ACR Meeting Abstracts

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Abstracts tagged "Macrophage"

  • Abstract Number: 24 • 2019 ACR/ARP Annual Meeting

    Role of Trained Immunity in the Pathogenesis of Erdheim-Chester Disease

    Giulio Cavalli1, Riccardo Biavasco 1, Marina Ferrarini 2, Elisabetta Ferrero 2, Eugenio Montini 2, Simone Cenci 2, Cardaci Simone 2 and Lorenzo Dagna 1, 1Vita-Salute San Raffaele University, Milan, Italy, 2IRCCS San Raffaele Hospital, Milan, Italy

    Background/Purpose: Erdheim-Chester disease (ECD) is a chronic inflammatory disease characterized by infiltration of bone and other tissues by foamy macrophages. These cells exhibit activating mutations…
  • Abstract Number: 27 • 2019 ACR/ARP Annual Meeting

    Altered Inflammatory Response of Macrophages in the Fosl-2 Transgenic Mouse Model of Systemic Sclerosis

    Chantal Rufer 1, Michal Rudnik1, Siim Uhtjärv 1, Mara Stellato 1, Florian Renoux 2, Oliver Distler 3 and Gabriela Kania 1, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, 3Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland

    Background/Purpose: Fos-like 2 (Fosl-2) is a transcription factor belonging to the Fos family of proteins which is part of the AP-1 transcription complex. The Fosl-2…
  • Abstract Number: 75 • 2019 ACR/ARP Annual Meeting

    Microglia-Specific Transcriptional Signatures Correlate with Behavioral Deficits in ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’

    Hadijat Makinde1, Elise Mike 2, Chaim Putterman 3, Deborah Winter 4 and Carla Cuda 5, 1Northwestern University, Chicago, IL, 2Albert Einstein College of Medicine, Bronx, NY, 3Albert Einstein College of Medicine, New York, NY, 4Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, 5Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune syndrome affecting multiple organs, including the brain. More than 50% of patients experience neuropsychiatric symptoms of…
  • Abstract Number: 76 • 2019 ACR/ARP Annual Meeting

    Effect of Ifnα and Costimulatory Blockade on Brain Infiltration in a Model of ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’

    Hadijat Makinde1, Chirag Raparia 2, Anne Davidson 2 and Carla Cuda 3, 1Northwestern University, Chicago, IL, 2Feinstein Institutes for Medical Research, Manhasset, 3Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects many end organs including the brain. Despite a prevalence of over 50% in…
  • Abstract Number: 692 • 2019 ACR/ARP Annual Meeting

    Correlation of Urinary Soluble CD163 Levels with Clinicopathological Features in Lupus Nephritis: Its Role as a Potential Biomarker

    Shilpa Venkataraman1, Ankita Singh 2, Manjula Murari 3, Vinita Agrawal 2, Amita Aggarwal 3 and Rakesh Pandey 4, 1Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India, 2Sanjay Gandhi Post Graduate institute of medical science, Lucknow, India, Lucknow, Uttar Pradesh, India, 3Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India, 4Sanjay Gandhi Postgraduate Institute for Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India

    Background/Purpose: Lupus nephritis (LN), is seen in 30-50% patients with SLE and 5-10% patients progress to end-stage renal disease. The clinical disease activity indices do…
  • Abstract Number: 1918 • 2019 ACR/ARP Annual Meeting

    Urine CD163 Significantly Discriminates Active Lupus Nephritis and Strongly Correlates with Proliferative Glomerulonephritis

    Ting Zhang1, Ramesh Saxena 2, Chi Chiu Mok 3, Michelle Petri 4 and Chandra Mohan 5, 1Biomedical Engineering, University of Houston, Houston, TX, 2UTSW, Dallas, 3Department of Medicine, Tuen Mun Hospital, Hong Kong, China (People's Republic), 4Johns Hopkins University School of Medicine, Baltimore, MD, 5University of Houston, Houston

    Background/Purpose: CD163 is a marker for alternatively activated M2 macrophages, which have been implicated in the pathogenesis of lupus nephritis (LN). The potential of urine…
  • Abstract Number: 1987 • 2019 ACR/ARP Annual Meeting

    CCN3 Regulates Macrophage Function in MSU-induced Inflammation

    Lihua Duan1, Jie Chen 1 and Jixin Zhong 2, 1Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, China (People's Republic), 2Cardiovascular Research Institute, School of Medicine, Case Western Reserve University, Cleveland, OH

    Background/Purpose: Gout is the most common metabolic disease in which monosodium urate (MSU) crystals form and deposit in the joints and soft tissues of patients.…
  • Abstract Number: 2806 • 2019 ACR/ARP Annual Meeting

    Single Cell RNA-sequencing Reveals Distinct Macrophage Subsets in the Joint with Differing Ontogenies During Steady-state and Arthritis

    Anna Montgomery 1, Shang-Yang Chen1, Philip Homan 1, Gaurav Gadhvi 1, Deborah Winter 2 and Harris Perlman 2, 1Northwestern University, Chicago, 2Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago

    Background/Purpose: Macrophages in the synovial lining of the joint are critical players in the pathogenesis of rheumatoid arthritis (RA). However, their heterogeneity remains poorly characterized.Methods:…
  • Abstract Number: 1112 • 2018 ACR/ARHP Annual Meeting

    Downregulated Expression of Interferon Regulatory Factor 8 in Circulating Monocytes Exhibits Pro-Fibrotic Phenotype in Patients with Systemic Sclerosis

    Yasushi Ototake1, Yukie Yamaguchi1, Miho Asami1, Noriko Ikeda1, Daisuke Kurotaki2, Tomohiko Tamura2 and Michiko Aihara1, 1Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Background/Purpose: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by autoimmunity, vasculopathy, and excessive organ fibrosis. Although the etiology of the disease is…
  • Abstract Number: 1823 • 2018 ACR/ARHP Annual Meeting

    Loss of Synovial Tissue Resident Macrophages Permits Monocyte to Macrophage Differentiation and Inflammation in Hupo Mice

    Qi Quan Huang1, Renee E. Doyle2, Alexander Misharin3, Shang-Yang Chen4, Deborah R. Winter5 and Richard M. Pope2, 1Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Medicine/pulmonary, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, chicago, IL, 5Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: We established a mouse model (HUPO) by deletion of Flip in CD11c+ cells that spontaneously develops erosive inflammatory arthritis resembling rheumatoid arthritis (RA). Since…
  • Abstract Number: 2098 • 2018 ACR/ARHP Annual Meeting

    NRF2 Downregulates Inflammation and Protects Against Autoimmune Lung Disease in Experimental Lupus

    Shuhong Han1, Haoyang Zhuang1, Pui Lee2, Lijun Yang3 and Westley Reeves1,4, 1Medicine, University of Florida, Gainesville, FL, 2Harvard Medical School, Boston, MA, 3Pathology, Immunology and laboratory medicine, University of Florida, Gainesville, FL, 4Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL

    Background/Purpose: The transcription factor nuclear factor erythroid 2-related factor (Nrf2) is a master regulator of genes involved in cellular defense against oxidative and electrophilic stresses.…
  • Abstract Number: 35 • 2018 ACR/ARHP Annual Meeting

    Arthritis and Atherosclerosis in KRN Ag7 Mice Involve Distinct Inflammatory Cell Populations and Are Independent of CCR2

    Anna B Montgomery1, Carla M. Cuda2, Salina Dominguez2, Maximilian Mayr3, Deborah R. Winter2 and Harris Perlman3, 1Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory disease of the joints associated with cardiovascular disease, which accounts for 40% of RA mortality. Macrophages are implicated…
  • Abstract Number: 2851 • 2018 ACR/ARHP Annual Meeting

    NF-Κappa b Signaling in the Myeloid Cell Lineage Drives the Pathogenesis of Immune-Mediated Nephritis

    Samantha Chalmers1, Sayra Garcia1, Justine Shum1, Leal Herlitz2 and Chaim Putterman3, 1Albert Einstein College of Medicine, Bronx, NY, 2Cleveland Clinic, Cleveland, OH, 3Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY

    Background/Purpose: Immune-mediated glomerulonephritis is a serious end organ pathology that commonly affects patients with systemic lupus erythematosus (SLE). Nephrotoxic serum nephritis, induced by passive transfer…
  • Abstract Number: 125 • 2018 ACR/ARHP Annual Meeting

    Monocyte Transcriptome Delineates SSc Patients with Functionally Distinct Patterns of Gene Dysregulation That Persist through Differentiation

    Julia L.M. Dunn1, Philip J. Homan2, Salina Dominguez1, Carla M. Cuda1, Kathleen Aren3, Mary A. Carns3,4, Tracy M. Frech5, Dinesh Khanna6, Shervin Assassi7, Harris Perlman1, Monique Hinchcliff1 and Deborah R. Winter1, 1Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 4Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Division of Rheumatology, University of Utah, Salt Lake City, UT, 6Division of Rheumatology, University of Michigan, Ann Arbor, MI, 7Rheumatology, University of Texas Health Science Center at Houston, Houston, TX

    Background/Purpose: The etiology and pathogenesis of SSc are poorly understood; however, an increasing body of evidence supports an early inflammatory phase that precedes, and may…
  • Abstract Number: 2965 • 2018 ACR/ARHP Annual Meeting

    Targeting Glucose Metabolism in the Murine Air Pouch Model of Acute Gouty Inflammation

    Anyan Cheng1, Roxana Coras1,2, Robert Terkeltaub3,4, Ru Liu-Bryan1,3 and Monica Guma1,2, 1Medicine, University of California San Diego, La Jolla, CA, 2Medicine, Autonomous University of Barcelona, Bellatera, Spain, 3VA San Diego Healthcare System, San Diego, CA, 4Medicine, Division of Rheumatology, Allergy and Immunology. UCSD., La Jolla, CA

    Background/Purpose: Emerging evidence indicates that macrophage activation is critically supported by glucose metabolic shifts. Although macrophages are key contributors to inflammation, little is known about…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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