Abstracts tagged "Lupus"

Abstract Number: 1169 • 2016 ACR/ARHP Annual Meeting
A Systematic Review of Rheumatic Disease Epidemiology in the Indigenous Populations of Canada, the United States, Australia and New Zealand
Cairistin McDougall¹, Kelle Hurd¹ and Cheryl Barnabe², ¹University of Calgary, Calgary, AB, Canada, ²Division of Rheumatology, University of Calgary, Calgary, AB, Canada
Background/Purpose: Two important reviews have summarized the epidemiology of rheumatic disease (Peschken 1999) and RA (Ferucci 2005) in Indigenous populations of North America. Our objective…
Abstract Number: 1819 • 2016 ACR/ARHP Annual Meeting
Myocarditis in Systemic Lupus Erythematosus
Alexandra Perel-Winkler¹, Sabahat Bokhari², Anca D. Askanase³ and Laura Geraldino-Pardilla⁴, ¹Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ²Cardiology, Columbia University College of Physicians & Surgeons, NY, NY, ³Department of Medicine, Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ⁴Columbia University College of Physicians & Surgeons, new york, NY
Background/Purpose : Cardiovascular disease (CVD) is a leading cause of death in patients with SLE. Lupus patients have a 2-3 fold increased risk of heart…
Abstract Number: 2832 • 2016 ACR/ARHP Annual Meeting
Novel Gene Variants Associated with Cardiovascular Disease in Systemic Lupus Erythematosus
Dag Leonard¹, Andrei Alexsson¹, Johanna Dahlqvist², Kimberly Taylor³, Johanna K Sandling⁴, Christine Bengtsson⁵, Elisabet Svenungsson⁶, Christopher Sjöwall⁷, Andreas Jönsen⁸, Iva Gunnarsson⁶, Anders A. Bengtsson⁸, Solbritt Rantapaa-Dahlqvist⁵, Maija-Leena Eloranta¹, Ann-Christine Syvänen⁴, Lindsey A. Criswell⁹ and Lars Rönnblom¹, ¹Uppsala University, Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala, Sweden, ²Uppsala University, Department of Medical Biochemistry and Microbiology Science for Life Laboratory, Uppsala, Sweden, ³University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁴Uppsala University, Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala, Sweden, ⁵Umeå University, Department of Public Health and Clinical Medicine/ Rheumatology, Umeå, Sweden, ⁶Karolinska Institutet, Department of Medicine, Unit of Rheumatology, Stockholm, Sweden, ⁷Linköping University, Department of Clinical and Experimental Medicine Rheumatology/AIR, Linköping, Sweden, ⁸Lund University, Department of Clinical Sciences, Rheumatology, Lund, Sweden, ⁹Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA
Background/Purpose: Methods: An association between a locus located on chromosome 14 and stroke/TIA was shown in both the Swedish (OR 1.8, p=0.0002) and the US…
Abstract Number: 1171 • 2016 ACR/ARHP Annual Meeting
Obesity and the Risk of Systemic Lupus Erythematosus in the Nurses’ Health Studies
Sara K. Tedeschi¹, Medha Barbhaiya¹, Bing Lu¹, Susan Malspeis², Jeffrey A. Sparks², Elizabeth W. Karlson¹, Walter C. Willett³ and Karen H. Costenbader¹, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Obesity has become alarmingly common over the past four decades in the U.S., with a notable rise in obesity prevalence starting in the late…
Abstract Number: 1821 • 2016 ACR/ARHP Annual Meeting
Demethylated CD4+CD28+KIR+CD11ahi T Cells Are Characterized By a Pro-Inflammatory Transcriptome and Interact with Genetic Risk to Predict Disease Activity in Lupus
Paul Renauer¹, Patrick Coit¹, Faith Strickland², Elizabeth Gensterblum¹, Mikhail Ognenovski¹, Bruce Richardson³ and Amr Sawalha⁴, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Rheumatology, University of Michigan, Ann Arbor, MI, ³Rheumatology, University of Michigan and the Ann Arbor VA, Ann Arbor, MI, ⁴Internal Medicine-Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: T cell DNA methylation defects play an important role in the pathogenesis of systemic lupus erythematosus. A CD4+CD28+ T cell subset characterized by overexpression…
Abstract Number: 2848 • 2016 ACR/ARHP Annual Meeting
Near Patient Anti-Nuclear Antibody Multiplex Testing Using Whole Blood for the Diagnosis of Connective Tissue Diseases in a Tertiary Care Center
Makoto Miyara¹, Jean- Luc Charuel², Sasi Mudumba³, Alice Wu³, Pascale Ghillani-Dalbin², Zahir Amoura^4,5,6, Rufus Burlingame⁷ and Lucile Musset¹, ¹Department of immunology, Pitié-Salpêtrière Hospital (AP-HP), Paris, France, ²Department of Immunology, Pitié-Salpêtrière Hospital (AP-HP), Paris, France, ³Genalyte, Inc., San Diego, CA, ⁴Internal Medecine - Centre de Référence National pour les Lupus et et le Syndrome des Antiphospholipides, Internal Medecine - Centre de Référence National pour les Lupus et et le Syndrome des Antiphospholipides, Pitié-Salpêtrière Hospital (AP-HP), Paris, France, ⁵Department of Internal Medicine 2. Referal center for SLE/APS, Pitié-Salpêtrière Hospital (AP-HP), Paris, France, ⁶Internal medicine 2, French National Reference Center for Systemic Lupus and Antiphospholipid Syndrome, Pitié-Salpêtrière Hospital (AP-HP), Paris, France, ⁷Genaltye, San Diego, CA
Background/Purpose: Detection of anti-nuclear antibodies for the diagnosis of connective tissue diseases (CTD) often requires complex algorithms to obtain conclusive results , including immunofluorescence on…
Abstract Number: 123 • 2016 ACR/ARHP Annual Meeting
A Panel of Urinary Biomarkers to Assess Renal Involvement in Latin American Patients with Systemic Lupus Erythematosus
José A. Gómez-Puerta^1,2, Blanca L Ortiz Reyes¹, Tomás Urrego¹, Adriana L Vanegas^2,3, Carlos Horacio Muñoz^3,4, Mauricio Restrepo², Wilmer Rojas-Zuleta², Sofia Arteaga², Luis Alonso Gonzalez⁴ and Gloria Vásquez^1,4, ¹Grupo de Inmunología Celular e Inmunogenética, Universidad de Antioquia, Medellín, Colombia, ²Rheumatology Unit, Universidad de Antioquia, Medellín, Colombia, ³Hospital Universitario de San Vicente Fundación, Medellín, Colombia, ⁴Rheumatology Unit, Universidad de Antioquia, Medellin, Colombia
Background/Purpose: Some previous studies in Caucasian, Asian, and African-american patients have shown promising results for several urinary biomarkers in patients with lupus nephritis (LN). However,…
Abstract Number: 1174 • 2016 ACR/ARHP Annual Meeting
Perceived Stress and Reported Cognitive Symptoms Among Patients with Systemic Lupus Erythematosus
Laura Plantinga¹, Cristina Drenkard², C. Barrett Bowling¹ and S. Sam Lim³, ¹Department of Medicine, Emory University, Atlanta, GA, ²Department of Medicine, Emory University School of Medicine, Atlanta, GA, ³Medicine, Emory University School of Medicine, Atlanta, GA
Background/Purpose: Higher stress is associated with lower cognitive functioning in many populations. We examined associations of perceived stress with cognitive symptoms among adults with systemic…
Abstract Number: 1834 • 2016 ACR/ARHP Annual Meeting
Commensal Ro60 Autoantigen Ortholog Cross-Reactivity in Human Lupus and Gnotobiotic Models
Teri Greiling¹, Carina Dehner², Stephen Renfroe³, Xinguo Chen⁴, Kevin Hughes⁴, Silvio M. Vieira³, William Ruff³, Marco Boccitto⁴, Andrew Goodman⁵, Sandra L. Wolin⁴ and Martin Kriegel^3,6, ¹Dermatology and Immunobiology, Yale School of Medicine, New Haven, CT, ²Immunobiology, Yale School of Medicine, new haven, CT, ³Immunobiology, Yale School of Medicine, New Haven, CT, ⁴Cell Biology, Yale School of Medicine, New Haven, CT, ⁵Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, ⁶Medicine/Division of Rheumatology, Yale School of Medicine, New Haven, CT
Background/Purpose: The earliest autoantibodies in lupus are directed against the autoantigen Ro60, an RNA binding protein with orthologs that we identified in a subset of…
Abstract Number: 2849 • 2016 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus Patients with Antibodies Against U1-Ribonucleoprotein Exhibit a Specific Pattern of Disease Manifestations
David Fernandez¹, Mikhail Olferiev¹, Leila Khalili¹, Kyriakos A. Kirou² and Mary K. Crow¹, ¹Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies against nucleic acids and a variety of self-antigens. Recent work…
Abstract Number: 446 • 2016 ACR/ARHP Annual Meeting
A Multi-Group Confirmatory Factor Analyses of the Lupuspro Between Southern California and Filipino Samples of Patients with SLE
Desiree Azizoddin¹, R. Olmstead², Chelsie Cost³, Geraldine Zamora Racaza⁴, Julia Ayeroff⁵, Lekeisha Sumner⁶, Michael Weisman⁷, Perry M. Nicassio⁸ and Meenakshi Jolly⁹, ¹Department of Psychology, Loma Linda University, Loma Linda, CA, ²UCLA, Los Angeles, CA, ³Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, ⁴Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Postbaccalaureate Premedical Program, University of Southern California, Los Angeles, CA, CA, ⁶Department of Psychology, Cedars Sinai Medical Center, Los Angeles, CA, ⁷Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Cousins Center for PNI, UCLA, LA, CA, ⁹Rush, Chicago, IL
Background/Purpose: Systemic lupus erythematosus (SLE) leads to a variety of health outcomes through complex disease paths. The LupusPro (LP) is a comprehensive self-report measure which…
Abstract Number: 1175 • 2016 ACR/ARHP Annual Meeting
Thirty Day Readmission Rates for Patients Diagnosed with Systemic Lupus Erythematosus: Analysis at a Tertiary Care Center
Sadiq Ali¹, Stephen Mullis², Nkechi Emejuaiwe¹ and Dennis Ang¹, ¹Section on Rheumatology and Immunology, Wake Forest University, Winston Salem, NC, ²Department of Internal Medicine, Wake Forest University, Winston Salem, NC
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic illness that has been associated with high hospital readmission rates. Based on a recently published (Arth Rheumatol…
Abstract Number: 1838 • 2016 ACR/ARHP Annual Meeting
Antibodies Against Bacterial Products Curli/DNA Are Found in Lupus Patients and Are Associated with Disease Flares
Ryan Pachucki¹, Sarah Tursi², Chelsea Corradetti¹, Lynne Kohler³, Stefania Gallucci², Cagla Tukel² and Roberto Caricchio¹, ¹Medicine Rheumatology, Lewis Katz School of Medicine, Philadelphia, PA, ²Microbiology and Immunology, Lewis Katz School of Medicine, Philadelphia, PA, ³Lewis Katz School of Medicine, Philadelphia, PA
Background/Purpose: Bacterial infections are a major contributor to morbidity and mortality in SLE, a known trigger of flares and they are often difficult to distinguish…
Abstract Number: 2863 • 2016 ACR/ARHP Annual Meeting
High Frequency of Terminally Differentiated CD8+ T Cells Characterize Systemic Lupus Erythematosus Patients with Renal Involvement
Nataly Manjarrez-Orduño¹, Laurence Menard¹, Julie Carman¹, Suzanne Suchard¹, Francesca Casano¹, Deborah Lee¹, Sium Habte¹, Sherif Daouti², Selena Kansal³, Dana Banas³, Can Jiang³, Dawn Stetsko³, Mark Cunningham³, Vivek Jayaswal⁴, Somnath Bandyopadhyay³, Sarah Hu³, Richard A. Furie⁵ and Steven G. Nadler⁶, ¹Discovery Translational Sciences Group, Bristol-Myers Squibb, Princeton, NJ, ²Bristol-Myers Squibb, Princeton, NY, ³Bristol-Myers Squibb, Princeton, NJ, ⁴Biocon Bristol-Myers Squibb Research Center, Bangalore, India, ⁵Division of Rheumatology, Northwell Health, Great Neck, NY, ⁶Immunosciences Translational Research, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: SLE is a highly heterogeneous disease. The identification of disease subtypes with different pathological mechanisms is crucial to identify subjects with different disease progression…
Abstract Number: 743 • 2016 ACR/ARHP Annual Meeting
Long-Term Hydroxychloroquine Therapy and Low-Dose Aspirin May Have an Additive Effectiveness in the Primary Prevention of Cardiovascular Events in Patients with Systemic Lupus Erythematosus
Serena Fasano¹, Michele Iudici², Ilenia Pantano³, Luciana Pierro³ and Gabriele Valentini⁴, ¹Internal and Experimental Medicine Naples, Italy, Rheumatology Unit, Second University of Naples, Naples, Italy, ²National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ³Rheumatology Unit, Second University of Naples, Naples, Italy, ⁴Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy
Background/Purpose: Hydroxychloroquine (HCQ) is a mainstay of treatment in patients with SLE. It has been demonstrated to reduce disease activity and prevent damage accrual and…

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