Abstract Number: 75 • 2019 ACR/ARP Annual Meeting
Microglia-Specific Transcriptional Signatures Correlate with Behavioral Deficits in ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune syndrome affecting multiple organs, including the brain. More than 50% of patients experience neuropsychiatric symptoms of…Abstract Number: 76 • 2019 ACR/ARP Annual Meeting
Effect of Ifnα and Costimulatory Blockade on Brain Infiltration in a Model of ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects many end organs including the brain. Despite a prevalence of over 50% in…Abstract Number: 692 • 2019 ACR/ARP Annual Meeting
Correlation of Urinary Soluble CD163 Levels with Clinicopathological Features in Lupus Nephritis: Its Role as a Potential Biomarker
Background/Purpose: Lupus nephritis (LN), is seen in 30-50% patients with SLE and 5-10% patients progress to end-stage renal disease. The clinical disease activity indices do…Abstract Number: 1918 • 2019 ACR/ARP Annual Meeting
Urine CD163 Significantly Discriminates Active Lupus Nephritis and Strongly Correlates with Proliferative Glomerulonephritis
Background/Purpose: CD163 is a marker for alternatively activated M2 macrophages, which have been implicated in the pathogenesis of lupus nephritis (LN). The potential of urine…Abstract Number: 1987 • 2019 ACR/ARP Annual Meeting
CCN3 Regulates Macrophage Function in MSU-induced Inflammation
Background/Purpose: Gout is the most common metabolic disease in which monosodium urate (MSU) crystals form and deposit in the joints and soft tissues of patients.…Abstract Number: 2806 • 2019 ACR/ARP Annual Meeting
Single Cell RNA-sequencing Reveals Distinct Macrophage Subsets in the Joint with Differing Ontogenies During Steady-state and Arthritis
Background/Purpose: Macrophages in the synovial lining of the joint are critical players in the pathogenesis of rheumatoid arthritis (RA). However, their heterogeneity remains poorly characterized.Methods:…Abstract Number: 24 • 2019 ACR/ARP Annual Meeting
Role of Trained Immunity in the Pathogenesis of Erdheim-Chester Disease
Background/Purpose: Erdheim-Chester disease (ECD) is a chronic inflammatory disease characterized by infiltration of bone and other tissues by foamy macrophages. These cells exhibit activating mutations…Abstract Number: 27 • 2019 ACR/ARP Annual Meeting
Altered Inflammatory Response of Macrophages in the Fosl-2 Transgenic Mouse Model of Systemic Sclerosis
Background/Purpose: Fos-like 2 (Fosl-2) is a transcription factor belonging to the Fos family of proteins which is part of the AP-1 transcription complex. The Fosl-2…Abstract Number: 1008 • 2018 ACR/ARHP Annual Meeting
Presence of a Specific Defect in M2 Polarization of Blood Monocytes from Patients with Rheumatoid Arthritis, Associated with Increased microRNA-155
Background/Purpose: Macrophages contribute in situ to the RA pathogenesis. Two distinct states of polarization for macrophages have been recognized: the classically activated macrophage phenotype (M1),…Abstract Number: 1009 • 2018 ACR/ARHP Annual Meeting
Monocytes Membrane TNF Expression and Anti-TNF Treatment in Rheumatoid Arthritis
Background/Purpose: Three monocyte subsets have been described based on their CD14 and CD16 expression profiles. The subpopulation CD14+CD16+ being expanded in rheumatoid arthritis (RA) patient.…Abstract Number: 1010 • 2018 ACR/ARHP Annual Meeting
Inhibition of Bruton’s Tyrosine Kinase (BTK) Prevents Inflammatory Macrophage Differentiation: A Potential Role in RA and SLE
Background/Purpose: Bruton’s Tyrosine Kinase (BTK) mediates B cell receptor (BCR) and Fc receptor (FcR) signalling in several hematopoietic cell lineages, including B cells, macrophages and…Abstract Number: 1012 • 2018 ACR/ARHP Annual Meeting
Inhibition of Inflammation and Oxidative Stress in Systemic Sclerosis (SSc) Macrophages
Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disease of unknown etiology that is characterized by vasculopathy, fibrosis, and inflammation. Our work and that of…Abstract Number: 1014 • 2018 ACR/ARHP Annual Meeting
Distinct Macrophage Phenotype and Bioenergetic Profiles in Rheumatoid Arthritis
Background/Purpose: Synovial macrophages play a key role in RA disease progression, yet the diversity of macrophage subsets within the joint remains unknown. The concept of…Abstract Number: 1015 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Peripheral CD14+ Monocytes Are Hyper-Inflammatory, Hyper-Glycolytic and Retain a Memory Bias Toward M1 Macrophages
Background/Purpose: Myeloid cells with a monocyte/macrophages phenotype are present in large numbers in the rheumatoid arthritis (RA) joint, significantly contributing to disease. This study aimed…Abstract Number: 1021 • 2018 ACR/ARHP Annual Meeting
Impact of TLR7 Ligation in RA Pathology
Background/Purpose: Expression of Toll-like receptor 7 (TLR-7) is highly elevated in rheumatoid arthritis (RA) and osteoarthritis (OA) compared to normal (NL) synovial tissue lining and…
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