ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "Macrophage"

  • Abstract Number: 24 • 2019 ACR/ARP Annual Meeting

    Role of Trained Immunity in the Pathogenesis of Erdheim-Chester Disease

    Giulio Cavalli1, Riccardo Biavasco 1, Marina Ferrarini 2, Elisabetta Ferrero 2, Eugenio Montini 2, Simone Cenci 2, Cardaci Simone 2 and Lorenzo Dagna 1, 1Vita-Salute San Raffaele University, Milan, Italy, 2IRCCS San Raffaele Hospital, Milan, Italy

    Background/Purpose: Erdheim-Chester disease (ECD) is a chronic inflammatory disease characterized by infiltration of bone and other tissues by foamy macrophages. These cells exhibit activating mutations…
  • Abstract Number: 27 • 2019 ACR/ARP Annual Meeting

    Altered Inflammatory Response of Macrophages in the Fosl-2 Transgenic Mouse Model of Systemic Sclerosis

    Chantal Rufer 1, Michal Rudnik1, Siim Uhtjärv 1, Mara Stellato 1, Florian Renoux 2, Oliver Distler 3 and Gabriela Kania 1, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, 3Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland

    Background/Purpose: Fos-like 2 (Fosl-2) is a transcription factor belonging to the Fos family of proteins which is part of the AP-1 transcription complex. The Fosl-2…
  • Abstract Number: 75 • 2019 ACR/ARP Annual Meeting

    Microglia-Specific Transcriptional Signatures Correlate with Behavioral Deficits in ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’

    Hadijat Makinde1, Elise Mike 2, Chaim Putterman 3, Deborah Winter 4 and Carla Cuda 5, 1Northwestern University, Chicago, IL, 2Albert Einstein College of Medicine, Bronx, NY, 3Albert Einstein College of Medicine, New York, NY, 4Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, 5Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune syndrome affecting multiple organs, including the brain. More than 50% of patients experience neuropsychiatric symptoms of…
  • Abstract Number: 76 • 2019 ACR/ARP Annual Meeting

    Effect of Ifnα and Costimulatory Blockade on Brain Infiltration in a Model of ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’

    Hadijat Makinde1, Chirag Raparia 2, Anne Davidson 2 and Carla Cuda 3, 1Northwestern University, Chicago, IL, 2Feinstein Institutes for Medical Research, Manhasset, 3Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects many end organs including the brain. Despite a prevalence of over 50% in…
  • Abstract Number: 692 • 2019 ACR/ARP Annual Meeting

    Correlation of Urinary Soluble CD163 Levels with Clinicopathological Features in Lupus Nephritis: Its Role as a Potential Biomarker

    Shilpa Venkataraman1, Ankita Singh 2, Manjula Murari 3, Vinita Agrawal 2, Amita Aggarwal 3 and Rakesh Pandey 4, 1Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India, 2Sanjay Gandhi Post Graduate institute of medical science, Lucknow, India, Lucknow, Uttar Pradesh, India, 3Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India, 4Sanjay Gandhi Postgraduate Institute for Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India

    Background/Purpose: Lupus nephritis (LN), is seen in 30-50% patients with SLE and 5-10% patients progress to end-stage renal disease. The clinical disease activity indices do…
  • Abstract Number: 1918 • 2019 ACR/ARP Annual Meeting

    Urine CD163 Significantly Discriminates Active Lupus Nephritis and Strongly Correlates with Proliferative Glomerulonephritis

    Ting Zhang1, Ramesh Saxena 2, Chi Chiu Mok 3, Michelle Petri 4 and Chandra Mohan 5, 1Biomedical Engineering, University of Houston, Houston, TX, 2UTSW, Dallas, 3Department of Medicine, Tuen Mun Hospital, Hong Kong, China (People's Republic), 4Johns Hopkins University School of Medicine, Baltimore, MD, 5University of Houston, Houston

    Background/Purpose: CD163 is a marker for alternatively activated M2 macrophages, which have been implicated in the pathogenesis of lupus nephritis (LN). The potential of urine…
  • Abstract Number: 1987 • 2019 ACR/ARP Annual Meeting

    CCN3 Regulates Macrophage Function in MSU-induced Inflammation

    Lihua Duan1, Jie Chen 1 and Jixin Zhong 2, 1Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, China (People's Republic), 2Cardiovascular Research Institute, School of Medicine, Case Western Reserve University, Cleveland, OH

    Background/Purpose: Gout is the most common metabolic disease in which monosodium urate (MSU) crystals form and deposit in the joints and soft tissues of patients.…
  • Abstract Number: 2806 • 2019 ACR/ARP Annual Meeting

    Single Cell RNA-sequencing Reveals Distinct Macrophage Subsets in the Joint with Differing Ontogenies During Steady-state and Arthritis

    Anna Montgomery 1, Shang-Yang Chen1, Philip Homan 1, Gaurav Gadhvi 1, Deborah Winter 2 and Harris Perlman 2, 1Northwestern University, Chicago, 2Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago

    Background/Purpose: Macrophages in the synovial lining of the joint are critical players in the pathogenesis of rheumatoid arthritis (RA). However, their heterogeneity remains poorly characterized.Methods:…
  • Abstract Number: 125 • 2018 ACR/ARHP Annual Meeting

    Monocyte Transcriptome Delineates SSc Patients with Functionally Distinct Patterns of Gene Dysregulation That Persist through Differentiation

    Julia L.M. Dunn1, Philip J. Homan2, Salina Dominguez1, Carla M. Cuda1, Kathleen Aren3, Mary A. Carns3,4, Tracy M. Frech5, Dinesh Khanna6, Shervin Assassi7, Harris Perlman1, Monique Hinchcliff1 and Deborah R. Winter1, 1Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 4Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Division of Rheumatology, University of Utah, Salt Lake City, UT, 6Division of Rheumatology, University of Michigan, Ann Arbor, MI, 7Rheumatology, University of Texas Health Science Center at Houston, Houston, TX

    Background/Purpose: The etiology and pathogenesis of SSc are poorly understood; however, an increasing body of evidence supports an early inflammatory phase that precedes, and may…
  • Abstract Number: 2965 • 2018 ACR/ARHP Annual Meeting

    Targeting Glucose Metabolism in the Murine Air Pouch Model of Acute Gouty Inflammation

    Anyan Cheng1, Roxana Coras1,2, Robert Terkeltaub3,4, Ru Liu-Bryan1,3 and Monica Guma1,2, 1Medicine, University of California San Diego, La Jolla, CA, 2Medicine, Autonomous University of Barcelona, Bellatera, Spain, 3VA San Diego Healthcare System, San Diego, CA, 4Medicine, Division of Rheumatology, Allergy and Immunology. UCSD., La Jolla, CA

    Background/Purpose: Emerging evidence indicates that macrophage activation is critically supported by glucose metabolic shifts. Although macrophages are key contributors to inflammation, little is known about…
  • Abstract Number: 132 • 2018 ACR/ARHP Annual Meeting

    Novel Therapeutic Peptides Which Target CD206 Inhibit Macrophage Dependent Fibroblast Activation in Scleroderma

    Bahja Ahmed Abdi1, Henry Lopez2, George Martin3, Charles Garvin3, Jesse Jaynes3, James Stanway4, Christopher P. Denton5, David Abraham6, Shivanee Vigneswaran7, Sian Morris7 and Richard J Stratton8, 1Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 2Murigenics, Vallejo, CA, 3Riptide Bioscience, Vallejo, CA, 4Centre for Rheumatology and Connective Tissue diseases, University College London, London, United Kingdom, 5UCL Division of Medicine, Royal Free Campus, London, United Kingdom, 6Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, 7Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 8Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom

    Background/Purpose: Alternatively activated macrophages expressing CD206 are believed to promote fibrosis in a range of disorders including systemic sclerosis (SSc). Novel therapeutic peptides (RP) which…
  • Abstract Number: 2981 • 2018 ACR/ARHP Annual Meeting

    Mitochondrial Extrusion and Autoimmunity in Juvenile Dermatomyositis

    Christian Lood1, Bhargavi Duvvuri2, Richard Moore2, Gabrielle A. Morgan3, Marisa Klein-Gitelman4, Megan L. Curran5 and Lauren M. Pachman6, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2Division of Rheumatology, University of Washington, Seattle, WA, 3Cure JM Program of Excellence in Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 4Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 5Section of Rheumatology, Children's Hospital of Colorado, Denver, CO, 6Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL

    Background/Purpose: We recently made the fundamental observation that mitochondrial extrusion is instrumental in mediating inflammation, autoimmunity and organ damage in lupus. Mitochondrial stress and mitochondrial…
  • Abstract Number: 849 • 2018 ACR/ARHP Annual Meeting

    Constructing a Macrophage Infiltration Timeline in a Murine Model of Osteoarthritis

    Cheng Zhou1,2, Vu Nguyen1,3, Nisha Sambamurthy1,2, Michael Dodge1,4 and Carla Scanzello1,2, 1Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, 2Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 3University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 4Department of Orthopaedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

    Background/Purpose: Macrophage infiltration in synovium (SM) and intraarticular fat pads (FP) is common in Osteoarthritis (OA), and can contribute to catabolic cytokine and protease production…
  • Abstract Number: 1007 • 2018 ACR/ARHP Annual Meeting

    Macrophage Mediators of Autoimmune Valvular Carditis and Fibrosis

    Lee Meier1, Mayra Gonzalez-Torres2, Jennifer L. Auger2, Aubyn Marath3 and Bryce A. Binstadt2, 1Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapols, MN, 2Department of Pediatrics and Center for Immunology, University of Minnesota, Minneapolis, MN, 3CardioStart International, Tampa, FL

    Background/Purpose: K/B.g7 TCR transgenic mice spontaneously develop both autoimmune arthritis and valvular carditis. We utilize this model to define mediators of rheumatic disease-associated cardiovascular inflammation…
  • Abstract Number: 1008 • 2018 ACR/ARHP Annual Meeting

    Presence of a Specific Defect in M2 Polarization of Blood Monocytes from Patients with Rheumatoid Arthritis, Associated with Increased microRNA-155

    Audrey Paoletti1, Julien Rohmer2, Juliette Pascaud3, Bineta Oumouly1, Elodie Rivière3, Samuel Bitoun4, Gaetane Nocturne5 and Xavier Mariette6, 1U1184 IMVA, INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, 2National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Internal medicine, France, Paris, France, 3Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre & Fontenay aux Roses, France, 4INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, le kremlin bicetre, France, 5INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, 6Rheumatology department, Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique- Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, Paris, France

    Background/Purpose: Macrophages contribute in situ to the RA pathogenesis. Two distinct states of polarization for macrophages have been recognized: the classically activated macrophage phenotype (M1),…
  • 1
  • 2
  • 3
  • …
  • 8
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology