Date: Sunday, October 21, 2018
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: To evaluate the outcome of stroke in patients with systemic lupus erythematosus (SLE) in comparison with non-SLE patients.
Methods: Patients who fulfilled ≥4 SLICC/ACR criteria for SLE and had a history of cerebrovascular accident (stroke) were retrieved from our SLE database. The outcome of stroke in these patients was evaluated retrospectively and compared with a group of randomly selected age and
40 SLE patients (age 53.7±11.5, 87.5% women) with stroke were identified (stroke prevalence 0.39/100 patient-year) and 120 non-SLE control patients (age 52.8±14.8, 87.5% women) with stroke were randomly selected. All were ethnic Chinese. The prevalence of atherosclerotic risk factors was similar between the two groups, except SLE patients had a higher atherogenic index (Log serum [triglyceride/HDL-cholesterol]. Ischemic stroke was more common in SLE than non-SLE patients (90% vs 63%; p=0.001). Among patients with ischemic stroke, SLE patients had more extensive infarction (defined as diffuse white matter lesions, multiple infarcts involving >1 major vascular territory or one single major vessel >50% involvement) than controls on CAT scan (69.4% vs 28%; p<0.001). Significantly more SLE patients had functional dependence (
Conclusion: Stroke in SLE patients is more likely to be ischemic in origin and more extensive than matched controls. Short-term functional outcome of stroke is poorer in SLE patients. Over 7.5 years, stroke recurrence, post-stroke epilepsy and all-cause mortality is significantly more frequent in SLE than non-SLE patients.
To cite this abstract in AMA style:Mok CC, Tsoi LK, Fu YP. Outcome of Stroke in Patients with Systemic Lupus Erythematosus: A Nested Case-Control Study [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/outcome-of-stroke-in-patients-with-systemic-lupus-erythematosus-a-nested-case-control-study/. Accessed December 9, 2019.
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