Abstracts tagged "Lupus"

Abstract Number: 2636 • 2017 ACR/ARHP Annual Meeting
EZH2 Modulates the DNA Methylome and Controls T Cell Adhesion through Junctional Adhesion Molecule-a in Lupus Patients
Pei-Suen Tsou¹, Patrick Coit¹, Nathan Kilian² and Amr H Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: EZH2 is an epigenetic regulator that trimethylates lysine 27 of histone 3 (H3K27me3) and modulates DNA methylation patterns. We have previously suggested that EZH2…
Abstract Number: 678 • 2017 ACR/ARHP Annual Meeting
Systemic Hypertension Is Associated with Presence of Vascular Injury on Lupus Nephritis Renal Biopsies: A Retrospective Cohort Study
Cianna Leatherwood, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Vascular injury in lupus nephritis is often described on renal biopsy, but its clinical correlates are not well understood. Recent evidence suggests it may…
Abstract Number: 1296 • 2017 ACR/ARHP Annual Meeting
Hydroxychloroquine Level Decreases throughout Pregnancy: Implications for Maternal and Neonatal Outcomes
Stephen Balevic¹, Michael Cohen-Wolkowiez², Amanda M. Eudy³, Laura E. Schanberg⁴ and Megan E. B. Clowse⁵, ¹Rheumatology, Adult and Pediatric, Duke University Medical Center, Durham, NC, ²Pharmacometrics Center, Duke Clinical Research Institute, Durham, NC, ³Duke University Medical Center, Chapel Hill, NC, ⁴Pediatrics, Duke University Medical Center, Durham, NC, ⁵Duke University Medical Center, Durham, NC
Background/Purpose: Pregnancies in women with active rheumatic disease often result in poor neonatal outcomes. Prior data suggests that hydroxychloroquine (HCQ) can reduce disease activity and…
Abstract Number: 1861 • 2017 ACR/ARHP Annual Meeting
Evaluation of a Longstanding Telephone Peer Counseling Service on People with Systemic Lupus Erythematosus and Their Loved Ones
Priscilla Toral¹, Melissa T. Flores¹, Roberta Horton¹ and Jillian Rose², ¹Social Work Programs, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY
Background/Purpose: Studies show telephone peer support has been used to address a range of health concerns in people living with chronic illness. A phone evaluation…
Abstract Number: 2655 • 2017 ACR/ARHP Annual Meeting
Contribution of Monocytes to Circulating microRNAs Related to Cardiovascular Disease in Systemic Lupus Erythematosus. Effects of In Vivo Treatment with Rituximab
Carlos Perez-Sanchez¹, Irene Cecchi², Massimo Radin³, Maria Ángeles Aguirre Zamorano¹, Patricia Ruiz-Limon⁴, Nuria Barbarroja¹, Yolanda Jiménez-Gómez¹, Maria Carmen Abalos-Aguilera⁴, Ivan Arias de la Rosa⁴, Eduardo Collantes-Estévez¹, Maria Jose Cuadrado⁵, Savino Sciascia⁶ and Chary Lopez-Pedrera¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ³Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁴Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁵Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, ⁶Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy
Background/Purpose: Despite emerging data on disease-specific associations for various blood- and plasma-derived miRNAs, consensus is lacking as to whether a cellular, extracellular, or a mixed…
Abstract Number: 679 • 2017 ACR/ARHP Annual Meeting
Distinct Interferon Scores Are Separately Associated with Activity and Long Term Sequelae in SLE
Katherine Dutton¹, Antonios Psarras², Md Yuzaiful Md Yusof², Paul Emery³, Yasser M El-Sherbiny⁴ and Edward M Vital¹, ¹University of Leeds, Leeds, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁴NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals, NHS Trust, Leeds, United Kingdom
Background/Purpose: Type I interferon (IFN-I) has a crucial role in the pathogenesis and activity of Systemic Lupus Erythematosis (SLE). IFN-I targeted therapies are currently in…
Abstract Number: 1304 • 2017 ACR/ARHP Annual Meeting
Lack of Uptake of Prophylactic Human Papilloma Virus (HPV) Vaccination Among Women with SLE in Saginaw Valley, a High Risk Population
J. Patricia Dhar^1,2, Lynnette Essenmacher³, Renee Dhar⁴, Neli Ragina⁵ and Robert Sokol⁶, ¹Internal Medicine, Wayne State University School of Medicine, Detroit, MI, ²Internal Medicine, Central Michigan University College of Medicine, Saginaw, MI, ³Wayne State University School of Medicine, Detroit, MI, ⁴CMED medical student, Central Michigan University College of Medicine, Mt. Pleasant, MI, ⁵Foundational Sciences, Central Michigan University College of Medicine, Mount Pleasant, MI, ⁶Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, MI
Background/Purpose: Women with SLE are at increased risk for cervical neoplasia likely due to infection with high risk (HR) HPV and thus should be considered…
Abstract Number: 1862 • 2017 ACR/ARHP Annual Meeting
Association between Hydroxychloroquine Nonadherence and Adverse Outcomes Among Patients with Systemic Lupus Erythematosus
Candace H. Feldman¹, Zhi Zhang², Rishi J. Desai³, Tzu-Chieh Lin⁴, Jamie E. Collins⁵, S.V. Subramanian⁶, Ichiro Kawachi⁷, Daniel H. Solomon⁸ and Karen H. Costenbader⁴, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³PharmacoEpidemiology & PharmacoEconomics, Brigham & Women's Hospital, Boston, MA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham & Women's Hospital, Boston, MA, ⁶Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, ⁷Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, ⁸Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Prior observational studies suggest that SLE patients receiving hydroxychloroquine (HCQ) may have reduced risk of infections, cardiovascular disease and end-stage renal disease (ESRD). However,…
Abstract Number: 2715 • 2017 ACR/ARHP Annual Meeting
NKTR-358: A Selective, First-in-Class IL-2 Pathway Agonist Which Increases Number and Suppressive Function of Regulatory T Cells for the Treatment of Immune Inflammatory Disorders
John Langowski, Peter Kirk, Murali Addepalli, Thomas Chang, Vidula Dixit, Grace Kim, Yolanda Kirksey, Peiwen Kuo, Myong Lee, Mekhala Maiti, Werner Rubas, Paul Sims, Yuan Song, Yinyan Tang, Laurie VanderVeen, Ping Zhang, Stephen Doberstein and Jonathan Zalevsky, Nektar Therapeutics, San Francisco, CA
Background/Purpose: Impaired IL-2 production and regulatory T cell (Treg) dysfunctions have been implicated as an immunological mechanism in multiple autoimmune diseases. While low-dose IL-2 can…
Abstract Number: 699 • 2017 ACR/ARHP Annual Meeting
Impact of Anti-RBP Antibodies on Disease Activity and Quality-of-Life in Immunosuppressant Naive Systemic Lupus Erythematosus
Rene Bermea¹, Tammy Utset² and Kichul Ko³, ¹Medicine, University of Chicago, Chicago, IL, ²Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, ³Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL
Background/Purpose: There is a lack of phenotypic data on SLE patients who have never been on immunosuppressive therapy. Anti-RNA binding protein (anti-RBP) antibodies (anti-Smith, anti-RNP,…
Abstract Number: 1586 • 2017 ACR/ARHP Annual Meeting
Resistant Hypertension Is Associated with Inflammation, Renal Function, and Increased Mortality in Patients with Systemic Lupus Erythematosus
Jocelyn Gandelman¹, Megan Shuey², April Barnado³, Li Wang⁴, C. Michael Stein³ and Cecilia P. Chung³, ¹Vanderbilt University School of Medicine, Nashville, TN, ²Department of Pharmacology, Vanderbilt University, Nashville, TN, ³Medicine, Vanderbilt University Medical Center, Nashville, TN, ⁴Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Resistant hypertension (RHTN) is defined as blood pressure that remains >140/90 mm Hg despite concurrent use of three different antihypertensive drugs. RHTN has an…
Abstract Number: 1953 • 2017 ACR/ARHP Annual Meeting
Dietary Quality and Risk of SLE in the Nurses’ Health Studies
Medha Barbhaiya¹, Bing Lu¹, Sara K. Tedeschi², Susan Malspeis³, Jeffrey A. Sparks⁴, Walter C. Willett^5,6, Elizabeth Karlson⁷ and Karen H. Costenbader⁷, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy,, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Department of Nutrition, Harvard School of Public Health, Boston, MA, ⁷Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Prior studies suggest that high intake of antioxidants, fish, olive oil, and nuts may decrease risk of chronic inflammatory diseases and reduce inflammatory biomarkers.…
Abstract Number: 2810 • 2017 ACR/ARHP Annual Meeting
The Impact of Psychiatric Comorbidity on Health Care Utilization for Youth with Systemic Lupus Erythematosus
Andrea M. Knight^1,2, Alaina M. Davis³, Marisa S. Klein-Gitelman⁴, Zuleyha Cidav⁵ and David Mandell⁶, ¹Division of Rheumatology, Center for Pediatric Clinical Effectiveness & PolicyLab, Children's Hospital of Philadelphia, Philadelphia, PA, ²Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ³Pediatric Rheumatology, Monroe Carell Junior Children's Hospital at Vanderbilt, Division of Pediatric Rheumatology, Nashville, TN, ⁴Division of Pediatric Rheumatology/PDD PTD, Lurie Children's Hospital of Chicago/Northwestern University, Chicago, IL, ⁵Perelman School of Medicine, Center for Mental Health Policy and Services Research, University of Pennsylvania, Philadelphia, PA, ⁶Psychiatry and Pediatrics, Center for Mental Health Policy and Services Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Background/Purpose: Youth with systemic lupus erythematosus (SLE) have high health care utilization, which may be exacerbated by psychiatric disorders, a common comorbidity in this group.…
Abstract Number: 832 • 2017 ACR/ARHP Annual Meeting
Single Cell Analysis Reveals Heterogeneity of Type I IFN Gene Expression in Developing Autoreactive B Cells
Jennie Hamilton¹, PingAr Yang², Qi Wu³, Bao Luo⁴, Shanrun Liu⁵, Jun Li⁶, Mark Walter⁷, Eleanor Fish⁸, Hui-Chen Hsu³ and John D. Mountz⁹, ¹Medicine/Division of Clinical Immunology and Rhematology, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, ⁶Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Microbiology, University of Alabama at Birmingham, Birmingham, AL, ⁸University Health Network & Department of Immunology, University of Toronto, Toronto General Research Institute, Toronto, ON, Canada, ⁹University of Alabama at Birmingham, Department of Medicine, Birmingham, AL
Background/Purpose: B cell development involves passage through a formative transitional B cell stage in the spleen. In SLE, self-nucleic acid reactive B cells fail to…
Abstract Number: 1596 • 2017 ACR/ARHP Annual Meeting
Effect of the Metabolic Syndrome on Organ Damage, Renal Function and Mortality in Patients with Systemic Lupus Erythematosus: A Longitudinal Analysis
Chi Chiu Mok¹, Sau Mei Tse¹ and Ling Yin Ho², ¹Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Dept of Medicine, Tuen Mun Hospital, Hong Kong SAR, Hong Kong
Background/Purpose: To study the effect of the metabolic syndrome (MetS) on organ damage, renal function and mortality in patients with SLE. Methods: Consecutive patients who…

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