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain, ²Joint and Bone Research Unit, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain
Background/Purpose: Patients with active rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality, paradoxically in association with reduced circulating levels of total cholesterol…

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