Abstracts tagged "Macrophage"

Abstract Number: 24 • 2019 ACR/ARP Annual Meeting
Role of Trained Immunity in the Pathogenesis of Erdheim-Chester Disease
Giulio Cavalli¹, Riccardo Biavasco ¹, Marina Ferrarini ², Elisabetta Ferrero ², Eugenio Montini ², Simone Cenci ², Cardaci Simone ² and Lorenzo Dagna ¹, ¹Vita-Salute San Raffaele University, Milan, Italy, ²IRCCS San Raffaele Hospital, Milan, Italy
Background/Purpose: Erdheim-Chester disease (ECD) is a chronic inflammatory disease characterized by infiltration of bone and other tissues by foamy macrophages. These cells exhibit activating mutations…
Abstract Number: 27 • 2019 ACR/ARP Annual Meeting
Altered Inflammatory Response of Macrophages in the Fosl-2 Transgenic Mouse Model of Systemic Sclerosis
Chantal Rufer ¹, Michal Rudnik¹, Siim Uhtjärv ¹, Mara Stellato ¹, Florian Renoux ², Oliver Distler ³ and Gabriela Kania ¹, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, ³Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland
Background/Purpose: Fos-like 2 (Fosl-2) is a transcription factor belonging to the Fos family of proteins which is part of the AP-1 transcription complex. The Fosl-2…
Abstract Number: 75 • 2019 ACR/ARP Annual Meeting
Microglia-Specific Transcriptional Signatures Correlate with Behavioral Deficits in ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’
Hadijat Makinde¹, Elise Mike ², Chaim Putterman ³, Deborah Winter ⁴ and Carla Cuda ⁵, ¹Northwestern University, Chicago, IL, ²Albert Einstein College of Medicine, Bronx, NY, ³Albert Einstein College of Medicine, New York, NY, ⁴Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, ⁵Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune syndrome affecting multiple organs, including the brain. More than 50% of patients experience neuropsychiatric symptoms of…
Abstract Number: 76 • 2019 ACR/ARP Annual Meeting
Effect of Ifnα and Costimulatory Blockade on Brain Infiltration in a Model of ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’
Hadijat Makinde¹, Chirag Raparia ², Anne Davidson ² and Carla Cuda ³, ¹Northwestern University, Chicago, IL, ²Feinstein Institutes for Medical Research, Manhasset, ³Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects many end organs including the brain. Despite a prevalence of over 50% in…
Abstract Number: 692 • 2019 ACR/ARP Annual Meeting
Correlation of Urinary Soluble CD163 Levels with Clinicopathological Features in Lupus Nephritis: Its Role as a Potential Biomarker
Shilpa Venkataraman¹, Ankita Singh ², Manjula Murari ³, Vinita Agrawal ², Amita Aggarwal ³ and Rakesh Pandey ⁴, ¹Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India, ²Sanjay Gandhi Post Graduate institute of medical science, Lucknow, India, Lucknow, Uttar Pradesh, India, ³Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India, ⁴Sanjay Gandhi Postgraduate Institute for Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India
Background/Purpose: Lupus nephritis (LN), is seen in 30-50% patients with SLE and 5-10% patients progress to end-stage renal disease. The clinical disease activity indices do…
Abstract Number: 1918 • 2019 ACR/ARP Annual Meeting
Urine CD163 Significantly Discriminates Active Lupus Nephritis and Strongly Correlates with Proliferative Glomerulonephritis
Ting Zhang¹, Ramesh Saxena ², Chi Chiu Mok ³, Michelle Petri ⁴ and Chandra Mohan ⁵, ¹Biomedical Engineering, University of Houston, Houston, TX, ²UTSW, Dallas, ³Department of Medicine, Tuen Mun Hospital, Hong Kong, China (People's Republic), ⁴Johns Hopkins University School of Medicine, Baltimore, MD, ⁵University of Houston, Houston
Background/Purpose: CD163 is a marker for alternatively activated M2 macrophages, which have been implicated in the pathogenesis of lupus nephritis (LN). The potential of urine…
Abstract Number: 1987 • 2019 ACR/ARP Annual Meeting
CCN3 Regulates Macrophage Function in MSU-induced Inflammation
Lihua Duan¹, Jie Chen ¹ and Jixin Zhong ², ¹Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, China (People's Republic), ²Cardiovascular Research Institute, School of Medicine, Case Western Reserve University, Cleveland, OH
Background/Purpose: Gout is the most common metabolic disease in which monosodium urate (MSU) crystals form and deposit in the joints and soft tissues of patients.…
Abstract Number: 2806 • 2019 ACR/ARP Annual Meeting
Single Cell RNA-sequencing Reveals Distinct Macrophage Subsets in the Joint with Differing Ontogenies During Steady-state and Arthritis
Anna Montgomery ¹, Shang-Yang Chen¹, Philip Homan ¹, Gaurav Gadhvi ¹, Deborah Winter ² and Harris Perlman ², ¹Northwestern University, Chicago, ²Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago
Background/Purpose: Macrophages in the synovial lining of the joint are critical players in the pathogenesis of rheumatoid arthritis (RA). However, their heterogeneity remains poorly characterized.Methods:…
Abstract Number: 125 • 2018 ACR/ARHP Annual Meeting
Monocyte Transcriptome Delineates SSc Patients with Functionally Distinct Patterns of Gene Dysregulation That Persist through Differentiation
Julia L.M. Dunn¹, Philip J. Homan², Salina Dominguez¹, Carla M. Cuda¹, Kathleen Aren³, Mary A. Carns^3,4, Tracy M. Frech⁵, Dinesh Khanna⁶, Shervin Assassi⁷, Harris Perlman¹, Monique Hinchcliff¹ and Deborah R. Winter¹, ¹Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁴Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Division of Rheumatology, University of Utah, Salt Lake City, UT, ⁶Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁷Rheumatology, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: The etiology and pathogenesis of SSc are poorly understood; however, an increasing body of evidence supports an early inflammatory phase that precedes, and may…
Abstract Number: 2965 • 2018 ACR/ARHP Annual Meeting
Targeting Glucose Metabolism in the Murine Air Pouch Model of Acute Gouty Inflammation
Anyan Cheng¹, Roxana Coras^1,2, Robert Terkeltaub^3,4, Ru Liu-Bryan^1,3 and Monica Guma^1,2, ¹Medicine, University of California San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Bellatera, Spain, ³VA San Diego Healthcare System, San Diego, CA, ⁴Medicine, Division of Rheumatology, Allergy and Immunology. UCSD., La Jolla, CA
Background/Purpose: Emerging evidence indicates that macrophage activation is critically supported by glucose metabolic shifts. Although macrophages are key contributors to inflammation, little is known about…
Abstract Number: 132 • 2018 ACR/ARHP Annual Meeting
Novel Therapeutic Peptides Which Target CD206 Inhibit Macrophage Dependent Fibroblast Activation in Scleroderma
Bahja Ahmed Abdi¹, Henry Lopez², George Martin³, Charles Garvin³, Jesse Jaynes³, James Stanway⁴, Christopher P. Denton⁵, David Abraham⁶, Shivanee Vigneswaran⁷, Sian Morris⁷ and Richard J Stratton⁸, ¹Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ²Murigenics, Vallejo, CA, ³Riptide Bioscience, Vallejo, CA, ⁴Centre for Rheumatology and Connective Tissue diseases, University College London, London, United Kingdom, ⁵UCL Division of Medicine, Royal Free Campus, London, United Kingdom, ⁶Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁷Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁸Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom
Background/Purpose: Alternatively activated macrophages expressing CD206 are believed to promote fibrosis in a range of disorders including systemic sclerosis (SSc). Novel therapeutic peptides (RP) which…
Abstract Number: 2981 • 2018 ACR/ARHP Annual Meeting
Mitochondrial Extrusion and Autoimmunity in Juvenile Dermatomyositis
Christian Lood¹, Bhargavi Duvvuri², Richard Moore², Gabrielle A. Morgan³, Marisa Klein-Gitelman⁴, Megan L. Curran⁵ and Lauren M. Pachman⁶, ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Division of Rheumatology, University of Washington, Seattle, WA, ³Cure JM Program of Excellence in Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁴Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁵Section of Rheumatology, Children's Hospital of Colorado, Denver, CO, ⁶Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL
Background/Purpose: We recently made the fundamental observation that mitochondrial extrusion is instrumental in mediating inflammation, autoimmunity and organ damage in lupus. Mitochondrial stress and mitochondrial…
Abstract Number: 849 • 2018 ACR/ARHP Annual Meeting
Constructing a Macrophage Infiltration Timeline in a Murine Model of Osteoarthritis
Cheng Zhou^1,2, Vu Nguyen^1,3, Nisha Sambamurthy^1,2, Michael Dodge^1,4 and Carla Scanzello^1,2, ¹Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, ²Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ³University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁴Department of Orthopaedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Background/Purpose: Macrophage infiltration in synovium (SM) and intraarticular fat pads (FP) is common in Osteoarthritis (OA), and can contribute to catabolic cytokine and protease production…
Abstract Number: 1007 • 2018 ACR/ARHP Annual Meeting
Macrophage Mediators of Autoimmune Valvular Carditis and Fibrosis
Lee Meier¹, Mayra Gonzalez-Torres², Jennifer L. Auger², Aubyn Marath³ and Bryce A. Binstadt², ¹Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapols, MN, ²Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapolis, MN, ³CardioStart International, Tampa, FL
Background/Purpose: K/B.g7 TCR transgenic mice spontaneously develop both autoimmune arthritis and valvular carditis. We utilize this model to define mediators of rheumatic disease-associated cardiovascular inflammation…
Abstract Number: 1008 • 2018 ACR/ARHP Annual Meeting
Presence of a Specific Defect in M2 Polarization of Blood Monocytes from Patients with Rheumatoid Arthritis, Associated with Increased microRNA-155
Audrey Paoletti¹, Julien Rohmer², Juliette Pascaud³, Bineta Oumouly¹, Elodie Rivière³, Samuel Bitoun⁴, Gaetane Nocturne⁵ and Xavier Mariette⁶, ¹U1184 IMVA, INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, ²National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Internal medicine, France, Paris, France, ³Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre & Fontenay aux Roses, France, ⁴INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, ⁵INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, ⁶Rheumatology department, Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique- Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, Paris, France
Background/Purpose: Macrophages contribute in situ to the RA pathogenesis. Two distinct states of polarization for macrophages have been recognized: the classically activated macrophage phenotype (M1),…

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