Abstracts tagged "Lupus nephritis"

Abstract Number: 0772 • ACR Convergence 2025
Redefining When to Biopsy the Kidney in Patients with SLE
Michelle Petri¹, Andrea Fava², Mohamed Atta³, Avi Rosenberg³, Sanchit Sanyal³, Peter Izmirly⁴, Erin Carter⁵, Mala Masson⁶, Michael Belmont⁷, Jennifer Barnas⁸, Jennifer Anolik⁹, Brad Rovin¹⁰ and Jill Buyon⁴, ¹Johns Hopkins University School of Medicine, Timonium, MD, ²Johns Hopkins University, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴NYU Grossman School of Medicine, New York, NY, ⁵New York University Grossman School of Medicine, New York, NY, ⁶NYU Langone Medical Center- Division of Rheumatology, New York, NY, ⁷NYU Langone Health, New York, NY, ⁸University of Rochester, Rochester, NY, ⁹University of Rochester Medical Center, Rochester, NY, ¹⁰The Ohio State University, Columbus, OH
Background/Purpose: Current ACR, EULAR and KDIGO guidelines recommend kidney biopsy in SLE patients with urine protein to creatinine (UPCR) ratio of >= 0.50 g/g. However,…
Abstract Number: 2698 • ACR Convergence 2025
Comparative Efficacy of Tacrolimus-Based Induction Therapy with and without Mycophenolate Mofetil in Lupus Nephritis: A Target Trial Emulation Study
Yun Kyu Kim¹, Hajeong Lee², Jun Won Park³, Eun Bong Lee³, You-Jung Ha⁴ and Jin Kyun Park², ¹Seoul National University, Seoul, Republic of Korea, ²Seoul National University Hospital, Seoul, Republic of Korea, ³Seoul National University Hospital, Seoul, South Korea, ⁴Seoul National University Bundang Hospital, Seongnam, South Korea
Background/Purpose: The efficacy of calcineurin inhibitors in the induction treatment of lupus nephritis (LN) has been increasingly supported by recent studies. Based on these findings,…
Abstract Number: 2410 • ACR Convergence 2025
Immune Cell/Pathway-Specific Polygenic Risk Scores Reveal Immune Pathway Associations in Childhood-Onset Lupus Nephritis
Liyoung Kim¹, Daniela Fernandez-Salinas², Gonzalo Villanueva Martin³, Vitor Aguiar³, Laura Lewandowski⁴, Tiphanie Vogel⁵, Carola Vinuesa⁶, Linda Hiraki⁷, Tracey Wright⁸, Virginia Pascual⁹, Joyce Chang², Maria Gutierrez-Arcelus² and Peter Nigrovic¹, ¹Boston Children's Hospital, Brookline, MA, ²Boston Children's Hospital, Boston, MA, ³Boston Children's Hospital, Boston, ⁴NIAMS, NIH, Bethesda, MD, ⁵Baylor College of Medicine, Houston, TX, ⁶Francis Crick Institute, London, United Kingdom, ⁷The Hospital for Sick Children, Toronto, ON, Canada, ⁸UT Southwestern, Children's Medical Center, and Scottish Rite for Children, Dallas, TX, ⁹Weill Cornell Medical College, New York, NY
Background/Purpose: Polygenic risk scores (PRS) quantify an individual’s genetic susceptibility to diseases by integrating genotype data across multiple loci. However, conventional PRS are limited in…
Abstract Number: 1830 • ACR Convergence 2025
Single-Cell and Spatial Profiling Reveal Proinflammatory and Profibrotic Fibroblast-Macrophage Niches in Lupus Nephritis
Chirag Raparia¹, Paul Hoover², Nir Hacohen³, Arnon Arazi⁴ and Anne Davidson¹, ¹Feinstein Institutes for Medical Research, Manhasset, NY, ²Brigham and Women's Hospital, Boston, MA, ³Broad Institute of MIT Harvard, Cambridge, MA, ⁴Feinstein Institutes for Medical Research, Acton, MA
Background/Purpose: Lupus nephritis (LN) is a severe complication of SLE that can progress to chronic kidney disease, renal fibrosis, and eventual renal failure. Fibroblasts activated…
Abstract Number: 1513 • ACR Convergence 2025
Race, Renal Failure, and Risk: A five-to-ten year retrospective cohort study of Racial differences in outcomes of patients with dialysis-dependent Lupus nephritis
Ufuoma Mamoh¹, Queeneth Edwards², Chukwuemelie Okeke³, Justin Riley Lam⁴, Soziema Salia⁵ and Christhopher Haas⁶, ¹Medstar Health Georgetown University Internal Medicine Residency Program, Baltimore, MD, ²Georgia Southern University, Statesboro, GA, ³Maimonides Medical Center, Brooklyn, NY, ⁴Albert Einstein Medical Center, Philadelphia, PA, ⁵MedStar Health Georgetown University (Baltimore) Internal Medicine Program, Baltimore, MD, ⁶MedStar Health Georgetown University (Baltimore) Internal Medicine Program, Baltimore
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that disproportionately affects racial and ethnic minority populations, particularly Black/African American and Hispanic/Latino individuals. In…
Abstract Number: 0940 • ACR Convergence 2025
Resident Macrophages Localize Near Fibroblasts and Drive Reprogramming in Lupus Nephritis Through Direct and Soluble Signaling
Chirag Raparia¹, Paul Hoover², Arnon Arazi³, Nir Hacohen⁴ and Anne Davidson¹, ¹Feinstein Institutes for Medical Research, Manhasset, NY, ²Brigham and Women's Hospital, Boston, MA, ³Feinstein Institutes for Medical Research, Acton, MA, ⁴Broad Institute of MIT Harvard, Cambridge, MA
Background/Purpose: Lupus nephritis (LN) is a severe manifestation of SLE that can progress to renal fibrosis, and eventual renal failure. In LN, tubulointerstitial inflammation and…
Abstract Number: 0620 • ACR Convergence 2025
The usefulness of neutrophil-to-lymphocyte ratio as a biomarker to predict lupus flares in patients under remission
Luis Daniel Fajardo Hermosillo and María Karina Lizbeth López Ramírez, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, GUADALAJARA, Jalisco, Mexico
Background/Purpose: Remission in Systemic Lupus Erythematosus (SLE) is described by the Definition of Remission in SLE (DORIS), but it is hardly achieved in clinical practice,…
Abstract Number: 0373 • ACR Convergence 2025
Implementation of a Lupus Self-Management mHealth App: Using Incentives to Drive Engagement
Melissa French¹, Katherine Carpenter², Eric Johnson², Melicent Miller² and Mary Crimmings², ¹Lupus Foundation of America, Alexandria, VA, ²Lupus Foundation of America, Washington, DC
Background/Purpose: As part of a five-year cooperative agreement with the Centers for Disease Control and Prevention, the Lupus Foundation of America (LFA) has implemented the…
Abstract Number: 2600 • ACR Convergence 2025
Deconstructing Lupus Nephritis Kidney Tissue at Single-Cell Resolution
Nicholas Sugiarto¹, Michelle Curtis², Siddarth Gurajala², Thomas Eisenhaure³, Qian Xiao⁴, Joseph Mears⁵, Arnon Arazi⁶, Paul Hoover⁷, Celine Berthier⁸, Saori Sakaue⁹, Andrea Fava¹⁰, David Hildeman¹¹, E. Steve Woodle¹², Brad Rovin¹³, Jennifer Barnas¹⁴, Maria Dall'Era¹⁵, Chaim Putterman¹⁶, Diane Kamen¹⁷, Maureen McMahon¹⁸, Jennifer Grossman¹⁹, Kenneth Kalunian²⁰, Jeffrey Hodgin²¹, Fernanda Payan Schober²², Mariko Ishimori²³, Michael Weisman²³, William Apruzzese²⁴, Joel Guthridge²⁵, Michael Brenner²⁶, Jennifer Anolik²⁷, David Wofsy²⁸, Judith James²⁵, Deepak Rao⁷, Anne Davidson²⁹, Michelle Petri³⁰, Jill Buyon³¹, Nir Hacohen³², Betty Diamond³³ and Soumya Raychaudhuri⁷, ¹Harvard Medical School, Brookline, MA, ²Harvard Medical School, Boston, ³Broad Institute, Cambridge, MA, ⁴Harvard Medical School, Boston, MA, ⁵Michigan University, Ann Arbor, MI, ⁶Feinstein Institutes for Medical Research, Acton, MA, ⁷Brigham and Women's Hospital, Boston, MA, ⁸University of Michigan, Ann Arbor, MI, ⁹University of Washington, Yokohama, Japan, ¹⁰Johns Hopkins University, Baltimore, MD, ¹¹Cincinnati Children's Hospital, Cincinnati, OH, ¹²UC Health, Cincinnati, ¹³The Ohio State University, Columbus, OH, ¹⁴University of Rochester, Rochester, NY, ¹⁵Division of Rheumatology, University of California, San Francisco, CA, ¹⁶Albert Einstein College of Medicine, Safed, Israel, ¹⁷Medical University of South Carolina, Johns Island, SC, ¹⁸UCLA David Geffen School of Medicine, Los Angeles, CA, ¹⁹UCLA, Sherman Oaks, CA, ²⁰UC San Diego, La Jolla, CA, ²¹University of Michigan, Ann Arbor, ²²TTUHSC, El Paso, TX, ²³Cedars-Sinai Medical Center, Los Angeles, CA, ²⁴Pfizer, Boston, ²⁵Oklahoma Medical Research Foundation, Oklahoma City, OK, ²⁶Brigham and Women's Hospital, Harvard Medical School, Newton, MA, ²⁷University of Rochester Medical Center, Rochester, NY, ²⁸University of California San Francisco, SF, CA, ²⁹Feinstein Institutes for Medical Research, Manhasset, NY, ³⁰Johns Hopkins University School of Medicine, Timonium, MD, ³¹NYU Grossman School of Medicine, New York, NY, ³²Broad Institute of MIT Harvard, Cambridge, MA, ³³The Feinstein Institutes for Medical Research, Manhasset, NY
Background/Purpose: Lupus nephritis (LN) is a heterogeneous disease driven by diverse immune and tissue cell types. We defined the cell states in the tissue and…
Abstract Number: 2403 • ACR Convergence 2025
Differential Risk of Inpatient Admissions Among SLE Subgroups: A Population-Based Analysis
Jaime Flores-Gouyonnet¹, Erika Navarro-Mendoza¹, Mario Bautista-Vargas¹, Ali Ardekani¹, Maria Cuellar-Gutierrez¹, Gabriel Figueroa-Parra², Mariana Gonzalez-Treviño³, Alain Sanchez-Rodriguez⁴, Andrew C. Hanson¹, Cassondra Hulshizer⁵, Cynthia Crowson⁶ and Ali Duarte-Garcia¹, ¹Mayo Clinic, Rochester, MN, ²Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, ³Vanderbilt University Medical Center, Nashville, TN, ⁴ABC Medical Center, Ciudad de México, Federal District, Mexico, ⁵Mayo Clinic, Rochester, ⁶Mayo Clinic, Stewartvillle, MN
Background/Purpose: SLE is clinically heterogeneous and associated with increased hospitalizations. However, it remains unclear which patient subgroups drive this excess in unplanned healthcare use. We…
Abstract Number: 1814 • ACR Convergence 2025
Trapped in the NET: Impaired DNase function and targeted antibodies in the pathogenesis of pediatric lupus nephritis
Sohei Makita¹, Joyce Hui-Yuen², Bharati Matta³, Betsy Barnes⁴, Jenna Battaglia⁵, Tatiana Borja⁶, Boris Reizis⁷, Lydia Thomas⁸ and Kim Simpfendorfer⁹, ¹NYU, New York, ²North Shore LIJ Health System, Great Neck, NY, ³The Feinstein Institutes for Medical Research, Manhasset, NY, ⁴Northwell Health, Manhasset, NY, ⁵Northwell Health, Manhasset, ⁶Northwell Health- Cohen Children’s Medical Center, Elmhurst, NY, ⁷New York University Grossman School of Medicine, New York, NY, ⁸Northwell Health - Cohen Children's Medical Center, Lake Success, NY, ⁹Feinstein Institutes for Medical Research, Manhasset, NY
Background/Purpose: Up to 80% of patients with pediatric systemic lupus erythematosus (pSLE) can present with renal abnormalities. Treatment of pSLE is often difficult and includes…
Abstract Number: 1499 • ACR Convergence 2025
Predictors of Proteinuria Flares in Biopsy Positive Lupus Nephritis
Michelle Petri¹, Andrea Fava², Daniel Goldman¹ and Laurence Magder³, ¹Johns Hopkins University School of Medicine, Timonium, MD, ²Johns Hopkins University, Baltimore, MD, ³University of Maryland, Baltimore, Baltimore, MD
Background/Purpose: Over 20% of lupus nephritis (LN) patients progress to end stage kidney disease. One of the most important predictors is renal flare.Methods: The analysis…
Abstract Number: 0913 • ACR Convergence 2025
Potent and Selective Oral IRF5 Degrader, KT-579, Demonstrates In Vitro and In Vivo Activity Comparable or Superior to Approved or Clinically Active Agents in Human Cellular Assays and Lupus Efficacy Models
Veronica Campbell¹, Yi Zhang¹, Virginia Massa¹, Jordan Leedberg¹, Erik Corcoran¹, Emily Lurier¹, Ryan Camire², Chris Carroll¹, Chris Ho¹, Dapeng Chen¹, Bradley Enerson¹, Revonda Mehovic¹, Ziyan Zhao¹, Lincoln Howarth¹, Susanne Breitkopf¹, Sarah Martinez¹, Melissa Ford¹, Xue Fei¹, Murugappan Sathappa¹, Juliet Williams³, Matthew Weiss³, Arsalan Shabbir³ and Nello Mainolfi⁴, ¹Kymera Therapeutics, Watertown, MA ⁰²⁴⁷², ²Kymera Therapeutics, Watertown, MA ⁰²⁴⁷², MA, ³Kymera Therapeutics, Watertown, ⁴Kymera Therapeutics, Watertown, MA
Background/Purpose: IRF5 is a transcription factor and regulator of immune responses activated downstream of pattern recognition receptors, in particular endosomal toll-like receptors (TLR), TLR7, TLR8…
Abstract Number: 0618 • ACR Convergence 2025
Therapeutic landscape of systemic lupus erythematosus pure membranous nephropathy: a nationwide population-based study
Kevin Chevalier¹, Romain Brousse², alexandre karras³, Nathalie Costedoat-Chalumeau⁴, Julien Dang⁵, Maxence Taillar⁶, Noémie JOURDE-CHICHE⁶, Charles Ronsin⁷, Moglie Le Quintrec-Donnette⁸, Marie Julien⁹, Antoine Huart¹⁰, Aymeric Couturier¹¹, Pierre Pommerolle¹², Céline Lebas¹³, Antoine Coussement¹⁴, Marion Chapal¹⁵, Christophe Barba¹⁶, Alexia Gauffre¹⁷, Maxime Teisseyre¹⁸, Johan Noble¹⁹, Chloé Comarmond²⁰, Eve Vilaine²¹, Jean-François Augusto²², Aurélie Hummel²³, Evangeline Pillebout²⁴, Jean-Michel Halami²⁵, Olivier Moranne²⁶, Eric Daugas²⁷, Jean-Jacques Boffa² and Emmanuel Esteve², ¹Université Paris Cité, Montrouge, France, ²Tenon hospital, Paris, France, ³HEGP - assistance publique hopitaux de paris, paris, France, ⁴Cochin hospital, Paris, France, ⁵Bicêtre hospital, Kremlin Bicêtre, France, ⁶Centre de Néphrologie et Transplantation Rénale, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France., Marseille, France, ⁷Department of Nephrology and Immunology, Nantes University Hospital, Nantes, France., Nantes, France, ⁸Service de Néphrologie-Soins Intensifs-Dialyse et Transplantation, Hôpital Lapeyronie, Montpellier, France., Montpellier, France, ⁹Service de néphrologie, CHU de la Réunion, Saint-Denis, France., Saint-Denis, France, ¹⁰Département de Néphrologie et Transplantation d’Organes, Axe Transplantation – Immunité – Environnement, CHU de Toulouse, France, Toulouse, France, ¹¹Nephrology Unit, American Hospital of Paris, Neuilly-sur-Seine, France, Neuilly-sur-seine, France, ¹²Department of Nephrology, Dialysis, and Transplantation, University of Picardie Jules Verne, Amiens University Hospital, Amiens, France., Amiens, France, ¹³Service de Néphrologie et Transplantation rénale, Centre Hospitalier Régional Universitaire de Lille, Lille, France., Lille, France, ¹⁴Service de Néphrologie, CHU de Dijon, Dijon, France., Dijon, France, ¹⁵Departement of Nephrology, Hospital of Vendée, La Roche-Sur-Yon, ⁸⁵⁰⁰⁰, France., La Roche-sur-yon, France, ¹⁶Department of Nephrology and Nutrition, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre- Bénite, France, Lyon, France, ¹⁷Service de néphrologie, CHU de Rouen, Rouen, France, Rouen, France, ¹⁸Département de Néphrologie, Dialyse et Transplantation, CHU de Nice, Université Côte d'Azur, France., Nice, France, ¹⁹Department of Nephrology, Grenoble-Alpes University Hospital, Grenoble, France., Grenoble, France, ²⁰Internal Medicine Department, Département Médico-Universitaire INVICTUS, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris (APHP).Nord-Université Paris-Cité, ⁷⁵⁰¹⁰ Paris, France., Paris, France, ²¹Ambroise Paré hospital, Boulogne, France, ²²Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, CHU Angers, Angers, France., Angers, France, ²³Department of Nephrology, Necker-Enfants Malades Hospital, APHP, Paris, France., Paris, France, ²⁴Nephrology Unit, Saint Louis Hospital, Paris, France., Paris, France, ²⁵Department of Nephrology, UMR¹³²⁷ ischemia, INI-CRCT, Tours University Hospital, Tours University, Tours, France., Tours, France, ²⁶Service de Néphrologie, dialyse et aphérèse, CHU de Nîmes, IDESP Universite de Montpellier, France, Montpellier, France, ²⁷Department of Nephrology, Hospital Bichat - Claude-Bernard, Paris, France
Background/Purpose: Renal involvement is a major prognostic factor in systemic lupus erythematosus. Pure lupus membranous nephropathy (PLMN, class V) represents 5–20% of lupus nephritis cases,…
Abstract Number: 0136 • ACR Convergence 2025
Beyond Thrombosis: Histological Spectrum, Predictors and Outcomes of Renal Involvement in Primary Antiphospholipid Syndrome: A Single-Centre Cohort Study
RITESH KUMAR MISHRA¹, SUBIN PHILIP², RIZWANA NAUSHAD², AISHWARYA GOPAL³, Chengappa Kavadichanda², CHRISTINA MARIASELVAM², RAJESH N G², Molly mary Thabah³ and VIR SINGH NEGI², ¹JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH, Bhubaneswar, India, ²JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH, PUDUCHERRY, Puducherry, India, ³JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH, PUDUCHERRY, India
Background/Purpose: Renal involvement in primary APS is underrecognized and histologically diverse, encompassing both vascular and glomerular pathology. We aimed to describe the histopathology, outcomes of…

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