Abstracts tagged "Lupus"

Abstract Number: 1082 • 2018 ACR/ARHP Annual Meeting
Peripheral Blood CD11c+ CD21- Age-Associated B Cells (ABCs) in Human Systemic Lupus Erythematosus Are Associated with Innate Type III Interferon and Disease Activity
Jennifer L. Barnas, Lin Gao, Mary O'Connell, Jennifer Albrecht, Nida Meednu, R. John Looney and Jennifer Anolik, Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by an interferon-stimulated gene (ISG) signature typically attributed to interferon (IFN)-α. However, ISGs can be induced by other…
Abstract Number: 1898 • 2018 ACR/ARHP Annual Meeting
Type I Interferon-Induced Proteins May Facilitate the Occurrence of Long QT Syndrome (LQTS) in Parallel with Anti-Ro/SSA and Anti-Ro52/TRIM21 Antibody Levels in Patients with Systemic Lupus Erythematous (SLE): A Bench to Bedside Approach
Luis F. Perez-Garcia^1,2, Irving O. Estevez-Garcia³, Ricardo Marquez-Velasco³, Pedro Iturralde⁴, Luis H. Silveira⁵ and Luis M. Amezcua-Guerra^2,6,7, ¹Rheumatology, Erasmus MC, Rotterdam, Netherlands, ²Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, ³Immunology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, ⁴Cardiology - Electrophysiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, ⁵Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City DF, Mexico, ⁶Cardiovascular Research Laboratory, Unidad de Investigacion Traslacional, Universidad Nacional Autonoma de Mexico/Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, ⁷Department of Health Care, Universidad Autonoma Metropolitana, Xochimilco, Mexico City, Mexico
Background/Purpose: Long QT syndrome (LQTS) is an abnormal QT corrected (QTc) interval prolongation, strongly associated with increased risk of sudden death. Studies have associated LQTS…
Abstract Number: 2645 • 2018 ACR/ARHP Annual Meeting
The Impact of Metformin on Disease Activity in Systemic Lupus Erythematosus
Cara McLeod¹, Gbemisola Olayemi¹, Nitasha Bhatia², Frank Migliore³ and Robert Quinet¹, ¹Rheumatology, Ochsner Medical Center, New Orleans, LA, ²Ochsner Medical Center, New Orleans, LA, ³Rheumatology, Allegheny Health Network, Pittsburgh, PA
Background/Purpose: Metformin is a mainstay of therapy for type 2 diabetes mellitus. Newer evidence suggests that metformin may reduce lupus flares. An entity called neutrophil…
Abstract Number: 94 • 2018 ACR/ARHP Annual Meeting
Circulating Soluble MICA Is Associated to Lupus Nephritis and to a TLR/IFN-I Signature in T Cells in a Cohort of Adult SLE Patients
Maria Perez-Ferro¹, Fredeswinda I. Romero-Bueno¹, Cristina Serrano del Castillo², Raquel Largo³, Gabriel Herrero-Beaumont³ and Olga Sanchez-Pernaute⁴, ¹Section for Autoimmune Diseases, Rheumatology, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, ²Immunology, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, ³Bone and Joint Research Unit, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, ⁴Rheumatology Division. Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
Background/Purpose: The MHC class I-related chain A (MICA) is a major ligand for the NKG2D receptor of NK and CD8 T cells. MICA expression at…
Abstract Number: 717 • 2018 ACR/ARHP Annual Meeting
The Burden of Chronic Kidney Disease in Systemic Lupus Erythematosus (SLE): A Nationwide Epidemiologic Study
Arthur Mageau¹, Jean Francois Timsit¹, Anne Perozziello¹, Stephane Ruckly¹, Claire Dupuis¹, Lila Bouadma¹, Thomas Papo¹ and Karim Sacre², ¹Université Paris-Diderot, Paris, France, ²Bichat Hospital, Paris Diderot University, Paris, France
Background/Purpose: Lupus nephritis occurs in about 50% of SLE patients. We aimed to analyze the impact of chronic kidney disease (CKD) on major clinical outcomes…
Abstract Number: 1096 • 2018 ACR/ARHP Annual Meeting
Unexpected Association between Health-Related Quality of Life and the Blood Interferon Modular Transcriptional Signatures in Patients with Systemic Lupus Erythematosus
Laurent Chiche¹, julie seguier², stephanie gentile², stephane burtey², bertrand dussol², philippe halfon³, wahiba bidaut³, elisabeth jouve² and Noémie Jourde-Chiche⁴, ¹Internal medicine, Hopital europeen, Marseille, France, ²aphm, marseille, France, ³hopital europeen, marseille, France, ⁴Vascular Research Center of Marseille, Aix-Marseille Univ., Vascular Research Center of Marseille, Marseille, France
Background/Purpose: SLE has important effects on health-related quality of life (HRQOL) and is not well correlated to disease activity. As most SLE patients in remission…
Abstract Number: 1960 • 2018 ACR/ARHP Annual Meeting
Exome Sequencing Reveals Rare Recessive Mutations in Multiple Genes Including FAS, RAD51B, and ISG15 in a Single Family with Lupus and Suggests a Unique Genetic Model
Jessie Alperin¹, Khader Mustafa², Ola Hijjawi², Patrick Coit³, Kenneth Kaufman⁴ and Amr H Sawalha³, ¹University of Michigan Medical System, Ann Arbor, MI, ²Division of Rheumatology, The University of Jordan, Amman, Jordan, ³Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁴Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Lupus is a complex heterogeneous disease, which can affect almost any organ system. The genetic etiology of lupus is complex, with multiple genetic susceptibility…
Abstract Number: 2654 • 2018 ACR/ARHP Annual Meeting
Exposure to Air Pollution and the Onset and Progression of Systemic Lupus Erythematosus
Gaurav Gulati¹, Cole Brokamp², Patrick Ryan² and Hermine I. Brunner³, ¹Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, ²Department of Biostatistics and Epidemiology, Cincinnati Childrens Hospital and Medical Center, Cincinnati, OH, ³Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Background/Purpose: Air pollution may contribute to many autoimmune diseases including systemic lupus erythematosus (SLE), but limited information is available on its role in the onset…
Abstract Number: 104 • 2018 ACR/ARHP Annual Meeting
Identification of a Gut Pathobiont Immunostimulatory Lipoglycan Antigen Linked to Lupus Nephritis
Gregg Silverman¹, Nicolas Gisch², Aidana Omarbekova³ and Doua F. Azzouz⁴, ¹Department of Medicine, New York University School of Medicine, New York, NY, ²Research Center Borstel, Schleswig-Holstein, Germany, ³New York University School of Medicine, New York, NY, ⁴Medicine, New York University School of Medicine, New York, NY
Background/Purpose: A transmissible agent has long been suspected in SLE. In a discovery cohort we found that,compared with healthy subjects, Lupus patients had a five-fold…
Abstract Number: 721 • 2018 ACR/ARHP Annual Meeting
The Burden of Renal Arteriosclerosis in Lupus Nephritis: A Cohort Study Examining Prevalence and Predictors of Renal Arteriosclerosis
Shivani Garg¹, Sarah Panzer², Mike Semanik³ and Christie M. Bartels⁴, ¹Rheumatology/ Medicine, University of Wisconsin - Madison, Fitchburg, WI, ²Nephrology/ Medicine, University of Wisconsin, Madison, WI, ³Nephrology/ Pediatrics, University of Wisconsin, Madison, WI, ⁴Rheumatology/Medicine, University of Wisconsin - Madison, Madison, WI
Background/Purpose: Cardiovascular disease (CVD) is significantly accelerated in young systemic lupus erythematous (SLE) patients including those with lupus nephritis (LN). Despite literature suggesting that renal…
Abstract Number: 1352 • 2018 ACR/ARHP Annual Meeting
Low Density Granulocytes in Idiopathic Inflammatory Myopathy
David Fernandez¹, Linjia Jia², Mikhail Olferiev³, Annel M. Fernandez⁴, JoAnn Vega⁵, Kerri Merritt⁶, Michael Lockshin⁷ and Peggy Crow¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ³Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY, ⁴Medicine- Rheumatology/ Research, Hospital for Special Surgery, New York, NY, ⁵Medicine - Rheumatology / Research, Hospital for Special Surgery, New York, NY, ⁶Hospital for Special Surgery, New York, NY, ⁷Barbara Volcker Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Idiopathic Inflammatory Myopathy (IIM) is a group of autoimmune diseases characterized by immune-mediated injury to skeletal muscle, including polymyositis (PM) and dermatomyositis (DM). Recent…
Abstract Number: 2030 • 2018 ACR/ARHP Annual Meeting
Patients with Childhood-Onset SLE (cSLE) and Hypertension Have Consistently Higher Serum Concentrations of C3 and C4 Than Those without Hypertension
Evan Mulvihill¹, Stacy P. Ardoin², Susan D Thompson³, Bi Zhou⁴, Gakit Yu⁵, Nora G. Singer⁶, Deborah M. Levy⁷, Hermine I. Brunner⁸, Yee Ling Wu⁹, Haikady Nagaraja¹⁰, Laura E. Schanberg¹¹ and Chack-Yung Yu², ¹Pediatrics and Rheumatology, Nationwide Children's Hospital, Columbus, OH, ²Division of Rheumatology, Nationwide Children’s Hospital, Columbus, OH, ³Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁵Center for Molecular and Human Genetics, Nationwide Children's Hospital, Columbus, OH, ⁶Departments of Medicine and Pediatrics, Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH, Cleveland, OH, ⁷Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, ⁸Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁹Department of Microbiology and Immunology, Loyola University Chicago, Chicago, IL, ¹⁰College of Public Health, The Ohio State University, Columbus, OH, ¹¹Duke University Medical Center, Durham, NC
Background/Purpose: Chronic systemic inflammation, mediated in part by complement, and inadequate vascular repair mechanisms affect patients with cSLE from a young age and are associated…
Abstract Number: 2657 • 2018 ACR/ARHP Annual Meeting
Assessment of Habitual Physical Activity and Performance during Maximal Exercise Test in Systemic Lupus Erythematosus Patients
Rosane Machado¹, Nilzio A. da Silva^1,2, Vitalina Barbosa¹, Jozelia Rêgo¹, Heloísa Machado¹, Claúdio Lira¹ and Ricardo Viana¹, ¹Universidade Federal de Goiás, Goiânia, Brazil, ²GLADEL, Goias, Brazil
Background/Purpose: Patients with systemic lupus erythematosus (SLE) present low physical capacity when compared to healthy controls. In addition to chronotropic incompetence during exercise, slow recovery…
Abstract Number: 193 • 2018 ACR/ARHP Annual Meeting
Practice Improvement Using Virtual Online Training: A Novel App-Based Platform to Teach Clinical Reasoning in Rheumatology
Megan Lockwood¹, Jennifer Mandal², Sebastian Andreatta³ and Maria Dall'Era³, ¹Internal Medicine, University of California, San Francisco, San Francisco, CA, ²Rheumatology, University of California, San Francisco, San Francisco, CA, ³University of California, San Francisco, San Francisco, CA
Background/Purpose: The demand for rheumatologists continues to increase due to the high prevalence of rheumatic disease in a growing population. As outlined in ACR's 2015…
Abstract Number: 722 • 2018 ACR/ARHP Annual Meeting
Increased Blood Pressure Visit-to-Visit Variability in Patients with Systemic Lupus Erythematosus: Association with Inflammation, Comorbidities and Increased Mortality
Tyler Reese¹, Alyson Dickson¹, Jacquelyn E. Neal², Jocelyn S. Gandelman³, Omair A. Khan², April Barnado⁴, William Dupont², C. Michael Stein¹ and Cecilia P. Chung¹, ¹Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, ³Vanderbilt University School of Medicine, Nashville, TN, ⁴Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have increased mortality compared to the general population. As outcomes related to disease control have improved, this mortality…

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